Publications (4)12.02 Total impact
Article: Atypical histiocytosis in the lung[Show abstract] [Hide abstract]
ABSTRACT: To report a rare case of atypical histiocytic tumor of the lung with a review of literature. The clinical materials were noted. Literature related to this condition from the past 50 years was reviewed from the group of histiocytic tumors. Clinical manifestations were non-specific. The imaging characteristics of our case were infiltrative lesions with multiple cysts in both lungs. Pathology showed nodular proliferation of atypical cells. Immunohistochemistry suggested a histiocytic origin of the infiltrating atypical cells. Because the pathological findings did not fall into any particular category of typical histiocytic tumors, the final diagnosis was atypical histiocytic tumor. The presentation of atypical histiocytic tumor of the lungs, only, with infiltrative lesions and multiple air cysts seems very rare, with pathological examination being "gold standard" for the diagnosis.
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ABSTRACT: To investigate the clinicopathological features of primary intravascular large B-cell lymphoma of lung. A case of primary pulmonary intravascular large B-cell lymphoma was analysed in histopathology and immunophenotype. The patient is a 42-year-old female who had cough for one year. Computed tomography showed ground-glass opacities and small nodules in bilateral lung fields. Histopathology demonstrated accumulation of similar sized neoplastic cells within alveolar capillaries, widening the alveolar septae. The alveolar structure sustained in part of districtions. Immunohistologically, the tumor cells were positive for CD20 and negative for CD3,CK, which were similar to the diffuse large B-cell lymphoma. Intravascular large B-cell lymphoma is an uncommon type of non-Hodgkin's lymphoma. Primary pulmonary presentation is even more rare. The diagnosis is based on the histopathology and immunohistochemistry. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2076991810705433.
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ABSTRACT: Investigate the clinical characteristics of pulmonary cryptococcosis (PC) patients in China, with analysis of immunocompetent and immunocompromised subjects.Retrospective review of 76 patients diagnosed with tissue confirmed PC at the Shanghai Pulmonary Hospital during a 9 years period (2001-2009).Of 76 patients (males 54, females 22), 41 were immunocompetent (53.95%), and 35/41 were asymptomatic. Approximately 80% patients have histories suspicious of environmental fungal exposure. Radiological (Computer Tomographic) findings showed predominantly peripheral findings (85.53%, 65/76) including nodular masses (55.26%, 42/76), pneumonic infiltrates (23.68%, 18/76) and mixed (21.05%, 16/76). 43.42% (33/76) were initially misdiagnosed, often as cancer by false-positive 18F-FDG-PET (28/46 cases). 51 patients received antifungal therapy, 25 patients were clinically observed without treatment. As of December 31, 2010, 71 cases showed total recovery, 4 cases improvement (efficacy rate of 98.68%, 75/76). One HIV-positive case died of cryptoccal meningitis.Incidence of PC in China may be related to environmental fungal exposures. Most presented as asymptomatic peripheral lung lesions. False positive 18FDG-PET examinations often lead to initial clinical misdiagnosis of cancer. Unlike immunocompromised or clinically symptomatic patients, all immunocompetent patients had a good response, either to fluconazole monotherapy, or observation with a tendency of spontaneous remissions in the asymptomatic immunocompetent subjects.