X.-B. Zhang

Hunan University, Ch’ang-sha-shih, Hunan, China

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Publications (9)13.02 Total impact

  • Z.P. Chen · J.H. Jiang · X.B. Zhang · G.L. Shen · R.Q. Yu
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    ABSTRACT: A novel electrochemical immunosensor with amplification effect based on the enzyme inhibition of silver deposition was proposed. In this method, the capture antibody was first immobilized onto a gold electrode via a self-assembled layer. After a sandwich immunoreaction, HRP labeled antibody was bound to the gold electrode. The HRP on the electrode inhibited silver deposition when the electrode was incubated in hydroquinone-H2O 2 solution and silver ion solution. The linear sweep voltammetry was chosen to detect the deposited silver and the result showed that the peak current was linearly proportional to the content of IgG in the range of 50 to 2500 ng/mL with a detection limit of 35 ng/mL.
    No preview · Article · Apr 2006 · Chinese Chemical Letters
  • C.-C. Guo · K.-L. Li · R.-B. Tong · L. Chen · X.-B. Zhang
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    ABSTRACT: Modifications of alkylation, chlorination and Vilsmeier reaction were employed for the synthesis of aromatic aldehydes bearing nitrogen mustard derivatives and halogenoalkylpiperazinyl. Thus seven new aromatic aldehydes were synthesized from commercially available aniline and phenylpiperazine by the modified method. All of the desired compounds were characterized by MS, IR, 1H NMR spectra and elemental analysis.
    No preview · Article · Mar 2005 · Chinese Journal of Organic Chemistry
  • C.-C. Guo · H.-P. Li · X.-B. Zhang · R.-B. Tong
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    ABSTRACT: A novel pyrrolidino-porphyrin, meso-5, 10, 15, 20-tetra[4-(N-pyrrolidinyl)phenyl] porphyrin (TBPPH2), was synthesized based on the porphyrin's,special affinity for cancer cells and the antitumor. activity of pyrrolidine compounds. Its structure was characterized by UV-Vis spectra, elemental analysis and H-1 NMR. In order to study the possible anticancer activity of TBPPH2, the interaction model based on TBPPH2 and bovine serum albumin (BSA) was built, and the binding mechanism was studied with UV-Vis spectra and fluorescence spectra. The research results indicate that BSA strongly bind. to TBPPH2 with the molar ratio of 1 : 1; the hydrophobic force was the main binding force, the shortest binding distance r was 2. 4 nm, the equilibrium constant K-A was 2. 51 x 10(4) L/mol, the reaction entropy DeltaS, was 84. 18 J/(mol . K), the binding constant K-B was 5. 13 x 10(5) L/mol. The research results show that it, is possible for the porphyrins with pyrrolidinyl groups to become a new type of the antitumor drugs.
    No preview · Article · Feb 2003 · Chemical Journal of Chinese Universities -Chinese Edition-
  • X B Zhang · C C Guo · S H Chen · G L Shen · R Q Yu
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    ABSTRACT: For preparing a berberine-sensitive electrode, 5,10,15,20-tetrakis[2-(2,3,4,6-tetraacetyl-beta-D-glucopyranosyl)-1-O- phenyl]porphyrin (T(o-glu)PPH2) was synthesized from the reaction of pyrrole with ortho-acetylglycosylated benzaldehyde by Lindsay's method. The electrode based on T(o-glu)PPH2 with an optimized membrane composition exhibits Nernstian response to berberine in the concentration range 2.4 x 10(-7)-5.0 x 10(-3) mol L-1, with a pH range from 3.9 to 10.2, and a fast response time of 30 s. The electrode shows fair selectivity towards berberine with respect to common co-existing species. T(o-glu)PPH2 shows better potentiometric response characteristics comparing to chloro[5,10,15,20-tetrakis[2-(2,3,4,6-tetraacetyl-beta-D- glucopyranosyl)-1-O-phenyl]-porphinato]-manganese (MnT(o-glu)PPCl) and better selectivity towards berberine than tetraphenylporphyrin (TPPH2). The effect of the composition of the electrode membrane has been studied and the experimental conditions optimized. The contents of berberine in pharmaceutical tablets were determined by direct potentiometry and the results agreed with values obtained by the pharmacopoeia method.
    No preview · Article · Apr 2001 · Fresenius Journal of Analytical Chemistry
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    X B Zhang · C C Guo · L X Jian · G L Shen · R Q Yu
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    ABSTRACT: Several mu-oxo-bismetalloporphyrin complexes were synthesized for preparing fluoroborate sensors. The electrode based on mu-oxo-bis[tetra(p-chlorophenyl)porphinatomanganese(III)] with an optimized membrane composition shows a potentiometric response towards fluoroborate ion over the concentration range from 4.3 x 10(-7) to 1.0 x 10(-1) mol l-1 with a Nernstian slope, a wide working pH range from 5.5 to 12.0 and a fast response time of 30 s. The electrode shows anti-Hofmeister selectivity towards BF4- with respect to common co-existing ions, which is an improvement over methods reported so far. As electroactive materials, several mu-oxo-bismetalloporphyrins with different substituents on the benzene rings were compared for potentiometric response characteristics. The interaction between BF4- and bismetalloporphyrin was investigated using UV/VIS spectrophotometry. The electrode was applied to the determination of fluoroborate in electroplating solutions.
    Full-text · Article · Jan 2001 · The Analyst
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    X B Zhang · C C Guo · J B Xu · G L Shen · R Q Yu
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    ABSTRACT: Lanthanide porphyrin complexes synthesized by a solid state method were used to prepare a novel ethacrynic acid (EA) sensor. The sensor, based on pentane-2,4-dionato(meso-tetraphenylporphinato)terbium [TbTPP(acac)] with an optimized membrane composition, exhibits a Nernstian response to EA- ion in the concentration range 7.4 x 10(-6)-1.0 x 10(-1) mol l-1 with a pH range from 3.2 to 6.8 and a fast response time of 30 s. The electrode shows improved selectivity towards EA- ion with respect to common co-existing ions compared with the previously reported EA sensor. As electroactive materials, lanthanide porphyrin complexes show better potentiometric response characteristics than copper porphyrin complexes. The effect of solvent mediators and lipophilic ion additives was studied and the experimental conditions were optimized. The electrode was applied to the determination of EA in human urine samples with satisfactory results.
    Full-text · Article · Jun 2000 · The Analyst
  • C.-C. Guo · X.-B. Zhang · J.-X. Song · H.-P. Li
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    ABSTRACT: Two glycoconjugated porphines, tetra[2-acetylglucosyl-oxo-phenyl]porphine [T(o-glu)PPH2] and tetra[3-acetylglycosy-oxo-phenyl]porphine[T(m-glu)PPH2], were synthesized from the reaction of pyrrole with ortho-acetylglycosylate benzaldehyde and meta-acetylglycosylate benzaldehyde, respectively, by using Lindsey's method. Four glycoconjugated metalloporphyrins, chloro[tetra(o-2, 3, 4, 6-O-acetylglucose-1-O-phenyl) porphinato] iron [T(o-glu) PPFeCl], chloro[tetra(o-2, 3, 4, 6-O-acetylglucose-1-O-phenyl) porphinato] manganese, [T(o-glu) PPMnCl], chloro[tetra(m-2, 3, 4, 6-O-acetylglucose-1-O-phenyl) porphinato]iron [T(m-glu) PPFeCl] and chloro[tetra(m-2, 3, 4, 6-O-acetylglucose-1-O-phenyl)porphinato] manganese [T(m-glu) PPMnCl] were prepared from these glycoconjugated porphines. The newly synthesized compounds were characterized by UV-vis spectroscopy, elemental analysis and 1H NMR. The catalytic oxidation of 2-methylbutane with PhIO as an oxidant at room temperature and under atmospheric pressure by four glycoconjugated metalloporphyrins was studied. The research showed that glycoconjugated metalloporphyrins catalyzed regiospecifically the hydroxylation of the primary carbon-hydrogen bonds of 2-methylbutane, and that non-glycoconjugated metalloporphyrins catalyzed selectively the oxidation of secondary and tertiary carbonhydrogen bonds of 2-methylbutane. In contrast with metalloporphyrins without sugar groups, the selective catalysis of these glycoconjugated metalloporphyrins for hydrocarbon oxidation was closer to cytochrome P-450 monooxygenase.
    No preview · Article · Jan 2000 · Acta Chimica Sinica -Chinese Edition-
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    ABSTRACT: The effects of both the constructions of metalloporphyrins and environment factors such as reaction solvents, reaction temperature and reaction time on the percentages of cyclohexanone in cyclohexane hydroxylation with PhIO catalyzed by monometalloporphyrins or bismetalloporphyrins and the reaction kinetics were studied systematically. The cyclohexanol oxidation with PhIO catalyzed by the metalloporphyrins was compared with the cyclohexane oxidation. The mechanism of the ketone formation in the alkane hydroxylation with PhIO catalyzed by metalloporphyrins was supposed.
    No preview · Article · May 1998
  • C.-C. Guo · X.-D. Hao · X.-B. Zhang · B.-X. Liang · X.-B. Chen
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    ABSTRACT: Monometalloporphyrin and μ-oxo-bismetalloporphyrin compounds of metal iron , manganese and cobalt were synthesized , and used as the model compounds of cytochrome P-450 monooxygenase in catalytic oxidation of cyclohexane with iodosobenzene. The influence of the addition of magnetic field on the catalytic properties of these metalloporphyrins was inspected. The studies reveal that the influence of the addition of magnetic field on the catalytic behavior of other metalloporphyrins does not go beyond 37% except monoironporphyrin. But the addition of magnetic field makes the reaction yield of cyclohexane oxidation catalyzed by monoironporphyrin be increased to 53% , and makes the rate of reaction be twice as much. This fact means that the catalytic processes of cytochrome P-450 monooxygenase in human bodies may be bound up with earth magnetic field closely. This discovery has singular meaning to unlock the mystery of biosphere consisting of human and earth.
    No preview · Article · Jan 1997