Atsushi Kondo

KKR Sapporo Medical Center, Sapporo, Hokkaidō, Japan

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Publications (13)9.4 Total impact


  • No preview · Article · Jan 2015 · Nihon Kikan Shokudoka Gakkai Kaiho
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    Atsushi Kondo · Makoto Kurose · Tetsuo Himi
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    ABSTRACT: We report on 29 patients with stage III/IV hypopharyngeal squamous cell carcinoma who underwent operations. 27 patients underwent total pharyngo-laryngectomy, and two patients underwent larynx-preserving partial pharingectomy. The cause-specific survival rate was 60.5% at 5 years. Fifteen patients were treated with postoperative radiotherapy, but seven patients had recurrence or metastasis. It might be reasonable to preserve elective neck dissection for N0 and N1 patients. The occult metastasis rate to the contralateral neck was 13%. Retropharyngeal node metastasis was detected in five patients before treatment, and all cases were treated with postoperative radiotherapy. However, four patients had recurrence or metastasis. These results indicate that high-risk patients are recommended to receive adjuvant concurrent chemo-radiotherapy.
    Preview · Article · Jan 2015
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    ABSTRACT: This study investigated the maximum tolerated dose (MTD) of S-1 with concurrent radiotherapy in patients with head and neck cancer, based on the frequency of dose-limiting toxicities (DLT). S-1 was administered orally at escalating doses from 40 mg/m2 b.i.d. on the days of delivering radiotherapy, which was given at a total dose of 64–70 Gy in 32–35 fractions over 6–7 weeks. A total of 12 patients (3 patients at 40 mg/m2, 6 patients at 60 mg/m2, and 3 patients at 80 mg/m2) were enrolled in this trial. At the dose of 80 mg/m2, two of the three patients developed DLT (Grade 3 anorexia and rhabdomyolysis) due to S-1, so the MTD was determined to be 80 mg/m2. Among the 12 enrolled patients, 9 (75%) showed a complete response and 3 (25%) showed a partial response. The overall response rate was 100%. The recommended dose of S-1 with concurrent radiotherapy is 60 mg/m2.
    Full-text · Article · Jan 2013 · Journal of Radiation Research
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    ABSTRACT: Tonsillar metastasis from lung cancer is a rare event. We present herein on the unusual case of a 52-year-old man who developed metastasis to the left palatine tonsil from a large-cell neuroendocrine carcinoma. He was treated with chemotherapy, resulting in complete remission.
    No preview · Article · Jan 2013 · Practica Otologica
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    ABSTRACT: Mucosal melanoma of the head and neck is rare and is associated with a poor prognoses because of locoregional failure and distant metastasis. The aim of our study was to review the characteristics of these patients in northern Japan and to analyze their outcomes. The medical records of 94 patients who had been provided initial treatment in 12 institutes from 1998 to 2007 were reviewed. When the 5-year overall survival rates of patients were evaluated, we found that the survival rates of patients treated by chemotherapy were significantly lower than those of patients treated by surgery or radiation. The survival rates of the single-treatment modality, 2-modality, and ≥3-modality groups were 23.4%, 38.0%, and 33.6%, respectively. Our results suggest that patients who underwent combined treatment had better prognoses. However, we found that chemotherapy had no additional survival benefits. © 2012 Wiley Periodicals, Inc. Head Neck, 2012.
    No preview · Article · Nov 2012 · Head & Neck
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    ABSTRACT: We retrospectively investigated the relationship between the duration of hospitalization and the regimen of definitive radiotherapy for patients with early stage glottic laryngeal cancer in our institution during the period from 2006 to 2011. The total number of hospitalized patients who underwent radiation therapy in this period was 45 (43 men, 2 women). Twenty-one patients had been treated by accelerated hyperfractionation (AHF), 19 patients by conventional fractionation (CF, and 5 patients by accelerated fractionation (AF). Average duration of radiation therapy was 23.4, 48.5, 38.4 days respectively and average duration of hospitalization was 37.3, 57.4, and 49 days respectively. Our data suggest that the AHF method can shorten the period of hospitalization by 20 days on average compared to the CF method.
    No preview · Article · Jan 2012 · Japanese Journal of Head and Neck Cancer
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    ABSTRACT: The upper respiratory tract including the nasal cavity, which is the first site of invading antigen exposure, plays a crucial role in host defense via the mucosal immune response. The epithelium of nasal mucosa forms a continuous barrier against a wide variety of exogenous antigens. The epithelial barrier function is regulated in large part by the apical-most intercellular junction, referred to as the tight junction. Antigen-presenting cells, particularly dendritic cells (DCs), are known to play an important role in human nasal mucosa. Recently, the author and colleagues discovered a new mechanism for pathogen uptake in the nasal mucosa, by which DCs open the tight junctions between epithelial cells and send dendrites outside the epithelium to directly sample the pathogen. In order to preserve the integrity of the epithelial barrier and penetrate beyond well-developed epithelial tight junctions, DCs express tight junction proteins. We also found that these DCs are activated by nasal epithelial-derived TSLP induced by stimuli such as cytokines and Toll-like receptor ligands. In this lecture, I will talk about the novel mechanisms in host defense in terms of innate immunity of the nasal mucosa from the point of view of the mucosal barrier function.
    No preview · Article · Aug 2011 · Advances in Oto-Rhino-Laryngology
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    ABSTRACT: Mikulicz's disease (MD) is differentiated from Sjögren's syndrome as an immunoglobulin G4 (IgG4) systemic disease. MD patients often report olfactory dysfunction (OD). To analyze cases of OD associated with MD, we studied clinicopathological and serological findings of MD patients. A total of 44 MD patients (17 males and 27 females) were examined for OD. We evaluated clinicopathological and serological findings of these patients by dividing them into OD(+) and OD(-) groups. The mean IgG4 concentration (SD) in such cases was 950.5 (797.5)mg/dl. Of the 44 patients, 20 (45%) had OD even though no abnormalities, such as obstructive and inflammatory disease, were detected in their nasal cavities and sinuses. The two groups did not show significant differences in background characteristics, such as age, sex, IgG4 concentration, presence or absence of allergic rhinitis, and presence or absence of extrasalivary gland lesions. We found abundant IgG4-positive plasmacytes in the nasal mucosa specimens of the OD(+) group but not in that of the OD(-) group. Nasal mucosa in the MD patients with OD was infiltrated with IgG4-positive plasmacytes. We concluded that OD may be associated with infiltration by IgG4-positive cells.
    Full-text · Article · Jun 2011 · Auris, nasus, larynx
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    ABSTRACT: Chronic sclerosing sialadenitis, which clinically resembles a salivary gland tumor, is considered a salivary gland lesion of the IgG4-related inflammatory disease. Corticosteroids are effective for the treatment of chronic sclerosing sialadenitis, but the natural clinical course of this disease is not fully understood. We report a 67-year-old man with chronic sclerosing sialadenitis who showed lung lesions, which spontaneously regressed without steroid therapy after excision of the submandibular gland. He presented with several weeks' history of continuous swelling in the right submandibular region. Physical examination showed a hard swelling of the right submandibular gland; the cytological finding was Papanicolaou class III. A chest X-ray demonstrated bilateral infiltration of the right middle and left lower lobes. The right submandibular gland was excised under general anesthesia for definite diagnosis, and histopathological examination revealed an IgG4-positive plasmacytic infiltration accompanied by periductal fibrosis and interlobular sclerosis, consistent with chronic sclerosing sialadenitis. Five months after operation, the lung lesions regressed spontaneously.
    No preview · Article · May 2011 · Auris, nasus, larynx
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    Full-text · Article · Oct 2009 · Otolaryngology Head and Neck Surgery
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    ABSTRACT: Analysis of the mucosal barrier function using a primary culture system of human nasal mucosal epithelium is important to establish a methodology of inflammation control by the transnasal drug delivery route. Tight junctions are one of the important factors contributing to the permeability of the nasal mucosa to drugs, and it is important to study the factors regulating the nasal mucosal permeability to drugs. Furthermore, examination of the immunocompetence of an individual by sampling cells such as dendritic cells and M cells may be expected to contribute to the establishment of immunotherapy for allergic rhinitis or upper respiratory infections using the transnasal approach. In addition, tight junctions are also known as one of the viral receptors, and it is important for the future to study the characteristics of tight junctions to develop treatment strategies for the prevention of viral infections.
    No preview · Article · Aug 2009 · Oto-Rhino-Laryngology Tokyo
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    ABSTRACT: Mikulicz's disease (MD) has been considered part of primary Sjögren's syndrome (SS) since Morgan's report in 1953. However, MD shows a unique condition involving persistent swelling of the lachrymal and salivary glands characterized by good responsiveness to glucocorticoids, leading to the recovery of gland function. Recently, it has been revealed that MD patients show elevated serum immunoglobulin G4 (IgG4) concentrations and prominent infiltration of IgG4-positive plasma cells. The complications of MD include autoimmune pancreatitis, retroperotoneal fibrosis, tubulointerstitial nephritis, autoimmune hypophysitis, and Riedel's thyroiditis, all of which show IgG4 involvement in their pathogenesis. Thus, MD is a systemic IgG4-plasmacytic disease. On the other hand, Kuttner's tumor (KT) is chronic sclerosing sialadenitis that presents with asymmetrical firm swelling of the submandibular glands. Immunohistochemical analyses have revealed that a proportion of IgG4-positive plasma cells was also elevated in KT. MD and KT differ from SS and are thought to possibly form a singular systemic IgG4-related plasmacytic disease.
    No preview · Article · Jan 2009 · Oral Medicine & Pathology
  • A Harimaya · H Tsubota · K Hoki · J Sato · A Kondo · T Yamada · N Seki · H Ikeda · T Himi
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    ABSTRACT: Ossifying fibroma is an uncommon benign osteogenic neoplasm arising from cells of the periodontal ligament, typically with a slowly progressive enlargement of the affected bone. The neoplasm sometimes presents with hyperparathyroidism, most of which cases are due to familial parathyroid tumours. We report a rare case of ossifying fibroma of the mandible which showed very rapid growth and presented with primary hyperparathyroidism due to non-familial parathyroid adenoma. Despite improvement of parathyroid dysfunction after removal of the parathyroid adenoma, the tumour continued to grow very aggressively. The case required partial mandibular resection for complete resection of the tumour, and fixation of the remaining mandible with a titanium plate.
    No preview · Article · Apr 2007 · The Journal of Laryngology & Otology