[Show abstract][Hide abstract] ABSTRACT: Background: Our aim was to assess the value of brain apparent diffusion coefficient (ADC) in Intra Cytoplasmic Sperm Injection (ICSI) and spontaneously conceived preterm singletons. Methods: Twenty ICSI-conceived preterm singletons and 20 gestational age matched spontaneously conceived preterm singletons were studied. All subjects underwent diffusion-weighted imaging (DWI). The main outcome measure was the brain ADC value in the in ICSI-conceived and naturally conceived newborns. Results: Children born after ICSI had an increased ADC value than the controls. The ADC values of ICSI-conceived singletons were higher than those of spontaneously conceived singletons at cerebellum, corpus striatum, frontal lobe, occipital lobe, and temporal lobe white matter. The mean Apgar score, birth weight, height, and head circumference of ICSI children were found to be similar to naturally conceived children. Conclusions: Measuring ADC value may be a promising marker in identifying neurological outcome of ICSI-conceived newborns.
No preview · Article · Jun 2012 · The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
[Show abstract][Hide abstract] ABSTRACT: To assess preptin concentrations in pregnant women with and without gestational diabetes mellitus (GDM) and in the cord blood of their fetuses.
In all, 31 pregnant women with GDM and 31 gestational age-matched healthy pregnant subjects participated. Maternal serum and cord blood preptin levels were measured with ELISA. The relationships between maternal serum and cord blood preptin levels, anthropometric and metabolic parameters were also assessed.
Maternal serum and cord blood preptin levels were found higher in patients with GDM compared with control pregnant women. Preptin concentration in maternal serum was positively correlated with maternal age, fasting insulin levels, 1-h blood glucose after glucose load and cord preptin concentrations at birth. However, relationships between maternal and/or cord serum preptin and fetal growth parameters at birth were not detected.
Our results indicate that preptin concentrations increase in maternal serum of women with GDM. Preptin levels may provide a novel approach to identify women with GDM.
No preview · Article · Dec 2010 · Journal of perinatology: official journal of the California Perinatal Association