Yoo Jin Kang

Catholic University of Korea, Sŏul, Seoul, South Korea

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Publications (16)

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    [Show abstract] [Hide abstract] ABSTRACT: We previously demonstrated that there are acute and delayed phases of renal protection against renal ischemia and reperfusion (IR) injury with renal ischemic preconditioning (IPC). This study assessed whether hepatic IPC could also reduce distant renal IR injury through the blood stream-mediated supply of reactive oxygen species (ROS). Male C57BL/6 mice were randomly divided into four groups: group I, sham operated including right nephrectomy; group II (IR), left renal ischemia for 30 min and reperfusion injury; group III (IPC-IR), hepatic ischemia for 10 min followed by 10 min of reperfusion before left renal IR injury; group IV (MPG - IPC + IR), pretreated with 100 mg/kg N-(2-mercaptopropionyl)-glycine (MPG) 15 min before hepatic IPC and left renal IR injury. Renal function, histopathologic findings, proinflammatory cytokines, and cytoprotective proteins were evaluated 15 min or 24 hr after reperfusion. Hepatic IPC attenuated the expression of proinflammatory cytokines, tumor necrosis factor α, intercellular adhesion molecule 1, and induced inducible nitric-oxide synthase, and the phosphorylation of Akt in the murine kidney. Renal function was better preserved in mice with hepatic IPC (group III) than groups II or IV. Hepatic IPC protects against distant renal IR injury through the blood stream-delivery of hepatic IPC-induced ROS, by inducing cytoprotective proteins, and by inhibiting inflammatory reactions.
    Full-text Article · May 2012 · Journal of Korean medical science
  • [Show abstract] [Hide abstract] ABSTRACT: In addition to causing the loss of voluntary sensory and motor function, spinal cord injury (SCI) often creates a state of central neuropathic pain. Rats given SCI display increases in the activated form of transcription factors ERK 1/2 MAPK and CREB in the spinal cord, which correspond to allodynia in a model of neuropathic pain. This study was conducted to determine if low dose ketamine had an effect on the activation of ERK 1/2 and CREB in the development of neuropathic pain.
    Article · Jan 2009 · Korean journal of anesthesiology
  • Jin Deok Joo · Dae Woo Kim · Yoo Jin Kang · [...] · Yeon Jin Park
    [Show abstract] [Hide abstract] ABSTRACT: Acute renal failure (ARF) results from renal ischemic reperfusion (IR) injury and is a major contributor to the morbidity and mortality encountered during the perioperative period. It was previously demonstrated that ischemic preconditioning (IPC) of the heart, brain, and kidney offered protection against IR injury. Therefore, this study examined whether or not distant IPC can also be effective against IR injury in other organs.
    Article · Aug 2007 · Korean Journal of Anesthesiology
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    Yoo Jin Kang · Yeon Su Jeon · Yong Shin Kim · Hyeon Tak Lee
    [Show abstract] [Hide abstract] ABSTRACT: Trigeminal neuralgia (TGN) is a relatively well-known disorder with characteristic brief attacks of shooting pain in the facial regions. Atypical signs like constant pain and/or sensory abnormalities can develop as the disease progresses. Some cases begin with atypical signs and later develop all the hallmarks of TGN. The atypical forms of TGN can be misdiagnosed as other pain disorders. We present a patient with facial pain who demonstrated a transformation in signs of glossopharyngeal neuralgia into typical trigeminal neuralgia. A 71 year-old man was referred for sharp episodic pain in his right side of the face and neck. The pain was mainly in the neck, which was worsened especially by swallowing. The condition was initially diagnosed as a glossopharyngenl neuralgia. While controlling the pain conservatively with a sympathetic blockade, the neck pain disappeared suddenly and lower jaw pain triggered by speaking and chewing became prominent, which are the characteristic signs of trigeminal neuralgia.
    Full-text Article · Jan 2006 · Korean Journal of Anesthesiology
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    [Show abstract] [Hide abstract] ABSTRACT: BACKGROUND: Anesthetic procedures are major potent stimulus for the neuroendocrine hormonal axis, which results in release of the stress hormone. It is important to know the influence of specific anesthetic procedures on those host responses. We compared endocrine stress response and anesthesia characteristics for TIVA (total intravenous anesthesia) and VIMA (volatile induction and maintenance of anesthesia).
    Full-text Article · Jan 2006 · Korean Journal of Anesthesiology
  • [Show abstract] [Hide abstract] ABSTRACT: Besides its general anesthetic effect, ketamine interacts with sodium channels in a local anesthetic-like fashion, including the sharing of binding sites with those commonly used by clinical local anesthetics. This study evaluated the dose related effects of ketamine during epidural anesthesia with 0.5% ropivacaine.
    Article · Jan 2005 · The Korean Journal of Pain
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    Yoo Jin Kang · Yong Gul Lim · Ghi Hyun Kim
    [Show abstract] [Hide abstract] ABSTRACT: We successfully managed one-lung ventilation in a 5-yr-old boy who underwent thoracoscopic removal of an emphysematosed right lower lobe. We used a 5-French 70 cm balloon-tipped Fogarty embolectomy catheter as a bronchial blocker. Its single lumen, which ends blindly, contains a guidewire and is used to inflate a spherical balloon. First, we threaded the distal end of the blocker through the Murphy hole of a 5.5 cuffed endotracheal tube. The tip of the blocker was adjusted to the end of the endotracheal tube, and the remainder of the blocker was attached closely to the outer wall of the tube and fixed once at the neck of the tube with tape. The tube and catheter were intubated as a set. After intubation, a bronchoscope was introduced through the tube. Under bronchoscopic view, Fogarty catheter was drawn back by 1 2 cm to withdraw the catheter tip from the Murphy hole and then advanced until the balloon tip reached the right main bronchus. With balloon inflation, we were able to achieve satisfactory one-lung ventilation.
    Full-text Article · Jan 2005 · Korean Journal of Anesthesiology
  • Jin Deok Joo · Dae Woo Kim · Yoo Jin Kang · [...] · Yong Gul Lim
    [Show abstract] [Hide abstract] ABSTRACT: Myokymia is one of involuntary movement, which is characterized by undulatory muscle spasm, similar to the worm's crawl. Sometimes muscle pain, itchy sensation, dysautonomia and other symptoms are associated with it. Derangement of the peripheral or central nervous system after nerve or tissue damage is suspected as the source of impulse generators causing this symptom. We encountered a patient with neuropathic pain and myokymia after thoracotomy. Although several medications and nerve blocks have been applied, all have failed to provide symptom relief. We experienced improvement of the pain and involuntary movement with a thoracic sympathetic ganglion block and gabapentin.
    Article · Jan 2002 · Korean Journal of Anesthesiology
  • Hyun Ju Oh · Yoo Jin Kang · Sun Seek Min · [...] · Seung Kil Hong
    [Show abstract] [Hide abstract] ABSTRACT: BACKGROUND: Recent findings suggest that a coupling between the somatic and sympathetic nervous system is critical not only for the development but also for the maintenance of pain behavioral changes. However, studies on the effect of sympathetic efferent system on sensory receptors in the visceral organ that is more dependent on the autonomic nervous system are lacking. This study examined whether norepinephrine (NE) had an influence on the mechanoreceptors in the feline urinary bladder. METHODS: Ten adult male cats were used and anesthetized with alpha-chloralose and artificially ventilated. A cannula with the pressure transducer was inserted through the urethra to apply mechanical stimuli and monitor the pressure of bladder. A tiny cannula inserted into the bilateral side branches of vesical arteries were used as a route for a NE (10A.M 9:40 01-10-08 bilaterally) injection. Nerve fiber recordings were obtained from the distal stump of the pelvic nerve. RESULTS: After the NE injection, the response of mechanoreceptors (n = 13) to the isotonic pressure stimulus (50 - 60 mmHg) decreased significantly (p < 0.05) in terms of sensitivity (i.e., ratio of nerve activity change to urinary bladder pressure change). The responses to pressure stimuli after an injection of an alpha1 adrenoceptor blocker (terazosin) reversed the effect of NE. The responses of mechanoreceptors to isotonic pressure stimulus were not affected significantly by NE with preinjection of an alpha2 adrenoceptor blocker (yohimbine). CONCLUSIONS: These results suggest that NE may have influence on the sensitivity of mechanoreceptors in the normal feline urinary bladder via an alpha1 adrenoceptor.
    Article · Jan 2001 · Korean Journal of Anesthesiology
  • Yoo Jin Kang · Dae Woo Kim
    [Show abstract] [Hide abstract] ABSTRACT: BACKGROUND: Many drugs are commonly administered according to total body weight or age basis. However, drugs are primarily distributed to the lean body mass. This study was undertaken to find out the best determinant for drug requirements during induction in elderly. METHODS: Forty-five ASA 1 to 3 male and female patients older than 65 years scheduled for elective surgery were divided into 3 groups and received thiopental sodium 62.5 mg/min (group T, n = 15), propofol 25 mg/min (group P, n = 15), or etomidate 5 mg/min (group E, n = 15) respectively. Kendall's tau test for correlations was used to describe the relationship between drug requirements for induction and total body weight, lean body mass determined by Weisburg's modification of Gubner's formula, ideal body weight calculated by Devine's method, and body surface area. RESULTS: Loss of consciousness was obtained with a thiopental sodium dose of 128.4 +/- 29.3 mg, propofol 59.8 +/- 13.6 mg, and etomidate 9.8 +/- 1.4 mg. Kendall's tau correlation test showed that requirements of drugs were related to lean body mass (group T, r = 0.490*, group P, r = 0.433*, group E, r = 0.493*, global P < 0.05) and ideal body weight (group P, r = 0.426*, group E, r = 0.434*, p < 0.05), but not to total body weight or body surface area. CONCLUSIONS: Our results indicate that drug requirements for induction of anesthesia correlate better with lean body mass and ideal body weight than with total body weight or body surface area in elderly patients.
    Article · Jan 2000 · Korean Journal of Anesthesiology
  • Yong Shin Kim · Yoo Jin Kang · Dae Woo Kim · [...] · Yong Gul Lim
    [Show abstract] [Hide abstract] ABSTRACT: BACKGROUND: Unintended intravenous injection of bupivacaine causes severe cardiovascular complication, which is known for its difficulty in resuscitation. This study was performed to evaluate the effects of pretreatment with midazolam and droperidol in the cardiac toxicity caused by intravenous infusion of bupivacaine. METHODS: Thirty rabbits were divided into three groups; saline- as a control, midazolam, and droperidol pretreated group. We observed the time intervals for the arrhythmia, 25% and 50% reduction in baseline mean arterial blood pressure, and arrest. We also checked the dose of infused bupivacaine to be required for arrest during continuous intravenous infusion of bupivacaine at the rate of 1 mg/kg/min. RESULTS: The onset of dysrhythmia and the time to 50% reduction in baseline mean arterial blood pressure and arrest were significantly more delayed in the midazolam group than the control group (P < 0.05). With respect to the time to 25%, 50% reduction in baseline mean arterial blood pressure and arrest, the data of the droperidol group was significantly shorter than that of the control group (P < 0.05). CONCLUSIONS: Droperidol pretreatment hastened bupivacaine induced cardiac arrest in rabbits. Midazolam pretreatment exerted protective effects on arrhythmia and cardiac arrest. Thus midazolam would be a preferable agent as a supplement for regional anesthesia using bupivacaine.
    Article · Jan 2000 · Korean Journal of Anesthesiology
  • Yong Shin Kim · Yoo Jin Kang · Yeon Su Jeon · [...] · Dong Seok Jeong
    [Show abstract] [Hide abstract] ABSTRACT: Many benefits are reported after laparoscopy. As experience, equipment, and techniques have improved, minimally invasive laparoscopic surgery is being applied to younger children. With the advent of this new surgical approach, specific modifications become necessary in anesthetic techniques. During laparoscopy, the pneumoperitoneum performed by peritoneal insufflation of CO2 may induce intraoperative ventilatory and hemodynamic changes that complicate anesthetic management. We present a case of laparoscopic Duhamel operation in a 10-month-old infant weighing 10 kg. After induction with thiopental sodium and vecuronium, anesthesia was maintained with enflurane and 50% nitrous oxide in oxygen. Rapid hypercarbia developed about 5 minutes after introduction of pneumoperitonium, so we gave intermittent manual hyperventilation to avoid hypercarbia untill we finished the surgery. In children, CO2 absorption may be more efficient due to the physiological properties of the immature peritoneum. The functional residual capacity (FRC) is low in children. During laparoscopy, FRC is decreased further due to a variety of factors. In spite of the changes in FRC, arterial oxygenation has not been shown to deteriorate in normal infants. In our case, the changes in end-tidal CO2 tension (PETCO2) during laparoscopy did not influence the hemodynamic change. But insufflation of CO2 induced a significant increase in PETCO2, and produced a fast reaction time of PETCO2.
    Article · Jan 1999 · Korean Journal of Anesthesiology
  • Yoo Jin Kang · Dae Woo Kim · Jang Hyeok In · [...] · Yong Gul Lim
    [Show abstract] [Hide abstract] ABSTRACT: The inheritance of ABO blood type group is actually determined by triple allelic gene, A, B and O. Transmission of blood group AB by a single chromosome, instead of by two separate chromosomes, was reported and called cis AB. The anesthesiologists, who meet many cases of the transfusions, may anesthetize cis AB patients for surgery. Recently the authors have experienced one case of patient with cis AB blood type undergoing emergency craniotomy and removal of hematoma. We transfused the patient with Rh+O packed red blood cell without any significant transfusion reactions.
    Article · Jan 1999 · Korean Journal of Anesthesiology
  • Yoo Jin Kang · Jin Hye Min
    [Show abstract] [Hide abstract] ABSTRACT: Pheochromocytoma is an unusual tumor in pediatric age group and there are several different aspects from adult counterparts. Children have fewer malignant, more extra-adrenal, and greater bilaterality and multiplicity of tumor. We present a case of 14-year old boy with pheochromocytoma who has symptoms such as episodic headaches, vomiting, seizure and paroxysmal hypertension which is less common in children. Although the duration of preoperative preparation was not long enough, we decided to remove the tumor because symptoms were disappeared rather rapidly after alpha and beta adrenergic blocker treatment. The patient was managed with continuous epidural block and light general anesthesia but extra use of adrenergic receptor blocker and vasodilator were demanded during tumor manipulation. The patient has remained well postoperatively but long-term follow up is essential because of the possibilities of recurrence.
    Article · Jan 1999 · Korean Journal of Anesthesiology
  • Yong Gul Lim · Yoo Jin Kang · Dae Woo Kim · Won Sun Cho
    [Show abstract] [Hide abstract] ABSTRACT: Background: It has been reported that steroid and lidocaine reduce inflammatory responses to endotoxin. The aim of this study is to compare the effects of lidocaine with those of steroid on inflammatory responses to Escherichia coli endotoxemia in the rabbit lung. Methods: Twenty four animals were randomly assigned to one of four groups. Group I (endotoxemic group; control, n=6): They were received E. coli endotoxin (500 microg/kg) intravenously through the ear vein and followed by saline infusion at 20 ml/kg/hr for 4 hours. Group II (steroid treated group, n=6): They were treated with steroid (30 mg/kg) intravenously just after endotoxin injection and then saline was given at 20 ml/kg/hr for 4 hours. Group III (lidocaine treated group, n=6): They were received same as the endotoxemic group and lidocaine (3 mg/kg IV bolus, then continuous infusion at the rate of 2 mg/kg/hr) was administered with saline at 20 ml/kg/hr for 4 hours. Group IV (steroid
    Article · Jan 1998 · Korean Journal of Anesthesiology
  • Yong Gul Lim · Eun Ju Lee · Kwang Ick Ok · Yoo Jin Kang
    [Show abstract] [Hide abstract] ABSTRACT: Apert's syndrome is rare autosomal dominant defect characterized by craniosynostosis, midface hypoplasia and symmetrical syndactyly. Multiple surgical procedures will be needed for the child with this syndrome. Especially surgery for craniosynostosis is most often performed between 2 and 6 months of life, a period of physiologic anemia. Perioperative complications can occur from numerous sources-massive blood loss, venous air embolism, cerebral edema, hypothermia and hazardous airway management, thus more monitoring, large bored central venous line and early transfusion are recommended. We report a case of 5 month-old female Apert patient undergoing frontal bone advancement and cranioplasty. At the end of uneventful surgery, we removed endotracheal tube in operating room and permitted early feeding because the procedure was limited above the orbital ridge. As soon as feeding the patient presented cyanosis with generalized seizure. Patient was immediately intubated, sucked out secretions and inhaled with oxygen. Blood gas showed moderate hypoxemia which was improved by oxygen therapy. Suspicious aspiration pneumonia was marked on chest film but disappered I week later. The condition was favorable thereafter and discharged without complication. Keypoints in management of Aperts syndrome are close observation, early detection and preventive treatment of possible complications in perioperative period. (Korean J Anesthesiol 1995; 29: 300~303)
    Article · Jan 1995 · Korean Journal of Anesthesiology

Publication Stats

12 Citations


  • 2007
    • Catholic University of Korea
      • Department of Anesthesiology and Pain Medicine
      Sŏul, Seoul, South Korea