Cord Langner

Klinikum Bayreuth GmbH, Bayreuth, Bavaria, Germany

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Publications (362)

  • Annika Resch · Andreas Eherer · Cord Langner
    Article · Oct 2016 · Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association
  • Johannes Betge · N. I. Schneider · L. Harbaum · [...] · C. Langner
    Conference Paper · Sep 2016
  • Johannes Betge · L. Harbaum · M. J. Pollheimer · [...] · C. Langner
    Conference Paper · Sep 2016
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    Full-text available · Article · Sep 2016 · Wiener klinische Wochenschrift
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    Cord Langner
    Full-text available · Article · Aug 2016
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    [Show abstract] [Hide abstract] ABSTRACT: Corpus-dominant lymphocytic gastritis (LyG) is characterized by a CD8(+) T-cell infiltration of the stomach epithelium due to a so far uncharacterized mechanism. While Helicobacter pylori is typically undetectable in LyG, patients respond to H. pylori antibiotic eradication therapy, suggesting a non-H. pylori microbial trigger for the disease. Comparative microbiota analysis of specimens from LyG, H. pylori gastritis and healthy controls precluded involvement of H. pylori in LyG but identified Propionibacterium acnes as a possible disease trigger. In addition, the natural killer group 2 member D (NKG2D) system and the proinflammatory cytokine IL15 are significantly upregulated in the gastric mucosa of LyG patients, and gastric epithelial cells respond to microbe-derived stimuli, including live P. acnes and the microbial products short-chain fatty acids, with induction of NKG2D ligands. In contrast, H. pylori infection does not activate or even repress NKG2D ligands. Together, our findings identify P. acnes as a possible causative agent for LyG, which is dependent on the NKG2D system and IL15 activation.
    Full-text available · Article · Aug 2016 · The Journal of Pathology
  • J Betge · NI Schneider · L Harbaum · [...] · C Langner
    Article · Aug 2016 · Zeitschrift für Gastroenterologie
  • Catarina Calle · Andreas Pentsch · Cord Langner
    Article · Jul 2016 · Digestive Endoscopy
  • Article · Jun 2016 · Wiener klinische Wochenschrift
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    Johannes Betge · Nora I. Schneider · Lars Harbaum · [...] · Cord Langner
    File available · Dataset · Jun 2016
  • Johannes Betge · Nora I. Schneider · Lars Harbaum · [...] · Cord Langner
    [Show abstract] [Hide abstract] ABSTRACT: Mucin glycoprotein expression can be altered during the carcinogenic process. The impact on the prognosis of patients with colorectal cancer (CRC) is controversial. We analyzed tumors from 381 patients for MUC1, MUC2, MUC5AC, and MUC6 expression by immunohistochemical staining, using tissue microarrays. Progression-free and cancer-specific survival were determined using the Kaplan-Meier method. Expression of intestinal mucin MUC2 was lost in 85 (23 %) CRCs, and patients with MUC6-negative tumors showed shorter progression-free survival (PFS, p = 0.043). Gastric mucins MUC5AC and MUC6 showed high (>50 %) aberrant expression in 28 (8 %) and 9 (2 %) cases, respectively. High expression of MUC5AC was associated with longer PFS (p = 0.055). High expression of MUC6 was associated with 100 % PFS (p = 0.024) and longer cancer-specific survival (CSS, p = 0.043). MUC1 was expressed in 238 (64 %) tumors and had no impact on outcome. When analysis was restricted to stages II and III, loss of MUC2 was associated with adverse outcome. Overexpression of both MUC5AC and MUC6 significantly predicted favorable PFS and CSS. In conclusion, loss of MUC2 expression proved to be a predictor of adverse outcome, while the gain of aberrant expression of MUC5AC and particularly of MUC6 was associated with favorable outcome in CRC, notably in intermediate stages II and III.
    Article · Jun 2016 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  • Cord Langner
    Article · Apr 2016 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  • Nicole Max · Alexander Rothe · Cord Langner
    [Show abstract] [Hide abstract] ABSTRACT: Mixed adenoneuroendocrine carcinomas (MANECs) are rare biphasic tumour types, which are morphologically recognisable as both gland-forming and neuroendocrine neoplasms. Within the gastrointestinal tract, MANECs occur predominantly in the stomach or colorectum. The present study described a case of a MANEC originating from the ampullary region. The patient presented with widespread metastatic disease. Biopsy samples obtained from the ampullary primary tumour disclosed a complex lesion with adenocarcinoma and neuroendocrine small cell carcinoma components, positive for the intestinal transcription factor caudal type homeobox-2 and for neuroendocrine markers, including chromogranin A, synaptophysin, cluster of differentiation 56/neural cell adhesion molecule. By contrast, biopsy samples obtained from metastatic tissue revealed pure neuroendocrine carcinoma. As exemplified by this true mixed tumour, tumour heterogeneity evolves as the major challenge in oncology today, with potentially severe implications for the choice of chemotherapy. The assessment of metastatic sites may render valuable diagnostic information that is crucial for clinical decision-making and patient management.
    Article · Apr 2016 · Molecular and Clinical Oncology
  • [Show abstract] [Hide abstract] ABSTRACT: Background It is unclear whether the reported variation in the diagnosis of intraductal carcinoma of the prostate (IDC-P) is due to variable interpretation of borderline morphology, use of different diagnostic criteria or both. Aims We sought to determine the degree of variation in the diagnostic criteria and reporting rules for IDC-P in prostate biopsies employed by expert uropathologists. Methods A questionnaire survey was circulated to 23 expert uropathologists from 11 European countries. Results Criteria used for diagnosis of IDC-P included solid intraductal growth (100%), dense cribriform (96%), loose cribriform/micropapillary with nuclear size >6× normal (83%) or comedonecrosis (74%) and dilated ducts >2× normal (39%). ‘Nuclear size’ was interpreted as nuclear area by 74% and nuclear diameter by 21%. Pure IDC-P in needle biopsies was reported by 100% and Gleason graded by 30%. All would perform immunohistochemistry in such cases to rule out invasive cancer. An IDC-P component associated with invasive cancer would be included in the determination of tumour extent and number of cores involved by 74% and 83%, respectively. 52% would include IDC-P component when grading invasive cancer. 48% would perform immunohistochemistry in solid or cribriform nests with comedonecrosis to exclude IDC-P (17% routinely, 30% if the focus appeared to have basal cells on H&E). 48% graded such foci as Gleason pattern 5 even if immunohistochemistry demonstrated the presence of basal cells. Conclusions There is a need for more clarity in the definition of some of the diagnostic criteria for IDC-P as well as for greater standardisation of IDC-P reporting.
    Article · Feb 2016 · Journal of Clinical Pathology
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    Annika Resch · Lars Harbaum · Marion J. Pollheimer · [...] · Cord Langner
    [Show abstract] [Hide abstract] ABSTRACT: Purpose Tumor grade is a traditional prognostic parameter in colorectal cancer. Remarkably, however, there is still no generally accepted consensus how to perform tumor grading. In this study, we systematically compared the prognostic value of traditional grading based upon histological features, that is, gland formation alone with grading based upon both histological and cytological features, such as nuclear pleomorphism and anaplasia (“alternative grade”). Methods Three hundred eighty-one tumors of randomly selected patients were retrospectively reviewed. Traditional and alternative tumor grades were related to various clinicopathological features and to progression-free and cancer-specific survival applying both univariate and multivariate testing. Results Traditional and alternative tumor grades were significantly associated with T and N classification, tumor size, lymphovascular invasion, as well as both progression-free and cancer-specific survival. In Cox’s proportional hazards regression models, the alternative grade was superior to the traditional tumor grade and was significantly associated with progression-free survival (hazard ratio 1.57, 95 % confidence interval 1.04–2.35; p = 0.031), independent of patients’ age and gender, T and N classification, and lymphovascular invasion. Likewise, patients with tumors with high alternative grade were more likely to die of disease (hazard ratio 1.30, 95 % confidence interval 0.85–2.00), but this difference was not statistically significant (p = 0.22). Conclusions Tumor grade based upon both histological and cytological features was superior to grade based upon histological features alone and proved to be an independent prognostic parameter. Thus, tumor grade based upon both histological and cytological features may help to improve prognostic stratification and may thereby affect clinical decision-making and patient management.
    Full-text available · Article · Jan 2016 · International Journal of Colorectal Disease
  • Nicole Max · Lars Harbaum · Marion J Pollheimer · [...] · Cord Langner
    [Show abstract] [Hide abstract] ABSTRACT: Background: Tumour budding is an adverse prognostic indicator in colorectal cancer (CRC). Marked overall peritumoural inflammation has been associated with favourable outcome and may lead to the presence of isolated cancer cells due to destruction of invading cancer cell islets. Methods: We assessed the prognostic significance of tumour budding and peritumoural inflammation in a cohort of 381 patients with CRC applying univariate and multivariate analyses. Results: Patients with high-grade budding and marked inflammation had a significantly better outcome compared with patients with high-grade budding and only mild inflammation. Outcome in these cases, however, was still worse compared with cases with low-grade budding, in which the extent of peritumoural inflammation had no further prognostic effect. Conclusions: Tumour budding proved to be a powerful prognostic variable in patients with CRC. Scattering of invading cancer cell islets by marked overall peritumoural inflammation seems to have a minor role.British Journal of Cancer advance online publication, 14 January 2016; doi:10.1038/bjc.2015.454
    Article · Jan 2016 · British Journal of Cancer
  • [Show abstract] [Hide abstract] ABSTRACT: No abstract available.
    Article · Jan 2016 · Endoscopy
  • Nicole Max · Franz Siebert · Cord Langner
    Article · Dec 2015 · Endoscopy
  • Lisa Setaffy · Cord Langner
    [Show abstract] [Hide abstract] ABSTRACT: Although often viewed as a single disease, colorectal cancer more accurately represents a constellation of heterogeneous subtypes that result from different combinations of genetic events and epigenetic alterations. Chromosomal instability (CIN), microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) have been identified as the three major molecular characteristics, which interact with other significant mutations, such as mutations in the KRAS and BRAF genes. High-level MSI (MSI-H) is of eminent clinical importance. It is the seminal molecular feature for the identification of individuals with Lynch syndrome, but it may also occur in sporadic cancers with CIMP phenotype, which arise from serrated precursor lesions. MSI-H status is a marker of favorable prognosis and may be used for outcome prediction, that is, molecular grading. Among others, mucinous and medullary histology, signet-ring cell differentiation, and a marked anti-tumoral immune response are histological features suggesting MSI. Universal tumor testing is recommended and may be performed using immunohistochemistry (mismatch repair protein expression) or molecular analysis, as has recently been recommended by an international task force. In this review, we consider in detail the molecular pathogenesis of colorectal cancer, focusing on the diagnosis of MSI in both hereditary and sporadic tumors. © 2015, Versalius University Medical Publisher. All rights reserved.
    Article · Nov 2015 · Polish journal of pathology: official journal of the Polish Society of Pathologists
  • Iva Brcic · Gieri Cathomas · Alessandro Vanoli · [...] · Cord Langner
    [Show abstract] [Hide abstract] ABSTRACT: Aims: Medullary carcinoma of the large bowel mainly occurs right-sided in elderly females. The tumour is almost invariably microsatellite instable and has been associated with favourable outcome. Our study aimed to present three cases of medullary carcinoma originating from the small bowel. Methods and results: We describe three cases of small bowel medullary carcinoma. Two patients had celiac disease, diagnosed at the age of 79 and 71 years, respectively. The tumours showed the characteristic syncytial growth pattern with marked intratumoural lymphocytic inflammation. Loss of MLH1 (and PMS2) expression was observed in all cases, consistent with high-level microsatellite instability. All tumours were negative for Epstein-Barr virus. Follow-up information was available for one patient, who is recurrence-free six years after resection. Discussion: Medullary carcinoma of the small bowel is exceedingly rare. Our data and a review of the literature suggest that this tumour type is characteristic for celiac disease and may be the histological type underlying small bowel cancers with high-level microsatellite instability in patients with celiac disease. This article is protected by copyright. All rights reserved.
    Article · Nov 2015 · Histopathology

Publication Stats

5k Citations


  • 2013
    • Klinikum Bayreuth GmbH
      Bayreuth, Bavaria, Germany
  • 2006-2011
    • IST Austria
      Klosterneuberg, Lower Austria, Austria
  • 2010
    • University of Bayreuth
      Bayreuth, Bavaria, Germany
    • Ruhr-Universität Bochum
      • Institut für Pathologie
      Bochum, North Rhine-Westphalia, Germany
  • 2008
    • Keio University
      Edo, Tōkyō, Japan
  • 2001-2002
    • Karl-Franzens-Universität Graz
      • Institute of Psychology
      Gratz, Styria, Austria
  • 2000-2001
    • Klinikum Kassel
      Cassel, Hesse, Germany
  • 1999
    • Philipps University of Marburg
      • Institut für Physiologie und Pathophysiologie
      Marburg, Hesse, Germany