Lei-Fang Yang

Liaoning Medical University, Liaonan, Jiangxi Sheng, China

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Publications (1)0.93 Total impact

  • Yu-Bin Wang · Cai-Feng Ba · Lei-Fang Yang · Liang Wang
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    ABSTRACT: Background/aims: To observe the expression of differentiation inhibiting factor 1 (DIF1) and vascular endothelial growth factor (VEGF) and explore the relation between them and microvessel density (MVD) in gastric cancer tissue. Methodology: The expression of DIF1, VEGF, CD34 and MVD in gastric cancer and peri-cancerous tissues was qualitatively analyzed with immunohistochemistry. The protein expression of DIF1 and VEGF in gastric cancer and peri-cancerous tissue was semi-quantitatively analyzed with Western blot. Results: The expression of DIF1 and VEGF, and MVD were significantly higher in gastric cancer tissue than in peri-cancerous tissue (p<0.05). MVD was significantly higher in DIF-positive gastric cancer tissue than in DIF-negative gastric cancer tissue (p<0.001). Conclusions: In gastric cancer, DIF1 expression is related to VEGF expression and MVD. DIF1 may promote angiogenesis in gastric cancer.
    No preview · Article · Jul 2012 · Hepato-gastroenterology

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0.93 Total Impact Points

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  • 2012
    • Liaoning Medical University
      Liaonan, Jiangxi Sheng, China