Hui Wang

Nanjing Medical University, Nan-ching, Jiangsu, China

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Publications (75)133.07 Total impact

  • Junhong Wang · Bo Tang · Xinjian Liu · Xin Wu · Hui Wang · Di Xu · Yan Guo
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    ABSTRACT: Background: Monomeric CRP (mCRP) plays an important role in the process of atherosclerotic plaque rupture. Recently, it has been reported that mCRP was associated with acute myocardial infarction (AMI). Objectives: The aim of this study was to examine whether mCRP is increased in AMI patients and to investigate the possibility of using circulating mCRP as a biomarker for AMI diagnosis and severity assessment of disease. Methods: A mCRP monoclonal antibody was generated and verified for its specificity. Immunofluorescence was used to assess the localization of mCRP in the infarcted myocardium. Furthermore, 101 AMI, 38 unstable angina pectoris (UAP) and 41 stable angina pectoris (SAP) patients were enrolled, and 43 healthy volunteer were recruited as controls in the study. Venous blood samples were collected to measure the circulating mCRP, cardiac Troponin T and hs-CRP levels. Results: Significantly increased mCRP levels were observed in the infarcted myocardium of model mice. In addition, significantly increased plasma mCRP levels were also detected in AMI patients (20.96±1.64ng/ml) compared to those with UAP, SAP or in control patients (all 0ng/ml, p<0.001). ROC analysis revealed that circulating mCRP had considerable diagnostic accuracy for AMI with an AUC of 0.928 (95% confidence interval 0.887-0.969). Furthermore, nine patients (9/101, 8.91%) in AMI group died before the 30-day follow-up, and their plasma mCRP concentration was significantly higher than those in surviving patients (36.70±10.26 vs. 19.41±1.43ng/ml, P=0.002). Conclusions: These results indicate that mCRP is increased in AMI and that circulating mCRP might be a potential biomarker for diagnosis and severity assessment of disease in AMI.
    No preview · Article · Apr 2015 · Atherosclerosis
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    ABSTRACT: Reactive molecular dynamics (ReaxFF) simulations are used to explore the atomic-level tribochemical mechanism of amorphous silica (a-SiO2) of a nanoscale, single-asperity contact in an aqueous environment. These sliding simulations are performed in both a phosphoric-acid solution and in pure water under different normal pressures. The results show that tribochemical processes have profound consequences on tribological performance. Water molecules could help avoid direct adhesive interaction between a-SiO2 surfaces in pure water under low normal load. However, formation and rupture of interfacial siloxane-bonds are obviously observed under higher normal load. In phosphoric-acid solution, polymerization of phosphoric-acid molecules occurs yielding oligomers under lower load, and tribochemical reactions between the molecules and the sliding surfaces could enhance wear under higher load. The bridging oxygen atoms in silica play an important role in the formation of interfacial covalent bonds, and hydrogen is found to have a weakening effect on these bonds, resulting in the rupture during shear-related loading. This work sheds light on tribochemical reactions as a mechanism for lubrication and wear in water-based or other tribological systems.
    Full-text · Article · Jan 2015 · Langmuir
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    ABSTRACT: The microstructure and growth mechanism of hydrogenated amorphous carbon films, deposited from different hydrocarbon sources and at various incident energies, are investigated by molecular dynamics (MD) simulations. At low energies, molecular adsorption dominates the process of the film growth, so the incident molecules tend to preserve their original molecular structures. As the incident energy rises, film density increases firstly and then becomes stabilized, while hydrogen content decreases because of molecular fragmentation and the increase in sputtering yield of hydrogen atoms. Hydrogen atoms play an important role in the growth of hydrogenated amorphous carbon films. The formation of sp3 structures at low energies, for example, mainly attributes to the hydrogen adsorption and the formation of C-H bonds; while at high energies the subplantation of carbon atoms and formation of C-C bonds are most responsible to the formation of sp3 structures. An increase of hydrogen content in source gas could lead to lower film density, higher hydrogen content in film and a general increase of sp3 fraction. The existence of dangling bonds in incident radicals facilitates easier adsorption than neutral molecules at low energies, resulting in higher deposition yield and sp3 fraction. This trend, however, diminishes at high energies when extensive molecular fragmentation occurs.
    Full-text · Article · Nov 2014 · Surface and Coatings Technology
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    ABSTRACT: The atomic-scale friction of the fluorographene (FG)/MoS2 heterostructure is investigated using first-principles calculations. Due to the intrinsic lattice mismatch and formation of periodic Moiré patterns, the potential energy surface of the FG/MoS2 heterostructure is ultrasmooth and the interlayer shear strength is reduced by nearly two orders of magnitude, compared with both FG/FG and MoS2/MoS2 bilayers, entering the superlubricity regime. The size dependency of superlubricity is revealed as being based on the relationship between the emergence of Moiré patterns and the lattice mismatch ratio for heterostructures.
    Full-text · Article · Sep 2014 · Nanotechnology
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    ABSTRACT: To examine the association between hemoglobin (Hb) levels and cardiovascular risk factors in a large community-dwelling cohort. A total of 4,186 women and 4,851 men were enrolled in the study. Data on personal history, physical examination and biochemical parameters were collected. Subjects were categorized by gender and divided into different group according to the level of Hb or blood pressure, and the association between Hb levels and cardiovascular risk factors was examined using Pearson's correlation analysis. In both men and women even with normal Hb level, tertiles of Hb levels were positively associated with body mass index (BMI), total-cholesterol (TC), triglyceride (TG), uric acid (UA), diastolic blood pressures (DBP) and fasting plasma glucose (FPG) (all P=0.000 in men and women). Furthermore, significantly increased incidence of hyperuricemia (P=0.000 both in men and women) and obesity (P=0.000 both in men and women) were observed with the gradually increased Hb level. In addition, Pearson's correlation analysis revealed obvious correlation between Hb level and various cardiovascular risk factors including blood pressure and UA. Binary logistic regression analysis further demonstrated that the level of Hb was an important risk factor for elevated blood pressure (OR =1.216; 95% CI: 1.138-1.293, P=0.000 in men; OR =1.287; 95% CI: 1.229-1.363, P=0.000 in women). Increasing Hb levels, even in subjects with normal level were associated with increasing prevalence of cardiovascular risk factors, suggesting that a slightly low Hb level might be beneficial to Chinese community-dwelling individuals.
    No preview · Article · May 2014 · Journal of Thoracic Disease
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    ABSTRACT: A numerical analysis on the factors affecting the hydrodynamic performance for parallel surfaces with microtextures is presented in this paper. The semianalytical method and fast Fourier transform technique are implemented in the analysis. The numerical procedure is validated by comparing the results from the present model with the analytical solutions for the lubrication problem in an infinitewide sliding bearing with step-shaped textures. The numerical results show that the hydrodynamic performance can be greatly affected by the factors, such as the boundary conditions, cavitation pressure, microtextures, surface deformation, etc. This study can be of a great help for better understanding the mechanism of hydrodynamic pressure generated between parallel surfaces and realistically evaluating the improvement of tribological performance caused by textures.
    Full-text · Article · Apr 2014 · Journal of Tribology
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    ABSTRACT: This paper presented a numerical approach to solving the problem of a flat-ended punch in contact with a half-space matrix embedded with multiple three dimensional arbitrary-shaped inhomogeneities. Based on the semi-analytical method (SAM) and the equivalent inclusion method, numerical procedures were developed and the effects of inclusion shape and distribution were analyzed. Fast Fourier transform technique was implemented to accelerate the calculation of surface deformation and subsurface stress. Interactions of inter-inclusions and inclusion-matrix were taken into account. Numerical results showed the presence of inhomogeneities (i.e., microstructures in solids) indeed had a great effect on local contact pressure and a strong disturbance to the subsurface stress field in the vicinity of inclusions. The effects were dependent on the shape and distribution of inclusions and inter-inclusion interactions. The physical significance of this study is to provide an insight into the relation between the material microstructure and its response to the external load, and the solution approach and procedures may find useful applications, for example, the analysis of fatigue and crack propagation for composite materials, prediction of stress field in solids containing material defects, and study of the mechanism of chemical-mechanical polish (CMP) for inhomogeneous materials, etc.
    Full-text · Article · Mar 2014 · Science China: Physics, Mechanics and Astronomy
  • Ning Xie · Zhaorong Liu · Rui Wang · Hui Wang · Xiaohui Lin
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    ABSTRACT: A new diversity selection combining scheme in a multiple Base Stations (BSs) scenario is proposed, in order to minimize the impact of suddenly losing one active BS in the soft handover (SHO) region. By analyzing the average number of path estimations and the average number of combined paths, we can see that the proposed scheme has a satisfactory average bit error ratio (ABER) but with a low complexity, as compared by the conventional distributed combining schemes. Simulation results validate the superiority of the proposed scheme.
    No preview · Article · Jan 2014 · Digital Signal Processing
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    ABSTRACT: Amorphous carbon is one of the most lubricious materials known, but the mechanism is not well understood. It is counterintuitive that such a strong covalent solid could exhibit exceptional lubricity. A prevailing view is that lubricity of amorphous carbon results from chemical passivation of dangling bonds on surfaces. Here we show instead that lubricity arises from shear induced strain localization, which, instead of homogeneous deformation, dominates the shearing process. Shear localization is characterized by covalent bond reorientation, phase transformation and structural ordering preferentially in a localized region, namely tribolayer, resulting in shear weakening. We further demonstrate an anomalous pressure induced transition from stick-slip friction to continuous sliding with ultralow friction, due to gradual clustering and layering of graphitic sheets in the tribolayer. The proposed shear localization mechanism sheds light on the mechanism of superlubricity, and would enrich our understanding of lubrication mechanism of a wide variety of amorphous materials.
    Full-text · Article · Jan 2014 · Scientific Reports
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    Ning Xie · Zhaorong Liu · Rui Wang · Hui Wang · Xiaohui Lin
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    ABSTRACT: In this paper, we propose a new diversity combining scheme to save power, which is called as the generalized selection combining with double threshold (DT-GSC). It selects the branch whose SNR is above an input threshold to combine, and this process will keep running until the combined output SNR is larger than an output threshold or until all paths are examined. The values of both thresholds are required to be predetermined on the basis of the practical communication conditions. For comparing the complexity of various combining schemes, we will show the mathematical formulas of the average number of path estimation and the average number of combined branches. Moreover, we will also compare the average bit-error-ratio performance of the proposed DT-GSC with absolute threshold GSC (AT-GSC) and output threshold MRC (OT-MRC). Numerical examples and simulation results show that the proposed DT-GSC leads to a lower complexity than the conventional AT-GSC and OT-MRC while it has a satisfactory performance.Copyright © 2012 John Wiley & Sons, Ltd.
    Preview · Article · Jan 2014 · Wireless Communications and Mobile Computing
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    Liang Xu · Yuan-Zhong Hu · Tian-Bao Ma · Hui Wang
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    ABSTRACT: We investigate the in-plane confinement effect of two graphene layers on the diffusion behaviour of water sub-monolayers using molecular dynamics simulations. An unexpected fast diffusion state with giant anisotropy is observed when the two confining graphene walls have certain shifts applied to their relative positions. The phenomenon is mainly attributed to the smooth one-dimensional potential channels produced by the composition effect of the potential energy landscapes of the two graphene walls, and the concerted motion of water molecules due to hydrogen bonding. Unique duality in the diffusion mechanism is observed in the fast diffusion state, as is ballistic motion along the potential channels and Fickian diffusion across such channels. The smooth potential channels can be created in certain directions simply by shifting the confining walls, which provides a novel measure to manipulate the motion of confined molecules in real-time.
    Full-text · Article · Nov 2013 · Nanotechnology
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    ABSTRACT: Tribochemical processes have profound consequences on tribological performance. In the present paper, the tribochemical mechanism of low friction state in the silica/phosphoric acid system is elucidated by reactive molecular dynamics (ReaxFF) simulations. The friction coefficient is found having strong positive correlation with the number of interfacial hydrogen bonds, which suggests that a weaker interfacial hydrogen bond network would favor a lower friction. The friction reduction mechanisms have been analyzed in two temperature regimes: For 300 ≤ T ≤ 600 K, no indication of tribochemical reaction is observed, and the friction coefficient decreases because of the accelerated molecular rotational and translational motion and the corresponding weakened hydrogen bond network. For 800 K ≤ T ≤ 1400 K, the occurrence of tribochemical reactions leads to a clustering and polymerization of the phosphoric acid molecules and generation of a considerable quantity of water molecules distributed mainly in the sliding interface which could act as lubricant, and a low friction state is reached with a friction coefficient of 0.02.
    Full-text · Article · Nov 2013 · The Journal of Physical Chemistry C
  • Ning Xie · Yu Zhang · Hui Wang
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    ABSTRACT: The conventional sigma–delta modulators, such as L-0 MASH and inter-stage feedback topology, have some main drawbacks, e.g. L-0 MASH can only be applied in single loop topology and dynamic range is its big problem, and inter-stage feedback topology only cancels nonlinear errors introducing by multi-bit DAC in the final stage, but the rest stages still contain DAC nonlinearity errors without any noise shaping which still degrade overall system performance. In this letter, an improved version of cascaded multi-bit sigma–delta modulator is proposed to overcome these problems mentioned above. Simulation results will verify the superiority of the proposed modulator.
    No preview · Article · Jul 2013 · Wireless Personal Communications
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    ABSTRACT: The atomic-scale friction in fluorographene and graphane is investigated employing the density functional theory calculation including the dispersion correction (DFT-D). Fluorographene and graphane exhibit low friction because of the low interlayer interaction induced by the repulsive electrostatic forces between F or H atoms at the interfaces. Moreover, owing to the less electronegativity of H atoms than F atoms, the variation of interlayer spacing and system energy corrugation, which is predominantly determined by the variation of dispersion energy during both loading and sliding processes, as elucidated in this paper, is found to be much larger in graphane, which well explains the larger friction in graphane than in fluorographene. The more charged F atom in fluorographene diminishes the variation of the interlayer spacing, which finally decreases the variation of the dispersion energy in the fluorographene. The study theoretically reveals the general mechanism of atomic-scale friction in various graphene-based layered materials where the interlayer interaction is dominated by van der Waals and electrostatic interactions, which shed light on friction reduction and the design of new lubricant materials.
    Full-text · Article · Jun 2013 · The Journal of Physical Chemistry C
  • Ning Xie · Hui Wang · Xiaohui Lin
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    ABSTRACT: Frequency-domain equalization (FDE) is an effective technique that exhibits the property of relatively low complexity which grows with increasing the number of symbols of dispersion in multipath propagation environments for broadband wireless communications compared with the conventional time-domain equalization. However, in practical broadband wireless communications, there exists not only multipath but also narrowband interference (NBI). The conventional FDE methods do not consider NBI and their performance degrades obviously in such case. In this paper, we propose a new optimization criterion which can effectively suppress NBI to obtain the maximum decision signal-to-noise ratio. The proposed scheme employs a conventional adaptive algorithm such as least-mean-square or recursive-least-square and operates in the spatial-frequency domain, which is concerned with the use of FDE and space diversity within block transmission schemes jointly. The simulation results show that the proposed schemes have better error-rate performance with low complexity and can be used even in the presence of strong NBI, compared to other existing adaptive FDE algorithms.
    No preview · Article · May 2013 · Wireless Personal Communications
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    Yuan-zhong Hu · Tian-bao Ma · Hui Wang
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    ABSTRACT: The mechanisms of energy dissipation are discussed in this paper by reviewing the models and research in atomic-scale friction. The study is undertaken to answer a fundamental question in the study of friction: How is frictional work dissipated, particularly in cases where material damage and wear are not involved. The initiation of energy dissipation, the role of structural commensurability, and the estimation of the interfacial shear strength have been examined in detail by introducing the Tomlinson model, the Frenkel-Kontorova model, and the cobblestone model, respectively. The discussion is extended to energy dissipation progress described in terms of phononic and electronic damping. The contributions from other mechanisms of dissipation such as viscoelastic relaxation and material wear are also included. As an example, we analyzed a specific process of dissipation in multilayer graphene, on the basis of results of molecular dynamics (MD) simulations, which reveal a reversible part of energy that circulates between the system and the external driver. This leads us to emphasize that it is crucial in future studies to clearly define the coefficient of dissipation.
    Full-text · Article · Mar 2013

  • No preview · Article · Nov 2012 · International journal of cardiology
  • Xiao-Hui Lin · Hui Wang
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    ABSTRACT: In this paper, we consider energy fairness problem in wireless sensor networks. However, the heterogeneous hostile operating conditions - different transmission distances, varying fading environments and distinct remained energy levels, have made energy balancing a highly challenging design issue. To tackle this problem, we model the packet transmission of sensor nodes as a game. By properly designing the utility function, we get the Nash equilibrium, in which, while each node can optimize its own payoff, the global objective - energy balancing can also be achieved. In addition, by imposing penalty mechanism on sensors to punish selfish behaviors, the delivery rate and delay constraints are also satisfied. Through extensive simulations, the proposed game theoretical approach is proved to be effective in that the energy consumption is balanced and the energy resources are efficiently utilized, which can significantly improve the network lifetime.
    No preview · Conference Paper · Oct 2012
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    ABSTRACT: Atomic-scale friction in graphene oxide is investigated using density functional theory calculation including a long-range dispersion correction (DFT-D). The sliding behaviors between two graphene oxide layers with different functional groups or oxidation levels are quantitatively studied based on the constructed potential energy surfaces. Sliding paths with minimum energy corrugations and the corresponding static lateral forces and shear strengths for different systems are derived, suggesting moderately higher friction in graphene oxide compared with graphene. The effects of load on friction in different graphene oxide models are also investigated. Moreover, the largest lateral force existing in the graphene oxide system with both epoxide and hydroxyl groups is dominated by the interlayer hydrogen bond interaction, the instability of which also simultaneously leads to dissipation and hence gives rise to the friction. An in-depth understanding of the relationship between atomic-scale friction and interfacial interactions reveals that certain levels of friction can be achieved by controllable structural and chemical modifications to the sliding surfaces, which sheds light on friction control and design of new lubricant materials.
    Full-text · Article · Sep 2012 · Physical review. B, Condensed matter
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    ABSTRACT: The aim of the present study was to make use of the artificially induced aging model cardiomyocytes to further investigate potential anti-aging-associated cellular diastolic dysfunction effects of EGB761 and explore underlying molecular mechanisms. Cultured rat primary cardiomyocytes were treated with either D-galactose or D-galactose combined with EGB761 for 48 h. After treatment, the percentage of cells positive for SA-β-gal, AGEs production, cardiac sarcoplasmic reticulum calcium pump (SERCA) activity, the myocardial sarcoplasmic reticulum calcium uptake, and relative protein levels were measured. Our results demonstrated that in vitro stimulation with D-galactose induced AGEs production. The addition of EGB761 significantly decreased the number of cells positive for SA-β-gal. Furthermore, decreased diastolic [Ca(2+)](i), curtailment of the time from the maximum concentration of Ca(2+) to the baseline level and increased reuptake of Ca(2+) stores in the SR were also observed. In addition, the level of p-Ser16-PLN protein as well as SERCA was markedly increased. The study indicated that EGb761 alleviates formation of AGEs products on SERCA2a in order to mitigate myocardial stiffness on one hand; on other hand, improve SERCA2a function through increase the amount of Ser16 sites PLN phosphorylation, which two hands finally led to ameliorate diastolic dysfunction of aging cardiomyocytes.
    Full-text · Article · May 2012 · Oxidative Medicine and Cellular Longevity

Publication Stats

600 Citations
133.07 Total Impact Points


  • 2007-2015
    • Nanjing Medical University
      • • Department of Cardiology
      • • Department of Cardiovascular Medicine
      Nan-ching, Jiangsu, China
  • 1996-2015
    • Tsinghua University
      • Centre for Nano and Micro Mechanics
      Peping, Beijing, China
  • 2009-2014
    • Shenzhen University
      • College of Information Engineering
      Bao'an, Guangdong, China
  • 2002
    • National Tsing Hua University
      Hsin-chu-hsien, Taiwan, Taiwan