Mostafa Asadpoor

Tabriz University of Medical Sciences, Tebriz, East Azerbaijan, Iran

Are you Mostafa Asadpoor?

Claim your profile

Publications (3)0.31 Total impact

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Background: A growing body of preclinical data indicates that statins may possess antineoplastic properties; however, some studies have raised the possibility that statins may also have carcinogenic potential. Methods: An air pouch model was used for angiogenesis. Single or multiple applications of croton oil on the back of Swiss albino mice with or without initiation by dimethylbenz(a)antheracene (DMBA) were used to evaluate the skin tumorgenesis, ultrastructural and histological alterations. Results: Atorvastatin (orally, 10 mg/kg/day) produced a significant (P<0.05) reduction in angiogenesis. Concurrent administration of mevalonate reversed the anti-angiogenic effect of atorvastatin. However, local injection of atorvastatin (200 µg) into the pouches induced a significant (P<0.5) increase in angiogenesis that was not reversed by co-administration of mevalonate. The disturbance of cell polarity, inflammatory response, thickness of epidermal layer, and mitotic index induced by croton oil were inhibited markedly and dose-dependently (P<0.001) by pre-treatment with atorvastatin. In spite of the strong anti-inflammatory and anti-proliferative effects of atorvastatin on epidermal cell proliferation, it was identified that the same doses of atorvastatin in DMBA-initiated and croton oil-promoted skin tumorgenesis in mice increased the incidence of tumors and their conversion into malignant carcinoma. Conclusion: The reasons for these discrepancies remain unclear, and could be related to ambivalent effects of atorvastatin on angiogenesis or to specific differences in the experimental conditions. It is suggested that the pro-angiogenic effect of the drug, which could be responsible for promotion of skin tumors, is independent of the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibition that can be mediated directly by atorvastatin. Iran. Biomed. J. 16 (2): x-x, 2012
    Full-text · Article · May 2012 · Iranian biomedical journal
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A growing body of preclinical data indicates that statins may possess antineoplastic properties; however, some studies have raised the possibility that statins may also have carcinogenic potential. An air pouch model was used for angiogenesis. Single or multiple applications of croton oil on the back of Swiss albino mice with or without initiation by dimethylbenz(a)antheracene (DMBA) were used to evaluate the skin tumorgenesis, ultrastructural and histological alterations. Atorvastatin (orally, 10 mg/kg/day) produced a significant (P<0.05) reduction in angiogenesis. Concurrent administration of mevalonate reversed the anti-angiogenic effect of atorvastatin. However, local injection of atorvastatin (200 μg) into the pouches induced a significant (P<0.5) increase in angiogenesis that was not reversed by co-administration of mevalonate. The disturbance of cell polarity, inflammatory response, thickness of epidermal layer, and mitotic index induced by croton oil were inhibited markedly and dose-dependently (P<0.001) by pre-treatment with atorvastatin. In spite of the strong anti-inflammatory and anti-proliferative effects of atorvastatin on epidermal cell proliferation, it was identified that the same doses of atorvastatin in DMBA-initiated and croton oil-promoted skin tumorgenesis in mice increased the incidence of tumors and their conversion into malignant carcinoma. The reasons for these discrepancies remain unclear, and could be related to ambivalent effects of atorvastatin on angiogenesis or to specific differences in the experimental conditions. It is suggested that the pro-angiogenic effect of the drug, which could be responsible for promotion of skin tumors, is independent of the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibition that can be mediated directly by atorvastatin.
    Full-text · Article · Apr 2012 · Iranian biomedical journal
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Due to the lack of information about the porosity exponent (m) from core experiments, the impossibility of comparison between the results and the core data, and, finally, inattentiveness to fractured intervals, the correct determination of the porosity exponent value in the calculation of water saturation and also the core-log correlation have generally been neglected. In this article, an analysis of the Mishrif Unit was carried out in two wells in order to properly calculate the water saturation and determine the best producing intervals. Based on fractured zones detection and the results of petrophysical evaluation in the calculation of shale volume and true matrix properties for these zones, accurate values of the porosity (matched with core data) were used to determine the porosity exponent. Hence, one of the advantages of this study is applying the method introduced simply for the fractured parts of the reservoir unit, in order to obtain the correct value for water saturation. Detecting proper producing intervals in the Mishrif Unit was executed using integrated evaluation of petrophysical data, geological data, and core data using a new method of shaly carbonate formation interpretation based on petrophysical log results. In this method, a statistical parameter, P½, was used. The results from the application of the method show better interpretation and water saturation calculation using petrophysical logs of fractured shaly carbonate formations in combination with other available methods in the petroleum community.
    Full-text · Article · Aug 2011 · Petroleum Science and Technology