[Show abstract][Hide abstract] ABSTRACT: Highly active antiretroviral therapy for AIDS sometimes engenders inflammatory manifestations resulting from an inappropriate and unbalanced immune-system restoration, called Immune Reconstitution inflammatory Syndrome, which, in turn, can unmask a subclinical infection/pathology. Despite our patient's evident syndrome, the atypical clinical, microbiologic and radiologic feature of Pneumocystis pneumonia made its diagnosis difficult.
Full-text · Article · Jun 2012 · Journal of medicine and life
[Show abstract][Hide abstract] ABSTRACT: Using high resolution computed tomography (HRCT), to assess the lung involvement outcome after autologous hematopoietic stem cell transplant (AHSCT) in patients with scleroderma (systemic sclerosis, SSc).
HCRT scans prospectively performed before (n = 9 patients) and after (n = 47) AHSCT were blindly reviewed by 2 independent investigators using the Wells score.
After a median 60 months' followup, the overall disease extent score from HCRT scans decreased from 10 (0-45) to 4 (0-36) (p = 0.04) 6 months after AHSCT, and thereafter increased up to 36 months and stabilized; the modified Rodnan skin score fell (p < 0.05).
The extent of SSc lung involvement on HRCT rapidly but transiently regressed after AHSCT.
No preview · Article · Jul 2009 · The Journal of Rheumatology