C Haedecke

Ludwig-Maximilian-University of Munich, München, Bavaria, Germany

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Publications (4)10.96 Total impact

  • H J Anders · C Haedecke · T Sigl · K Krüger
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    ABSTRACT: Over the past 25 years, nailfold capillary microscopy (NCM) has gained diagnostic value in the field of rheumatology based on descriptive data from patients with distinct connective tissue diseases (CTD). We prospectively analysed NCM findings from 116 patients selected for NCM by one of the following indications: (1) suspected diffuse or limited scleroderma or dermatomyositis, (2) evaluation of Raynaud's phenomenon (RP) or (3) suspected small-vessel vasculitis. Nailfold haemorrhages, and enlarged and tortuous nailfold capillaries ('lupus pattern') were found to comparable degrees in patients with CTD and primary RP. Only giant loops, bushy capillaries and avascular areas indicated CTD; 92% of patients with Wegener's granulomatosis (WG) had avascular areas. From all nailfold capillary abnormalities, only bushy capillaries, giant loops and avascular areas support a suspected CTD. A lupus-like pattern is not diagnostic. Avascular areas are a typical abnormality in patients with WG, for which NCM findings have not been described previously.
    No preview · Article · Feb 2000 · Clinical Rheumatology
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    ABSTRACT: Scleroderma renal crisis is characterized by intimal thickening of the afferent glomerular arterioles resulting in hypertension and fibrinoid necrosis of the capillary tuff. We report a 67-year-old man with long-standing systemic sclerosis who developed normotensive progressive renal failure, proteinuria, and a nephritic urinary sediment with serum myeloperoxidase-antineutrophil cytoplasmatic antibodies (MPO-ANCA). Renal biopsy showed pauci-immune crescentic glomerulonephritis but none of the typical vascular changes of scleroderma renal crisis. Because comparable cases have recently been reported from Japan, normotensive MPO-ANCA-positive crescentic glomerulonephritis may form an entity of progressive renal failure in scleroderma.
    No preview · Article · May 1999 · American Journal of Kidney Diseases
  • C Haedecke · AJ Anders · H Kellner · N Weiss
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    ABSTRACT: Homozygous homocystinuria (McKusick 236200) due to cystathionine b-synthase (CBS) de—ciency is an autosomal recessively inherited disease characterized by mental retardation, skeletal deformities, ectopia lentis and arterial and venous thromboembolism. Plasma homocysteine and methionine levels are increased 20- to 60-fold (Mudd et al 1995). The musculoskeletal features of CBS de—ciency include a body habitus resembling the unrelated Marfan syndrome: levoscoliosis, foot defor- mities and genua valga. In contrast to Marfan syndrome, arthritis and bursitis have not been reported in homocystinuria. Bursitis is an in—ammatory reaction of the mesenchymal lining due to various causes such as local trauma, strain, crystal precipitation or any mixed-connective tissue disease that causes arthritis. We followed an adolescent boy with recurrent multifocal bursitis in whom homozygous homocystinuria was diagnosed after the —rst episode of deep venous thrombosis. A 16-year-old boy was referred to our hospital for treatment of deep vein throm- bosis of the left leg, which occurred during immobilization after surgical treatment for spontaneous left suprapatellar bursitis. He was born to healthy, noncon- sanguineous parents of Russian ancestry. Mental retardation was noted at the age of 2 years and bilateral ectopia lentis occurred at the age of 6 years. Clinical exami- nation showed a marfanoid body habitus with a height of 190 cm and an arm span of 210 cm, arachnodactylia and thoracic levoscoliosis. Iridocoloboma and left suprapatellar bursitis were present. Examination of the joints revealed no other abnormalities. All routine laboratory parameters were within normal range. Homocysteine plasma concentration was markedly elevated to 389 kmol/L (upper range 14 kmol/L). Homozygous homo- cystinuria was diagnosed, but homocysteine serum level did not respond to pharma- cological doses of pyridoxine as observed in around 60% of patients with CBS de—ciency (Mudd et al 1995). Treatment with betaine reduced but did not normalize plasma homocysteine levels. Two months later, the patient presented with warm and tender swelling of the right trochanter region. He had no history or evidence of trauma or any rheu- matological disease. Right trochanteric bursa eÜusion was noted by ultrasound examination. Aspiration of the —uid revealed 3 ) 106 leukocytes per ml, predomi- nantly polymorphonuclear cells. Bacteriological studies were negative. Bed rest and local treatment of the bursitis improved symptoms within days. During regular 185
    No preview · Article · May 1999 · Journal of Inherited Metabolic Disease
  • Cornelia. Haedecke
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    ABSTRACT: München, Univ., Diss. : 1994.
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