Tadamitsu Kameyama

Tokai University, Hiratuka, Kanagawa, Japan

Are you Tadamitsu Kameyama?

Claim your profile

Publications (147)135.23 Total impact

  • T. Sawabe · T. Sonoda · S. Kitajima · T. Kameyama
    [Show abstract] [Hide abstract]
    ABSTRACT: The properties of second-phase particles (SPPs) in Zircaloy-2 claddings are key factors influencing the corrosion resistance of the alloy. The chemical compositions of Zr (Fe, Cr)2 and Zr2(Fe, Ni) SPPs were investigated by means of pulsed laser atom probe tomography. In order to prevent specimen fracture and to analyse wide regions of the specimen, the pulsed laser energy was increased to 2.0 nJ. This gave a high yield of average of 3 × 107 ions per specimen. The Zr (Fe, Cr)2 SPPs contained small amounts of Ni and Si atoms, while in Zr2(Fe, Ni) SPPs almost all the Si was concentrated and the ratio of Zr: (Fe + Ni + Si) was 2:1. Atomic concentrations of the Zr-matrix and the SPPs were identified by two approaches: the first by using all the visible peaks of the mass spectrum and the second using the representative peaks with the natural abundance of the corresponding atoms. It was found that the change in the concentration between the Zr-matrix and the SPPs can be estimated more accurately by the second method, although Sn concentration in the Zr2(Fe, Ni) SPPs is slightly overestimated.
    No preview · Article · Nov 2013 · Journal of Nuclear Materials
  • [Show abstract] [Hide abstract]
    ABSTRACT: Mucoepidermoid carcinoma is a relatively common salivary gland cancer in the oral cavity; however, it is extremely rare in infants. We report a case of mucoepidermoid carcinoma arising in the palate of an infant.A 5-year-old girl had a painful, dome-like mass in the right side of the palate.Although the tumor was covered with normal mucosa, it was mobile on palpation. There was no lymph node adenopathy in the neck. Radiographically, the lesion showed no defined area of osteolytic destruction. A biopsy was performed, and the histopathological diagnosis was a mucoepidermoid carcinoma.The tumor was totally excised, including the palatal bone, with the patient under general anesthesia. Five years after surgery, the patient remains free of disease, and the postoperative development of the maxilla is good.
    No preview · Article · Jan 2010 · Nippon Koku Geka Gakkai zasshi
  • Kenichi Umene · Fukiko Yamanaka · Satoko Oohashi · Chihiro Koga · Tadamitsu Kameyama
    [Show abstract] [Hide abstract]
    ABSTRACT: Herpes simplex virus (HSV) is assumed to cause recrudescent lesions, usually through endogenous recurrence and rarely through exogenous re-infection. The occurrence of exogenous re-infection in genital and corneal HSV infections has been previously demonstrated using genomic analysis, while exogenous re-infection in oral-facial HSV infections has not been shown. To confirm the occurrence of exogenous HSV re-infection in oral-facial HSV infections. Seven isolates (isolates 1-7) of herpes simplex virus type 1 (HSV-1) were sequentially separated from the same individual. Genomic profiles of HSV-1 isolates were studied: (i) by analysis of 20 RFLPs (restriction fragment length polymorphisms) and (ii) by the determination of nucleotide sequences of a PCR-amplified DNA fragment encompassing reiteration VII (hypervariable region) that belongs to sequences containing short tandem repeats. Isolates 1-5 were the same (F83 genotype) and isolates 6 and 7 were the same (F84 genotype), although isolates 1-5 were markedly different from isolates 6 and 7 in genomic profiles. The infection associated with isolates 6 and 7 was due to exogenous re-infection with F84 genotype virus, thus indicating the occurrence of exogenous HSV re-infection in oral-facial HSV infections.
    No preview · Article · Sep 2007 · Journal of Clinical Virology
  • Kenichi Umene · Chihiro Koga · Tadamitsu Kameyama
    [Show abstract] [Hide abstract]
    ABSTRACT: The restriction fragment length polymorphism (RFLP) was analyzed using a set of herpes simplex virus type 1 (HSV-1) strains isolated from oro-facial lesions (oro-facial site collection), which was composed of two subsets: one subset consisted of 57 strains from primary oro-facial lesions, and the other of 47 strains from recurrent oro-facial lesions of patients complicated by factors possibly triggering the recurrence (e.g. malignancy, operation, and treatment of dental caries). RFLP analysis was carried out previously on two other sets of HSV-1 strains: one set was from genital lesions (genital site collection), and the other was from non-genital lesions (non-genital site collection). Discriminant analysis was carried out on the three sets of HSV-1 strains: the criterion variable had two values of primary infection or recurrence, and the predictor variables were 20 RFLPs. The degrees of separation between primary infection and recurrence increased in the order oro-facial site collection, genital site collection, and non-genital site collection. The results of discriminant analysis in this study confirmed that reactivation of HSV-1 infection is influenced by triggering factors and the site of infection, thereby suggesting the capabilities of multivariate analysis (including discriminant analysis) with DNA polymorphisms for molecular epidemiological studies.
    No preview · Article · Mar 2007 · Journal of Virological Methods
  • Source
    Chihiro Koga · Hiroshi Harada · Jingo Kusukawa · Tadamitsu Kameyama
    [Show abstract] [Hide abstract]
    ABSTRACT: Synovial sarcoma is rare in the head and neck, especially in the oral and maxillofacial region. We report a case of synovial sarcoma of the mandible in a 42-year-old man. The patient was referred with recurrent diffuse swelling in the right buccal area and underwent regional resection of the right mandibular bone with construction. He has been alive and well with no evidence of disease for seven years since final surgery. The histological features are described and diagnostic problems discussed.
    Full-text · Article · Mar 2005 · Oral Oncology Extra
  • [Show abstract] [Hide abstract]
    ABSTRACT: A 9-month-old boy with Coffin Siris syndrome is described. Characteristic features include eyebrow hypertrichosis, long eyelashes, flat nasal bridge, prominent philtrum, hypoplasia or absence of the distal phalanges, high palate, and enlarged gingiva. The child's condition worsened and he ultimately died of multiple organ failure at the age of 5 years and 3 months.
    No preview · Article · Sep 2003 · Asian Journal of Oral and Maxillofacial Surgery

  • No preview · Article · Jan 2003
  • [Show abstract] [Hide abstract]
    ABSTRACT: Hepatitis C virus (HCV) infection not only causes chronic liver diseases but shows extrahepatic manifestations as oral lichen planus (OLP) and oral cancer. To elucidate the direct relationships among these diseases and HCV infection, we investigated the detection of positive- and negative-strand HCV-RNA from serum, OLP (n=19), and oral cancer (n=17) tissues. We used a sensitive reverse transcription to polymerase chain reaction (RT-PCR) method, and analyzed sequences from the HCV E1/E2 region of the genome from serum and tissue. Positive and negative HCV-RNA strands were observed in 13 (92.9%) and 3 (21.4%) OLP tissues, respectively. In oral cancer tissues, positive HCV-RNA strands were detected in all tissues from anti-HCV positive patients. Negative HCV-RNA strands were observed in 5 of 7 (71.4%) patient’s tissues. Furthermore, it was confirmed that the sequence from one of each OLP and oral cancer patient differed between serum and tissue HCV-RNA. These results may indicate that HCV persists and replicates in these lesions, suggesting a pathological role for HCV, although the mechanisms are unclear.
    No preview · Article · Jan 2002 · Journal of Oral Pathology and Medicine
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to minimize the surgical invasiveness to the donor site and the amount of the primary reconstruction time after oromandibular tumor resection. Oromandibular reconstruction was performed only using a pectoralis major myocutaneous flap and a metal plate. The pectoralis major myocutaneous flap was grafted to the oral cavity defect by rolling and wrapping around the metal plate with the muscle of the flap. No early postoperative complications have been noted in all seven patients. An average of 2 years and 1 month has past since surgery, and to date no infections, plate exposure, or plate breakage have been observed in any of the patients. The safety of the oromandibular reconstruction using a metal plate was improved by rolling the muscle of the pectoralis major myocutaneous flap around the metal plate. The present method was shown to be a rational technique that allowed primary reconstruction of the oral cavity and mandible in a minimally invasive manner in a short time.
    No preview · Article · Aug 2001 · Journal of Craniofacial Surgery
  • [Show abstract] [Hide abstract]
    ABSTRACT: Psychological stress has an influence on natural killer cell (NK) activity, which plays a central role in protection against microbial infection and cancer. Anxiety concerning cancer is a typical type of psychological stress observed in patients and is associated with various diseases. In this study, we examined whether anxiety about cancer reduces the NK activity or quality of life (QOL), or both, of outpatients. NK activity was determined by means of a 4-hour 51 chromium-release assay, and a QOL questionnaire by the World Health Organization called QOL-BRIEF was also used. One hundred forty-four patients were asked a variety of questions about anxiety with respect to cancer and pain on their first visit to the outpatient clinic of our Department of Oral Surgery. The NK activity in patients with anxiety about cancer was significantly lower (P < .001) than that in those with no such anxiety. In contrast, NK activity was not influenced by any other factor tested, including differences in diseases and QOL scores. Anxiety about cancer may be one of the primary factors for suppression of NK activity in oral surgery outpatients.
    No preview · Article · Jun 2001 · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
  • Source
    Y Suefuji · T Sasatomi · S Shichijo · S Nakagawa · H Deguchi · T Koga · T Kameyama · K Itoh
    [Show abstract] [Hide abstract]
    ABSTRACT: We recently reported the SART3 tumour-rejection antigen as possessing tumour epitopes capable of inducing HLA-class I-restricted cytotoxic T lymphocytes (CTLs). This study investigated expression of the SART3 antigen in breast cancer to explore an appropriate molecule for use in specific immunotherapy of breast cancer patients. The SART3 antigen was detected in all of the breast cancer cell lines tested, 30 of 40 (75%) breast cancer tissue samples, and 0 of 3 non-tumourous breast tissue samples. SART3 derived peptides at positions 109-118 and 315-323 induced HLA-A24 restricted CTLs that reacted to breast cancer cells from the peripheral blood mononuclear cells (PBMCs) of breast cancer patients. Therefore, the SART3 antigen and its peptides could be an appropriate molecule for use in specific immunotherapy of the majority of HLA-A24-positive breast cancer patients.
    Full-text · Article · May 2001 · British Journal of Cancer
  • Jingo Kusukawa · Fuminori Ryu · Tadamitsu Kameyama · Eisuke Mekada
    [Show abstract] [Hide abstract]
    ABSTRACT: Because CD9 is implicated in cell growth, cell adhesion and cell motility, altered CD9 expression might be involved in cancer invasion and metastasis. We have studied the immunolocalization of CD9 in oral squamous cell carcinoma (SCC). Sections prepared from paraffin-embedded specimens from patients with SCC of the oral cavity were stained with a monoclonal anti-CD9 antibody by means of the streptoavidin biotin method. Significant reduction or complete loss of CD9 expression was observed in cancer cells at the periphery of the cancer nests in the advancing front of invading tumor. Among 78 cases of oral SCCs examined, 46 (59.0%) cases were completely negative for CD9 expression. Loss of CD9 expression in cancer tissue strongly correlated with a high incidence of cervical lymph node metastasis and poorer prognosis (P=0.001). Thus a close examination of CD9 in SCC tissue would be useful for the prognosis of patients with oral carcinoma.
    No preview · Article · Mar 2001 · Journal of Oral Pathology and Medicine
  • Source
    Yumiko NAGAO · Tadamitsu KAMEYAMA

    Preview · Article · Jan 2001

  • No preview · Article · Jan 2001
  • Jingo Kusukawa · Kenji Fukuda · Makoto Koga · Tadamitsu Kameyama

    No preview · Article · Jan 2001
  • Yumiko Nagao · Michio Sata · Masayoshi Kage · Tadamitsu Kameyama · Takato Ueno
    [Show abstract] [Hide abstract]
    ABSTRACT: Background: In recent years, it has been suggested that oral lichen planus (OLP), a chronic inflammatory keratotic lesion, is related to hepatitis C virus (HCV) infection. Therefore, we evaluated whether the presence or absence of HCV infection caused any histopathological differences in OLP tissues. Methods; The subjects consisted of 31 patients with HCV-related liver disease complicated by OLP (32 OLP lesions) and ten OLP patients without complications due to either HCV infection or liver disease (control). A histopathological evaluation was performed in these patients. In addition, immunostaining was done on nine OLP tissues infected with HCV and on six OLP tissues without HCV infection in order to evaluate lymphocyte subsets (T cells or B cells) infiltrating into topical regions with OLP. Furthermore, the severity of hepatic fibrosis and inflammation was evaluated in liver tissues obtained by liver biopsy from six patients with HCV-related liver disease to evaluate whether there were any relationships between the severity of hepatic fibrosis or inflammation and OLP tissues. Results: There were no significant differences in the histopathological characteristics specific to OLP or in the ratios of T and B cells among infiltrating lymphocytes regardless of the presence or absence of HCV infection. Moreover, there were no certain relationships between the severity of hepatic fibrosis or inflammation and the severity of lymphocytic infiltration in OLP. Conclusions: HCV infection does not appear to influence the histopathological and immunohistochemical features of OLP.
    No preview · Article · Nov 2000 · European Journal of Internal Medicine
  • [Show abstract] [Hide abstract]
    ABSTRACT: CD9 and CD63 belong to a tetramembrane-spanning glycoprotein family called tetraspanin, and are involved in a wide variety of cellular processes, but the structure-function relationship of this family of proteins has yet to be clarified. CD9 associates with diphtheria toxin receptor (DTR), which is identical to the membrane-anchored form of heparin-binding EGF-like growth factor (proHB-EGF). CD9 upregulates the diphtheria toxin (DT) binding activity of DTR/proHB-EGF, while CD63 does not upregulate the DT binding activity in spite of the fact that this protein also associates with DTR/proHB-EGF on the cell surface. CD9 molecules localize on the cell surface, while those of CD63 localize predominantly at lysosomes and intracellular compartments. We made CD9/CD63 chimeric molecules and then studied their intracellular localization and upregulation activities. The C-terminal regions of CD63, which includes the lysosome sorting motif, showed a strong inhibitory effect on the expression of the chimeric proteins at the cell surface, while mutants lacking the lysosome sorting motif delivered more efficiently on the cell surface, indicating that the lysosome sorting motif contributes to the inhibitory effect of the C-terminal region. However, the N-terminal half of this family of proteins containing the 1st to 3rd transmembrane domains also seems to influence the cell surface expression. For the upregulation of DT binding activity the large extracellular loop (EC2) of CD9 was essential, while the remaining regions influenced the upregulation activity by changing the efficiency of cell surface expression. From these results we discussed the structure-function relationship of this family of proteins.
    No preview · Article · Nov 2000 · Cell Structure and Function
  • [Show abstract] [Hide abstract]
    ABSTRACT: To examine whether cancer cell dissemination results from incisional biopsy, we tried to detect squamous cell carcinoma (SCC) cells in peripheral blood before and after incisional biopsy by means of cytokeratin 19 (CK19) reverse-transcriptase polymerase chain reaction (RT-PCR). The study population consisted of 20 patients with oral SCC; 10 were given incisional biopsies followed by radical excision (the incisional biopsy group), and the remaining 10 were treated by excisional biopsy alone (the excisional biopsy group). Ten non-oral cancer patients with benign oral lesions served as controls. Five-ml blood aspirates collected before and after incision were used for CK19 RT-PCR. Two (20.0%) of 10 patients from the incisional biopsy group were positive for CK19 transcripts in their peripheral blood drained 15 min after incision. In contrast, CK19 transcript was not detected either in the excisional biopsy group or in controls. Surgical invasiveness for oral cancer, including incisional biopsy, causes dissemination of cancer cells into circulation, resulting in increased risk of metastasis.
    No preview · Article · Sep 2000 · Journal of Oral Pathology and Medicine
  • Y Nagao · M Sata · S Noguchi · T Seno'o · M Kinoshita · T Kameyama · T Ueno
    [Show abstract] [Hide abstract]
    ABSTRACT: Hepatitis C virus (HCV) infection not only causes chronic liver diseases but shows extrahepatic manifestations as oral lichen planus (OLP) and oral cancer. To elucidate the direct relationships among these diseases and HCV infection, we investigated the detection of positive- and negative-strand HCV-RNA from serum, OLP (n=19), and oral cancer (n=17) tissues. We used a sensitive reverse transcription to polymerase chain reaction (RT-PCR) method, and analyzed sequences from the HCV El/E2 region of the genome from serum and tissue. Positive and negative HCV-RNA strands were observed in 13 (92.9%) and 3 (21.4%) OLP tissues, respectively. In oral cancer tissues, positive HCV-RNA strands were detected in all tissues from anti-HCV positive patients. Negative HCV-RNA strands were observed in 5 of 7 (71.4%) patient's tissues. Furthermore, it was confirmed that the sequence from one of each OLP and oral cancer patient differed between serum and tissue HCV-RNA. These results may indicate that HCV persists and replicates in these lesions, suggesting a pathological role for HCV, although the mechanisms are unclear.
    No preview · Article · Aug 2000 · Journal of Oral Pathology and Medicine
  • R Noguchi · S Ohishi · C Koga · Y Nagao · S Okinaga · J Kusukawa · T Kameyama
    [Show abstract] [Hide abstract]
    ABSTRACT: As society ages, the composition of the diseases that occur within it changes accordingly. With that in mind, we examined the characteristics and trends in the recent inpatients and compared these recent inpatients with those of a previous report to identify the changes that accompany the aging of society. Subjects were 1,534 cases (men 56.9%, female 43.1%, average age 47.1 years) who were hospitalized at Kurume University Hospital for treatment during the 5-year period from January 1st, 1994 through December 31st, 1998. The ratio of inpatients over 65 years old was about 1.8 times higher than in the previous study, showing a clear trend toward an increased overall age of inpatients. As for the types of disease observed, the most common malignancies were epithelial tumor, followed by other benign tumors, as well as 76 cases which included diseases resembling tumor (epulis and exostosis etc.). A majority of the patients (55.6%) were directed to the Hospital by their dentist, a finding similar to that of the previous report. As for geographical distribution, 93.3% of the inpatients lived within 40 km of the center of Kurume City where our oral surgery is located, an increase of about 10% from the last report. In other words, our results showed a reduction in the sphere of treatment distribution.
    No preview · Article · Feb 2000 · The Kurume Medical Journal

Publication Stats

2k Citations
135.23 Total Impact Points

Institutions

  • 2013
    • Tokai University
      Hiratuka, Kanagawa, Japan
  • 1985-2003
    • Kurume University
      • • School of Medicine
      • • Research Center for Innovative Cancer Therapy
      • • Department of Pathology
      Куруме, Fukuoka, Japan
  • 1992-1998
    • Central Research Institute of Electric Power Industry
      Edo, Tōkyō, Japan