Ji Hye Kim

Dankook University, Eidō, Chungcheongbuk-do, South Korea

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Publications (367)734.43 Total impact

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    ABSTRACT: To describe ultrasonography (US) findings of Fontan-associated liver disease (FALD) and to determine whether screening US examinations can identify FALD before biochemical hepatic dysfunction.
    No preview · Article · Feb 2016
  • Mi-Rim Choi · Seol-Bong Yoo · Ji Hye Kim

    No preview · Article · Jan 2016 · The Korean Journal of Internal Medicine
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    ABSTRACT: Background: Atopic dermatitis (AD) is exacerbated by psychological factors, such as stress. We previously reported that corticotrophin-releasing hormone (CRH) treatment in AD patients decreased the proportion of IL-10(+) Tr1 cells, a subset of inducible regulatory T cells (Tregs). However, changes in the function of Tregs in response to CRH have yet to be studied. Methods: We analyzed the total proteins taken from CRH treated- and untreated-Tregs from AD mice model (NC/Nga mice) by using a quantitative proteomic analysis for the different protein expressions. Results: We found a statistically decreased protein level of DOCK8 in CRH treated Tregs from AD mice. In human, DOCK8 protein levels were also significantly decreased in CRH treated-Tregs from AD patients. Moreover, the expression of DOCK8 in Tregs was inversely correlated with the anxiety levels in the AD patients. In addition to the clinical correlation of DOCK8 with the stress level of AD patients, the knockdown of DOCK8 in Tregs reduced the inhibitory cytokines, IL-10 and TGF-β, and inhibited the regulatory function of Tregs to suppress the proliferation and TNF-α release of CD4(+) T cells in vitro. Conclusion: This study provides new insights on the mechanisms of stress induced AD aggravation by showing that CRH downregulated DOCK8 expression in Tregs that not only clinically correlates with anxiety levels of AD patients but also regulates suppressive function of Tregs on CD4(+) T cells. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Allergy
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    ABSTRACT: Background: The purpose of this study was to evaluate the risk factors for mechanical ventilation in the patients with scrub typhus admitted to intensive care unit (ICU) at a university hospital. Methods: We retrospectively selected and analyzed clinical data from the medical records of 70 patients (32 men, 38 women) admitted to the ICU with scrub typhus between 2004 and 2014. The patients had a mean±standard deviation age of 71.2±11.1 years and were evaluated in two groups: those who had been treated with mechanical ventilation (the MV group, n=19) and those who had not (the non-MV group, n=51). Mean ages of the MV group and the non-MV group were 71.2±8.3 years and 71.2±11.1 years, respectively. Results: Significant differences between the two groups were observed with respect to acute respiratory failure (p=0.008), Acute Physiology and Chronic Health Evaluation (APACHE) II score (p=0.015), Sequential Organ Failure Assessment (SOFA) score (p=0.013), death (p=0.014), and ICU duration (p<0.01). Multivariate analysis indicated that the following factors were significantly associated with mechanical ventilation: acute respiratory failure (p=0.011), SOFA score (p=0.005), APACHE II score (p=0.011), platelet count (p=0.009), and lactate dehydrogenase (LDH) (p=0.011). Conclusion: Thus, five factors-acute respiratory failure, SOFA score, APACHE II score, platelet count, and LDH-can be the meaningful indicators for mechanical ventilation for the patients with scrub typhus admitted to ICU.
    Full-text · Article · Jan 2016 · Tuberculosis and Respiratory Diseases
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    ABSTRACT: Background: Bacterial flagellin, a Toll-like receptor 5 agonist, is used as an adjuvant for immunomodulation. In this study, we aimed to evaluate the effect and its mechanism following intralymphatic administration of OVA-flagellin (FlaB) mixture in the mouse model of allergic rhinitis. Materials and methods: BALB/c mice were sensitized with OVA and treated with an OVA-FlaB mixture via intranasal, sublingual and intralymphatic routes to evaluate the effect of each treatment. Several parameters for allergic inflammation and its underlying mechanisms were then evaluated. Results: Intralymphatic injection of the OVA-FlaB mixture reduced symptom scores, eosinophil infiltration in the nasal mucosa and total and OVA-specific IgE levels more significantly than intranasal and sublingual administration. Systemic cytokine (IL-4, IL-5, IL-6, IL-17 and IFN-γ) and local cytokine (IL-4 and IL-5) production were also reduced significantly after intralymphatic injection with OVA-FlaB. Double intralymphatic injection of the mixture was more effective than single injection. Moreover, the expression of innate cytokines such as IL-25 and IL-33 in nasal epithelial cells were reduced and the expression of chemokines such as CCL24 (eotaxin-2), CXCL1 and CXCL2 was decreased in the nasal mucosa, suggesting the underlying mechanism for intralymphatic administration of the OVA-FlaB mixture. Conclusion: Intralymphatic administration of an OVA-FlaB mixture was more effective in alleviating allergic inflammation than intranasal and sublingual administration in a mouse model of allergic rhinitis. This effect may be attributed to the reduced expression of innate cytokines and chemokines. This treatment modality can be considered as a new therapeutic method and agent. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Allergy
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    ABSTRACT: BIOGF1K, a compound K-rich fraction prepared from the root of Panax ginseng is widely applied in cosmetic purpose in Korea. We firstly investigated the functional mechanisms of anti-inflammatory and anti-oxidative activities of BIOGF1K by discovering target enzymes through various molecular studies.
    Preview · Article · Jan 2016 · Journal of ginseng research
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    Full-text · Article · Jan 2016 · Harmful Algae
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    Dataset: TRPV1

    Full-text · Dataset · Dec 2015
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    ABSTRACT: Transient receptor potential vanilloid 1 (TRPV1), which has been identified as a molecular target for the activation of sensory neurons by various painful stimuli, was reported to regulate the signaling and activation of CD4+ T cells. However, the role of TRPV1 in CD4+ T cell in allergic rhinitis remains poorly understood. In this study, TRPV1 expression was localized in CD4+ T cells. Both knockout and chemical inhibition of TRPV1 suppressed Th2/Th17 cytokine production in CD4 T cells and Jurkat T cells, respectively, and can suppress T cell receptor signaling pathways including NF-κB, MAP kinase, and NFAT. In TRPV1 knockout allergic rhinitis (AR) mice, eosinophil infiltration, Th2/Th17 cytokines in the nasal mucosa, and total and ova-specific IgE levels in serum decreased, compared with wild-type AR mice. The TRPV1 antagonists, BCTC or theobromine, showed similar inhibitory immunologic effects on AR mice models. In addition, the number of TRPV1+/CD4+ inflammatory cells increased in the nasal mucosa of patients with AR, compared with that of control subjects. Thus, TRPV1 activation on CD4+ T cells is involved in T cell receptor signaling, and it could be a novel therapeutic target in AR.
    Full-text · Article · Dec 2015 · Oncotarget
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    ABSTRACT: Our aim was to retrospectively review the imaging findings of patients with neonatal ovarian torsion, emphasizing prenatal and postnatal sonographic findings. Eleven patients who had had neonatal ovarian torsion diagnosed surgically (n = 9) or clinicoradiologically (n = 2) were enrolled. Prenatal and postnatal sonographic features, including sequential postnatal change, were reviewed. Clinical and pathologic features were also investigated. All patients except one had a fetal ovarian cyst (mean, 5.3 cm) detected on third-trimester sonography, either simple (n = 6) or complex (n = 4). In all 11 patients, initial postnatal sonography had revealed a complex cyst (mean, 4.7 cm) with intracystic clot or debris, the double-wall sign, a fluid–fluid level, and multiple septation. None of the patients had had symptoms or signs related to the ovarian torsion. Follow-up sonography in seven patients had revealed increased echogenicity of the cyst wall with frequent calcification and a decrease in size of the cyst. In two patients, the interval of the change in cyst position was noted, and autoamputation of the torsed ovary had been surgically confirmed. Serous cystadenoma had been identified in one patient. Neonatal ovarian torsion most commonly manifests as an asymptomatic complex cyst on sonography due to torsion of a fetal ovarian cyst. Serial monitoring of a fetal ovarian cyst for its resolution or changes in its appearance is mandatory for making an early diagnosis of torsion. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound, 2016;
    No preview · Article · Dec 2015 · Journal of Clinical Ultrasound
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    ABSTRACT: Mycobacterium chelonae (Mch) is an atypical rapidly growing mycobacterium (RGM) that belongs to the M. chelonae complex, which can cause a variety of human infections. During this type of mycobacterial infection, macrophagederived chemokines play an important role in the mediation of intracellular communication and immune surveillance by which they orchestrate cellular immunity. However, the intracellular signaling pathways involved in the macrophage- induced chemokine production during Mch infections remain unknown. Thus, the present study aimed to determine the molecular mechanisms by which Mch activates the gene expressions of chemokine (C-C motif) ligand 2 (CCL2) and CCL5 in murine bone marrow-derived macrophages (BMDMs) and in vivo mouse model. Toll-like receptor 2 (TLR2)-deficient mice showed increased bacterial burden in spleen and lung and decreased protein expression of CCL2 and CCL5 in serum. Additionally, Mch infection triggered the mRNA and protein expression of CCL2 and CCL5 in BMDMs via TLR2 and myeloid differentiation primary response gene 88 (MyD88) signaling and that it rapidly activated nuclear factor (NF)-κB signaling, which is required for the Mch-induced expressions of CCL2 and CCL5 in BMDMs. Moreover, while the innate receptor Dectin-1 was only partly involved in the Mch-induced expression of the CCL2 and CCL5 chemokines in BMDMs, the generation of intracellular reactive oxygen species (ROS) was an important contributor to these processes. Taken together, the present data indicate that the TLR2, MyD88, and NF-κB pathways, Dectin-1 signaling, and intracellular ROS generation contribute to the Mch-mediated expression of chemokine genes in BMDMs.
    No preview · Article · Dec 2015 · The Journal of Microbiology
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    ABSTRACT: Background: Airway remodeling is associated with irreversible, or partially reversible, airflow obstruction and ultimately unresponsiveness to asthma therapies such as corticosteroids. Roflumilast is a selective phosphodiesterase-4 inhibitor that has an anti-inflammatory effect in chronic obstructive pulmonary disease (COPD). Objective: To study the effect of roflumilast on airway inflammation and remodeling in a murine model of chronic asthma. Methods: BALB/c mice sensitized to ovalbumin (OVA) were chronically exposed to intranasal OVA administration twice a week for additional 3 months. Roflumilast was administered orally during the intranasal OVA challenge. A lung fibroblast cell line was used in the proliferation assay. Results: Compared to control mice, mice chronically exposed to OVA developed eosinophilic airway inflammation, airway hyper-responsiveness (AHR), and exhibited features of airway remodeling. Administration of roflumilast significantly inhibited airway inflammation and AHR. Roflumilast also significantly decreased goblet cell hyperplasia and pulmonary fibrosis, which are parameters of airway remodeling. The levels of interleukin (IL)-4, IL-5, and IL-13 in the bronchoalveolar lavage (BAL) fluids were significantly lower in the roflumilast group. In vitro, roflumilast significantly inhibited stem cell factor (SCF) -induced cell proliferation of fibroblasts. The SCF concentration and mRNA expression in a murine model also significantly decreased with roflumilast treatment. Conclusions: These results suggest that administration of roflumilast regulates airway inflammation, AHR, and airway remodeling in a model of chronic asthma. The beneficial effects from roflumilast may be related to the SCF/c-kit pathway. This article is protected by copyright. All rights reserved.
    No preview · Article · Nov 2015 · Clinical & Experimental Allergy
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    ABSTRACT: We present a simple method to fabricate flexible, transparent silver nanowire (AgNW) films. Homogenous AgNW networks were formed on a mixed cellulose ester (MCE) membrane by vacuum filtration and were easily transferable to self-adhesive poly(ethylene terephthalate). The opaque, white MCE membrane became transparent after being subjected to hot acetone vapor. The fabricated AgNW films had an average resistivity of 13 Ω/sq and a transmittance of approximately 67%. Moreover, the AgNW films showed excellent mechanical properties in repeated adhesion tests and bending tests. The AgNW films also showed good resistance against heat and NaCl solutions. AgNW films were patterned by a combination of soft lithography and a solution-based chemical etching technique. The area under the photoresist polymer maintained its conductivity and transmittance after etching, whereas increased resistance and transparency were observed in the etched area. The suitability of the patterned AgNW electrodes for electronic devices was demonstrated via a simple LED chip array. After using standard photolithography to define the working area, AgNW films were used as sensor electrodes for the electrochemical detection of hydrogen peroxide (H2O2). The AgNW sensors displayed a reasonable detection limit of 46 μM (S/N = 3), a rapid response time (within 2 s), and high sensitivity (749 μA mM-1 cm-2 and 1640 μA mM-1 cm-2). Furthermore, the AgNW sensor was resistant to other potential interfering electroactive species commonly present in physiological samples such as l-ascorbic acid, glucose, and sodium oxalate. These results indicate that the AgNW sensor is selective for electroreduction of H2O2. Additionally, the developed sensor exhibited a stable amperometric response to the reduction of H2O2 even after extended storage.
    No preview · Article · Nov 2015 · Sensors and Actuators B Chemical
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    ABSTRACT: For infants and children, an incredible resilience from injury is often observed. There is growing evidence that functional recovery after brain injury might well be a consequence of the reorganization of the neural network as a process of neuroplasticity. We demonstrate the presence of neuroplasticity at work in spontaneous recovery after neonatal hypoxic ischemic (HI) injury, by elucidating a precise picture in which such reorganization takes place using functional MRI techniques. For all 12 siblings, 6 rats were subjected to severe HI brain injury and 6 rats underwent sham operation only. Severe HI brain injury was induced to postnatal day 7 (p7) Sprague-Dawley rats according to the Rice-Vannucci model (right carotid artery occlusion followed by 150 minutes of hypoxia with 8% O2 and 92% of N2). Brain activation maps along with anatomical and functional connectivity maps related to the sensory motor function were obtained at adult (p63) using blood oxygen level dependent (BOLD)-functional MRI (fMRI), resting state-functional MRI (rs-fMRI) and diffusion tensor imaging (DTI); each of these MRI data was related to sensory motor functional outcome. In-depth investigation of the functional MRI data revealed: 1) intra-hemispheric expansion of BOLD signal activation in the contralesional undamaged hemisphere for ipsilesional forepaw stimuli to include the M2 and Cg1 in addition to the S1 and M1 wide spreading in the anterior and posterior directions, 2) inter-hemispheric transfer of BOLD signal activation for contralesional forepaw stimuli, normally routed to the injured hemisphere, to analogous sites in the contralesional undamaged hemisphere, localized newly to the M1 and M2 with a reduced portion of the S1, 3) inter-hemispheric axonal disconnection and axonal rewiring within the undamaged hemisphere as shown through DTI, and 4) increased functional interactions within the cingulate gyrus in the HI injured rats as shown through rs-fMRI. The BOLD signal amplitudes as well as DTI and rs-fMRI data well correlate with behavioral tests (tape to remove). We found function normally utilizing what would be the injured hemisphere is transferred to the uninjured hemisphere, and functionality of the uninjured hemisphere remains not untouched but is also rewired in an expansion corresponding to the newly formed sensorimotor function from both the contralesional and the ipsilesional sides. The conclusion drawn from the data in our current study is that enhanced motor function in the contralesional hemisphere governs both the normal and damaged sides, indicating that active plasticity with brain laterality was spontaneously generated to overcome functional loss and established autonomously through normal experience via modification of neural circuitry for neonatal HI injured brain.
    No preview · Article · Nov 2015 · NeuroImage
  • Bum Seok Lee · Ji Hye Kim · Tae Kyu Nam · Doo Ok Jang

    No preview · Article · Nov 2015 · ChemInform
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    Full-text · Dataset · Oct 2015
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    Full-text · Dataset · Oct 2015
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    Full-text · Dataset · Oct 2015
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    Full-text · Dataset · Oct 2015
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    ABSTRACT: Polykrikos hartmannii is a phototrophic dinoflagellate with chloroplasts, and it swims as a single zooid or forms a two-zooid pseudo-colony. To investigate the feeding ability of P. hartmannii, its feeding occurrence, prey species, and feeding mechanism were explored. Furthermore, the growth and ingestion rates of P. hartmannii on the mixotrophic dinoflagellate Cochlodinium polykrikoides, the optimal prey, as a function of prey concentration were measured. This study reported for the first time that P. hartmannii is a mixotrophic dinoflagellate. When diverse algal species were provided as potential prey, P. hartmannii could feed only on chain-forming toxic mixotrophic dinoflagellates C. polykrikoides and Gymnodinium catenatum. P. hartmannii ingested cells of these prey by engulfment after anchoring a prey cell using a nematocyst-taeniocyst complex. With increasing mean prey concentration, the ingestion rate of P. hartmannii on C. polykrikoides increased, but reached saturation at a prey concentration of 945ngCml-1 (1350cellsml-1). The maximum ingestion rate of P. hartmannii on C. polykrikoides was 1.9ngCpredator-1d-1 (2.7cellspredator-1d-1). However, the maximum mixotrophic growth rate of P. hartmannii with added C. polykrikoides cells (0.030d-1), at 20°C under a 14:10h light-dark cycle of 100μEm-2s-1, was slightly greater than of those without added prey (0.023d-1). The low maximum ingestion rate of P. hartmannii may be responsible for this small difference between the maximum mixotrophic and autotrophic growth rates. The calculated grazing coefficients for P. hartmannii on co-occurring C. polykrikoides were up to 0.324d-1 (28% of the population of C. polykrikoides was removed by P. hartmannii populations in 1d). The results of the present study suggest that P. hartmannii can have a considerable grazing impact on C. polykrikoides populations.
    Full-text · Article · Oct 2015 · Harmful Algae

Publication Stats

4k Citations
734.43 Total Impact Points


  • 2007-2016
    • Dankook University
      • Department of Microbiology
      Eidō, Chungcheongbuk-do, South Korea
    • Hankuk University of Foreign Studies
      • Department of Bioscience and Biotechnology
      Sŏul, Seoul, South Korea
    • Korea Medical Research Institute
      Sŏul, Seoul, South Korea
  • 2004-2016
    • Sungkyunkwan University
      • • Department of Genetic Engineering
      • • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2015
    • Seoul National University Hospital
      • Department of Orthopedic Surgery
      Sŏul, Seoul, South Korea
    • Gwangju Institute of Science and Technology
      • Department of Life Sciences
      Gwangju, Gwangju, South Korea
    • Chungnam National University
      Daiden, Daejeon, South Korea
    • Chonbuk National University
      Tsiuentcheou, Jeollabuk-do, South Korea
  • 2014-2015
    • Catholic University of Korea
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Konkuk University Medical Center
      Changnyeong, Gyeongsangnam-do, South Korea
    • Catholic University of Daegu
      • Department of Medicine
      Kayō, Gyeongsangbuk-do, South Korea
    • Pukyong National University
      • Department of Food Science and Nutrition
      Busan, Busan, South Korea
    • National Institute of Environmental Research
      Sŏul, Seoul, South Korea
  • 2013-2015
    • Max Planck Institute for Coal Research
      Mülheim-on-Ruhr, North Rhine-Westphalia, Germany
    • Korea Institute of Science and Technology
      Sŏul, Seoul, South Korea
    • Korea University of Science and Technology
      Sŏul, Seoul, South Korea
    • Dankook University Hospital
      Anjŏ, Gyeonggi Province, South Korea
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 2012-2015
    • Korea University
      Sŏul, Seoul, South Korea
    • Korea Institute of Ocean Science and Technology
      Sŏul, Seoul, South Korea
    • Ajou University
      • Department of Surgery
      Sŏul, Seoul, South Korea
    • The Chinese University of Hong Kong
      • Department of Sociology
      Hong Kong, Hong Kong
  • 2009-2015
    • Yonsei University
      • • Department of Oral Biology
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Daegu University
      • Department of Food and Nutrition
      Daikyū, Daegu, South Korea
  • 2008-2015
    • Kyung Hee University
      • • Department of Biomedical Engineering
      • • Institute of Oriental Medicine
      Sŏul, Seoul, South Korea
    • Sooam Biotech Research Foundation
      Sŏul, Seoul, South Korea
    • Kangwon National University
      • Department of Molecular Bioscience
      Gangneung, Gangwon, South Korea
  • 2006-2015
    • Inha University
      • • College of Medicine
      • • Department of Polymer Science and Engineering
      Chemulpo, Incheon, South Korea
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
  • 2005-2015
    • Korea Advanced Institute of Science and Technology
      • • Department of Electrical Engineering
      • • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
    • Seoul National University
      • • Department of Earth and Environmental Sciences
      • • Department of Orthopaedic Surgery
      • • Department of Health Policy and Management
      • • College of Veterinary Medicine
      Sŏul, Seoul, South Korea
  • 2004-2015
    • Samsung Medical Center
      • • Department of Radiology
      • • Cardiovascular Imaging Center
      Sŏul, Seoul, South Korea
  • 2002-2015
    • Hanyang University
      • Division of Chemical Engineering and Bioengineering
      Sŏul, Seoul, South Korea
  • 2013-2014
    • Soonchunhyang University
      Onyang, Chungcheongnam-do, South Korea
  • 2012-2014
    • Myongji University
      • Department of Material Science and Engineering
      Sŏul, Seoul, South Korea
    • Jeju National University
      • Faculty of Biotechnology
      Tse-tsiu, Jeju-do, South Korea
    • Kyungpook National University
      • School of Applied Biosciences
      Daikyū, Daegu, South Korea
  • 2011-2014
    • Konyang University
      • • College of Medicine
      • • Myunggok Research Institute of Medical Science
      Ronsan, Chungcheongnam-do, South Korea
    • CHA University
      • Department of Applied Bioscience
      Sŏul, Seoul, South Korea
    • Konyang University Hospital
      Gaigeturi, Jeju, South Korea
  • 2010-2014
    • University of Texas MD Anderson Cancer Center
      • Department of Experimental Therapeutics
      Houston, Texas, United States
    • Hanyang University Medical Center
      Sŏul, Seoul, South Korea
  • 2008-2014
    • Chosun University
      • College of Dentistry
      Gwangju, Gwangju, South Korea
  • 2012-2013
    • Pusan National University
      • Department of Internal Medicine
      Pusan, Busan, South Korea
  • 2010-2013
    • Ewha Womans University
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2009-2013
    • Gyeongsang National University
      • • Institute of Agriculture and Life Science
      • • Division of Applied Life Science
      Shinshū, South Gyeongsang, South Korea
  • 2010-2011
    • The Ohio State University
      • College of Pharmacy
      Columbus, Ohio, United States
  • 2006-2011
    • Konkuk University
      • • Department of Chemical Engineering
      • • Department of Bioscience and Technology
      Seoul, Seoul, South Korea
  • 2001-2009
    • Inha University Hospital
      Sinhyeon, Gyeongsangnam-do, South Korea
  • 2006-2007
    • University of Seoul
      Sŏul, Seoul, South Korea