Soodabeh Zandi's research while affiliated with Government of British Columbia, Canada and other places
Publications (5)
Fluorescence signals depend on the intensity of the exciting light, the absorption properties of the constituent molecules, and the efficiency with which the absorbed photons are converted to fluorescence emission. The optical features and appearance of vitiligo have been explained primarily on the basis of reduced epidermal pigmentation, which res...
One-photon absorption based traditional laser treatment may not necessarily be selective at the microscopic level, thus could result in un-intended tissue damage. Our objective is to test whether two-photon absorption (TPA) could provide highly targeted tissue alteration of specific region of interest without damaging surrounding tissues. TPA based...
Laser (or light) hair removal, also referred to as photoepilation, is the most commonly used laser or light-based cosmetic medical procedure. The extended theory of selective photothermolysis is the basic principle for destruction of hair follicles using light. In this type of laser application the chromophore is follicular melanin. Several types o...
High intensity long-wavelength ultraviolet A (340-400 nm; UVA1) lamps were initially developed as skin research tools; over time they have proven to be useful for treating a number of chronic dermatoses. UVA1 units and dosimetry are strikingly different from conventional UV phototherapy. The therapeutic effect of UVA1 is related to the fact that it...
Cutaneous autofluorescence properties were systematically studied using fluorescence excitation emission matrix spectroscopy. Twenty-six healthy subjects with a mean age of 34 (range 21-74) participated in this study. The fluorescence of major skin fluorophores such as tryptophan, collagen, elastin and NADH could be readily identified. On average,...
Citations
... This absorption is also restricted to the focal point only because, outside of this site, the power density is low. In preliminary work, we have demonstrated multiphoton absorptionbased photothermolysis through experiments with ex vivo tissue samples (19,20). We refer to this approach as spatially selective photothermolysis (SSP) to distinguish it from the conventional singlephoton absorption-based CSP. ...
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... The most common minor side effects of UVA1 phototherapy are hyperpigmentation, redness, dryness, pruritus and recrudescence of a herpes simplex infection [8,9]. Most notably, the frequency of UV induced burning and erythema seems to be lower for UVA1 than for the conventional UVB or PUVA [10]. Whereas the major side effects of UVB phototherapy include the skin aging, local and systemic immunosuppression as well as development of melanoma and non-melanoma skin cancer [11,12]. ...
... The one-photon emission spectrum of NADH was measured using a separate spectrofluorometer equipped with two double-grating monochromator. 19 In Fig. 4(b), before calibration, the peak of the two-photon fluorescence emission is at 480 nm, and after calibration the peak is shifted to 450 nm. The overlap of the oneand two-photon emission spectra over the whole wavelength range indicates that our calibration method is correct. ...
... In these experiments, extreme heating was not desired as continuous exposure of the skin to high temperatures (>48 °C) has been a factor for hair loss 46 . Thermolysis destroys the HF cells and is, in fact, an approach used in laser photoepilation, aiming to remove unwanted hair 47 . In order to avoid damage to the HF and body thermoregulatory responses (above 40 °C) as infiltration of inflammatory cells in the skin 48 , the heating protocol should be restricted to 40 °C. ...
