C. Panetta

Sapienza University of Rome, Roma, Latium, Italy

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Publications (21)16.18 Total impact

  • D Innocenzi · C Panetta · S Veneroso · M I Amabile · V Pasta · M Monti
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    ABSTRACT: Examination of more than 700 cutaneous melanoma cases, the authors have identified 19 so-called thin melanomas, which have evolved in the long time in metastases. Two tumor distinctive features, vascularization and regression, correlated between them, seem to be particularly important in outlining the future tumor behavior, and so these two parameters must be analysed and included in the histological report. In these cases it is undoubted the need to make a strict surveillance protocol, also more than 10 years. According to our opinion, surgical treatment can immediately provides, in selected cases, the use of sentinel lymph node technique or the integration with other therapies (immuno-treatment).
    No preview · Article · May 2006 · Il Giornale di chirurgia

  • No preview · Article · Apr 2006
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    ABSTRACT: The relationship between penile lichen sclerosus (LS) and cancer development has not been clearly assessed so far. In order to define these histological features of LS that may indicate or precede a malignant degeneration, 104 biopsy specimens from 86 patients with LS of the glans (90.5%) and from 9 patients with a penile malignancy (7 squamous cell carcinomas, 1 in situ carcinoma, and 1 verrucous carcinoma) arising on LS (9.5%) were reviewed. Three different histopathologic LS patterns were identified: pattern 1 with a prominent lichenoid inflammatory infiltrate in the dermis (9%), pattern 2 characterized by a band-like infiltrate separated from the epidermis by a band of dermal sclerosis (44%), and pattern 3 showing prominent sclerosis with minimal or absent inflammatory infiltrate (9%). These patterns have previously been described in vulvar LS, and have been considered typical of early, mature, and late LS, respectively. In our study, we also found a fourth pattern in 38% of cases, with overlapping features between the first and third pattern, occasionally showing areas of epidermal thickening, with loss of the normal keratinocyte cytoarchitectural differentiation, mitoses and apoptotic cells. In our opinion, the histological features observed in this last pattern may be interpreted as areas of disease reactivation within a chronic stage. Furthermore, 7 out of 9 cases of penile cancer from our series (78%) were associated with this pattern, suggesting that it may correlate with a malignant degeneration.
    Full-text · Article · Feb 2006 · Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo
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    ABSTRACT: Meta-typical carcinoma (MTC) or basosquamous carcinoma is a remarkable malignancy with features of both basal and squamous cell carcinoma. It is typically located on the back and face, often with clinical features of basal cell carcinoma but tending to be more aggressive with enhanced prospects of lymph node or distant metastases. Our report describes a huge neglected MTC of the back of ten-year duration, a giant ulcero-vegetative tumor measuring 20 x 25 cm. Histologic examination of specimens from the margins and periphery revealed aspects of both basal and squamous cell carcinoma, while the ulcerated center showed sclerotic tissue without tumor. Radical excision and reconstruction by grafts were performed. No metastases were observed after two years. There are many controversies surrounding the histologic definition and biologic behavior of MTC, including its metastasizing potential. The MTC we describe exhibited benign biologic behavior. This may have been related to an intense inflammatory host response with elimination of neoplastic tissue and consequent local sclerosis evident in the central tumor-free portion. This central tumor regression is to our knowledge a unique finding in MTC.
    Full-text · Article · Feb 2006 · Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo
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    ABSTRACT: Primary or idiopathic hyperhidrosis (PH) is a disorder of excessive eccrine sweating glands that mainly affects the axillae and the palms. The treatment options for PH involve a range of topical or systemic medication and/or surgical invasive techniques. The common topical treatments are aluminium salts which act by blocking the duct of the eccrine gland or by atrophying the secretory cells. Recently, a new low-residue thermophobic foam formulation (VersaFoam, Mipharm Spa, Milan, Italy), containing 20% of an aluminium salt (sesquichlorhydrate), has been developed. The foam is easy to apply especially in hairy body sites. to evaluate the efficacy and the tolerability of the new aluminium salt foam in the treatment of axillary and palmar PH. Twenty patients were enrolled in a single-centre, open-label follow-up study. The Minor test score (range 0-3) and the Dermatology Life Quality Index (DLQI), were used to evaluate the amount of sweating and the impact on quality of life. The foam was applied to dry, clean skin, every night during the first week of treatment, and three times a week during the second week of treatment. Evaluation of the results was performed at baseline and at 7 and 15 days after treatment. Patients were monitored throughout the study for adverse events. All of the 20 enrolled patients completed the study. The foam resulted in a significant reduction of the Minor score in comparison with baseline values in both the axillary (p = 0.0002) and palm regions (p = 0.0047). By the end of treatment (day 15) the foam had reduced the amount of sweating in the axillae and palm regions by 50% (Minor score: 4.1 vs. 8.1) and 53% (Minor score: 4.0 vs. 8.5), respectively. Use of the foam showed a positive impact in the DLQI for patients with axillary but not palm hyperhidrosis. No side effects were reported during the study duration by the patients. The new foam has been shown to be an effective topical treatment in reducing sweating in patients with axillary and palm PH. This formulation is well tolerated in the short term. Further studies are warranted to evaluate the efficacy and safety in the medium and long term.
    No preview · Article · Jan 2006 · Current Medical Research and Opinion
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    ABSTRACT: Sebaceous carcinoma is an unusual, aggressive, malignant tumor derived from the epithelium of sebaceous glands. It may arise in ocular or extra-ocular sites and is often evident as an ulcerated or non-ulcerated cystic nodule measuring up to 8 cm in diameter. A significant number of extra-ocular sebaceous carcinomas have been associated with metastases and high mortality rate. We reviewed the literature in the context of our report of a 68-year-old woman who had a morpheaform plaque of the upper lip of 15 years duration, extending into the left naso-genal groove, which histologically also showed marked stromal fibrosis. Three years after excision, there were no signs of recurrence or metastases. This patient is unusual in clinical and histologic pattern, as a morpheaform appearance has only been described previously in only one sebaceous carcinoma. In addition, no metastatic disease 15 years after tumor onset is a fortunate and remarkable feature.
    No preview · Article · Dec 2005 · Journal of Surgical Oncology
  • D. Innocenzi · F. Lupi · F. Bruni · M. Frasca · C. Panetta · M. Milani
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    ABSTRACT: Background: Primary or idiophatic hyperhidrosis (PH) is a chronic disorder of excessive eccrine sweating that mainly affects the axillae, the palms, the soles of the feet, and the face. The treatment options for PH involve a range of topical or systemic medications and/or surgical invasive techniques. Common topical treatments are aluminium salts that act by blocking the duct of the eccrine gland. Recently, a new low-residues thermophobic foam formulation containing 20% aluminium salts (sesquichlorhydrate) has been developped (R&D Mipharm, Milan, Italy). The foam formulation is easy to apply expecially in hairy body sites. Study Aim: The aim of this study was to evaluate the effectiveness of this new aluminum salts thermophobic foam in the treatment of axillary and palmar PH. Patients and Methods: In a single center, open-label, follow-up study, 19 patients affected by PH were enrolled. Minor test score and Dermatology Life Quality Index (DLQI) were utilized to evaluate amount and the impact on quality of life. The foam was applied to the dry and clean skin, every night during the first week and three times during the second week. The evaluation of the results was performed by patients' subjective reports (DLQI) collected at baseline, at 7 and 15 days after treatment; and by the objective comparison of Minor test at baseline, at 7 and 15 days after treatment. Patients were monitored throughout the study for adverse events. Results: All of the 19 enrolled patients completed the study. The foam induced a significant reduction of the Minor score in comparison with baseline values in both axillary (p=0.0002) and palm region (p=0.0047), The foam shows a positive impact in DLQI mainly in patients with axillary hyperhidrosis. No side effects were reported during the entire study duration by patients. Conclusion: This new foam has shown to be an effective topical treatment in reducing sweating in patients with primary axillary and palm hyperhidrosis. This formulation is well tolerated in the short term. Further studies are warranted to evaluate efficacy and safety in the medium and long term.
    No preview · Article · Jul 2005
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    ABSTRACT: Percutaneous transhepatic biliary decompression is a preoperative surgical adjunct in patients with obstructive jaundice that has been in use since 1973. It is recommended that this procedure be adopted for both palliative treatment in unresectable patients and as a preoperative means of lowering serum bilirubin in patients with potentially resectable malignancies of the pancreas or biliary tract. Metastatic tumor seeding along the transhepatic biliary catheter is an unusual complication resulting from this procedure but there have been a few cases reported in the literature. Below is a report on a 59-year-old woman in whom the percutaneous transhepatic catheter drainage of the biliary tree, performed before surgical resection of a cholangiocarcinoma, caused cutaneous tumor implantation at the catheter site 3 months later. The clinical aspect was morphea-like and histopathologic examination revealed typical features of a dermal metastasis of adenocarcinoma. Immunohistochemistry revealed cytoplasmic positivity for cytokeratin 7-19, specific for the biliary tract epithelium. A review of the literature available led us to conclude that port-site metastasis in patients with obstructive jaundice treated with percutaneous transhepatic biliary decompression was an unusual but possible complication. In fact, many catheter-tract metastatic deposits in the liver parenchyma, detected at autopsy or on operation, are mistakenly identified as hematogenous or lymphatic metastasis and are not attributed to a catheter-related process. We also report on this case because of the atypical morphea-like aspect of the skin metastasis.
    No preview · Article · Feb 2005 · Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo
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    ABSTRACT: The effects of mechanical forces have been extensively studied in different biological compartments. As regards the skin, it is constantly exposed to stretching and bending in physiologic as well as in pathologic conditions. However, little is known about the effect of mechanical forces on dermal fibroblasts. In order to investigate this issue, we evaluated the cutaneous histopathological features of 15 patients treated by mechanical forces with a new noninvasive, suction-assisted massage technique, in attempt to demonstrate morphological modifications of epidermis and dermis compared with non-treated skin. We quantified these alterations by image analysis, showing significant differences between stressed skin and unstressed controls. The most important changes were observed on fibroblasts and skin vessels.
    No preview · Article · Jan 2005
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    ABSTRACT: Cutaneous melanoma is often characterized by the presence of tumor-infiltrating lymphocytes (TILs). The degree of such infiltration and cell activation are considered significant prognostic factors reflecting the host's immune response to the tumor; thus, patients with peritumoral infiltration may have a better prognosis and may also achieve a better response to interleukin-2 (IL2) immunotherapy. There is evidence that the expression of cluster designation (CD) 25 antigen (IL2 receptor [IL2R]) is a good marker of activity of T lymphocytes against melanoma cells. The aim of this study was to evaluate in vivo the binding of 99mTc-IL2 to lymphocytes infiltrating cutaneous melanoma and to determine whether such uptake correlates with immunologic and histologic data, thus providing useful prognostic information for IL2 therapy in patients with advanced disease. Thirty patients with cutaneous lesions suspected of being melanoma were studied. Planar gamma-camera images over known tumor sites were acquired 1 h after the injection of 111-185 MBq of 99mTc-IL2. Tumor uptake of 99mTc-IL2 was measured as a target-to-background (T/B) radioactivity ratio. All patients underwent surgery, and histologic evaluation of the resected lesion was performed. The percentage of different peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD16, CD25) and the percentage of IL2R-positive tumor cells on histologic sections were also measured. At final histology, 21 lesions were found to be melanoma and 9 were classified as benign. In 15 of 21 (71%) melanomas and 2 of 9 (22%) benign cutaneous lesions, we found uptake of 99mTc-IL2. The calculated T/B ratios correlated significantly with the number of IL2R-positive TILs. 99mTc-IL2 scintigraphy provides a means of in vivo measurement of the extent of tumor infiltration of IL2R-positive cells, thereby providing valuable prognostic information for selection of patients who may benefit from IL2 immunotherapy.
    Full-text · Article · Nov 2004 · Journal of Nuclear Medicine

  • No preview · Article · Jan 2004
  • M R Nasca · C Panetta · G Micali · D Innocenzi
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    ABSTRACT: The case of a 70-year-old white man with a 10-year history of penile lichen sclerosus (LS) who developed microinvasive squamous cell carcinoma on LS is described. A high incidence of penile cancer arising on genital LS has recently been observed. The authors stress the importance of an adequate diagnosis and long-term follow-up in patients with penile LS because of the malignant potential of the disease.
    No preview · Article · Jun 2003 · Journal of the European Academy of Dermatology and Venereology
  • C. Panetta · F. Lupi · G. Montesi · A. Balzani · G. Soda · V. Silipo · S. Calvieri

    No preview · Article · Apr 2003

  • No preview · Article · Apr 2003

  • No preview · Article · Oct 2001

  • No preview · Article · Jan 2001
  • R Boldrini · D Innocenzi · C Panetta · C Bosman

    No preview · Article · May 2000 · Pathologica
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    ABSTRACT: The Nasal Glioma (NG) is a rare, benign congenital mass which arises extra or intranasally. It's a true heterotopia (it's possible to observe the presence of mature glial tissue outside the craniospinal axis) and it's not connected with the central nervous system. The term "nasal glioma" is often used because of its frequent perinasal predilection. M.B. Schmidt gave the first accurate description of NG in 1900. This mass is also refferred to as "nasal cerebral heterotopias" and it may be interpreted as ectopic neural hamartomas (choristoma) in which ectopic brain tissue undergoes a tumor-like evolution. Howewer, most Authors hypothesize that this congenital mass starts as encephaloceles, partially or completely separated from the cerebral lobes by closure of the cranial sutures during the growth. For this reason newborn infants and young children are most commonly affected.
    No preview · Article · Oct 1999
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    ABSTRACT: The Authors report a case of a ten years old girl who presented for two years multiple, irregularly ovalar, white atrofic macules on the trunk and abdomen. Angyna with high fever was anamnestically reported before the appearance of cutaneous lesions. Histological examination showed a typical finding of lichen sclerosus et atrophicus.
    No preview · Article · Oct 1999
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    ABSTRACT: A case of primary leiomyosarcoma of the skin localized on the back in a 63 years old female is described. The lesion was surgically excised and the histological examination revealed, in the superficial and middle dermis, a tumor consisting of cigar-shaped spindle cells with hyperchromatic nucei, arrangenged into irregular fascicles. Large atypical nuclei and mitotic figures were occasionally seen. Masson's trichrome, PAS and Gomori stainings documented the smooth muscle origin, whereas the immunohistochemical stainings revealed positivity for Vimentin, Actin and Desmin confirming the histological diagnosis of LMS. Primary LMS of the skin is commonly classified in cutaneous type, which is predominantly or exclusively intradermal and usually associated with local recurrence, and subcutaneous type that is recurrenting and metastatizanding. No recurrence has been observed after 5 year of follow up. The Autors discuss the clinical and histopathological aspect of LMS of the skin.
    No preview · Article · Jan 1998