A Biffin’s research while affiliated with Newport Hospital and other places

... It can be classified anatomically as supra-renal, juxta-renal or infrarenal in relation to the renal arteries, with infra-renal AAA being the most common. Rupture of a AAA is associated with a mortality rate of between 65% and 85% resulting in up to 8,000 deaths annually in the UK with approximately half of the deaths attributed to rupture occurring before the patient reaches hospital (Basnyat et al., 1999;Ashton et al., 2002). ...

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Cardiorespiratory fitness is impaired and predicts mid-term postoperative survival in patients with abdominal aortic aneurysm disease

... Synchronous liver metastases (LM) occur in approximately 20% of patients, while nearly 50% will develop them during the course of their illness. 2 Surgical resection is considered the most effective treatment option for LM, but only a subset of patients are candidates for resection, depending on factors such as tumor size, number, location, and liver function. Neoadjuvant chemotherapy (CT) significantly improves the prognosis of resectable cases and can make initially unresectable lesions amenable to surgery. 3 The pathological response of LM to neoadjuvant therapy is a crucial prognostic factor for recurrence and survival. ...

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Liver metastases from colorectal carcinoma: performance of pathological response scores

... During early 2000s, the underestimation of incidence rates of pathology-based cancer registration led to the the completeness of pathology reports. Ambiguity and incomplete reporting of pathology findings may adversely affect the clinical outcomes (12). ...

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Completeness of Colorectal Cancer Pathology Reports in Iranian National Population-Based Cancer Registry System

... However, there is still an ongoing debate on the appropriate management of recurrent CRC patients. Although there is an opinion supporting aggressive management of these patients to improve the outcome, another strategy is the intensive follow-up of the patients [3,8]. Thus, establishing the role of FDG PET-CT in predicting survival outcomes of recurrent CRC patients can help to clarify the most efficient management protocol. ...

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Prognostic value of FDG PET-CT in suspected recurrence of colorectal carcinoma: survival outcomes of a 10-year follow-up: FDG PET in recurrent colorectal CA

... Preoperative risk assessment plays a crucial role in predicting postoperative outcomes and guiding perioperative management. The American Society of Anaesthesiologists (ASA) classification, combined with the urgency and complexity of the surgery, has been shown to correlate with postoperative morbidity and mortality [1,2]. ...

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Pre-operative Serum Albumin as a Predictor of Adverse Outcomes in Open Abdominal Surgery: A Retrospective Study in Central Queensland

... Fixed risk factors include advancing age, with risk increasing by 40% every 5 years after the age of 65 years, being male (male to female ratio, 6:1) and having a positive family history, notably first degree male family members. Modifiable risk factors include smoking, hypertension and hypercholesterolaemia (Basnyat et al. 1999). Approximately 2–20% of AAAs are classified as juxtarenal (JR) if their proximal extent is close to the origin of the renal arteries but does not involve them (Crawford et al. 1986). ...

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Intervisceral artery origins in patients with abdominal aortic aneurysmal disease; evidence for systemic vascular remodeling

... Despite being typically asymptomatic, AAA is prone to rupture, 1 leading to devastating consequences with a mortality rate of nearly 80%. 2,3 The risk of AAA is associated with hypertension, atherosclerosis, smoking, and family history. [4][5][6] Given the stealthy nature of AAA symptoms and the lifethreatening complications associated with it, there is an urgent need for early prevention strategies focusing on modifiable risk factors. ...

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Sleep Pattern, Genetic Susceptibility, and Abdominal Aortic Aneurysm in UK Biobank Participants

... In addition to oncologists, other clinical staff such as surgeons and general physicians may need to interpret cancer pathology reports; these reports should therefore be readily comprehensible. 7 According to the 7 th edition of the TNM Staging Classification for carcinoma of the stomach, at least 15 LNs must be surgically resected and evaluated by a pathologist. Unfortunately only two reports (3.5%) in our study had sufficient LNs. ...

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The Accuracy of Sentinel Lymph Node Biopsy Compared with Axillary Lymph Node Dissection in Breast Cancer

... Therefore, it may indeed be reasonable to assign greater priority to the anonymity of ratings, as is currently the case in the " Connect " community. The fact that certain individuals did not hesitate to exert pressures on editors to disclose the identity of raters who negatively rated their contributions [41] lends additional support to the stated conclusion. ...

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Four Questions on Complexity and Learning

... However, survival is poor, with only approximately 40% alive 2 years after surgery 3,4 . Rates of surgical intervention vary [5][6][7][8] but in the UK are as low as 25% of all cases 8 . ...

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Quality assurance of the SCOPE 1 trial in oesophageal radiotherapy