Andrea Huth's research while affiliated with Philipps University of Marburg and other places
Publications (13)
Hepatocyte growth factor (HGF) is a promoter of hair follicle growth. We examined another HGF family member, macrophage-stimulating protein (MSP), for its hair follicle-modulating properties. Western blotting revealed presence of mature MSP in cultured human dermal papilla (DP) cells and bulbar dermal sheath (DS) cells, but not non-bulbar DS cells....
Green fluorescent protein (GFP)-expressing wild-type, and nontransgenic mouse vibrissa follicle cells were cultured and implanted to mouse ears and footpads. Dermal papiller (DP)-derived cells and cells from the peribulbar dermal sheath "cup" (DSC) induced new hair follicles in both implanted ears and footpads, while nonbulbar dermal sheath cells d...
For topical treatment of androgenetic alopecia (AGA) in women, solutions containing either estradiol benzoate, estradiol valerate, 17beta- or 17alpha-estradiol are commercially available in Europe and some studies show an increased anagen and decreased telogen rate after treatment as compared with placebo. At present it is not precisely known how e...
The in vitro growth of human hair follicles is inhibited by interleukin (IL)-1 beta and phorbol esters, such as phorbol-myristate-acetate (PMA), but enhanced by insulin-like growth factor (IGF)-I. Although this process is only incompletely understood, the dermal papilla as a pivotal part of the hair follicle is almost certainly involved. Since prot...
Factors that influence the growth of the anagen hair follicle or initiate the switch to a catagen growth pattern have so far not been definitely determined, but there is increasing evidence that cytokines and growth factors play an important role during these processes. Recently we detected an aberrant in situ expression pattern of cytokines of the...
The early immune response in alopecia areata is characterized by a Th1 T helper cell cytokine pattern and an aberrant expression of ICAM-1 and HLA-DR molecules on lesional hair bulbs. A counteracting cytokine pattern induced by a therapeutic contact dermatitis is supposed to mediate the hair regrowth. In addition to cytokines, growth factors have b...
Although the nature of the noxious signal and the anatomical target in alopecia areas (AA) are still unknown, it has been assumed that CD4+ T lymphocytes surrounding and infiltrating the hair bulb might trigger the hair loss. As these T lymphocytes do not promote cytotoxic activity we hypothesize that AA is triggered by cytokines. Topical immunothe...
Citations
... [11] Autoimmunity; Alopecia areata was at first thought to be an autoimmune disorder by Rothman following a paper presented by Van Scott. [12] Alopecia areata have been found to be associated with other autoimmune diseases such as atopy, autoimmune thyroid disease and vitiligo. [13] AA has been seen associated with type 1 Diabetes Mellitus in relatives of patients. ...
Reference: Alopecia Areata – A literature Review
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... This also could maintain the ability of proliferation of DP cells in vivo. MAC-EVs accelerate the motility of the DP cells in vitro and a previous study suggests that during the normal hair cycle, dermal sheath cup cells may also be a source of DP cells, via migration [49]. These results support the findings of our previous data on MSC-EVs [2]. ...
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... This observation provides one potential way that the studies by Garratt et al. and Steyn et al. may be linked. A mechanism of action whereby 17α-E2 alters testosterone metabolism either in the brain or peripheral tissues, as reported in vitro [8], or is itself signaling and/or metabolized in a sex-specific manner, could explain its sexually dimorphic effects on survival. Understanding these mechanisms, particularly the causal requirement of steroid activity in particular tissues including the brain, could lead to the development of more specific androgen and/or estrogen pathway modulators that help to slow aging in one or both sexes while minimizing adverse health outcomes. ...
... Numerous recent studies have used immune-cell-derived EVs for therapeutic strategies in many diseases [14][15][16][17]. Few studies have described the role of macrophages in hair growth and regeneration [18][19][20]. A recent study identified the novel involvement of perifollicular macrophages in the activation of skin epithelial stem cells, as an additional signal that regulates HF growth [18]. ...
... Peptides [204][205][206] and some growth factors [207][208][209] have also shown inhibitory effects on DPCs. In addition, certain other agents have exerted inhibition of DPCs activity in vitro [210][211][212][213][214][215][216][217][218]. ...
... Dear Editor: Yang et al. 1 recently reported an interesting case entitled, "Cutaneous Abscess as a Complication of Bisphosphonate-Related Osteonecrosis of the Jaw". Bisphosphonate-related osteonecrosis of the jaw (BRONJ) represents a rare complication of bisphosphonate treatment. ...
... Of note, TLR1 polymorphisms may be related to AA susceptibility. [34] Type II interferon IFNγ plays an important role in AA [35][36][37] ; ...
