E E Protopapa's research while affiliated with Harokopio University and other places

... Proteolytic enzymes applied by iontophoresis to skin of experimental animals have shown depilatory effects (Protopapa et al., 1999). As the depilatory action is long-lasting, the hypothesis had been put forward that hair follicle stem cells could be among the cells affected by the proteolytic enzyme. ...

... Thus, transgenic mice carrying only the E2 sequence of HPV11 were generated and the question was addressed whether expression of the viral protein will affect growth or differentiation of tissues, mainly skin, expressing the viral protein. This question is of high relevance in the light of experiments showing that the HPV11 promoter is able to drive specific expression of a reporter gene in the hair epithelium of transgenic mice ( Schenkel et al. 1999). In this report is demonstrated that the HPV11 E2 gene under the control of the human Ubiquitin C promoter is widely expressed in transgenic mice. ...