Takatoshi Kumamaru

Jichi Medical University, Totigi, Tochigi, Japan

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Publications (10)17.47 Total impact

  • [Show abstract] [Hide abstract] ABSTRACT: It gives important information in selecting the appropriate treatment for urolithiasis to confirm the component of urinary calculus. Presently component analysis of the urinary calculus is generally performed by infrared spectroscopy which is employed by companies providing laboratory testing services in Japan. The infrared spectroscopy determines the molecular components from the absorption spectra in consequence of atomic vibrations. It has the drawback that an accurate crystal structure cannot be analyzed compared with the X-ray diffraction method which analyzes the crystal constituent based on the diffraction of X-rays on crystal lattice. The components of the urinary calculus including carbonate are carbonate apatite and calcium carbonate such as calcite. Although the latter is reported to be very rare component in human urinary calculus, the results by infrared spectroscopy often show that calcium carbonate is included in calculus. The infrared spectroscopy can confirm the existence of carbonate but cannot determine whether carbonate is originated from carbonate apatite or calcium carbonate. Thus, it is not clear whether calcium carbonate is included in human urinary calculus component in Japan. In this study, we examined human urinary calculus including carbonate by use of X-ray structural analysis in order to elucidate the origin of carbonate in human urinary calculus. We examined 17 human calculi which were reported to contain calcium carbonate by infrared spectroscopy performed in the clinical laboratory. Fifteen calculi were obtained from urinary tract, and two were from gall bladder. The stones were analyzed by X-ray powder method after crushed finely. The reports from the clinical laboratory showed that all urinary culculi consisted of calcium carbonate and calcium phosphate, while the gallstones consisted of calcium carbonate. But the components of all urinary calculi were revealed to be carbonate apatite by X-ray diffraction. The components of gallstones were shown to be calcium carbonate (one calcite and the other aragonite) not only by infrared spectroscopy but by X-ray diffraction. It was shown that component analysis of the calculus could be more accurately performed by adding X-ray diffraction method to infrared spectroscopy. It was shown that calcium carbonate existed in a gallstone. As for the carbonate in human urinary calculi, present study showed that it was not calcium carbonate origin but carbonate apatite origin.
    No preview · Article · Oct 2008 · Nippon Hinyōkika Gakkai zasshi. The japanese journal of urology
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    [Show abstract] [Hide abstract] ABSTRACT: (Purpose) It gives important information in selecting the appropriate treatment for urolithiasis to confirm the component of urinary calculus. Presently component analysis of the urinary calculus is generally performed by infrared spectroscopy which is employed by companies providing laboratory testing services in Japan.The infrared spectroscopy determines the molecular components from the absorption spectra in consequence of atomic vibrations. It has the drawback that an accurate crystal structure cannot be analyzed compared with the X-ray diffraction method which analyzes the crystal constituent based on the diffraction of X-rays on crystal lattice.The components of the urinary calculus including carbonate are carbonate apatite and calcium carbonate such as calcite. Although the latter is reported to be very rare component in human urinary calculus, the results by infrared spectroscopy often show that calcium carbonate is included in calculus. The infrared spectroscopy can confirm the existence of carbonate but cannot determine whether carbonate is originated from carbonate apatite or calcium carbonate.Thus, it is not clear whether calcium carbonate is included in human urinary calculus component in Japan.In this study, we examined human urinary calculus including carbonate by use of X-ray structural analysis in order to elucidate the origin of carbonate in human urinary calculus.(Materials and methods) We examined 17 human calculi which were reported to contain calcium carbonate by infrared spectroscopy performed in the clinical laboratory. Fifteen calculi were obtained from urinary tract, and two were from gall bladder. The stones were analyzed by X-ray powder method after crushed finely.(Results) The reports from the clinical laboratory showed that all urinary calculi consisted of calcium carbonate and calcium phosphate, while the gallstones consisted of calcium carbonate.But the components of all urinary calculi were revealed to be carbonate apatite by X-ray diffraction.The components of gallstones were shown to be calcium carbonate (one calcite and the other aragonite) not only by infrared spectroscopy but by X-ray diffraction.(Conclusions) It was shown that component analysis of the calculus could be more accurately performed by adding X-ray diffraction method to infrared spectroscopy.It was shown that calcium carbonate existed in a gallstone. As for the carbonate in human urinary calculi, present study showed that it was not calcium carbonate origin but carbonate apatite origin.
    Full-text · Article · Sep 2008 · Nippon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • A. Matsuzaki · Y. Kobayashi · T. Kumamaru · T. Morita · A. Tokue
    [Show abstract] [Hide abstract] ABSTRACT: Two female patients visited our hospital with urinary stone, consisted of ammonium acid urate (AAU). Case 1 : a 25-year-old female who had a history of laxative abuse was treated by extracorporeal shock wave lithotripsy. Disintegrated stones were consisted of AAU. Case 2 : an 87-year-old woman was referred to our hospital for investigation of acute urinary retention. She suffered from chronic cystitis. The stone was located within the urethra, a tip of which was seen at the external urethral meatus. The calculus was subsequently dislodged from the urethra using forceps. Stone analysis revealed that the calculus was composed of AAU, magnesium ammonium phosphate and calcium carbonate. It seemed to be essential for the management of AAU to avoid the abuse of laxatives and to treatment of cystitis.
    No preview · Article · Jun 2001 · Japanese Journal of Clinical Urology
  • A. Matsuzaki · Y. Kobayashi · T. Kumamaru · T. Morita · A. Tokue
    [Show abstract] [Hide abstract] ABSTRACT: An 87-year-old woman was referred to our hospital for investigation of acute urinary retention. Plain X-ray of the lower abdomen demonstrated a large calculus, and we could see the edge of the stone at the external urethral meatus. The calculus was subsequently dislodged from the urethra using forceps. No remarkable diverticulum was found on the urethra. The stone measured 2.5×2.5×7.5 cm, and weighed 53.5 grams. Stone analysis revealed that the calculus was composed of ammonium acid urate, magnesium ammonium phosphate and calcium carbonate.
    No preview · Article · Jan 2001 · Nishinihon Journal of Urology
  • T. Morita · N. Tachikawa · T. Kumamaru · A. Nukui · H. Ikeda · K. Suzuki · A. Tokue
    No preview · Article · Sep 2000
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    [Show abstract] [Hide abstract] ABSTRACT: Controversy exists on how to diagnose the vanishing testis and the degree of investigation required. In this series, we reviewed anatomical and histological findings in vanishing testes and investigated the effectiveness of diagnostic laparoscopy and imaging studies. Between 1974 and March 1999, 107 boys with nonpalpable testis underwent surgery. Of the total, 52 had spermatic vessels, vas deferens, and/or nubbin, and as a result the diagnosis of vanishing testis was made. The affected side of vanishing testis was left 41, right 9 and bilateral 2.35 nubbins were found and the lengths of 24 nubbins were 5 mm or less. Histological examinations were performed in 43 cases including 27 nubbins. From that total, 31 had vas deferens and 11 had epididymis. Only two nubbins had seminiferous tubules but they included no germ cells. The two nubbins were greater than 5 mm long. Laparoscopic surgery was undertaken in 12 separate cases of the vanishing testis and as a result hypoplastic spermatic vessels were present in 7 of the 12 cases. The incidence of viable testicular tissue in vanishing testes was 4.7% in our series and it ranges from 0-16% in other series. We submit that one can diagnose the inguinal vanishing testis with preoperative imaging and laparoscopy, and that the nubbin seldom contains testicular tissue. Our results do not support the necessity to remove nubbins.
    Preview · Article · Jul 2000 · Nippon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [Show abstract] [Hide abstract] ABSTRACT: The purpose of this study was to evaluate the association between the serum anti-p53 antibodies (Abs) status and the p53 protein status in the sera and tumors as well as clinical or pathological parameters in bladder cancer patients retrospectively. Serum samples from 100 patients with bladder cancer were assayed for anti-p53 Abs and p53 protein by enzyme-linked immunosorbent assay (ELISA). A monoclonal antibody DO7 was used for immunohistochemical staining of tumor p53 protein. Prevalences of serum anti-p53 Abs, serum p53 protein and tumor p53 protein were 12, 1 and 63%, respectively. There was a significant correlation between serum anti-p53 Abs status and factors including tumor stage, tumor grade, and tumor p53 protein status. In the univariate analysis, tumor stage, tumor grade, serum anti-p53 Abs status, and tumor p53 protein status were significantly associated with an increased risk of death. Multivariate analysis showed that tumor stage was the only independent prognostic factor among the factors examined. The present study suggests that serum anti-p53 Abs had a limited value as a tumor marker in bladder cancer patients. Further studies to elucidate the mechanism of anti-p53 Abs production will be necessary for a better understanding of the immune status in bladder cancer patients.
    No preview · Article · Feb 2000 · European Urology
  • K. Suzuki · T. Kumamaru · Y. Shioji · T. Morita · A. Tokue · T. Osawa
    [Show abstract] [Hide abstract] ABSTRACT: A case of renal pelvic and ureteral cancer with an extremely high serum level of carbohydrate antigen 19-9 (CA19-9) is reported. A 70-year-old man presented with right leg edema, gross hematuria and body weight loss. Abdominal CT scan revealed the right severe hydronephrosis due to a right ureteral tumor of 6.5cm in diameter which had invaded the pelvic bone and bladder. Cystoscopy showed that the tumor had invaded the right lateral wall of the bladder, and the right ureteral orifice was unclear. Urinary cytology was positive and transurethral bladder biopsy revealed transitional cell carcinoma. Although levels of serum tumor markers including CA19-9, CEA and SCC were high, there were no abnormal findings in the gastrointestinal tract. The patient was died of sepsis complicated with psoas abscess 34 days after admission. Hematoxylin and eosin staining and immunohistochemical staining for CA19-9 and CEA in autopsy specimens of the renal pelvic and ureteral tumor showed that the tumor was transitional cell carcinoma with both squamous cell carcinoma and adenocarcinoma, and that the tumor was positive for both CA19-9 and CEA immunostaining. It was thought that this tumor produced CA19-9, CEA and SCC.
    No preview · Article · Jan 2000 · Nishinihon Journal of Urology
  • S. Kurokawa · T. Kumamaru · Y. Shioji · M. Yuzawa · Y. Kobayashi · A. Tokue
    [Show abstract] [Hide abstract] ABSTRACT: A 41-year old male patient who had a past history of right nephroureterectomy for carcinoma in situ of the renal pelvis and the ureter, showed class V urinary cytology and a mild dilatation at the left lower ureter demonstrated by excretory pyelography. A random biopsy of the bladder mucosa and the left lower ureter revealed negative findings, however the urinary cytology from the left ureter showed class V. We performed BCG instillation from a percutaneous nephrostomy tube suspecting in situ carcinoma of the left upper urinary tract. The urinary cytology became negative after 1 course of the treatment. No severe side effects were observed in our case, and BCG therapy is considered to be effective for in situ carcinoma of the upper urinary tract.
    No preview · Article · Jan 2000
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    O Muraishi · T Kumamaru · Y Nozaki · Y Mori · A Tokue
    Preview · Article · Mar 1999 · BJU International

Publication Stats

32 Citations
17.47 Total Impact Points

Institutions

  • 1999-2008
    • Jichi Medical University
      • Division of Urology
      Totigi, Tochigi, Japan