Publications (2)0 Total impact
- [Show abstract] [Hide abstract] ABSTRACT: An unusual granulomatous inflammatory lesion characterised by the presence of ring shaped hyaline bodies accompanied by foreign body giant cell reaction has been mentioned in the literature. A lack of agreement exists on the nature of these hyaline rings. Opinions ranging from their being hyaline degenerative blood vessels to remains of leguminous cells have been postulated. Although the nature and origin of these bodies is uncertain, there is now considerable evidence that they represent, at least in part, vegetable material, especially pulses, that have been implanted in the tissues. An inflammatory oral lesion in a 17-years-old male patient caused due to traumatic implantation of the vegetable matter (sugar cane) has been reported in this paper. Based on the histological finding of a granulation tissue surrounding a hyaline ring the lesion was diagnosed as hyaline ring granuloma.
- [Show abstract] [Hide abstract] ABSTRACT: Perlecan means pearl-like structures. Perlecan is a large proteoglycan (400-500 kDa) present in virtually all vascularized tissues with a distribution that is primarily confined to basement membranes including those of oral mucosa. It is a basement membrane-type heparan sulfate proteoglycan. Perlecan is synthesized by basal cells and fibroblasts adjacent to the basal lamina . Perlecan is also synthesized by vascular endothelial and smooth muscle cells present in the extracellular matrix. It has been demonstrated in recent years that perlecan is distributed in the stromal space of various pathophysiological conditions. The complex pleiotropy of perlecan suggests that this gene product is involved in several developmental processes, at both early and late stages of embryogenesis, as well as in cancer and diabetes. In the oral cavity, perlecan expression is reported to basal cells in normal mucosa and its expression increases in precancer and cancerous conditions. It is also expressed in various odontogenic tumors such as ameloblastoma, keratocyst odontogenic tumor, and also salivary gland tumors such as adenoid cystic carcinoma, mucoepidermoid carcinoma, etc.