Stephanie D Gan's research while affiliated with University of Michigan and other places
Publications (16)
Nonablative lasers heat but do not vaporize the skin. Many nonablative devices emit light in the infrared portion of the electromagnetic spectrum, including traditional intense pulsed light (IPL, 500–1200 nm) devices, neodymium/yttrium-aluminum-garnet (Nd/YAG, 1064 and 1320 nm), and diode lasers (980 and 1450 nm). The fractionated nonablative resur...
Background:
The authors previously reported the safety and short-term efficacy of ablative fractional laser (AFXL)-assisted delivery of topical fluorouracil in the treatment of superficial basal cell carcinoma (sBCC) and squamous cell carcinoma in situ (SCCis).
Objective:
This follow-up study was conducted to assess whether tumor clearance was s...
Pearly penile papules are asymptomatic, benign growths distributed around the corona of the penis that can frequently be a source of significant psychological distress for the patient. Various treatment options are limited mainly by their complications.
Two case reports and a review of the literature.
University academic setting.
Two subjects of sk...
The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease.
A woman in her 30s presented to a tertiary care Boston hospital with a 5-day history of fevers, malaise, headaches, and nausea with a concurrent asymptomatic solitary papule on her right foot. At the time, she was living in a house infested with mice but did not recall any rodent or insect bite. Physical examination revealed a round dusky papule 5...
The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease.
BACKGROUND: Unwanted hair growth is a common aesthetic problem. Laser hair removal has emerged as a leading treatment option for long-term depilation. OBJECTIVES: To extensively review the literature on laser hair removal pertaining to its theoretical basis, current laser and light-based devices, and their complications. Special treatment recommend...
Solar elastosis is observed in the dermis of photoaged skin and is characterized by an accumulation of abnormal elastin in the extracellular space. Several proteases that degrade elastin in the extracellular space have been implicated in its formation. The lysosomal protease cathepsin K (catK) has recently been described to be highly expressed in s...
Cutaneous T-cell lymphoma (CTCL) can have a profound impact on a patient's health-related quality of life; however, little is known about its actual impact. The authors evaluated patients' perspectives on the impact of CTCL on physical functioning, lifestyle, emotional well being, and satisfaction with treatment.
A 4-page, self-administered questio...
Citations
... 21 The CO 2 laser-assisted 5-FU delivery is evaluated in clinical trials for skin-cancer management. [22][23][24] Since the topical drug therapy is always applied on the barrier-defective diseased skin, we first pre-pared the impaired skin according to the standardized methods for examining permeation. The greater enhancement of siRNA flux by tape stripping indicated an important barrier of SC. ...
... This approach of conducting research is relatively quick and easy but does not permit a distinction between cause and effect [1]. Conversely, the case-control is a design that examines the relationship between an attribute and a disease by comparing those with and without the disease [1,2,12]. In addition, the case-control design is usually retrospective and aims to identify predictors of a particular outcome. ...
... After repetitive exposures to low doses of UVA, glycolysis and lactate production are increased (Warburg effect) (50). This effect persists for at least 5 days after the last UV exposure and is associated with an up-regulation of several matrix metalloproteinases (MMP2, MMP3, MMP9, MMP13, MMP15), with a consequent increment of melanoma invasiveness (51,52). Warburg effect increases the speed of tumoral cell mitosis too, because part of the glycolysis-derived pyruvate can be used for anabolic pathways (amino acid or fatty acid synthesis) (53). ...
... The most common filler type associated with filler-induced iatrogenic blindness mentioned in the literature was autologous fat (48%), followed by hyaluronic acid (HA, 23.5%) [3]. Moreover, vascular compromise causing alopecia after filler injections is extremely rare as only 2 cases of HA-induced alopecia have been reported [4,5]. We herein report, to the best of our knowledge, the first case of localized alopecia secondary to autologous fat grafting and review the literature regarding filler-induced alopecia. ...
... [1][2][3][4][5] CTCLs are characterized by the primary infiltration of malignant T cells in the skin without evidence of extracutaneous disease at the time of diagnosis. 1,6,7 Mycosis fungoides (MF) represents between 50-70% of cases of CTCL, 3,[8][9][10][11] being classified as a rare disease. 12,13 Although prevalence is difficult to determine, the age-adjusted incidence of MF is estimated to be between 0.12 and 0.55 cases per 100,000 inhabitants. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/447180847751172-1483627630332_Q64/Donald_Miller2.jpg)
... To develop an effective sandwich ELISA, the pair of selected antibodies (capture and detection antibodies) is key in determining the sensitivity and specificity of the assay [38]. To date, traditional antibodies are universally used to develop sandwich ELISAs [8,9,39]. Yet, procedures of preparation, purification and labelling of traditional antibodies are complicated and costly, which is a heavy burden for the development of commercial sandwich ELISA kits [9,25,40]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273780719222792-1442285818501_Q64/Kruti_Patel4.jpg)
... Using the fractionated CO 2 laser, one group reported more than 90% resolution after a single treatment (Krakowski, Feldstein, & Shumaker, 2015). Another group concluded that two to three treatments were sufficient to completely resolve lesions without adverse effects in both light and dark skin types (Gan & Graber, 2015). While the CO 2 laser exposes the underlying tissue, reepithelialization generally occurs within 5 to 7 days (Krakowski et al., 2015). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/277761865338880-1443234997115_Q64/Emmy_Graber.jpg)
... Lasers are being investigated as monotherapy and as adjunctive applications in AK treatment [84]. One split-face study using ablative fractional laser (AFXL) therapy compared to no treatment for AKs found a significant reduction of AKs at 1 month; however, at the 3-month follow-up, reduction of AKs on either side of the face was similar due to spontaneous regression on the non-treated side [85]. In this study, the Ultrapulse CO 2 laser ActiveFX handpiece (Lumenis) was used with the settings 70 mJ per pulse, power at 9 W, and density of 4 [85]. ...
... The acne may lead to scarring. [121][122][123][124][125][126][127][128][129][130][131][132][133] ...
Reference: Acne Vulgaris: Measures and Miseries
... 21 The CO 2 laser-assisted 5-FU delivery is evaluated in clinical trials for skin-cancer management. [22][23][24] Since the topical drug therapy is always applied on the barrier-defective diseased skin, we first pre-pared the impaired skin according to the standardized methods for examining permeation. The greater enhancement of siRNA flux by tape stripping indicated an important barrier of SC. ...
