Bulent Serhan Yurtlu

Dokuz Eylul University, Ismir, İzmir, Turkey

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Publications (7)2.17 Total impact

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    ABSTRACT: Objective: To compare the effects of neostigmine/atropine combination and sugammadex on intraocular pressure during tracheal extubation period. Methods: The single-blind prospective randomised controlled study was conducted at Ordu University Research and Training Hospital from August to October 2014, and comprised patients who were randomly assigned to 2 groups according to the agent used for reversal of neuromuscular blockade. Group N received 0.05mgkg-1 neostigmine and 0.02 mgkg-1 atropine and the patients in Group S received 2mgkg-1 sugammadex intravenously. Heart rate, mean arterial pressure and intraocular pressure were measured at baseline, before the induction (T1), after the application of reversal agent (T2), and 1 (T3), 3 (T4), 5 (T5) and 10 (T6) minutes after the extubation. SPSS 16 was used for statistical analysis. Results: There were 36 patients in the study; 18(50%) in each group. There was no significant difference between the groups in terms of age, gender and body mass index (p>0.05 each). Intraocular pressure was significantly higher when the baseline level was compared with all measurement intervals in Group N (p<0.05 each). In Group S, it showed no significant difference at T2 (p>0.05) whereas it was significantly higher at all other measurement intervals (p<0.05 each). Intergroup comparisons showed statistically significant difference in heart rate and mean arterial pressure levels at T2 interval which were higher in Group N (p<0.01). Intraocular pressure levels at T2 and T3 intervals were significantly higher in Group N (p<0.01). Conclusions: Lower end-extubation intraocular pressure levels were obtained when sugammadex was used as a neuromuscular block reversal agent in comparison with neostigmine-atropine combination. Sugammadex may be a better option for the reversal of neuromuscular blockade and intraocular pressure increase should be avoided in patients with glaucoma or penetrating eye injury.
    Full-text · Article · Nov 2015 · Journal of the Pakistan Medical Association
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    ABSTRACT: Postoperative pain is a major problem in clinical practice. Non-steroidal anti-inflammatory drugs have traditionally been used to relieve postoperative pain. Administration of intravenous products together can result incompatibility problems and this is clinically hazardous. Reference texts, published reports can provide information about drugs’ incompatibility characteristics but there have been limited data for new drugs such as lornoxicam, tenoxicam and dexketoprofen, commonly used non-steroidal antiinflammatory drugs. In this study, it was aimed to investigate whether there is precipitation between lornoxicam, tenoxicam and dexketoprofen with other commonly used drugs in anesthesiology practice © 2015, Latin American Journal of Pharmacy. All rights reserved.
    No preview · Article · Jan 2015 · LATIN AMERICAN JOURNAL OF PHARMACY
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    ABSTRACT: Previous studies have shown that cyclodextrins bind to various drugs. The hypothesis of our study is to determine whether sugammadex could bind to teophylline and delayed the toxicity of that drug. Twenty eight Wistar rats were infused with teophylline at 15 mg/kg/min (24 mg/mL). Five mins after the start of infusion animals were treated with a bolus of either 16 mg/kg (S16), 100 mg/kg (S100), or 1000 mg/kg (S1000) sugammadex. The control group infusion did not contain sugammadex. Heart rate, electrocardiography, and respiratory rate were monitored. The primary endpoint was time to asystole. Teophylline infusion continued until the animals arrested. The asystole time for the S16 group was significantly longer compared to those for the control group (p < 0.05). Mean lethal dose of teophylline 90.44 ± 27.58 mg/kg in the saline-treated rats. On the other hand, mean lethal dose of teophylline 128.54 ± 24.03 mg/kg in the S16 group (p < 0.05). Mean lethal dose of teophylline in the S16 group, was significantly higher than control group (p < 0.05). We found 16 mg/kg sugammadex significantly delayed teophylline toxicity, and raises mean lethal dose of teophylline in a rat model of teophylline toxicity. Further research must be conducted on the interaction between teophylline and sugammadex. © 2014, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All Rights Reserved.
    No preview · Article · Jan 2014 · LATIN AMERICAN JOURNAL OF PHARMACY
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    Volkan Hancı · Hasan Ali Kiraz · Dilek Ömür · Serpil Ekin · Berna Uyan · Bulent Serhan Yurtlu

    Full-text · Article · Feb 2013
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    Volkan Hancı · Hasan Ali Kiraz · Dilek Omür · Serpil Ekin · Berna Uyan · Bulent Serhan Yurtlu

    Full-text · Article · Feb 2013 · Revista brasileira de anestesiologia
  • Volkan Hancı · Hasan Ali Kiraz · Dilek Omür · Serpil Ekin · Berna Uyan · Bulent Serhan Yurtlu

    No preview · Article · Jan 2013
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    ABSTRACT: Aim: To evaluate the effect of tramadol addition to levobupivacaine in axillary plexus blockade in a prospective, randomized double-blind study. Materials and methods: A total of 60 patients scheduled to undergo hand and forearm surgery under axillary plexus blockade were randomly divided into 2 groups. Group L received 36 mL of racemic 0.5% levobupivacaine with 2 mL of saline, whereas Group LT received 2 mL (100 mg) of tramadol instead of saline. After routine monitorization, axillary block was performed with a multistimulation technique using a nerve stimulator. Motor (finger, wrist, and elbow movements) and sensory (pinprick sensation for the cutaneous supply) block characteristics for radial, median, ulnar, and musculocutaneous nerves were determined every 5 min. Postoperative motor and sensory block duration, analgesic consumption, and numeric rating scale (NRS) scores were also recorded. Results: In each group, 2 patients had block failures. The data for the remaining 56 patients were analyzed. There were no significant differences between the study groups according to motor and sensory block characteristics of 4 nerves, block durations, analgesic consumption, and NRS scores. Conclusion: The addition of 100 mg of tramadol to 0.5% levobupivacaine for axillary brachial plexus blockade neither improved the intraoperative block quality nor prolonged the duration of postoperative analgesia.
    No preview · Conference Paper · Feb 2012