[Show abstract][Hide abstract] ABSTRACT: Electrospray ionization (ESI) mass spectrometry was utilized to investigate noncovalent complexes between beta-cyclodextrin (beta-CD) and five novel polyamide acids containing N-methylpyrrole and N-methylimidazole. The 1:1 binding mode was specified by examining the binding stoichiometry from ESI mass spectra. It found that polyamide acids with beta-CD have binding affinities in the order: ImImImbetaCOOH > ImPyImbetaCOOH > ImPyPybetaCOOH > PyPyPybetaCOOH > NO(2)PyPyPybetaCOOH. The method gives, simultaneously, the binding constants between beta-CD and polyamide acids based on a novel linear equation.
Full-text · Article · Feb 2006 · Journal of the American Society for Mass Spectrometry
[Show abstract][Hide abstract] ABSTRACT: AbstractA simple procedure for the systematical synthesis of eight distamycin analogues containing N‐methylpyrrole (Py) and N‐methylimidazole (Im) has been developed by a chloroform reaction and DCC coupling reaction without amino protection and deprotection, and the interaction of the analogues with Herring Sperm DNA was investigated by fluorescence spectroscopy.
No preview · Article · Dec 2002 · Journal- Chinese Chemical Society Taipei
[Show abstract][Hide abstract] ABSTRACT: Two novel polyamides containing N-methylpyrrole (Py) and N-methylimidazole (Im) were designed and synthesized by a trichloroacetyl condensation reaction and DCC/HOBT coupling reaction without amino protection and deprotection in solution.
[Show abstract][Hide abstract] ABSTRACT: Three hairpin polyamides were designed and synthesized by a haloform reaction and DCC/HOBt coupling reaction without amino protection and deprotection. Their anticancer activity were investigated with three kinds of cell lines--hepatic carcinoma, lung carcinoma and gastric carcinoma, and the values of IC50 were at range of 10(-7) to approximately 10(-8) M.
No preview · Article · Nov 2002 · Archives of Pharmacal Research
[Show abstract][Hide abstract] ABSTRACT: The electrospray ionization tandem mass spectrometric (ESI-MS/MS) characteristics and fragmentation mechanisms of eight distamycin analogues containing N-methylpyrrole and N-methylimidazole were investigated. The members of two isomeric groups of distamycin analogues with the same elemental composition can be distinguished by MS/MS spectra of protonated molecules and of significant fragment ions.
No preview · Article · Jun 2002 · Rapid Communications in Mass Spectrometry