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ABSTRACT: PurposeTo correlate permeability (rktrans), extracellular volume fraction (rve), relative to muscle and initial area under the enhancement curve (IAUC60m) determined by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with in vivo measurements of interstitial fluid pressure (IFP) in patients with cervical cancer.Materials and MethodsDCE-MRI and IFP measurements were performed of cervical tumors of 32 patients prior to therapy. Median tumor rktrans and rve were derived from a bidirectional two-compartment model using an input function derived from muscle. Median IAUC60m was defined as the integral of tumor enhancement in the first 60 seconds divided by the similar muscle enhancement integral. These parameters were correlated with the mean tumor IFP.ResultsThere was a significant negative correlation between IAUC60m and IFP (r = –0.42, P = 0.016) and between rktrans and IFP (r = –0.47, P = 0.008). The was no significant correlation between IFP and rve.Conclusion
There is a moderate negative correlation between IAUC60m, rktrans, and IFP in cervical cancer. This suggests that these parameters may be of value in assessment of tumor behavior. J. Magn. Reson. Imaging 2007. © 2006 Wiley-Liss, Inc.
The Princess Margaret Hospital
Toronto, Ontario, Canada