Müfide Nuran Akçay

Ataturk University, Kalikala, Erzurum, Turkey

Are you Müfide Nuran Akçay?

Claim your profile

Publications (35)61.53 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Incidental removal of the parathyroid glands is common in some cases. In this trial, we investigated the risk factors, incidence, and outcomes associated with incidental excision of the parathyroid glands during thyroid surgery. The records of patients who had undergone thyroid surgery in our department between January 2006 and December 2011 were retrospectively evaluated. A total of 801 patients were enrolled in the trial. The number of incidental parathyroidectomies was determined as 19 (2.3%). Statistical evaluation revealed that sex (P > 0.05) and type of surgical operation (P > 0.05) were not associated with a significant impact on incidental parathyroidectomies. However, the rate of incidental parathyroidectomies was determined to be statistically significantly high among patients with malignant conditions (P < 0.05). Hypocalcemia was observed to be statistically significant in patients with an incidental parathyroidectomy (P < 0.05). Incidental parathyroidectomy is a rare condition in centers specializing in endocrine surgery. Furthermore, the parathyroid glands should always be explored during dissection in patients with malignancies. The clinical manifestation of hypocalcemia is a common condition observed after incidental parathyroidectomy.
    No preview · Article · Jan 2014 · Turkish Journal of Medical Sciences
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Aim: To show the effect of infection control measures (ICMs) on nosocomial infections (NIs) in a burn unit. Materials and methods: This study was conducted retrospectively at a 15-bed pediatric and adult burn unit, and 1329 hospitalized patients from 2003 to 2008 were enrolled. Detection and surveillance of NIs was performed by the infection control team (ICT), actively and prospectively, and was patient and laboratory based. Pan-resistant P. aeruginosa strains were seen in the unit in 2003. A periodical education program was applied by the ICT, and some changes were recommended. The hydrotherapy tank was abandoned, antimicrobials were used by the ICT, and new burn wound nursing techniques were applied by the surgeons. Results: During the study period, compliance to ICMs increased. Wet dressing, early debridement, and grafting were performed. The NI rate decreased from 28.3% to 4.5%, the mortality rates declined from 2.2% to 1.2%, and the mean hospital stay of the patients with NI was reduced from 45.4 to 34.0 days. The numbers of burn wound infection (BWI) and bacteremia were decreased, as were sepsis and mortality attributed to infection. The antibiotic resistance of gram-negative microorganisms declined and pan-resistant P. aeruginosa strains disappeared. Conclusion: NIs can be decreased by ICMs in burn units. Antibiotic usage should be rational. The hydrotherapy tank should not be used if possible. Wet dressing, early debridement, and grafting are the mainstays of the therapy.
    Preview · Article · Feb 2012 · Turkish Journal of Medical Sciences
  • Source
    Ayşe Parlak Gürol · Sevinç Polat · Müfide Nuran Akçay
    [Show abstract] [Hide abstract]
    ABSTRACT: Burn can be among the most severe physical and psychologic traumas a person may face. Patients with burns commonly have severe itching and pain. Severe itching has also been associated with anxiety, sleep disturbance, and disruption of daily living activities. The addition of complementary treatments to standard care may lead to improved pain management and may offer a safer approach for reducing pain and procedural anxiety for patients with burns. The authors conducted an experimental study to examine whether the effects of massage therapy reduced burned adolescents' pain, itching, and anxiety levels. Sixty-three adolescents were enrolled in this study shortly after admission (mean days = 3 +/- 0.48) at a burn unit in a large university hospital from February 2008 to June 2009. The measures including the pain, itching, and state anxiety were collected on the first and last days of the 5-week study period. The participants had an average age of 14.07 +/- 1.78 years and came usually from the lower socioeconomic strata. The authors observed that massage therapy reduced all these measures from the first to the last day of this study (P < .001). In most cultures, massage treatments are used to alleviate a wide range of symptoms. Although health professionals agree on the use of nonpharmacologic method for patients with burns, these applications are not yet common.
    Full-text · Article · May 2010 · Journal of burn care & research: official publication of the American Burn Association
  • Müfide Nuran Akçay · Güngör Akçay
    [Show abstract] [Hide abstract]
    ABSTRACT: Primary hyperparathyroidism (pHPT) is a disease in which the diagnosis depends increasingly on laboratory tests since the majority of patients are elderly people without typical symptoms. The aim of this study was to calculate the specificity and sensitivity rates, and positive predictive value of blood Ca, P, ALP, and iPTH levels in patients with PA. We calculated the specificity and sensitivity rates, and positive predictive value of blood calcium (Ca), phosphorous (P), alkaline phosphatase (ALP), and intact parathormone (iPTH) levels in patients with sporadic and solitary parathyroid adenoma (PA). Twenty six patients with PA were included in the study. The mean age was 44.5±14.9 (18-70) years. Blood levels of Ca, P, ALP, and iPTH were 2.5±0.3 mmol/L, 0.8±0.3 mmol/L, 21.4±31.5 μkat/L, and 518.0±633.4 ng/L, respectively. With respect to the diagnosis of pHPT, the sensitivity of blood levels of iPTH, P, Ca, and ALP were 96%, 94%, 81%, and 73%, respectively. The specificity and positive predictive value of all parameters were 100% for the diagnosis of PA. Routine laboratory parameters are specific and predictive for pHPT. However, the sensitivities of P and iPTH are higher than those other parameters.
    No preview · Article · Aug 2009 · Eurasian Journal of Medicine
  • Source
    G. Akçay · M. N. Akçay · H. A. Alici

    Full-text · Article · Oct 2008 · Anaesthesia
  • Müfide Nuran Akçay · Gürkan Oztürk · Bülent Aydinli · Bünyamin Ozoğul
    [Show abstract] [Hide abstract]
    ABSTRACT: Tandir is the name given to an oven used for baking bread in the eastern and south-eastern part of Anatolia. Tandir burn is a special kind of burns in which primarily women and small children fall in it and have deep extensive burns (TBSA %). The records of 60 patients with tandir burn who were treated in our Burn Center from September 1999 to January 2006 were reviewed. The patients consisted of 9.2% of all burned patients. The mean age was 17.10 years (1-60 years) and 61.50% of the patients were female. The mean total body surface area (TBSA) burned was 21.09% (6-58) and 88% of the patients had third-degree burns. Eight of the patients underwent amputation of an extremity, 10 had fasciotomies, and 25 partial thickness skin grafts. The mean hospitalization period was 31.64 days (3-73 days). Fifteen patients (25%) died. Tandir burn is a severe kind of burn with a higher morbidity and mortality.
    No preview · Article · Apr 2008 · Burns
  • [Show abstract] [Hide abstract]
    ABSTRACT: A serious complication of cystic echinococcus (CE) is the rupture of the cysts. Free intra-abdominal rupture occurs in approximately 3.2% of all cases. Posttraumatic rupture of liver CE is very rare. The objective of the current study was to evaluate the clinical and radiographic findings and surgical treatment of this complication. Twenty patients with posttraumatic ruptured liver CE were treated. The incidence rate of hydatid rupture was 3.06%. The common presenting symptom was abdominal pain. All patients were operated on under emergency conditions. There were 26 cysts in 20 patients, and all of the cysts were treated surgically. Hydatid cyst rupture must be kept in mind in the management of trauma patients with cystic mass in the liver in particular and free intra-abdominal fluid, especially in the endemic area. We preferred conservative (unroofing associated with various procedures for the management of the residual cavity) rather than radical procedures such as hepatic resection or pericystectomy for the surgical treatment.
    No preview · Article · Oct 2007 · American journal of surgery
  • [Show abstract] [Hide abstract]
    ABSTRACT: Hydatid cyst (HC) continues to be endemic in the Mediterranean countries, such as Turkey. Living in a rural area is an important risk factor for the disease. HC is most commonly seen in the liver and lungs, but retroperitoneal hydatid cyst is very rare. The objective of this study was to evaluate the clinical and radiographic findings and surgical treatment of this unusual lesion. Between 1979 and 2004, 14 cases with primary retroperitoneal hydatid cyst were treated surgically at our clinic. Symptoms included flank pain in eight (57.1%) and palpable mass in six patients (42.8%). The cyst was located in the right retroperitoneum in seven patients (50%), left retroperitoneum in five patients (35.7%), retrovesical region in one patient (7.1%) and paravesical region in one patient (7.1%). Surgical approaches were right paramedian extraperitoneal approach in four patients, left paramedian extraperitoneal approach in two patients and midline transperitoneal approach in eight patients. Total pericystectomy was chosen as the surgical procedure in all patients except in five (35.7%), who had partial cystectomy for cysts located near the vital structures. There were no complications and mortality postoperatively. A primary HC of the retroperitoneum is a distinct clinical entity that must be considered when caring for a patient with a retroperitoneal mass in endemic regions. It should be treated after the diagnosis is confirmed without any delay because of secondary spillages due to perforations and other possible complications.
    No preview · Article · Jul 2007 · ANZ Journal of Surgery
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: While tuberculosis of the breast is an extremely uncommon entity seen in western populations, it accounts for up to 3% of all treatable breast lesions in developing countries. We reviewed three female cases of mammary tuberculosis that were diagnosed and treated in Turkey during the same calendar year. All three patients presented with a painful breast mass. In all cases, fine needle aspiration was nondiagnostic for mammary tuberculosis. However, the diagnosis of mammary tuberculosis was confirmed by histopathologic evaluation at the time of open surgical biopsy. All three patients were treated with antituberculous therapy for six months. At the end of the treatment period, each patient appeared to be clinically and radiologically without evidence of residual disease. The diagnosis of mammary tuberculosis rests on the appropriate clinical suspicion and the histopathologic findings of the breast lesion. Its recognition and differentiation from that of a breast malignancy is absolutely necessary. Antituberculous chemotherapy, initiated immediately upon diagnosis, forms the mainstay of treatment for mammary tuberculosis.
    Preview · Article · Feb 2007 · World Journal of Surgical Oncology
  • [Show abstract] [Hide abstract]
    ABSTRACT: Well-differentiated thyroid cancer typically presents as a thyroid mass. Common sites of metastases presentation include cervical lymph nodes, lung, and bone; less common are brain, liver, and skin. We describe 4 cases with unusual presentations of differentiated thyroid carcinomas.
    No preview · Article · May 2006 · The Endocrinologist
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study was conducted to determine the risk factors for acquisition of imipenem-resistant Pseudomonas aeruginosa (IRPA) in the burn unit. Patients hospitalized in the burn unit from July 2003 to November 2004 were included in this study. The features of patients with isolated IRPA were compared with those of patients with isolated imipenem-susceptible P. aeruginosa (ISPA). Demographic features, total burn surface area (TBSA), burn depth, antimicrobials used in 15-day period before isolation, and presence of IRPA in the unit at the same period were included in the risk factors analysis. P. aeruginosa was recovered from 133 patients in this period, 93 were IRPA and 40 were ISPA. There was no significant difference between patients with ISPA and patients with IRPA in terms of age, TBSA, and burn depth. In multivariate logistic regression analysis, hospital stay before isolation (odds ratio (OR): 3.6), carbapenem usage (OR: 7.4), broad-spectra antibiotic usage (OR: 6.5), previous presence of ISPA in the patient (OR: 1.7) and presence of IRPA in the unit at the same period (OR: 2.6) were independent risk factors for acquisition of IRPA. Long hospitalization time, previous imipenem/meropenem use, previous broad-spectra antibiotic use, previous presence of ISPA in a patient and presence of IRPA in a unit at the same period were associated with acquisition of IRPA in the burn unit. In order to decrease the incidence of IRPA isolation, the usage of broad-spectra antibiotics, especially carbapenem, should be restricted, hospitalization time should be shortened if possible, and universal isolation precautions should be strictly applied to prevention cross-contamination.
    No preview · Article · Dec 2005 · Burns

  • No preview · Article · Jul 2005 · Digestive Diseases and Sciences
  • Source
    K.Y. Polat · M.N. AkÇay · B Aydinli · F Erdogan · M Kantarci · G Oztürk · K Peker
    [Show abstract] [Hide abstract]
    ABSTRACT: Hepatocellular carcinoma (HCC) has a tendency for fatal spontaneous rupture leading to massive haemorrhage. A 64-year-old man presented with sudden, severe epigastric pain for 6 h. Systolic blood pressure was 80/50 mmHg, and pulse rate was 100/min. The patient's history did not reveal any operation or disease up to date. Contrast enhancement-axial computed tomography (CT) scan showed a tumoral lesion with a necrotic centre measuring 6 x 5 cm within 6th segment of the liver and a fluid collection (haemoperitoneum) at the periphery of the liver. At exploratory laparotomy, the liver was found to be cirrhotic, and an actively bleeding tumour confirmed in 6th segment of the liver. The tumour was resected. Post-operative recovery was unremarkable, and the patient was discharged on the 14th post-operative day. Ruptured HCC should be included in the differential diagnosis of non-traumatic intra-abdominal haemorrhage.
    Full-text · Article · May 2005 · International journal of clinical practice. Supplement
  • M N Akçay · G Akçay · A Kiziltunç · G Oztürk · B Aydinli
    [Show abstract] [Hide abstract]
    ABSTRACT: Cellular adhesion molecules are expressed by activated endothelial cells in severe bum. The release of these molecules can lead to organ damage. We measured E-selectin levels in the blood of 20 severe-burn patients. Then the patients were divided into two groups of 10 patients each. In the study group, atorvastatin 20 mg/day was administered orally for 14 days. In the control group, an equal volume of placebo was administered orally for 14 days. In both groups, following the last dose of the agents, serum E-selectin levels were measured again. Mean burn size and the percentage of third-degree bums of total burned area were not significantly different between the groups. Serum E-selectin level obtained at the beginning of the treatment was 23.69 +/- 2.71 ng/ml in the atorvastatin group and 18.08 +/- 0.97 ng/ml in the control group. Serum E-selectin level obtained at the end of the treatment was 10.86 +/- 1.36 ng/ml in the atorvastatin group and 21.69 +/- 2.11 ng/ml in the control group. The difference between the two groups was statistically significant (p < 0.05). In the comparison of early and late serum E-selectin levels in the atorvastatin group, a significant decrease was obtained (p < 0.05). In the control group, serum E-selectin levels were found to be increased in the late period. However, the difference between the early and late values was nonsignificant (p > 0.05). We concluded that atorvastatin is effective in the prevention of E-selectin release in severely burned patients.
    No preview · Article · Feb 2005 · International journal of clinical pharmacology research

  • No preview · Article · Jan 2005 · International Journal of Antimicrobial Agents
  • M.N. AkÇay · K.Y. Polat · D. Ören · G. Öztürk
    [Show abstract] [Hide abstract]
    ABSTRACT: Tuberculous liver abscess (TLA) is an extremely rare condition, even in the country where tuberculosis is an alarming public health problem. Primary TLA, with no evidence of infection elsewhere, is even less common. Herein, we report a case with primary TLA and review the literature.
    No preview · Article · May 2004 · International Journal of Clinical Practice
  • Müfide Nuran Akçay · Güngör Akçay · Habib BIlen
    [Show abstract] [Hide abstract]
    ABSTRACT: The effects of intranasal calcitonin on bone metabolism were investigated in patients with hyperthyroidism. Urinary deoxypyridinoline (uDPD) levels were measured as a bone turnover marker and lumbar spine (L2) bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DEXA) in 7 patients who were given only antithyroid drug (group 1), in 10 patients who were given antithyroid drug plus intranasal calcitonin (group 2), and in 10 healthy subjects who were given placebo (group 3) at the beginning and at the end of the study. The study continued until the patients with hyperthyroidism became euthyroidic according to the laboratory values. This period was approximately 3 months in groups 1 and 2. At the beginning of the study, uDPD was 21.5 +/- 2.6 nM DPD/mM creatinine in group 1, 23.3 +/- 3.6 nM DPD/mM creatinine in group 2, and 4.3 +/- 1.2 nM DPD/mM creatinine in group 3. uDPD levels measured in groups 1 and 2 were significantly higher than those in group 3 ( P < 0.001). Area BMD Z scores of the patients in groups 1 and 2 were significantly lower than the healthy controls ( P < 0.01, for both). At the end of the study, uDPD was 11.5 +/- 1.6 nM DPD/mM creatinine in group 1, 5.3 +/- 0.6 nM DPD/mM creatinine in group 2, and 4.4 +/- 1.3 nM DPD/mM creatinine in group 3. The levels of uDPD obtained in group 1 were significantly higher than those obtained in groups 2 and 3 ( P < 0.05, for both). The difference between groups 2 and 3 was not significant. Area BMD Z scores measured at the end of the study were found to be increased in groups 1 and 2 compared to early values, but the values were slightly lower than the normal values. In comparison of early and late uDPD values, the decrease in late period was statistically significant in groups 1 ( P < 0.05) and 2 ( P < 0.001). We concluded that bone turnover is high in hyperthyroidism. The treatment of hyperthyroidism decreases the rate of bone turnover, but it is not sufficient to prevent the degradation of bone in hyperthyroidism. The addition of intranasal calcitonin to the treatment of hyperthyroidism prevents the degradation of bone.
    No preview · Article · Mar 2004 · Journal of Bone and Mineral Metabolism
  • Müfide Nuran Akçay · Güngör Akçay · A Ahmet Balik · Abdullah Böyük
    [Show abstract] [Hide abstract]
    ABSTRACT: Adrenal cysts are very rare lesions, especially with parasitic origin. But with the wider application of ultrasonography (US) and computed tomography (CT) more adrenal cysts are detected incidentally. To gain more insight into this entity, the records of nine patients with hydatid cysts of adrenal gland seen at our department from January 1980 till January 2002 are reviewed. There were four men and five women, and their ages ranged from 15 to 80 years (median: 41 years). All of the patients had unilateral cysts. Seven cysts were located on the right and two on the left side. Five of the cysts were primary and four were secondary. In three patients the cysts were found incidentally. The most common presenting symptom was pain, which was present in six patients. An indirect hemagglutination (IHA) test was positive in six cases. In all patients, US and CT successfully imaged all cysts, but the definitive diagnosis was made by macroscopic and microscopic examination of the cyst's content. The patients were treated surgically. In all patients adrenal glands with the cystic masses were removed. The median follow-up period was 16 months (range: 6-64 months). No evidence of recurrence was found in any patient. It should not be forgotten that cystic masses of the upper abdomen might also originate from the adrenal gland. The etiology and nature of the cyst should be well researched, and appropriate treatment should be given as soon as possible. Surgical excision of the gland, including the cyst is the treatment of choice.
    No preview · Article · Feb 2004 · World Journal of Surgery
  • M N Akçay · M F Polat · I Yilmaz · G Akçay
    [Show abstract] [Hide abstract]
    ABSTRACT: Serum paraoxonase (PON) is a calcium-dependent esterase that is known to contribute to the antioxidant protection conferred by high-density lipoprotein (HDL) on low-density lipoprotein (LDL) oxidation. Serum PON activity was shown to be reduced in patients with diseases such as myocardial infarction, diabetes mellitus, etc in comparison to healthy subjects. However, the relation of serum PON levels to cancer is still not known. So, we intended to measure serum PON, HDL, LDL and very low-density lipoprotein (VLDL) levels and to investigate the relation of serum PON to plasma lipoproteins in the patients with pancreatic cancer. We measured serum PON, HDL, LDL, and VLDL levels in 20 patients with pancreatic cancer and in 20 age-and gender-matched healthy controls. We investigated the relationship between PON and HDL, PON and LDL, and PON and VLDL. Serum HDL levels were lower in the patients than in controls (40.21 +/- 13.82 mg/dL, and 47.30 +/- 6.65 mg/dL, respectively) (p<0.05). Serum LDL and VLDL levels measured in the patient group were not significantly different from those of the control group. Serum PON levels were lower in the patients than in controls (61.57 +/- 22.44 U/L, and 87.50 +/- 23.39 U/L, respectively) (p<0.005). There was a positive correlation between serum PON and HDL levels (r: 0.69, p<0.05). We concluded that the patients with pancreatic cancer had low PON and HDL levels compared to healthy controls. The importance of PON as a predictive risk factor for cancer should be assessed in future studies.
    No preview · Article · Jan 2004 · Hepato-gastroenterology
  • Müfide Nuran Akçay · Adem Sari · Güngör Akçay
    [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate the blood levels of lipids, insulin resistance and the release of insulin in the patients with fatty liver. Ninety one patients with fatty liver and forty seven healthy subjects were included in the study. The diagnosis of fatty liver was established by measuring blood levels of lipids and measuring liver echogenity by ultrasound. Fasting plasma levels of lipids, glucose and insulin were measured in the patient group and control group, and the rate of insulin resistance was calculated. HOMA test was used to calculate the insulin resistance. INSULIN RESISTANCE: Fasting insulin value (microU/mL) x Fasting blood glucose value (mmol/L)/22.5 Liver echogenity was measured by a 3.75 mHz ultrasound probe and was graded by comparison with renal cortical paranchymal echogenity in both groups. Increased blood levels of lipids and increased liver echogenity on the ultrasonography were accepted as fatty liver. Liver biopsy was not applied. The patients with liver and/or renal paranchymal disease were excluded from the study. The rate of release of insulin was calculated according to the following formula. 20 x plasma levels of insulin (mIU/mL)/plasma levels of glucose (mmol/L)-3.5 In the fatty liver group, plasma levels of cholesterol were 253.5 +/- 41.0 (161-440) mg/dL, plasma levels of triglycerides were 231.8 +/- 74.4 (45-493) mg/dL, grading of liver echogenity was 1.9 +/- 0.6 (1-3), the rate of release of insulin was 111.5 +/- 82.2 (3-463.8) and the rate of insulin resistance was 22.4 +/- 4.1 (18.3-26.5). In the control group, plasma levels of cholesterol were 173.4 +/- 19.1 (122-207) mg/dL, plasma levels of triglycerides were 110.5 +/- 39.3 (40-185) mg/dL, grading of liver echogenity was 1.0 +/- 0.1 (1-1), the rate of release of insulin was 129.6 +/- 84.1 (14.5-360) and the rate of insulin resistance was 20.3 +/- 2.1 (18.2-22.4). The rate of release of insulin and insulin resistance were similar in both groups (p>0.5). We observed that the rate of release of insulin in the patients with fatty liver was not different from that of the healthy subjects.
    No preview · Article · Jan 2004 · Hepato-gastroenterology

Publication Stats

528 Citations
61.53 Total Impact Points


  • 1995-2014
    • Ataturk University
      • Department of General Surgery
      Kalikala, Erzurum, Turkey
  • 2007
    • University of Gaziantep
      Ayıntap, Gaziantep, Turkey