Y. Wang

University of California, Los Angeles, Los Ángeles, California, United States

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Publications (1160)2947.27 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: Estrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF). Furthermore, the heart has all the machinery to locally biosynthesize estrogen via aromatase, but the role of local cardiac estrogen synthesis in HF has not yet been studied. Here we hypothesized that cardiac estrogen is reduced in HF and examined whether exogenous estrogen therapy can rescue HF. Methods and results: HF was induced by transaortic constriction in mice, and once mice reached an ejection fraction (EF) of ≈35%, they were treated with estrogen for 10 days. Cardiac structure and function, angiogenesis, and fibrosis were assessed, and estrogen was measured in plasma and in heart. Cardiac estrogen concentrations (6.18±1.12 pg/160 mg heart in HF versus 17.79±1.28 pg/mL in control) and aromatase transcripts (0.19±0.04, normalized to control, P<0.05) were significantly reduced in HF. Estrogen therapy increased cardiac estrogen 3-fold and restored aromatase transcripts. Estrogen also rescued HF by restoring ejection fraction to 53.1±1.3% (P<0.001) and improving cardiac hemodynamics both in male and female mice. Estrogen therapy stimulated angiogenesis as capillary density increased from 0.66±0.07 in HF to 2.83±0.14 (P<0.001, normalized to control) and reversed the fibrotic scarring observed in HF (45.5±2.8% in HF versus 5.3±1.0%, P<0.001). Stimulation of angiogenesis by estrogen seems to be one of the key mechanisms, since in the presence of an angiogenesis inhibitor estrogen failed to rescue HF (ejection fraction=29.3±2.1%, P<0.001 versus E2). Conclusions: Estrogen rescues pre-existing HF by restoring cardiac estrogen and aromatase, stimulating angiogenesis, and suppressing fibrosis.
    No preview · Article · Jan 2016 · Journal of the American Heart Association
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    ABSTRACT: To understand the thermal insulation and failure problems of the thermal barrier coatings (TBCs) deeply is vital to evaluate the reliability and durability of the TBCs. Actually, experimental methods can not reflect the real case of the TBCs during its fabrication and service process. Finite element modeling (FEM) play an important role in studying these problems. Especially, FEM is very effective in calculating the thermal insulation and the fracture failure problems of the TBCs. In this paper, the research progress of the FEM on the study of the thermal insulation and associated failure problems of the TBCs has been reviewed. Firstly, from the aspect of the investigation of the heat insulation of the TBCs, the thermal analysis via FEM is widely used. The effective thermal conductivity, insulation temperature at different temperatures of the coating surface considering the thermal conduct, convection between the coating and the environment, heat radiation at high temperature and interfacial thermal resistance effect can be calculated by FEM. Secondly, the residual stress which is induced in the process of plasma spraying or caused by the thermal expansion coefficient mismatch between the coating and substrate and the temperature gradient variation under the actual service conditions can be also calculated via FEM. The solution method is based on the thermal-mechanical coupled technique. Thirdly, the failure problems of the TBCs under the actual service conditions can be calculated or simulated via FEM. The basic thought is using the fracture mechanic method. Previous investigation focused on the location of the maximum residual stress and try to find the possible failure positions of the TBCs, and to predict the possible failure modes of the TBCs. It belonged to static analysis. With the development of the FEM techniques, the virtual crack closure technique (VCCT), extended finite element method (XFEM) and cohesive zone model (CZM) have been used to simulate the crack propagation behavior of the TBCs. The failure patterns of the TBCs can be monitored timely and dynamically using these methods and the life prediction of the TBCs under the actual service conditions is expected to be realized eventually.
    No preview · Article · Jan 2016 · Journal of the European Ceramic Society
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    ABSTRACT: To quantify and compare the impact of interfractional setup and anatomy variations on proton therapy (PT) and intensity modulated radiotherapy (IMRT) for prostate cancer.
    No preview · Article · Dec 2015 · International journal of radiation oncology, biology, physics
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    ABSTRACT: RNA splicing is a major contributor to total transcriptome complexity; however, the functional role and regulation of splicing in heart failure remain poorly understood. Here, we used a total transcriptome profiling and bioinformatic analysis approach and identified a muscle-specific isoform of an RNA splicing regulator, RBFox1 (also known as A2BP1), as a prominent regulator of alternative RNA splicing during heart failure. Evaluation of developing murine and zebrafish hearts revealed that RBFox1 is induced during postnatal cardiac maturation. However, we found that RBFox1 is markedly diminished in failing human and mouse hearts. In a mouse model, RBFox1 deficiency in the heart promoted pressure overload-induced heart failure. We determined that RBFox1 is a potent regulator of RNA splicing and is required for a conserved splicing process of transcription factor MEF2 family members that yields different MEF2 isoforms with differential effects on cardiac hypertrophic gene expression. Finally, induction of RBFox1 expression in murine pressure overload models substantially attenuated cardiac hypertrophy and pathological manifestations. Together, this study identifies regulation of RNA splicing by RBFox1 as an important player in transcriptome reprogramming during heart failure that influence pathogenesis of the disease.
    Preview · Article · Nov 2015 · Journal of Clinical Investigation
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    ABSTRACT: The failure of thermal barrier coatings (TBCs) fabricated by atmospheric plasma spraying (APS) during thermal cycling is often attributed to the accumulation of the thermal stress. However, in the end it comes down to the growth of thermally grown oxide (TGO) and propagation of the cracks around the TGO. Based on the 8 wt.% yttria stabilized zirconia (YSZ) TBCs fabricated by APS (APS-TBCs), the geometrical shape of the TGO layer which is located between the bond-coat (BC) and top-coat (TC) was simplified as sinusoidal curve with a certain amplitude and wavelength. The influence of the horizontal crack and vertical crack in the ceramic layer on the stress around the TGO layer during thermal cycling has been calculated using finite element method. The investigation results indicate that the stress concentration in the TBCs is dependent on the location of the vertical and horizontal crack. The vertical crack can partially release the stress concentration around the TGO layer compared with the horizontal crack if the crack is located above the peak of the TGO layer. When there is horizontal crack, the maximum tensile stress is located at the peak of the TGO/BC interface, while the maximum compressive stress is located at the spinodal position at the inner of the TGO. When there is vertical crack, the stress concentration tends to appear near to the crack tip, and the influences of horizontal crack and vertical crack on the stress around the TGO are distinctly different. In addition, the location of the vertical crack also has a certain influence on the distribution of the maximum stress. The vertical crack and the TGO have mutual effect on the stress concentration of each other. As for the horizontal crack, if it is located below the peak of the TGO layer (at the inner of the top-coat and near to the TGO layer), the crack tip has also exhibited stress concentration effect compared with the case that the horizontal crack is located above the peak of the TGO layer. The fracture mechanic parameters of the crack which may propagate, the propagation patterns of single crack and failure mechanisms of the APS-TBCs have also been calculated and discussed in this paper.
    No preview · Article · Nov 2015 · Surface and Coatings Technology
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    ABSTRACT: MYB genes are extensively distributed in higher plants and constitute one of the largest transcription factors (TFs) families. These TFs have been proved to be implicated in the regulation of plant growth, development, metabolism, and multiple abiotic stress responses. In the present study, a new soybean MYB gene, denoted GmMYBJ2, was isolated and its function was characterized. The GmMYBJ2 cDNA is 1428 bp in length with an open reading frame (ORF) of 960 bp encoding 319 amino acids. Sequence and yeast one-hybrid analyses showed GmMYBJ2 contains two MYB domains and belongs to R2R3-MYB protein with transactivation activity. Transient expression analysis using the GmMYBJ2-GFP fusion gene in onion epidermal cells showed GmMYBJ2 protein is targeted to the nucleus. GmMYBJ2 was induced by drought, cold, salt, and exogenous abscisic acid (ABA). Arabidopsis overexpressing GmMYBJ2 exhibited a higher seed germination rates (GRs), a notable increase in the soluble sugar content under water-deficit stress, and a lower water loss rate (WLR) when water is sufficient. These results indicated the overexpression of GmMYBJ2 make transgenic Arabidopsis more tolerant to drought stress than wild-type (WT) plants, and GmMYBJ2 may be useful for improving drought stress tolerance in transgenic plant breeding. © 2015, Franciszek Górski Institute of Plant Physiology, Polish Academy of Sciences, Kraków.
    No preview · Article · Jul 2015 · Acta Physiologiae Plantarum
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    ABSTRACT: To investigate the effects of interfractional anatomy and setup variations on plans with anterior-oblique vs. lateral beams for prostate cancer pencil beam scanning (PBS) and passive scattered (PS) proton therapy. Six patients with low/intermediate risk prostate cancer treated with PS proton therapy at our institution were selected. All patients underwent weekly verification CT scans. Implanted fiducials were used for localization, and endorectal balloons for prostate immobilization. New PBS plans with lateral beams, as well as PBS and PS plans with anterior-oblique beams (±35 deg) were created. PBS plans used two different spot sizes: ∼10mm (large) and ∼5mm (medium) sigma at 25cm range and optimized as single-field-uniform-dose with ∼8% non-uniformity. No range uncertainty margins were applied in PBS plans to maximize rectal sparing. Field-specific apertures were used when planning with large spots to sharpen the penumbrae. The planned dose was recomputed on each weekly CT with fiducials aligned to the simulation CT, scaled and accumulated via deformable image registration. The dose volume analysis showed that although difference between planned and accumulated dose remains negligible for plans with conventional lateral beams using both PS and PBS, this is not the case for plans with anterior beams. The target coverage in anterior plans was largely degraded due to the variations in the beam path length and the absence of range margins. The average prostate D95 was reduced by 7.5/15.9% (using PS/PBS) after accumulation for anterior plans, compared with 0/0.4% for lateral plans. The average mean dose in organs-at-risk decreased by 1% for lateral and 2% for anterior plans, similarly for PS and PBS. Spot size did not affect the dose changes. Prostate plans using anterior beams may undergo clinically relevant interfractional dose degradation. Corrective strategies guided by in-vivo range measurements should be studied before clinical application of this technique.
    No preview · Article · Jun 2015 · Medical Physics
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    ABSTRACT: To ascertain the necessity of a proton gantry, as compared to the feasibility of using a horizontal fixed proton beam-line for treatment with advanced technology. To calculate the percentage of patients that can be treated with a horizontal fixed beam-line instead of a gantry, we analyze the distributions of beam orientations of our proton gantry patients treated over the past 10 years. We identify three horizontal fixed beam geometries (FIXED, BEND and MOVE) with the patient in lying and/or sitting positions. The FIXED geometry includes only table/chair rotations and translations. In BEND, the beam can be bent up/down for up to 20 degrees. MOVE allows for patient head/body angle adjustment. Based on the analysis, we select eight patients whose plan involves beams which are still challenging to achieve with a horizontal fixed beam. These beams are removed in the pencil beam scanning (PBS) plan optimized for the fixed beam-line (PBS-fix). We generate non-coplanar PBS-gantry plans for comparison, and perform a robustness analysis. The percentage of patients with head-and-neck/brain tumors that can be treated with horizontal fixed beam is 44% in FIXED, 70% in 20-degrees BEND, and 100% in 90-degrees MOVE. For torso regions, 99% of the patients can be treated in 20-degree BEND. The target coverage is more homogeneous with PBS-fix plans compared to the clinical scattering treatment plans. The PBS-fix plans reduce the mean dose to organs-at-risk by a factor of 1.1-28.5. PBS-gantry plans are as good as PBS-fix plans, sometimes marginally better. The majority of the beam orientations can be realized with a horizontal fixed beam-line. Challenging non-coplanar beams can be eliminated with PBS delivery. Clinical implementation of the proposed fixed beam-line requires use of robotic patient positioning, further developments in immobilization, and image guidance. However, our results suggest that fixed beam-lines can be as effective as gantries.
    No preview · Article · Jun 2015 · Medical Physics
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    ABSTRACT: New results are reported from a measurement of π^{0} electroproduction near threshold using the p(e,e^{'}p)π^{0} reaction. The experiment was designed to determine precisely the energy dependence of s- and p-wave electromagnetic multipoles as a stringent test of the predictions of chiral perturbation theory (ChPT). The data were taken with an electron beam energy of 1192 MeV using a two-spectrometer setup in Hall A at Jefferson Lab. For the first time, complete coverage of the ϕ_{π}^{*} and θ_{π}^{*} angles in the pπ^{0} center of mass was obtained for invariant energies above threshold from 0.5 up to 15 MeV. The 4-momentum transfer Q^{2} coverage ranges from 0.05 to 0.155 (GeV/c)^{2} in fine steps. A simple phenomenological analysis of our data shows strong disagreement with p-wave predictions from ChPT for Q^{2}>0.07 (GeV/c)^{2}, while the s-wave predictions are in reasonable agreement.
    Full-text · Article · May 2015 · Physical Review Letters
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    Arjun Deb · Yibin Wang

    Preview · Article · Mar 2015 · Circulation
  • Christoph D Rau · Aldons J Lusis · Yibin Wang
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    ABSTRACT: In contrast to many other human diseases, the use of genome-wide association studies (GWAS) to identify genes for heart failure (HF) has had limited success. We will discuss the underlying challenges as well as potential new approaches to understanding the genetics of common forms of HF. Recent research using intermediate phenotypes, more detailed and quantitative stratification of HF symptoms, founder populations and novel animal models has begun to allow researchers to make headway toward explaining the genetics underlying HF using GWAS techniques. By expanding analyses of HF to improved clinical traits, additional HF classifications and innovative model systems, the intractability of human HF GWAS should be ameliorated significantly.
    No preview · Article · Mar 2015 · Current Opinion in Cardiology
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    ABSTRACT: Vascularized composite allotransplantation (VCA) has emerged as a treatment option for treating nonlife-threatening conditions. Therefore, in order to make VCA a safe reconstruction option, there is a need to minimize immunosuppression, develop tolerance-inducing strategies and elucidate the mechanisms of VCA rejection and tolerance. In this study we explored the effects of hIL-2/Fc (a long-lasting human IL-2 fusion protein), in combination with antilymphocyte serum (ALS) and short-term cyclosporine A (CsA), on graft survival, regulatory T cell (Treg) proliferation and tolerance induction in a rat hind-limb transplant model. We demonstrate that hIL-2/Fc therapy tips the immune balance, increasing Treg proliferation and suppressing effector T cells, and permits VCA tolerance as demonstrated by long-term allograft survival and donor-antigen acceptance. Moreover, we observe two distinct types of acute rejection (AR), progressive and reversible, within hIL-2/Fc plus ALS and CsA treated recipients. Our study shows differential gene expression profiles of FoxP3 versus GzmB, Prf1 or interferon-γ in these two types of AR, with reversible rejection demonstrating higher Treg to Teff gene expression. This correlation of gene expression profile at the first clinical sign of AR with VCA outcomes can provide the basis for further inquiry into the mechanistic aspects of VCA rejection and future drug targets. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.
    Full-text · Article · Feb 2015 · American Journal of Transplantation
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    ABSTRACT: We report the first measurement of the target single-spin asymmetry, $A_y$, in quasi-elastic scattering from the inclusive reaction $^3$He$^{\uparrow}(e,e^\prime)$ on a $^3$He gas target polarized normal to the lepton scattering plane. Assuming time-reversal invariance, this asymmetry is strictly zero for one-photon exchange. A non-zero $A_y$ can arise from the interference between the one- and two-photon exchange processes which is sensitive to the details of the sub-structure of the nucleon. An experiment recently completed at Jefferson Lab yielded asymmetries with high statistical precision at $Q^{2}=$ 0.13, 0.46 and 0.97 GeV$^{2}$. These measurements demonstrate, for the first time, that the $^3$He asymmetry is clearly non-zero and negative with a statistical significance of (8-10)$\sigma$. Using measured proton-to-$^{3}$He cross-section ratios and the effective polarization approximation, neutron asymmetries of $-$(1-3)% were obtained. The neutron asymmetry at high $Q^2$ is related to moments of the Generalized Parton Distributions (GPDs). Our measured neutron asymmetry at $Q^2=0.97$ GeV$^2$ agrees well with a prediction based on two-photon exchange using a GPD model and thus provides a new, independent constraint on these distributions.
    Full-text · Article · Feb 2015 · Physical Review Letters
  • Y. Wang · X.-T. Rui · B.-B. Feng · T. Chen · G.-P. Wang
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    ABSTRACT: To characterize the fragmentation degree of propellant charge quantitatively, the concepts of dynamic vivacity ratio and initial dynamic vivacity ratio (IDVR) were introduced. The dynamic vivacity ratio, which is the ratio of burning surface area of fragmented propellant charge to the corresponding not-fragmented propellants charges, and IDVR, which is the ratio of burning surface area of fragmented propellant charge to the corresponding not-fragmented propellants charges at the initial time were deduced using the gas state equations of the closed bomb. The close bomb tests were done with three kinds of petal propellants with 19 holes and different lengths of 13.6 mm, 10 mm and 5 mm. The p-t curves of the propellants with different lengths were obtained. The IDVR of the corresponding propellants was gained by processing the p-t curves. The initial surface area of propellants with different lengths was obtained via calculation based on the geometrical shape, and then the IDVRs of the propellants were obtained. Results show that the IDVRs' results of tests are close to the calculated values, showing that the IDVR of the propellant can denote the fragmentation degree of fragmented propellant charge quantitatively. ©, 2014, Institute of Chemical Materials, China Academy of Engineering Physics. All right reserved.
    No preview · Article · Jan 2015

  • No preview · Article · Jan 2015 · Journal of Cardiothoracic and Vascular Anesthesia
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    F. Zhao · P. Zhuang · T. Zhang · Y. Wang · J. Hou · J. Liu · L. Zhang
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    ABSTRACT: Serum osmolality and ion concentrations were measured in juvenile Chinese sturgeon Acipenser sinensis at different salinities to determine the isosmotic point. Isosmotic and isoionic concentrations were calculated from the regressions for serum and ambient osmolality, with Na+, Cl− and K+ as salinities 9·19, 8·17, 7·89 and 9·70, respectively. These values were consistent with the salinity of the habitat where juvenile A. sinensis occur in the Yangtze Estuary, suggesting that an isosmotic salinity is an important factor driving their habitat choice.
    Full-text · Article · Jan 2015 · Journal of Fish Biology
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    ABSTRACT: New results are reported from an experiment to measure $\pi^0$ electroproduction at and above threshold using the $p(e,e^{\prime} p)\pi^0$ reaction. The experiment was designed to precisely determine the energy dependence of $s-$ and $p-$wave electromagnetic multipoles as a stringent test of the predictions of Chiral Perturbation Theory (ChPT). The data were taken with an electron beam energy of 1192 MeV using a two-spectrometer setup in Hall A at Jefferson Lab. For the first time, complete coverage of the $\phi^*_{\pi}$ and $\theta^*_{\pi}$ angles in the $p \pi^0$ center-of-mass was obtained for invariant energies above threshold from 0.5~MeV up to 15~MeV. The 4-momentum transfer $Q^2$ coverage ranges from 0.05 to 0.155 (GeV/c)$^2$ in fine steps. A simple phenomenological analysis of our data shows strong disagreement with $p-$wave predictions from ChPT for $Q^2>0.07$ (GeV/c)$^2$, while the $s-$wave predictions are in reasonable agreement.
    Full-text · Article · Jan 2015
  • Zhihua Wang · Yibin Wang
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    ABSTRACT: Myheart is a cardiac-specific long-noncoding (lnc) RNA with targeted modulation of chromatin-modifying switching-defective/sucrose-nonfermenting complex via direct interaction with Brg1. Genetic induction of Myheart in mouse heart has a significant protective effect against the pathogenesis of heart failure. LncRNAs are emerging epigenetic regulators with potentially important roles in cardiac development and diseases.
    No preview · Article · Jan 2015 · Circulation Research
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    ABSTRACT: The Moderate Resolution Imaging Spectroradiometer (MODIS) Collection 5.1 Aerosol Optical Depth (AOD) data retrieved at 0.55 μm with spatial resolution of 10 km (MYD04) and the new 1 km Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm from MODIS is investigated in this work. We focus on evaluating the ability of these two products to characterize the spatial distribution of aerosols within urban areas. This is done through the comparison with PM10 measurements from 126 of the Italian Regional Agency for Environmental Protection (ARPA) ground monitoring stations during 2012. The Po Valley area (northern Italy) was chosen as the study domain since urban air pollution is one of the most important concerns in this region. Population and industrial activities are located within a large number of urban areas within the valley. We find that the annual correlations between PM10 and AOD are R2 = 0.90 and R2 = 0.62 for MYD04 and for MAIAC respectively. When the depth of the planetary boundary layer (PBL) is used to normalize the AOD, we find a significant improvement in the PM–AOD correlation. The introduction of the PBL information is needed for AOD to capture the seasonal cycle of the observed PM10 over the Po valley and significantly improves the PM vs. AOD relationship, leading to a correlation of R2 = 0.98 for both retrievals when they are normalized by the PBL depth. The results show that the normalized MAIAC retrieval provides a higher resolution depiction of the AOD within the Po Valley and performs as well in a statistical sense as the normalized standard MODIS retrieval for the same days and locations.
    Full-text · Article · Jan 2015 · Atmospheric Chemistry and Physics
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    Ding S · Xu Y · Wang Y · He Y · Hou J · Chen L · He J-S
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    ABSTRACT: The methylation index of branched tetraethers (MBT) and cyclization ratio of branched tetraethers (CBT) based on the distribution of bacteria-derived branched glycerol dialkyl glycerol tetraethers (bGDGTs) are useful proxies for the reconstruction of continental paleotemperature and soil pH. Several calibrations of the MBT-CBT index have been proposed based on global and regional soils and lake sediments. However, little is known about the distribution and applicability of GDGTs proxies in the Qinghai–Tibet Plateau (QTP), a critical region of the global climate system. Here, we investigated 33 surface soils covering a large area of the QTP. Redundancy analysis showed that soil pH was the most important factor affecting GDGT distributions, followed by mean annual precipitation (MAP) and mean annual air temperature (MAT). The branched-isoprenoid tetraether (BIT) index, an indicator for estimation of soil organic matter in aquatic environments, varied from 0.48 to 1 and negatively correlated with soil pH (r2 = 0.38), suggesting that the BIT index should be used with caution in the QTP. A transfer function of the CBT index-soil pH was established to estimate paleo-soil pH in the QTP: pH = 8.33–1.43 × CBT (r2 = 0.80, RMSE = 0.27 pH unit). The local calibration of MBT-CBT index presented a weak, still significant correlation with MAT (r2 = 0.36) mainly owing to the additional influence of MAP (r2 = 0.50). Combining our data with previously reported GDGTs for Chinese soils resulted in a new calibration of MBT/CBT-MAT: MAT = 2.68+26.14 × MBT–3.37 × CBT (r2 = 0.73; RMSE = 4.2 °C, n = 164). The correlation coefficient and residual error of this new transfer function is comparable with global calibrations, suggesting that MBT-CBT paleotemperature proxy is still valid in the QTP.
    Full-text · Article · Jan 2015 · Biogeosciences

Publication Stats

17k Citations
2,947.27 Total Impact Points


  • 1999-2016
    • University of California, Los Angeles
      • • Department of Anesthesiology
      • • Department of Medicine
      • • Institute for Molecular Medicine
      Los Ángeles, California, United States
    • Beijing FivePlus Molecular Medicine Institute
      Peping, Beijing, China
    • Harvard Medical School
      Boston, Massachusetts, United States
    • Beijing Medical University
      • Department of Surgery
      Peping, Beijing, China
    • Henan Normal University
      河南岸, Guangdong, China
    • Beijing Hospital
      Peping, Beijing, China
  • 2015
    • Massachusetts General Hospital
      • Department of Radiation Oncology
      Boston, Massachusetts, United States
    • Rutgers, The State University of New Jersey
      Нью-Брансуик, New Jersey, United States
  • 2014-2015
    • Chinese Academy of Fishery Sciences
      Peping, Beijing, China
    • Virginia Polytechnic Institute and State University
      Блэксбург, Virginia, United States
  • 2011-2015
    • University of Illinois, Urbana-Champaign
      • Department of Physics
      Urbana, Illinois, United States
    • Xiangtan University
      Siangtan, Hunan, China
    • Tianjin University
      • Department of Molecular and Cellular Pharmacology
      T’ien-ching-shih, Tianjin Shi, China
    • Chinese Academy of Fishery Sciences
      北江, Zhejiang Sheng, China
    • Gilead Sciences
      Foster City, California, United States
    • The University of Tokyo
      • Department of Nuclear Engineering and Management
      白山, Tōkyō, Japan
    • Shandong Qianfoshan Hospital
      Chi-nan-shih, Shandong Sheng, China
    • National University of Defense Technology
      • College of OptoElectronic Science and Engineering
      Ch’ang-sha-shih, Hunan, China
    • China Agricultural University
      • College of Water Conservancy and Civil Engineering
      Peping, Beijing, China
    • Nantong University
      Tungchow, Jiangsu Sheng, China
  • 2005-2015
    • Harbin Institute of Technology
      • • School of Materials Science and Engineering
      • • Department of Materials Science
      • • School of Computer Science and Technology
      Charbin, Heilongjiang Sheng, China
    • Texas Instruments Inc.
      Dallas, Texas, United States
    • Henan Institute of Science and Technology
      Honanfu, Henan Sheng, China
    • James Madison University
      Harrisonburg, Virginia, United States
    • Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
      Torrance, California, United States
  • 2003-2015
    • Jilin University
      • • College of Plant Science
      • • State Key Lab of Superhard Materials
      • • State Key Laboratory of Supramolecular Structure and Materials
      Yung-chi, Jilin Sheng, China
    • Norfolk State University
      Norfolk, Virginia, United States
  • 2000-2015
    • Peking University
      • • College of Urban and Environmental Sciences
      • • Institute of Microelectron
      • • Center for Human Disease Genomics
      Peping, Beijing, China
    • China Criminal Police University
      Feng-t’ien, Liaoning, China
    • Hebei Normal University
      Chentow, Hebei, China
    • Alpert Medical School - Brown University
      • Department of Pathology and Laboratory Medicine
      Providence, Rhode Island, United States
  • 2006-2014
    • Central Geological Survey (CGS)
      T’ai-pei, Taipei, Taiwan
    • University of Toronto
      • Heart and Stroke/Richard Lewar Centre of Excellencein Cardiovascular Research
      Toronto, Ontario, Canada
    • 宁德师范学院学报
      Chiao-ch’eng-chen, Guangdong, China
    • Chinese Academy of Geological Sciences
      • Institute of Geology
      Peping, Beijing, China
    • Guangxi University
      Yung-ning, Guangxi Zhuangzu Zizhiqu, China
    • Industrial Technology Research Institute
      Hsin-chu-hsien, Taiwan, Taiwan
    • China Institute of Atomic Energy
      Peping, Beijing, China
    • George Mason University
      • Department of Computational and Data Sciences
      페어팩스, Virginia, United States
    • The Hong Kong University of Science and Technology
      • Department of Physics
      Chiu-lung, Kowloon City, Hong Kong
    • CFDRC - CFD Research Corporation
      Huntsville, Alabama, United States
  • 1988-2014
    • Shanghai Jiao Tong University
      • • MOE Key Laboratory for Cell Differentiation and Apoptosis
      • • Department of Mechanical Engineering (ME)
      • • Department of Electrical Engineering
      Shanghai, Shanghai Shi, China
  • 2013
    • Peking University School of Stomatology
      Peping, Beijing, China
    • Dalian Medical University
      • Department of Physiology
      Lü-ta-shih, Liaoning, China
    • Massachusetts Institute of Technology
      Cambridge, Massachusetts, United States
    • UPMC
      Pittsburgh, Pennsylvania, United States
  • 2012-2013
    • Harbin Medical University
      • College of Bioinformatics Science and Technology
      Charbin, Heilongjiang Sheng, China
    • Tongji Hospital
      Wu-han-shih, Hubei, China
    • Arizona State University
      • Department of Chemistry and Biochemistry
      Phoenix, Arizona, United States
    • Nagoya University
      • Graduate School of Engineering
      Nagoya, Aichi, Japan
    • Sichuan University of Science and Engineering
      Tzu-kung, Sichuan, China
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China
    • China University of Petroleum
      Tsingtao, Shandong Sheng, China
  • 2011-2013
    • Taiyuan University of Technology
      Yangkü, Shanxi Sheng, China
  • 2008-2013
    • Louisiana State University in Shreveport
      Shreveport, Louisiana, United States
    • University of Texas at Austin
      • • Center for Microelectronics Research
      • • Department of Electrical & Computer Engineering
      Austin, Texas, United States
    • Case Western Reserve University
      • Institute of Pathology
      Cleveland, Ohio, United States
    • Northeastern University (Shenyang, China)
      • Key Laboratory for Anisotropy and Texture of Materials
      Feng-t’ien, Liaoning, China
    • South China University of Technology
      • Key Lab for Special Functional Materials, Ministry of Education
      Shengcheng, Guangdong, China
    • Lawrence Berkeley National Laboratory
      Berkeley, California, United States
    • Agriculture and Agri-Food Canada
      • Dairy and Swine Research and Development Centre (DSRDC)
      Ottawa, Ontario, Canada
    • Rensselaer Polytechnic Institute
      • Department of Physics, Applied Physics, and Astronomy
      Troy, New York, United States
    • Dalian University of Technology
      • State Key Laboratory of Structural Analysis for Industrial Equipment
      Lü-ta-shih, Liaoning, China
    • GuangDong University of Technology
      • Faculty of Chemical Engineering and Light Industry
      Shengcheng, Guangdong, China
    • Southeast University (China)
      Nan-ching-hsü, Jiangxi Sheng, China
    • University of Alabama at Birmingham
      • Department of Pathology
      Birmingham, Alabama, United States
    • Seoul National University
      • Department of Physics and Astronomy
      Seoul, Seoul, South Korea
  • 2007-2013
    • Shandong University
      • School of Environmental Science and Engineering
      Chi-nan-shih, Shandong Sheng, China
    • Harvard-Smithsonian Center for Astrophysics
      • Smithsonian Astrophysical Observatory
      Cambridge, Massachusetts, United States
    • University of Michigan
      Ann Arbor, Michigan, United States
    • General Research Institute for Nonferrous Metals (GRINM)
      Peping, Beijing, China
    • Xinjiang Medical University
      Ouroumtchi, Xinjiang Uygur Zizhiqu, China
    • Lanzhou Jiaotong University
      Kao-lan-hsien, Gansu Sheng, China
    • National Institute for the Control of Pharmaceutical and Biological Products
      Peping, Beijing, China
    • Beijing Normal University
      • State Key Laboratory of Remote Sensing Sciences
      Beijing, Beijing Shi, China
  • 2001-2013
    • Wuhan University
      • School and Hospital of Stomatology
      Wu-han-shih, Hubei, China
    • Xi'an Medical University
      Ch’ang-an, Shaanxi, China
    • Meharry Medical College
      • School of Medicine
      Nashville, Tennessee, United States
  • 2000-2013
    • Capital Medical University
      • • Department of Radiology
      • • Department of Surgery
      Peping, Beijing, China
  • 1999-2013
    • Fourth Military Medical University
      • • Department of Prosthodontics
      • • Department of Ophthalmology
      Xi’an, Liaoning, China
  • 1998-2013
    • Chinese Academy of Sciences
      • • Institute of Physics
      • • Shenyang National Laboratory for Materials Science
      • • Key Laboratory of Particle Astrophysics
      • • Institute of Hydrobiology
      • • Beijing Laboratory of Electron Microscopy
      • • Institute of Genetics and Developmental Biology
      • • Dalian Institute of Chemical Physics
      • • Institute of Biophysics
      Peping, Beijing, China
  • 1996-2013
    • Memorial Sloan-Kettering Cancer Center
      • Department of Medical Physics
      New York, New York, United States
    • University of Washington Seattle
      • Department of Bioengineering
      Seattle, Washington, United States
    • Chinese Academy of Medical Sciences
      Peping, Beijing, China
  • 1985-2013
    • Zhejiang University
      • • Department of Mechanical Engineering
      • • Department of Material Science and Engineering
      • • Department of Physics
      Hang-hsien, Zhejiang Sheng, China
  • 2011-2012
    • Hunan University of Science and Technology
      Siangtan, Hunan, China
  • 2006-2012
    • Nankai University
      • • Institute of Polymer Chemistry
      • • Institute of Photo Electronic Thin Film Devices and Technology
      T’ien-ching-shih, Tianjin Shi, China
  • 2001-2012
    • Louisiana State University Health Sciences Center Shreveport
      • Department of Obstetrics and Gynecology
      Shreveport, Louisiana, United States
    • Sichuan University
      • • Institute of Nuclear Science and Technology
      • • Institute of Forensic Medicine
      Hua-yang, Sichuan, China
  • 2000-2012
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • University of Chicago
      Chicago, Illinois, United States
  • 1999-2012
    • Georgia Institute of Technology
      • School of Earth and Atmospheric Sciences
      Atlanta, Georgia, United States
    • Tsinghua University
      • • Department of Computer Science and Technology
      • • Department of Precision Instruments and Mechanical Engineering
      • • School of Materials Science and Engineering
      • • Department of Physics
      • • Department of Chemistry
      Peping, Beijing, China
  • 2010-2011
    • Zhengzhou University
      • Division of Anesthesiology
      Cheng, Henan Sheng, China
    • Clemson University
      • Department of Physics and Astronomy
      CEU, South Carolina, United States
    • The Northwest Normal University
      Kao-lan-hsien, Gansu Sheng, China
    • Nanfang Hospital
      Shengcheng, Guangdong, China
    • Kunming Institute of Zoology CAS
      Yün-nan, Yunnan, China
    • University of Tuebingen
      • Institute of Physical and Theoretical Chemistry
      Tübingen, Baden-Württemberg, Germany
    • University of Newcastle
      Newcastle, New South Wales, Australia
    • Aston University
      Birmingham, England, United Kingdom
    • University of Nottingham
      Nottigham, England, United Kingdom
    • Baoji University of Arts and Sciences
      Baojia, Liaoning, China
    • Xinjiang University
      Hsin-chien, Jiangxi Sheng, China
    • Beijing University of Aeronautics and Astronautics (Beihang University)
      • School of Chemistry and Environment
      Beijing, Beijing Shi, China
    • Beijing Institute Of Technology
      Peping, Beijing, China
    • Wenzhou Medical College
      Yung-chia, Zhejiang Sheng, China
    • Jiangnan University
      • School of Food Science and Technology
      Wu-hsi, Jiangsu Sheng, China
  • 2008-2011
    • Pennsylvania State University
      • Department of Materials Science and Engineering
      University Park, Maryland, United States
    • University of Pittsburgh
      • • Department of Plastic and Reconstructive Surgery
      • • Department of Surgery
      Pittsburgh, Pennsylvania, United States
  • 2007-2011
    • Southwest Jiaotong University
      • • School of Materials Science and Engineering
      • • Key Laboratory of Advanced Technology of Materials (Chinese Education Ministry)
      Hua-yang, Sichuan, China
  • 2004-2011
    • University of Manitoba
      • • Department of Physics and Astronomy
      • • Department of Biosystems Engineering
      Winnipeg, Manitoba, Canada
    • Brown University
      Providence, Rhode Island, United States
    • Lanzhou Railway Institute
      Kao-lan-hsien, Gansu Sheng, China
  • 2003-2011
    • Central South University
      • • State Key Laboratory of Powder Metallurgy
      • • Department of Chemistry Engineering
      Ch’ang-sha-shih, Hunan, China
    • University of Southern California
      • • Department of Physiology and Biophysics
      • • Department of Pharmacology and Pharmaceutical Sciences
      Los Ángeles, California, United States
    • Indiana University-Purdue University Indianapolis
      • • Department of Surgery
      • • Department of Medicine
      Indianapolis, Indiana, United States
  • 2002-2011
    • Peking University Health Science Center
      Peping, Beijing, China
    • Shanghai Research Institute of Chemical Industry
      Shanghai, Shanghai Shi, China
    • Luoyang Institute of Science and Technology
      Honanfu, Henan Sheng, China
    • Johns Hopkins University
      • Department of Medicine
      Baltimore, Maryland, United States
    • Max Planck Society
      München, Bavaria, Germany
  • 2000-2011
    • Tongji University
      • Department of Material Science and Engineering
      Shanghai, Shanghai Shi, China
  • 1997-2011
    • Fudan University
      • • Department of Pharmacology
      • • Department of Physics
      Shanghai, Shanghai Shi, China
    • General Hospital of Shenyang Military Region
      Feng-t’ien, Liaoning, China
  • 1993-2011
    • Academia Sinica
      • • Research Center for Applied Sciences
      • • Institute of Physics
      T’ai-pei, Taipei, Taiwan
  • 2009-2010
    • Beijing Jiaotong University
      Peping, Beijing, China
    • Liaoning ShiHua University
      Fu-shan, Liaoning, China
    • Xidian University
      • School of Telecommunications Engineering
      Ch’ang-an, Shaanxi, China
    • Procter & Gamble
      Cincinnati, Ohio, United States
    • Nanjing University of Science and Technology
      Nan-ching, Jiangsu Sheng, China
    • Buddhist Tzu Chi General Hospital
      T’ai-pei, Taipei, Taiwan
    • Chongqing University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Beijing Forestry University
      Peping, Beijing, China
    • Renji Hospital
      Shanghai, Shanghai Shi, China
  • 2008-2010
    • Los Alamos National Laboratory
      • Materials Science and Technology Division
      Los Alamos, CA, United States
    • Hunan University
      • College of Physics and Microelectronics Science
      Ch’ang-sha-shih, Hunan, China
    • Northeast Normal University
      • • School of Life Sciences
      • • The Institute of Genetics and Cytology
      Hsin-ching, Jilin Sheng, China
    • California Institute of Technology
      • Division of Geological and Planetary Sciences
      Pasadena, California, United States
  • 2007-2010
    • Shanghai University
      Shanghai, Shanghai Shi, China
    • Institute for Infocomm Research
      Tumasik, Singapore
    • University of Queensland
      • Centre for Microscopy and Microanalysis
      Brisbane, Queensland, Australia
  • 2006-2010
    • University of Texas MD Anderson Cancer Center
      • • Department of Pathology
      • • Department of Molecular Pathology
      • • Department of Biochemistry and Molecular Biology
      Houston, Texas, United States
  • 2003-2010
    • The Hong Kong Polytechnic University
      • Department of Applied Physics
      Hong Kong, Hong Kong
    • The University of Hong Kong
      • Department of Earth Sciences
      Hong Kong, Hong Kong
  • 2001-2010
    • General Hospital of the Air Force, PLA
      Peping, Beijing, China
  • 2006-2009
    • Sun Yat-Sen University
      Shengcheng, Guangdong, China
  • 2004-2009
    • University of British Columbia - Vancouver
      • • Department of Dermatology and Skin Science
      • • Department of Chemistry
      Vancouver, British Columbia, Canada
  • 2000-2009
    • Beijing University of Technology
      Peping, Beijing, China
  • 2005-2008
    • Chinese PLA General Hospital (301 Hospital)
      Peping, Beijing, China
  • 2003-2008
    • Huazhong University of Science and Technology
      • • State Key Laboratory of Digital Manufacturing Equipment and Technology
      • • Wuhan National Laboratory for Optoelectronics
      • • State Key Laboratory of Laser Technology
      • • Department of Control Science and Engineering
      Wuhan, Hubei, China
  • 2006-2007
    • Chang Gung University
      Hsin-chu-hsien, Taiwan, Taiwan
    • Nanjing Normal University
      Nan-ching, Jiangsu Sheng, China
  • 2005-2007
    • University of Ulster
      • School of Built Environment
      Aontroim, Northern Ireland, United Kingdom
  • 2004-2007
    • Nanyang Technological University
      • • School of Chemical and Biomedical Engineering
      • • School of Electrical and Electronic Engineering
      Tumasik, Singapore
    • Argonne National Laboratory
      • Division of Physics
      Lemont, Illinois, United States
  • 2003-2007
    • University of Maryland, Baltimore
      • • Department of Physiology
      • • Department of Medicine
      Baltimore, Maryland, United States
    • University of Oslo
      • Research Institute for Internal Medicine (IIM)
      Kristiania (historical), Oslo, Norway
  • 2001-2007
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2005-2006
    • Shanghai Institute of Microsystem And Information Technology
      Shanghai, Shanghai Shi, China
    • University of Wisconsin - Milwaukee
      • Department of Chemistry and Biochemistry
      Milwaukee, Wisconsin, United States
  • 2004-2006
    • Tennessee State University
      • Department of Biological Sciences
      Nashville, Tennessee, United States
  • 2001-2006
    • Fritz Haber Institute of the Max Planck Society
      • Department of Physical Chemistry
      Berlín, Berlin, Germany
    • Xi'an Jiaotong University
      • Department of Endocrinology
      Ch’ang-an, Shaanxi, China
  • 2003-2005
    • Beijing Cancer Hospital
      Peping, Beijing, China
  • 2002-2005
    • University of Surrey
      • Department of Electronic Engineering
      Guilford, England, United Kingdom
    • Uppsala University
      Uppsala, Uppsala, Sweden
  • 1998-2005
    • Nanjing University
      • Department of Chemistry
      Nan-ching, Jiangsu Sheng, China
    • University of Science and Technology of China
      • National Synchrotron Radiation Laboratory
      Luchow, Anhui Sheng, China
  • 2003-2004
    • University of Alberta
      • Department of Chemical and Materials Engineering
      Edmonton, Alberta, Canada
  • 2002-2003
    • Northeastern University
      • Department of Electrical and Computer Engineering
      Boston, Massachusetts, United States
  • 1998-2002
    • University of California, San Diego
      • Department of Medicine
      San Diego, California, United States
  • 1998-2001
    • Lanzhou University
      Kao-lan-hsien, Gansu Sheng, China
  • 1998-1999
    • Shanghai Medical University
      • Department of Epidemiology
      Shanghai, Shanghai Shi, China
  • 1997-1999
    • Harvard University
      • Department of Earth and Planetary Sciences
      Cambridge, Massachusetts, United States
  • 1996-1999
    • City University of New York - Brooklyn College
      Brooklyn, New York, United States
  • 1982
    • National Tsing Hua University
      • Department of Chemical Engineering
      Hsinchu, Taiwan, Taiwan