[Show abstract][Hide abstract]ABSTRACT: Aim:
To characterize the computed tomography (CT) and magnetic resonance imaging (MRI) findings of inflammatory myofibroblastic tumours (IMTs) of the maxillary sinus.
Materials and methods:
The imaging findings of eight patients with IMTs of the maxillary sinus were reviewed retrospectively. Of the eight patients, four patients underwent unenhanced and contrast-enhanced CT, and one patient underwent unenhanced CT only; three patients underwent unenhanced and contrast-enhanced MRI.
Five cases of IMTs occurred in the left maxillary sinus, while three cases were right-sided. Four cases occupied the entire sinus, and the other four cases only partially occupied the sinus. Unenhanced CT images showed heterogeneous masses in four cases and a homogeneous mass in one case. One of the tumours showed some areas of calcification. T1-weighted MRI images showed isointense lesions. T2-weighted images showed mixed isointense and mild hyperintense lesions. All cases showed bone destruction and had infiltrated into the nasal fossa, orbit, infratemporal fossa, and other adjacent tissues. Seven cases showed mild to moderate heterogeneous enhancement on contrast-enhanced CT or T1-weighted MRI images.
IMTs of the maxillary sinus can be characterized as a soft-tissue mass with bony destruction and infiltration of the adjacent tissues, with mild to moderate enhancement after the injection of contrast medium. CT and MRI can help to diagnose IMTs, determine the extent of the lesion and its relationship with adjacent tissues, and thus facilitate the prediction of surgical resectability.
[Show abstract][Hide abstract]ABSTRACT: Objective: To evaluate the feasibility of single-pin puncture asymmetrical hydroablation in liver using the multipole cluster conformable radiofrequency ablation electrode.Methods: The conformable electrode (WHK-3-8-4; Wellfare Electronic Technological Company, Beijing, China) used in this study consists of both a main electrode in a central cannula and a circle of subelectrodes comprising two groups of six subelectrodes located on opposite sides (A and B) of the circle. The two subelectrode groups can be extended to different lengths independently of one another, resulting in asymmetric shapes. Ablation experiments were performed using ex vivo ox liver. The experiments included six groups based on six potential electrode deployments in which the subelectrodes on sides A and B were fully extended, half extended or fully retracted. After ablation, the transverse diameters of the resulting necrotic tissue from sides A and B were measured. The experiment was conducted in 12 separate sites for each group.Results: When the subelectrodes were arranged symmetrically (either fully extended or half extended on both sides), the mean transverse diameter of necrotic tissue was similar for both sides A and B. When the subelectrodes were arranged asymmetrically, the fully extended side showed a significantly greater mean transverse diameter of necrotic tissue than the half extended or fully retracted side.Conclusion: In this study, the WHK 3-8-4 multipole cluster conformable radiofrequency ablation electrode was able to produce both symmetrical and asymmetrical necrotic tissue patterns in the liver.Advances in knowledge: The size and shape of the ablation can be altered by both withdrawing and extending the subelectrodes to different lengths.
Article · Aug 2012 · The British journal of radiology
[Show abstract][Hide abstract]ABSTRACT: To evaluate the computed tomography (CT) imaging findings of primary pleuropulmonary synovial sarcoma.
Five cases of synovial sarcoma confirmed by histopathology and cytogenetic study were retrospectively analysed. All patients had undergone chest radiography and unenhanced and contrast-enhanced CT examinations, and three had also undergone multiphase CT enhancement examinations. Image characteristics, including shape, size, margin, and attenuation of each lesion before and after contrast enhancement, were analysed.
The chest radiographs of the five patients showed well-defined or partly well-defined masses, which were homogeneous and without associated calcification or lymphadenopathy. Pneumothorax was present in one patient. The unenhanced CT images showed well-defined, heterogeneous masses with patchy low density in all five patients. The contrast-enhanced CT images showed heterogeneous enhancement in all cases, three of which demonstrated cystic and necrotic areas. The tumour showed no prolonged or delayed enhancement in three cases using multiphase CT. There were small pleural effusions in four cases. No calcification was observed in any of the cases. There was no evidence of hilar or mediastinal lymphadenopathy.
In these five patients, primary pleuropulmonary synovial sarcoma presented as a well-defined mass with patchy low density and heterogeneous enhancement, with no evidence of regional lymphadenopathy. It should be included in the differential diagnosis of regional tumours.
[Show abstract][Hide abstract]ABSTRACT: The study aimed to understand better the somatic mutations in the human MutL Homolog 1 (hMLH1) and human MutS Homolog 2 (hMSH2) genes in colorectal cancer (CRC) and to investigate the differences derived from ethnicity, family history, detection method and microsatellite instability (MSI).
The terms 'hMSH2' or 'hMLH1' and 'colorectal cancer' 'colorectal carcinoma' or 'colorectal tumour' were searched in the PubMed, Springer, Lippincott, Williams & Wilkins and HighWire Press databases for the publication period December 1993 to September 2010. The Comprehensive Meta Analysis V2 software (Biostat Inc.) was used to explore the prevalence and 95% confidence intervals.
The prevalence of somatic mutations in the hMLH1 and hMSH2 genes in CRC was 0.15 (95% CI 0.10-0.22) and 0.10 (95% CI 0.07-0.16), respectively. A higher prevalence of somatic mutations in hMSH2 was found in hereditary non-polyposis CRC than in sporadic CRC: 0.36 (95% CI 0.14-0.67) and 0.10 (95% CI 0.07-0.13) respectively. In addition, a higher prevalence of somatic mutations in the hMLH1 gene was observed relative to hMSH2 in the European group. The prevalence was higher in the high-level instability (MSI-H) group than in both the low-level instability (MSI-L) and the microsatellite stable (MSS) groups.
Somatic mutations in the hMLH1 and hMSH2 genes play a vital role in CRC and a high prevalence was found in this meta-analysis. Furthermore, more studies are needed which focus on somatic mutations in the American population and in patients with MSI-L and MSS.