M.A. Juárez-Oropeza

Universidad Nacional Autónoma de México, Ciudad de México, Mexico City, Mexico

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Publications (61)90.22 Total impact

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    ABSTRACT: Several chronic transmissible (e.g. AIDS) and non transmissible diseases like cadiovascular disease, are associated with oxidative stress (EOX) and dyslipidemia. Has been reported that Spirulina can reduce them, this has been demonstrated in vitro and in animal models but scarcely in humans. Through a systematic review on last 5 years (keywords: Spirulina AND cholesterol, Spirulina AND oxidative stress) 8 intervention studies with humans were reported, finding that oral (1-10 g/d) subchronic (0.5-6 month) administration of Spirulina appears to have and hypolipidemic and antioxidant effect. However, no study was properly randomized and/or controlled and no biological mechanism was proposed to support these findings. The level of evidence and the absence of appropriate experimental designs do not allow validating Spirulina as a functional food for preventing dyslipidemic diseases and EOX, and hereby decrease the CVD. We do not found papers relating harmful effect.
    Full-text · Article · Aug 2015 · Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
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    ABSTRACT: Background: The early detection of glucose metabolism impairment is a very important goal, mainly in individuals with a family history of diabetes (FHD) or in those with borderline insulin resistance (BIR: HOMA-IR > 2.0). Aims/hypothesis: To document the differences in glucose metabolism between healthy subjects with and without FHD and with BIR, in response to a maximal exercise test in both fasting and postprandial conditions. Methods: Twenty nine healthy and physically active subjects (15 female and 14 male) volunteered to participate in three maximal exercise tests, in fasting and postprandial states. Maximal O2 consumption, heart rate, blood pressure, anthropometry, glucose (basal and after exercise), and insulin measurements were obtained. Results: glycemia diminished at the end of maximal exercise and decreased the most in FHD and/or HOMA-IR > 2.0 compared to without FHD and/or HOMA-IR < 2.0. Recovery of post-exercise glycemia was slower in subjects with FHD and HOMA-IR > 2.0. Conclusions: the maximal exercise test in fasting or postprandial conditions proved to detect glucose metabolism differences between subjects with vs. without FHD and with vs. without BIR.
    Full-text · Article · Jun 2014 · Experimental and clinical cardiology
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    Full-text · Dataset · Jun 2014
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    ABSTRACT: Introduction: There is scarce and inconsistent information about gender-related differences in the hydration of sports persons, as well as about the effects of hydration on performance, especially during indoor sports. Objective: To determine the physiological differences between genders during in indoor physical exercise, with and without hydration. Methods: 21 spinning sportspeople (12 men and 9 women) participated in three controlled, randomly assigned and non-sequential hydration protocols, including no fluid intake and hydration with plain water or a sports drink (volume adjusted to each individual every 15 min), during 90 min of spinning exercise. The response variables included body mass, body temperature, heart rate and blood pressure. Results: During exercise without hydration, men and women lost ~2% of body mass, and showed higher body temperature (~0.2°C), blood pressure (~4 mmHg) and heart rate (~7 beats/min) compared to exercises with hydration. Body temperature and blood pressure were higher for men than for women during exercise without hydration, differences not observed during exercise with hydration. Between 42-99% of variance in body temperature, blood pressure and heart rate could be explained by the physical characteristics of subjects and the work done. Conclusions: During exercise with hydration (either with water or sport drink), the physiological response was similar for both genders. Exercise without hydration produced physical stress, which could be prevented with either of the fluids (plain water was sufficient). Gender differences in the physiological response to spinning (body temperature, mean blood pressure and heart rate) can be explained in part by the distinct physical characteristics of each individual.
    Full-text · Article · Mar 2014 · Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
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    ABSTRACT: The aim of this study was to evaluate the actions of coenzyme Q10 (CoQ10) on rats with a cholesterol-rich diet (HD) and high doses of atorvastatin (ATV, 0.2, 0.56 or 1.42 mg/day). Two experiments were done, the first one without coenzyme Q10 supplementation. On the second experiment all groups received coenzyme Q10 0.57 mg/day as supplement. After a 6-week treatment animals were sacrificed, blood and liver were analyzed and liver mitochondria were isolated and its oxygen consumption was evaluated in state 3 (phosphorylating state) and state 4 (resting state) in order to calculate the respiratory control (RC). HD increased serum and hepatic cholesterol levels in rats with or without CoQ10. ATV reduced these values but CoQ10 improved even more serum and liver cholesterol. Triacylglycerols (TAG) were also lower in blood and liver of rats with ATV + CoQ10. HDL-C decreased in HD rats. Treatment with ATV maintained HDL-C levels. However, these values were lower in HD + CoQ10 compared to control diet (CD) + CoQ10. RC was lessened in liver mitochondria of HD. The administration of ATV increased RC. All groups supplemented with CoQ10 showed an increment in RC. In conclusion, the combined administration of ATV and CoQ10 improved biochemical parameters, liver function and mitochondrial respiration in hypercholesterolemic rats. Our results suggest a potential beneficial effect of CoQ10 supplementation in hypercholesterolemic rats that also receive atorvastatin. This beneficial effect of CoQ10 must be combined with statin treatment in patient with high levels of cholesterol.
    Full-text · Article · Jan 2014 · Lipids in Health and Disease
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    ABSTRACT: Introduction: Oral rehydration drinks help maintain physical capacity and hydration during exercise. Objective: Evaluate, in a case and self-control study, the effectiveness of three hydration and exercise protocols on work capacity and physical and psychosomatic stress during indoor cycling (InC). Methods: 14 middle-aged eutrophic men participated in three controlled randomly and not sequentially hydration (~278 mL 6/c 15 min) and exercise (InC/90 min) protocols: No liquids, plain water, or sports drinks (SD). The response variables were: Body temperature (BT), heart rate (HR), and mean blood pressure (MBP). The covariables: Distance traveled (DT), ergometer resistance (R), body fat (BF), difference in body weight between tests (rBW), and age of the participants. The differences between protocols were evaluated using GLM Repeated Measures, the independence of associations by multiple linear regression. Results: In non-liquids, the subjects showed higher BT, HR, and MBP than when they drank plain water or SD (p < 0.01). Work capacity was the same in the three hydration protocols. BT was the most sensitive variable detected by the hydration status of the subjects. 34%, 99%, and 21% of the associated variance to HR, MBP, and BT was explained by DT + BT, BT + BF, and ?BW + age + R + DT + BF, respectively. Conclusions: Liquid intake with or without electrolytes does not affect work capacity, and they are equally effective as hydration sources during =?90 min of InC at strong and very strong intensities. Body temperature is the most sensitive variable detected by the subject's hydration status during exercise.
    Full-text · Article · Oct 2013 · Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
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    ABSTRACT: Background: elementary school students usually stay in school 4.5 hours a day in Mexico. The main food consumption is outside school. The objective was to explore behaviors on food consumption beyond the school environment. Methods: descriptive trial that included 173 children, both sexes, from public elementary school in Mexico City. Eating habits were obtained through questionnaire and anthropometric characteristics from physical measurement. Results: participants reported to consume soft drinks and canned juices at high frequency and quantity (80 %) and low consumption of animal foods. They also eat industrialized dairy products with high caloric content and low in protein. Moreover, 30 % of children eat 4 or 5 times a day, whereas 10 % eat one or two times a day. These results were associated with the somatometric characteristics of the children, 37.6 % of whom presented as overweight or obese while 12 % were underweight. Conclusions: it is necessary that health education involves teachers, parents and children in programs for obesity prevention with the objective of increasing healthy behaviors.
    No preview · Article · Sep 2013 · Revista medica del Instituto Mexicano del Seguro Social
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    ABSTRACT: Background: elementary school children spend little time at the school in Mexico. The aim was to investigate the activities after school time in children and to determine the presence of overweight and obesity. Methods: one hundred and seventy two children of both sexes were included. They belonged to the first and second grade of an official primary school from a marginalized zone. Somatometry was obtained and the type of physical practice and motifs for no practice physical activity were investigated. Descriptive statistics were applied. Results: the frequency of underweight was 12.1 %, overweight 19 %, and obesity 18.5 %. Sedentary activities like watching television and playing video games were the most common registered, whereas sports were the lowest physical activity practiced, especially in girls. The parents' lack of time, low family income, and the scarcity of safe spaces where children can play and practice physical activity or sports were the most related factors. Conclusions: poverty and insecurity of the neighborhoods influence the outside activities in after school time. The high frequency of underweight, overweight and obesity in school children were associated to the lack of physical activity.
    No preview · Article · Sep 2013 · Revista medica del Instituto Mexicano del Seguro Social
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    ABSTRACT: Background: End-ileostomy or colostomies are constructed for source control in patients with severe abdominal sepsis. After takedown, enterocutaneous fistula represents one of the most feared complications. Methods: A prospective base was created with all patients that underwent, during a 90 month period, end-ileostomy or colostomy takedown after abdominal sepsis. Pre-, intra- and postoperative data were obtained to identify the factors related to enterocutaneous fistula. Results: There were 293 patients. Thirty patients (10%) developed enterocutaneous fistulas. In twenty-four patients the site was at the anastomosis. Identified risk factors related to enterocutaneous fistula were ASA score III or higher (p< 0.01), ostomy takedown >365 days after its creation (p< 0.05), reoperation (p< 0.001) and anastomotic dehiscence (p< 0.001). Of these patients, twenty (67%) had spontaneous closure of the fistula, and three more (10%) had surgical closure, and three patients (10%) died. Conclusions: Ten percent of patients develop enterocutaneous fistula after end-ileostomy or colostomy takedown. Patient selection and delaying time of surgery to obtain complete recovery of the patient are the most important factors to avoid this complication. Prognosis is related to the characteristics of the fistula (output and site) and medical treatment.
    No preview · Article · Sep 2013 · Cirugia y cirujanos
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    ABSTRACT: Aim. To evaluate the blood lactate ([La-]b) recovery kinetics and determinate the associations between the [La-]b recovery kinetics and physical capacity on physically active men. Methods: Seventeen healthy and physically active men took part in three recovery protocols (passive, cycling and walking), subsequent to a Wingate Anaerobic Test. The [La-]b was measured by a potentiometer-enzymatic analysis, the maximum O2 consumption (VO2max) using a metabolic cart, the heart rate by a heart rate monitor and the body mass from anthropometry. Results: Active recovery (walking and cycling recovery) had smaller peak [La-]b concentration time, [La-]b smaller area under the curve ([La-]b auc), and higher [La-]b removal (@2) than passive recovery. Moreover, the walking recovery had the smallest [La-]b accumulation final, the smallest [La-]b auc, and the highest [La-]b recovery index (p<0.05). The [La-]b recovery kinetics was depend on physical capacity of the subjects: during passive recovery >79% of the variance were explained by workload auc, muscle mass and lactate threshold (LT); during active recovery >73% of the variance were explained by age, muscle mass, VO2max and LT. Conclusion: The variations on [La-]b recovery kinetics depended principally by the subject’s physical capacity. The [La-]b recovery kinetics were more efficient during active than during passive recovery (walking > cycling > passive recovery).
    Full-text · Dataset · May 2013
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    ABSTRACT: Aim. To evaluate the blood lactate ([La-]b) recovery kinetics and determinate the associations between the [La-]b recovery kinetics and physical capacity on physically active men. Methods: Seventeen healthy and physically active men took part in three recovery protocols (passive, cycling and walking), subsequent to a Wingate Anaerobic Test. The [La-]b was measured by a potentiometer-enzymatic analysis, the maximum O2 consumption (VO2max) using a metabolic cart, the heart rate by a heart rate monitor and the body mass from anthropometry. Results: Active recovery (walking and cycling recovery) had smaller peak [La-]b concentration time, [La-]b smaller area under the curve ([La-]b auc), and higher [La-]b removal (@2) than passive recovery. Moreover, the walking recovery had the smallest [La-]b accumulation final, the smallest [La-]b auc, and the highest [La-]b recovery index (p<0.05). The [La-]b recovery kinetics was depend on physical capacity of the subjects: during passive recovery >79% of the variance were explained by workload auc, muscle mass and lactate threshold (LT); during active recovery >73% of the variance were explained by age, muscle mass, VO2max and LT. Conclusion: The variations on [La-]b recovery kinetics depended principally by the subject’s physical capacity. The [La-]b recovery kinetics were more efficient during active than during passive recovery (walking > cycling > passive).
    Full-text · Article · May 2013 · Archivio per le scienze mediche
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    ABSTRACT: The aim of this paper was to evaluate the blood lactate ([La-]b) recovery kinetics and determinate the associations between the [La-]b recovery kinetics and physical capacity on physically active men. Methods: Seventeen healthy and physically active men took part in three recovery protocols (passive, cycling and walking), subsequent to a Wingate Anaerobic Test. The [La-]b was measured by a potentiometer-enzymatic analysis, the maximum O2 consumption (VO2max) using a metabolic cart, the heart rate by a heart rate monitor and the body mass from anthropometry. Results: Active recovery (walking and cycling recovery) had smaller peak [La-]b concentration time, [La-]b smaller area under the curve ([La-]b auc), and higher [La-]b removal (γ2) than passive recovery. Moreover, the walking recovery had the smallest [La-]b accumulation final, the smallest [La-]b auc, and the highest [La-]b recovery index (p<0.05). The [La-]b recovery kinetics was depend on physical capacity of the subjects: during passive recovery >79% of the variance were explained by workload auc, muscle mass and lactate threshold (LT); during active recovery >73% of the variance were explained by age, muscle mass, VO2max and LT. Conclusion: The variations on [La-]b recovery kinetics depended principally by the subject’s physical capacity. The [La-]b recovery kinetics were more efficient during active than during passive recovery (walking >cycling >passive recovery).
    Full-text · Article · Apr 2013
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    ABSTRACT: Trained people exhibit low plasma concentrations of triacylglcyerols in both fasting and postprandial states. Exercise practice is commonly believed to improve postprandial lipemia. In addition, elevated postprandial lipemia is an indicator of poor lipid clearance, and it has been associated with atherosclerosis, insulin resistance, and obesity. Spirulina maxima is an edible microorganism with a high nutritional value. When it is consumed, beneficial properties to health have been demonstrated, such as hypolipemic and antihypertensive properties in human beings. This work evaluates the effects of orally administrated S. maxima on postprandial lipemia in a young Mexican sporting population after 15 days of consumption, as a possible alternative treatment to improve their lipid clearance. Forty-one runners (10-26 years old; 21 men and 20 women) volunteered to participate in the study. All of them were physically active for at least 1 year before the study and were not undergoing training during the study. The subjects consumed 5 g of Spirulina during 15 days. Before and after the treatment with Spirulina, they consumed (12 h fasting) a standardized meal with high fat content (53.2% total calories). Postprandial lipemia was measured at 1.5, 3, and 4.5 h after the fatty meal. Fasting plasma triacylglycerol (TAG) concentrations were lower after Spirulina treatment than before treatment. In addition, the postprandial area under the curve of TAG concentrations was lower after the treatment with Spirulina. Sixty-two percent of the youngest runners (10-16 years) studied exhibited the best response to the treatment. Orally administered S. maxima decreased postprandial lipemia in sporting teenagers. The youngest people were the most responsive to the beneficial effects of Spirulina on postprandial lipemia.
    Full-text · Article · Jun 2012 · Journal of medicinal food
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    ABSTRACT: It is generally accepted that electromagnetic fields (EMF) can exert biological effects; however, the mechanisms by which EMF elicits responses are still unknown. The present study was designed to assess the immediate effects of acute EMF exposure, movement restriction, and the combination of both on the antioxidant systems and lipid content in the whole brain of rat. Thirty two male Wistar rats were arranged in four groups: control, EMF exposed, movement restrained (MR), and EMF + MR for 2 h. Rats were then sacrificed and their brains analyzed for superoxide dismutase and catalase activities, reduced glutathione, nitric oxide, total cholesterol, and triacylglycerol levels, as well as plasma corticosterone concentrations. Acute exposure to EMF induces reduction in catalase and superoxide dismutase activities, whereas the combination of EMF + MR also decreases both reduced glutathione and nitric oxide levels. Our results show that the acute exposure to EMF does not induce elevation of stress-hormone corticosterone but impairs the antioxidant status in rat brain. Plasma corticosterone concentration and antioxidant data indicate that the acute exposure to EMF appears to be a mild stressor that leads to some adaptive responses due to the activation of systems controlling the brain oxidative balance.
    No preview · Article · May 2012 · Archives of medical research
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    ABSTRACT: Objective: To know the self-perception and body dissatisfaction in school and comparing it in with the body mass index in children from first and second year of a public school. Material and methods: A questionnaire designed to determine the degree of satisfaction of a person body (Body Attitude Test), applied to schoolchildren who were somatometric measurements were made to find out your body mass index, according to the known standards. Results: Measurements were made in 75 children: 44 women and 31 men according to the BMI recital 9 (12%) children with low birth weight, 34 (45.3%) with normal weight. 16 (21.3%) are overweight and 16 (21.3%) with obesity, while by perception, 42 (56%) children are perceived low-weight, 9 (12%) normal, 19 (26%) children with overweight and 1.3% as obese. The highest correlation was in the felt thin and were thin, 41 (54.6%) children had an inadequate perception of your body and 33.73% ± 15% had body dissatisfaction: 27 (36.0%) wanted to change something about your body and 14 (18.7%) said they have felt rejected by your body.
    No preview · Article · Mar 2012 · Revista Mexicana de Pediatria
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    ABSTRACT: Many enterocutaneous fistulas (ECF) require operative treatment. Despite recent advances, rates of recurrence have not changed substantially. This study aims to determine factors associated with recurrence and mortality in patients submitted to surgical repair of ECF. Consecutive patients submitted to surgical repair of ECF during a 5-year period were studied. Several patient, disease, and operative variables were assessed as factors related to recurrence and mortality through univariate and multivariate analysis. There were 35 male and 36 female patients. Median age was 52 years (range, 17-81). ECF recurred in 22 patients (31%), 18 of them (82%) eventually closed with medical and/or surgical treatment. Univariate analyses disclosed noncolonic ECF origin (p = 0.04), high output (p = 0.001), and nonresective surgical options (p = 0.02) as risk factors for recurrence; the latter two remained significant after multivariate analyses. A total of 14 patients died (20%). Univariate analyses revealed risk factors for mortality at diagnosis or referral including malnutrition (p = 0.03), sepsis (p = 0.004), fluid and electrolyte imbalance (p = 0.001), and serum albumin <3 g/dl (p = 0.02). Other significant variables were interval from last abdominal operation to ECF operative treatment ≤20 weeks (p = 0.03), preoperative serum albumin <3 g/dl (p = 0.001), and age ≥55 years (p = 0.03); the latter two remained significant after multivariate analyses. Interestingly, recurrence after surgical treatment was not associated with mortality (p = 0.75). Among several studied variables, recurrence was only independently associated with high output and type of surgical treatment (operations not involving resection of ECF). Interestingly, once ECF recurred its management was as successful as non-recurrent fistulas in our series. Mortality was associated to previously-reported bad prognostic factors at diagnosis or referral.
    No preview · Article · Jan 2012 · Journal of Gastrointestinal Surgery

  • No preview · Article · Jun 2011 · Atherosclerosis Supplements
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    ABSTRACT: The aim of the present study was to evaluate the early effects of acute (2 h) exposure to extremely low frequency electromagnetic fields (ELF-EMF), as well as movement restraint (MR) and the combination of both on the antioxidant systems in the plasma, liver, kidney, and heart of rats. Twenty-four adult male Wistar rats were divided in two groups, restrained and unrestrained. The restrained animals were confined into an acrylic tube for 120 min. Half of the animals of each group were exposed to ELF-EMF (60 Hz, 2.4 mT) during the period of restriction. Immediately after treatment, reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and thiobarbituric acid reactive substances (TBARS) were measured in tissues. GSH concentration was significantly lower in the heart of all experimental animals when compared to the control group; furthermore, the decrease was higher in the liver of restrained animals. SOD activity was lower in the plasma of restrained and EMF exposed animals compared to unrestrained rats. There were no significant differences in CAT activity and TBARS levels among all the experimental groups vs. the control group. Two hours of 60 Hz EMF exposure might immediately alter the metabolism of free radicals, decreasing SOD activity in plasma and GSH content in heart and kidney, but does not induce immediate lipid peroxidation. Oxidative stress induced by movement restraint was stronger than that produced by EMF.
    No preview · Article · Dec 2010 · International Journal of Radiation Biology
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    Aldo Ferreira-Hermosillo · Patricia V Torres-Duran · Marco A Juarez-Oropeza
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    ABSTRACT: Non-alcoholic fatty liver diseases range from simple steatosis to non-alcoholic steatohepatitis. The "two hits" hypothesis is widely accepted for its pathogenesis: the first hit is an increased fat flux to the liver, which predisposes our patient to a second hit where increasing free fatty acid oxidation into the mitochondria leads to oxidative stress, lipoperoxidation and a chain reaction with increased ROS. Clinical indications include abdominal cramps, meteorism and fatigue. Most patients, however, are asymptomatic, and diagnosis is based on aminotransferase elevation and ultrasonography (or "brilliant liver"). Spirulina maxima has been experimentally proven to possess in vivo and in vitro hepatoprotective properties by maintaining the liver lipid profile. This case report evaluates the hepatoprotective effects of orally supplied Spirulina maxima. Three Hispanic Mexican patients (a 43-year-old man, a 77-year-old man and a 44-year-old woman) underwent ultrasonography and were treated with 4.5 g/day of Spirulina maxima for three months. Their blood samples before and after the treatment determined triacylglycerols, total cholesterol, high-density lipoprotein cholesterol, alanine aminotransferase and low-density lipoprotein cholesterol levels. The results were assessed using ultrasound. Treatment had therapeutic effects as evidenced by ultrasonography and the aminotransferase data. Hypolipidemic effects were also shown. We conclude that Spirulina maxima may be considered an alternative treatment for patients with non-alcoholic fatty liver diseases and dyslipidemic disorder.
    Full-text · Article · Apr 2010 · Journal of Medical Case Reports
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    ABSTRACT: Oxidative damage has been proposed as a possible mechanism involved in lead toxicity, specially affecting the liver and kidney. Previous studies have shown the antioxidant effect of Spirulina maxima in several experimental models of oxidative stress. The current study was carried out to evaluate the antioxidant activity of Spirulina maxima against lead acetate-induced hyperlipidemia and oxidative damage in the liver and kidney of male rats. Control animals were fed on a standard diet and did not receive lead acetate (Control group). Experimental animals were fed on a standard laboratory diet with or without Spirulina maxima 5% in the standard laboratory diet and treated with three doses of lead acetate (25 mg each/weekly, intraperitoneal injection) (lead acetate with Spirulina, and lead acetate without Spirulina groups). The results showed that Spirulina maxima prevented the lead acetate-induced significant changes on plasma and liver lipid levels and on the antioxidant status of the liver and kidney. On the other hand, Spirulina maxima succeeded to improve the biochemical parameters of the liver and kidney towards the normal values of the Control group. It was concluded that Spirulina maxima has protective effects on lead acetate-induced damage, and that the effects are associated with the antioxidant effect of Spirulina.
    Full-text · Article · Mar 2010 · Lipids in Health and Disease

Publication Stats

766 Citations
90.22 Total Impact Points

Institutions

  • 1988-2015
    • Universidad Nacional Autónoma de México
      • • Department of Geochemistry
      • • Department of Biochemistry
      • • Department of Biochemistry at the School of Medicine
      • • School of Medicine
      • • Department of Embriology
      Ciudad de México, Mexico City, Mexico
  • 2014
    • Universidad Juárez Autónoma de Tabasco
      • División Académica de Ciencias de la Salud
      Villahermosa, Tabasco, Mexico
  • 2005
    • Instituto Nacional de Cardiología
      • Department of Biochemistry
      Ciudad de México, Mexico City, Mexico