Publications (2)0.22 Total impact
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ABSTRACT: Objective: To study effects of special brain area regional cerebral blood flow (rCBF) perfusion abnormality on learning memory function and its molecular mechanism in rats. Method: A total of 64 adult male healthy SD rats were randomly divided into two groups, the false operation group (control group) and the operation group (model group). The false operation group was randomly sub-divided into four subgroups (A 0, B 0, C 0 and D 0); the operation group was randomly sub -divided into four subgroups (A, B, C and D), there were eight rats in each group. The operation groups were given bilateral common carotid artery permanent ligation, the other groups were given skin surgical operation only. Result: The rCBF of right frontal lobe division and right hippocampus division in operation group were significantly lower than that of false operation group (P<0.05). The error number (EN) and the day of reach standard and total reaction time (TRT) of learning index sign in operation group rats were significantly higher than that of false operation group rats (P<0.05); but the active avoid rate in operation group rats was significantly lower than that of false operation group rats. The Fos and Jun positive expression and average absorbency of right frontal lobe division and right hippocampus division in all operation groups were significantly higher than that in false operation groups (P<0.05). Bax and Bcl-2 positive cells were all increasing in operation groups, and the expression ratio of Bax/Bcl-2 in operation groups was significantly higher than that in false operation groups (P<0.01). Conclusion: rCBF decrease can impair learning and memory abilities of rats, which may be related to the increase of expression ratio of c-fos or c-jun or Bcl-2 or Bax in frontal cortex and hippocampus.
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ABSTRACT: Background Presently, clinic memory scale is used to evaluate learning memory ability in most studies, and the influence of difference in measurement condition of individuals exists.Objective To study the correlation between regional cerebral blood flow (rCBF) perfusion and learning memory function in special brain regions of patients with cerebral infarction at convalescent period, and to try to find out a method which can quantitatively evaluate learning ability.DesignCase observation, and correlation analysis.SettingsShandong Institute for Behavioral Medicine; the Affiliated Hospital of Jining Medical College.ParticipantsTotally 70 patients with cerebral infarction admitted to Department of Neurology, Jining Medical College between January 2004 and December 2005 were involved. The involved patients, 58 male and 12 female, were averaged (52±3)years, and they were all right handed. They all met the diagnosis criteria instituted by the Fourth National Conference on Cerebrovascular Disease, and were confirmed as cerebral infarction by skull CT or MRI. Informed consents of detected items were obtained from all the patients and relatives.Methods When the patients were at convalescent period, their learning and memory ability were measured with “clinic memory scale (set A)”. The 18 patients whose total mark over 100 were regarded as good learning memory function group; The 23 cases whose total mark less than 70 were regarded as poor learning memory function group. RCBF of hippocampus, nucleus amygdalae, temporal cortex and prefrontal lobe of patients between two groups were measured and compared by single photon emission computed tomography (SPECT). The total scores of the 18 good learning memory patients and 23 poor learning memory patients were taken as dependent variable Y, and their rCBFs of hippocampus, nucleus amygdale, temporal cortex and prefrontal lobe respectively as independent variable X for linear correlation analysis.Main outcome measuresCorrelation of rCBF in different brain regions and learning memory ability in patients with cerebral infarction.Results The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of good learning memory function group were significantly higher than those of poor learning memory function group (P < 0.05). In the good learning memory function group, rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex were significantly positively correlated with memory scale scores(r = 0.961, 0.926, 0.954, 0.907, P < 0.05), and also in the poor learning memory function group (r = 0.979, 0.976, 0.991, 0.953, P < 0.05).Conclusion The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of patients with cerebral infarction are significantly positively correlated with memory scale scores. Predicting learning memory ability of patients by quantitative determination of rCBF provides a quantitative and objective method for evaluating learning memory ability.
Jining Medical UniversityChi-ning-shih, Shandong Sheng, China