M. Xue

University of Maryland, Baltimore, Baltimore, Maryland, United States

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Publications (17)25.56 Total impact

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    ABSTRACT: To study the stability of 4,10-dinitro-2,6,8,12-tetraoxa-4,10-diazatetracyclo-[5.5.0.05,903,11]-dodecane (TEX), a high performance liquid chromatography (HPLC) analysis method for TEX was developed. The thermal behavior of TEX was studied by thermogravimetry-derivative thermogravimetry (TG-DTG) and differential scanning calorimetry (DSC), the peak temperatures at different heating rates (5,10,15,20 and 25 K/min) were determined. The apparent activation energy (Ek) and preexponential constant(A) of the exothermic decomposition reaction were calculated by Kissinger's method. Activation enthalpy (△S≠), activation entropy (△H≠) and activation Gibbs free energy (△G≠) for the exothermic decomposition reaction of TEX were calculated according to thermodynamic equations. The results indicate that TEX is stable to heat. The values of △S≠, △H≠ and △G≠ are 501.03 J/(K·mol), 432.48 kJ/mol and 145.26 kJ/mol, respectively. ©, 2015, China Ordnance Industry Corporation. All right reserved.
    No preview · Article · Aug 2015 · Huozhayao Xuebao/Chinese Journal of Explosives and Propellants
  • J. Wang · Z.-B. Xu · Z.-H. Meng · M. Xue
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    ABSTRACT: Recent research progresses in supramolecular host-guest energetic composites with the different host compounds which include cyclodextrin, carbon nanotube, graphene and mesoporous materials, and the co-crystallization energetic materials were reviewed. The defect of preparing the supramolecular energetic composite with cyclodextrin was pointed out. The feasibility of the research and research methods for preparation of the insensitive high-energy supramolecular energetic composites with cyclodextrin, carbon nanotube, graphene and mesoporous materials, and the co-crystallization energetic materials were analyzed. Application prospects of supramolecular chemistry method in the field of energetic materials were expected with 55 references. ©, 2015, China Ordnance Industry Corporation. All right reserved.
    No preview · Article · Jun 2015 · Huozhayao Xuebao/Chinese Journal of Explosives and Propellants
  • W Choi · M Xue · M Kang · K Patel · W Regine · P Klahr · J Wang · W D'Souza · W Lu
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    ABSTRACT: This study presents quantitative and qualitative assessment of the image qualities in contrast-enhanced (CE) 3D-CT, 4D-CT and CE 4D-CT to identify feasibility for replacing the clinical standard simulation with a single CE 4D-CT for pancreatic adenocarcinoma (PDA) in radiotherapy simulation. Ten PDA patients were enrolled and underwent three CT scans: a clinical standard pair of CE 3D-CT immediately followed by a 4D-CT, and a CE 4D-CT one week later. Physicians qualitatively evaluated the general image quality and regional vessel definitions and gave a score from 1 to 5. Next, physicians delineated the contours of the tumor (T) and the normal pancreatic parenchyma (P) on the three CTs (CE 3D-CT, 50% phase for 4D-CT and CE 4D-CT), then high density areas were automatically removed by thresholding at 500 HU and morphological operations. The pancreatic tumor contrast-to-noise ratio (CNR), signal-tonoise ratio (SNR) and conspicuity (C, absolute difference of mean enhancement levels in P and T) were computed to quantitatively assess image quality. The Wilcoxon rank sum test was used to compare these quantities. In qualitative evaluations, CE 3D-CT and CE 4D-CT scored equivalently (4.4±0.4 and 4.3±0.4) and both were significantly better than 4D-CT (3.1±0.6). In quantitative evaluations, the C values were higher in CE 4D-CT (28±19 HU, p=0.19 and 0.17) than the clinical standard pair of CE 3D-CT and 4D-CT (17±12 and 16±17 HU, p=0.65). In CE 3D-CT and CE 4D-CT, mean CNR (1.8±1.4 and 1.8±1.7, p=0.94) and mean SNR (5.8±2.6 and 5.5±3.2, p=0.71) both were higher than 4D-CT (CNR: 1.1±1.3, p<0.3; SNR: 3.3±2.1, p<0.1). The absolute enhancement levels for T and P were higher in CE 4D-CT (87, 82 HU) than in CE 3D-CT (60, 56) and 4DCT (53, 70). The individually optimized CE 4D-CT is feasible and achieved comparable image qualities to the clinical standard simulation. This study was supported in part by Philips Healthcare.
    No preview · Article · Jun 2015 · Medical Physics
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    ABSTRACT: To determine the trace ions in energetic compound 2, 4-dinitroanisole (DNAN) sample, the qualitative and quantitative analysis of ions in DNAN sample were performed by an ion chromatography method. Results show that the sample contains 8 kinds of ions of Li+, Na+, NH4+, Mg2+, Ca2+, Cl-, NO3-, SO42-. Their mass fractions are 13.2348, 70.4080, 15.3270, 83.2659, 154.1580, 156.4740, 21.6544, 210.3100μg/mL, respectively. The method has the advantages of rapid detection and reliable quantification. ©, 2015, China Ordnance Industry Corporation. All right reserved.
    No preview · Article · Jun 2015 · Huozhayao Xuebao/Chinese Journal of Explosives and Propellants
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    ABSTRACT: Polynitroadamantanes are the precursors both in pharmaceutical synthesis and energetic material preparation. In this paper, the determination method of 2, 2-nitroadamantane and 2, 2, 4, 4, 8, 8-hexanitroadamantane was established by High Performance Liquid Chromatography (HPLC) with optimal chromatographic conditions including the detector, mobile phase and stationary phase. The Ultraviolet detector and DIONEX C18 column (5 μm, 120 A, 4.6 mm×250 mm) were confirmed to get base line separation and high limit of detection for these two compounds mixture. The acetonitrile/water (80/20, V/V) was employed as mobile phases, which presented exceptional separation effect on these two targets when the flow rate was 1.0 mL·min-1. Results show that the detection limit, linear range, the linear correlation coefficient and precision of 2, 2-nitroadamantane are 0.003 mg·mL-1, 0.005-1.000 mg·mL-1, 0.9987 and 1.382%, respectively. Correspondingly, the same parameters of 2, 2, 4, 4, 8, 8 -hexanitroadamantane are 0.001 mg·mL-1, 0.005-1.000 mg·mL-1, 0.9984 and 1.300%, respectively ©, 2015, Institute of Chemical Materials, China Academy of Engineering Physics. All right reserved.
    No preview · Article · May 2015 · Hanneng Cailiao/Chinese Journal of Energetic Materials
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    ABSTRACT: The thermal decomposition performance and compatibility of 4, 10-dinitro-2, 6, 8, 12-tatraoxa-4, 10-diazatatracyclo [5, 5, 0, 05, 9, 03, 11]-decane (TEX) with main components of propellants such as cyclotrimethylenetrinitramine(RDX), N-nitrodihydroxyethylaminedinitrate(DINA), nitrocellulose (NC), absorbentia(NC+NG), diethylphthalate(DEP), leadphthalate(Φ-Pb) and aluminium powder(micron order) were studied by differential scanning calorimetry(DSC). The results show that TEX is relatively stable to heat, the binary system of TEX was compatible with RDX, Φ-Pb, NC, DINA and aluminium powder, and was slightly sensitive with absorbentia(NC+NG) and NC. Thus TEX can be used as component in propellants. ©, 2015, China Ordnance Industry Corporation. All right reserved.
    No preview · Article · Apr 2015 · Huozhayao Xuebao/Chinese Journal of Explosives and Propellants

  • No preview · Article · Sep 2014 · International journal of radiation oncology, biology, physics
  • M Xue · K Patel · W Regine · B Lane · W D'Souza · P Klahr · W Lu
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    ABSTRACT: Purpose: To study the feasibility of individually optimized contrastenhancement (CE) 4D-CT for pancreatic adenocarcinoma (PDA) in radiotherapy simulation. To evaluate the image quality and contrast enhancement of tumor in the CE 4D-CT, compared to the clinical standard of CE 3D-CT and 4D-CT.
    No preview · Article · Jun 2014 · Medical Physics
  • M Xue · S Feigenberg · S Tan · A Reese · B Yi · W D'Souza · W Lu
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    ABSTRACT: Purpose: To quantitatively evaluate the inter-fractional variations in ITVs over the course of treatment using multiple 4DCTs and CBCTs for patients treated with SBRT for lung targets. To compare using ITV generated from all phases of a 4D or average intensity projection (ITV-AIP) as reference contours for image guidance.
    No preview · Article · Jun 2014 · Medical Physics
  • S Tan · M Xue · W Chen · H Li · W D'Souza · W Lu
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    ABSTRACT: Purpose: To design a reliable method to determine the optimal parameter in the adaptive region-growing (ARG) algorithm for tumor segmentation in PET.
    No preview · Article · Jun 2014 · Medical Physics
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    ABSTRACT: Purpose: To improve the diagnostic quality of CT pulmonary angiography (CTPA) by individually optimizing a biphasic contrast injection function to achieve targeted uniform contrast enhancement. To compare the results against a previously reported discrete Fourier transform (DFT) approach. Methods: This simulation study used the CTPA datasets of 27 consecutive patients with pulmonary thromboembolic disease (PE). An optimization approach was developed consisting of (1) computation of the impulse enhancement function (IEF) based on a test bolus scan, and (2) optimization of a biphasic contrast injection function using the IEF in order to achieve targeted uniform enhancement. The injection rates and durations of a biphasic contrast injection function are optimized by minimizing the difference between the resulting contrast enhancement curve and the targeted uniform enhancement curve, while conforming to the clinical constraints of injection rate and total contrast volume. The total contrast volume was limited first to the clinical standard of 65 ml, and then to the same amount used in the DFT approach for comparison. The optimization approach and the DFT approach were compared in terms of the root mean square error (RMSE) and total contrast volume used. Results: When the total contrast volume was limited to 65 ml, the optimization approach produced significantly better contrast enhancement (closer to the targeted uniform contrast enhancement) than the DFT approach (RMSE 17 HU vs 56 HU, p < 0.00001). On average, the optimization approach used 63 ml contrast, while the DFT approach used 50 ml with four patients exceeding 65 ml. When equivalent total contrast volume was used for individual patient, the optimization approach still generated significantly better contrast enhancement (RMSE 44 HU vs 56 HU, p < 0.01). Constraints for the injection function could be easily accommodated into the optimization process when searching for the optimal biphasic injection function. Conclusions: The optimization approach generated individually optimized biphasic injection functions yielding significantly better contrast enhancement compared to the DFT approach. This new approach has the potential to improve the diagnostic quality of CTPA for PE.
    No preview · Article · Dec 2013 · Medical Physics
  • M Xue · H Zhang · S Kligerman · W D'Souza · P Klahr · W Lu
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    ABSTRACT: Purpose: To improve the diagnostic quality of CT angiography (CTPA) for pulmonary thromboembolic disease by individually optimizing a bi‐phasic contrast injection function to achieve uniform target contrast enhancement. To compare the results against a previously reported discrete Fourier transform (DFT) approach. Methods: This simulation study uses a retrospective dataset of 27 consecutive patients. We developed an optimization approach consists of two steps: 1. Compute the impulse enhancement function (IEF) based on the test bolus scan; 2. Optimize the contrast injection function using the IEF in order to achieve uniform target enhancement. We chose a bi‐phasic contrast injection function in which the injection rates and durations are optimized by minimizing the difference between its contrast enhancement curve and the uniform target enhancement curve. The contrast volume is limited either to the clinical standard of 65 mL or to the same amount used in the DFT approach. The optimization approach is compared against the DFT approaches in terms of the root mean square errors (RMSE) from the uniform target contrast enhancement curve and the contrast volume used. Results: When the contrast volume is limited to 65 mL, the optimization approach produces contrast enhancement significantly (p<.00001) closer to the uniform target contrast enhancement (mean RMSE 17 HU) than the DFT approach (mean RMSE 56 HU), for which the contrast volume is not even limited. When the contrast volume is limited to be the same amount used in the DFT approach, the optimization approach still generate significantly improved contrast enhancement than the DFT approach (RMSE 44 HU vs. 56 HU, p<.0099). Conclusion: The optimization approach generates individually optimized bi‐phasic injection functions yielding significantly improved contrast enhancement than the DFT approach. Its implementation in clinic has great potential to improve the diagnostic quality of CTPA. This work is supported in part by Philips Healthcare, Inc.
    No preview · Article · Jun 2013 · Medical Physics
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    ABSTRACT: A high performance liquid chromatography (HPLC) method was developed for the analysis of hydrazonium salt of 3, 5-dinitroamine-1, 2, 4-triazole (HDNAT) and the anions and cations in crude HDNAT were determined by ion chromatography (IC). The thermal stability of HDNAT was investigated by TG-DTA and DSC. The result shows that there are CH3COO-, Na+, NH4+, K+, Mg2+ and Ca2+ in the HDNAT sample. Its initial decomposition temperature is 183°C, and decomposition heat is 589.14 J/g.
    No preview · Article · Jun 2013 · Huozhayao Xuebao/Chinese Journal of Explosives and Propellants
  • M Xue · S Tan · A Reese · B Yi · W D'Souza · S Feigenberg · W Lu
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    ABSTRACT: Purpose: To quantitatively evaluate the inter‐fractional variation in tumor volumes with repeated 4D‐CTs and repeated CBCTs for lung patients. To evaluate the uncertainties in patient set‐up that uses internal target volume (ITV) of 4D‐CT to match the soft tissue on CBCTs. Methods: We retrospectively selected 5 lung cancer patients: each with three 4D‐CTs (4D1, 4D2, and 4D3) and three CBCTs (C1, C2, and C3), and each CBCT was scanned within one week of a corresponding 4D‐CT. All CT images are registered to 4D1, together with contours on each image: ITV for 4D‐CT and gross tumor volumes (GTV) for CBCT. Then, these volumes are compared to ITV in 4D1 in terms of tumor volume, centroid distance, and volume overlap coefficient. Results: In each CBCT/4D‐CT pair, GTV in CBCT underestimate the ITV in 4D‐CT by 41.22±1.39 %. When normalized to the ITV volume in the 4D1, other ITVs of 4D‐CTs have an average volume of 1.07±0.13, and GTV in CBCTs have an average volume of 0.58±0.01. The centroid distance between ITV of 4D1 and a GTV of CBCT (5.6±11.9 mm) is larger than that between ITVs of 4D1and 4D2/4D3 (4.6±8.1 mm), while the CBCT GTV volumes are more included in the ITV of 4D1 (BinA: 0.863±0.018) than those of 4D2/4D3 (BinA: 0.735±0.033). From visual observation, the tumors presented in CBCTs are more similar to those in average projections compared to the ITVs of 4D‐CTs. Conclusions: The soft tissue alignment using 4D ITV on CBCT image has room for improvement. Although CBCT tumor seems more included, the centroid distance between CBCT‐GTV and 4D1‐ITV is larger than that between 4D2/4D3‐ITV and 4D1‐ITV. This, together with the underestimation of tumor volume from CBCT, makes current soft tissue alignment not as reliable as it seems. This work is supported in part by Philips Healthcare, Inc.
    No preview · Article · Jun 2013 · Medical Physics
  • M. Xue · X. Zhong · Z.-H. Meng · Z.-Q. Chen · M. Xu · L. Jia · G. Zhang
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    ABSTRACT: The analytical method of trace ionic impurities in 3, 4-Dinitrofurazan (DNTF) was established using ion chromatography considering their significant effect up on the quantity control in this explosive preparation process. Precise quantitative determination of anions and cations existing in DNTF with and without refining had been performed. The concentrations of Na +, Mg 2+, Ca 2+, HCOO -, Cl -, NO 2-, and NO 3- in crude sample are 53.3, 5.5, 32.4, 2.46, 1.28, 12.8, 28.2 μg·g -1, respectively, while those of the corresponding ions were obviously reduced after the product was refined.
    No preview · Article · Oct 2012 · Hanneng Cailiao/Chinese Journal of Energetic Materials
  • M Xue · W D'Souza · G Lasio · P Klahr · W Lu
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    ABSTRACT: Purpose: Contrast-enhanced (CE) 4D-CT has the advantage of both visualizing an abdominal tumor and estimating its motion in a single scan. Considering the large variation in the peak CE time from one patient to another, we propose to optimize the contrast injection delay time for individual patients so that the CE is maximized when scanning the tumor region in CE 4D-CT. Methods: We designed a flow phantom simulating the contrast enhancement and washing out in an organ. Peak CE time of a test injection (Tpeak.test) with 10 ml contrast was used to estimate the peak CE time of a full injection (Tpeak) with 140 ml contrast in the CE 4D-CT: Tpeak = Tpeak.test + (TID-TID.test), where TID.test and TID are the corresponding injection durations. We then computed an optimal contrast injection delay time, TIV = TO - Tpeak, where TO is the 4D-CT scan time from the starting position to the center of phantom. To verify that maximal CE is achieved with TIV, we performed five CE 4D-CT scans using an injection delay time of TIV + AT, where ΔT = +6, +3, 0, -3, and -6 s. The CE in a volume of interest at the center of the phantom was measured in each 4D-CT. Results: The phantom showed good reproducibility about ±1 s in the peak CE time of both test injection and full injection. The 4D-CT using the optimal TIV (ΔT = 0) showed the maximum contrast enhancement. The larger deviation from TIV, the lower was contrast enhancement. These results verified that the estimated optimal injection time delay achieved maximum contrast enhancement. Conclusions: It is feasible to estimate individually optimized injection delay time to maximally enhance a region or organ of interest in CE 4D-CT. This study is supported in part by Philips Healthcare. This study is supported in part by Philips Healthcare.
    No preview · Article · Jun 2012 · Medical Physics
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    ABSTRACT: In the production process of natural rubber (NR), large quantities of wastewater containing substantial amounts of L-quebrachitol are discharged. To date, published methods of extracting L-quebrachitol from wastewater are still at the laboratory stage. In this study, membrane separation technology was applied to the extraction of L-quebrachitol from wastewater and the experimental parameters were studied in order to determine optimal experimental conditions. Results show that the optimum source material for L-quebrachitol extraction was the serum collected by squeezing the latex coagulum. When this serum was passed through a microfiltration (MF) membrane and two ultrafiltration (UF) membranes, majority of the organic impurities were removed. The resulting ultrafiltrate was concentrated by a nanofiltration (NF) membrane and washed twice. Finally, a new and convenient approach for large scale extraction of L-quebrachitol is proposed combining membrane separation and crystallisation. The output achieved with this approach would be 10 kg per year under laboratory conditions with 99.20% purity. The structure of L-quebrachitol was confirmed by elementary analysis, infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectroscopy (MS) and single-crystal X-ray diffraction.
    No preview · Article · · Journal of Rubber Research