Sathish Pitta's research while affiliated with National Institute of Pharmaceutical Education and Research Guwahati and other places
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Publications (5)
A mouse model of depression has been recently developed by exogenous corticosterone (CORT) administration, which has shown to mimic HPA-axis induced depression-like state in animals. The present study aimed to examine the antidepressant-like effect and the possible mechanisms of resveratrol, a naturally occurring polyphenol of phytoalexin family, o...
Objective: To investigate the ulcer protective effect of Leucas aspera (L. aspera) aerial parts in
various experimental ulcer models.
Methods: Aerial parts of L. aspera were collected and extracted with methanol (70% v/v).
Preliminary phytochemical screening and toxicity evaluation of methanolic extract of L. aspera
were performed. Ulcer protective...
Objective: To evaluate the effect of resveratrol, a naturally
occurring polyphenol of phytoalexin family, found in the skin of
red grapes and in other fruits as well as in the roots of Japanese
knotweed (Polygonum cuspidatum), on depressive-like behavior
induced by chronic corticosterone injections in mice. Materials
and Methods: Mice were injected...
Background
Honokiol, an active component isolated and purified from Chinese traditional herb Magnolia officinalis. It is known to have a wide range of biological activities including antidepressant-like effects which have been observed in stress-induced depression models. This study was designed to investigate the antidepressant potential of honoki...
The aim of the present study was to investigate the effect of Mirabilis jalapa Linn flowers in formaldehyde and Freund's adjuvant induced arthritis. Hydro ethanolic extract of Mirabilis jalapa flowers (HEMJ) were prepared and subjected to preliminary phytochemical investigations. Anti-arthritic activity of HEMJ was evaluated in formaldehyde and Com...
Citations
... The chronic treatment with corticosterone increased the level of plasma corticosterone (p = 0.042, after the Thompson-test revealing one outlier for 19 mice in both groups), yet in a lesser extent than expected. As reported recently, in order to reach a 1.8-to 2-fold increase of the blood corticosterone concentration in mice after 21 days, a dose of 40 mg/Kg/day would be required (Ali et al., 2015; Weng et al., 2016). In our experiment, the designed pellet delivery was close to 20 mg/Kg/day and the increase of the measured plasma corticosterone concentration was 1.5-fold compared to PL group. ...
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... We used a continuous subcutaneous injection of CORT for 30 days to create external stress stimulation and induce depression model mice [39][40][41][42][43]. In the external stimulation process, the wallpaper adhered with the bionic plus nano-aromatic drugs was pasted on the wall of the mouse cage to relieve stress, thereby achieving the effect of preventing depression. ...
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... N. cataria is widely used to treat diarrhea, Alzheimer's disease, Parkinson's disease, and hepatic injury (Hussain et al., 2018;Sarin & Bafna, 2012;Wan & Jiang, 2018). Leaves of L. aspera are used in psoriasis, rheumatism, snakebites (Kirtikar & Basu, 1975;Trease & Evans, 2002), and ulcer protection (Augustine et al., 2014). The remunerative value in pharmaceutical industries for these four medicinal plant species is notable. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272212057915441-1441911821242_Q64/Bibin-Augustine.jpg)
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... Additionally, a notable reduction in BDNF levels within the hippocampus was observed in mice treated with corticosterone. The administration of honokiol to mice resulted in a notable reduction in depressive behavior and a concurrent elevation in BDNF levels in mice treated with corticosterone (Table 1) [76]. ...
... The extract significantly reduced paw edema in both models (P<0.001). CFA rats' body weight, hematological, and antioxidant changes have been restored to normal" [92]. • The alcoholic, aqueous, and petroleum ether extracts prepared from Mirabilis jalapa leaves were used in a study to determine the plant's anti-inflammatory activity. ...
