Zedan Z Ibraheim

Assiut University, Lycopolis, Asyūţ, Egypt

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Publications (20)21.19 Total impact

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    ABSTRACT: Abstract Context: Polygonum species have been used in the treatment of several types of inflammatory disorders and cancer. Nevertheless, there are no reports related to the anti-inflammatory and anti-proliferative activities of Polygonum bellardii All. (Polygonaceae). Objective: This study investigated the chemical composition of the methanol extract of P. bellardii. The anti-inflammatory and cytotoxic activities of methanol, n-butanol, ethyl acetate extracts and isolated polyphenols were determined. Materials and methods: The chemical structure of the isolated compounds was elucidated using different spectral techniques. MTT assay was used to evaluate the anti-proliferative activity in HeLa, MCF-7 and HepG-2 cells. Inhibition of 5-lipoxygenase (5-LOX) activity and prostaglandin E2 (PGE2) production in stimulated HepG-2 cells were used to assess the anti-inflammatory activity. Results: The present study resulted in isolation of five compounds (new for the species). They were identified as gallic acid (1), quercetin (2), myricetin (3), quercetin-3-O-β-d-glucopyranoside (5) and myricetin-3-O-α-arabinofuranoside (7). Additionally, a couple of previously isolated compounds such as quercetin-3-O-(5″-acetyl-α-arabinofuranoside) (4) and myricetin-3-O-(5″-acetyl-α-arabinofuranoside) (6) were detected. The n-butanol extract has the highest cytotoxicity in HeLa, MCF-7 and HepG-2 cells, with IC50 values of 15.26, 50.66 and 30.09 µg/ml, respectively. Compound 6 exhibited a marked cytotoxicity in HeLa (IC50 75.04 µg/ml) and HepG-2 (IC50 41.03 µg/ml) cells. Crude extracts and pure compounds inhibited the 5-LOX activity and PGE2 production in a dose-dependent manner (0.1-250 µg/ml). Discussion and conclusion: These results explain the traditional uses of P. bellardii and indicate that polyphenols, despite structural similarity, have different cytotoxic and anti-inflammatory effects.
    Full-text · Article · Jun 2013 · Pharmaceutical Biology
  • Adel M Abd El-Kader · Amany S Ahmed · Alaa M Nafady · Zedan Z Ibraheim
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    ABSTRACT: A new long chain fatty alcohol acetate identified as 17-hydroxypentacosanyl acetate, (1) together with a new xanthone identified as 1,8-Dihydroxy-3,6-dimethoxy-xanthone-5-O-[α-L-rhamnopyranosyl-(1''→2')]-β-D-glucopyranoside (3), as well as two new lignans identified as (+)-Lyoniresinol-3a-O-[α-L-rhamnopyranosyl-(1'''→6'')]-β-D-glucopyranoside (4) and (+)-Isolariciresinol-3a-O-[α-L-rhamnopyranosyl-(1'''→2'')-α-L-rhamnopyranosyl-(1''''→6'')]-β-D-glucopyranoside (5), in addition to β-sitosterol-3-O-acetate (2) were isolated from the methanolic extract of the aerial parts of Polygonum bellardii growing in Egypt. Their structures were elucidated on the basis of different chemical and spectroscopic evidences. The total extract and its fractions, in addition to compounds (3, 4 and 5) showed significant antioxidant potential by DPPH(·) scavenging activity technique.
    No preview · Article · Apr 2013 · Pharmacognosy Magazine
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    Zedan Z. Ibraheim · Amany S. Ahmed · Wael M. Abdel-Mageed
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    ABSTRACT: From the aerial part of Euphorbia aphylla, nine compounds were isolated (1-9) and identified by different spectral techniques as well as comparison with authentic samples. The isolated compounds included two triterpenes(β-amyrone (1) and euphol(2)), two sterols (β-sitosterol (3) and β-sitosterolglucoside (4)) and five phenolic compounds (gallic acid (5), quercetin (6), quercetin-3-O-(2'',3''-digalloyl)-α-L-rhamnoside (7), 3,4,3'-O-trimethyl ellagic acid 4'-O-β-D-glucopyranoside (8) and (3,4,3'-tri-O-methyl ellagicacid4'-ruti noside)(9)). The anti-inflammatory, anti pyretic,and antioxidant and antimicrobial activities were carried out on different plant fractions.
    Full-text · Article · Jan 2013 · Journal of Natural Remedies
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    ABSTRACT: Seventeen daucane sesquiterpenoid esters, including a new one (4), were isolated from the root of Ferula hermonis Boiss. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidence and correlated with known compounds. The relative stereochemistry of the new compound was determined using 2D NOESY and the most stable and the lowest energy conformation was determined using molecular modelling. The antimicrobial activity was evaluated by determination of MIC using the broth microdilution method against six bacterial strains and one fungal strain (Pseudomonas aeruginosa PAO1, Escherichia coli, Bacillus subtilis ATCC6633, Mycobacterium bovis BCG Pasteur, Mycobacterium tuberculosis H37Rv, Staphylococcus aureus ATCC6538 and Candida albicans SC5314). There was a significant indication that compounds 15, 16, 17 demonstrated potent activity against Gram +ve (S. aureus, B. subtilis), as well as Mycobacterium strains M. bovis BCG and M. tuberculosis H37Rv. None of the isolated compounds exhibited a significant antifungal activity. In the antioxidant study using the DPPH assay method, the highest radical scavenging activity was observed for compounds 15, 16, 17.
    Full-text · Article · Apr 2012 · Phytotherapy Research
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    Zedan Z. Ibraheim · Wael M. Abdel-Mageed · Marcel Jaspars
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    ABSTRACT: This work reports the isolation and characterization of three saponins, including a new one (3), from an n-BuOH extract of the root of Ferula hermonis Boiss. Their structures (1-3) were elucidated on the basis of spectroscopic evidence using 1D and 2D-NMR data, high resolution MS and chemical methods and identified as 3 beta-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-(1 -> 2)-beta-D-glucuronopyranosyl-oleanolic acid (Sandrosaponin X, 1), 3 beta-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-(1 -> 2)-beta-D-glucuronopyranosyl-oleanolic acid 28-O-beta-D-glucopyranoside (Sandrosaponin IX, 2) and 3 beta-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-(1 -> 2)-beta-D-glucuronopyranosyl-oleanolic acid-28-O-beta-D-glucopyranoside methyl ester (Sandrosaponin XI, 3). The chemotaxonomic significance of these compounds was summarized.
    Full-text · Article · Feb 2012 · Biochemical Systematics and Ecology
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    ABSTRACT: A radical scavenging guided phytochemical study on the stem bark of Tecoma mollis afforded seven active phenylpropanoid glycosides (1-7), including a new one (4), and one iridoid (8). The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Compounds (1-7) displayed promising antioxidant activity (DPPH assay) in relation to ascorbic acid (positive control). The antimicrobial activity for compounds (1-8) was evaluated against five bacterial and five fungal strains. The isolated compounds exhibited nonselective weak to moderate antimicrobial activity. The highest antileishmanial activity against Leishmania donovani was observed for compound (7) with an IC₅₀ value of 6.71 μg/ml, using pentamidine and amphotericin B as drug controls. Compound (5) exhibited moderate antimalarial activity (45% inhibition) against chloroquine sensitive (D6) clones of Plasmodium falciparum.
    Full-text · Article · Jan 2012 · Fitoterapia
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    ABSTRACT: The methanolic extract of Polygonum bellardii All. (flowering aerial parts) and its fractions in addition to the isolated compounds (1-6) showed significant antioxidant potential by DPPH • scavenging activity technique. It also showed hepatoprotective activity against carbon tetrachloride (CCl 4) induced hepatic injury in albino rats. The fractions exhibited antibacterial activity against both Gram positive and Gram negative bacteria in addition to antifungal activity. The total methanolic extract of Polygonum bellardii All. did not show signs of toxicity and mortality up to 4 g/kg dose. Determination of total flavonoid content with respect to quercetin spectrophotometrically indicated the presence of 185.2±1.03 mg/g dried extract.
    No preview · Article · Jan 2012 · Bulletin of Pharmaceutical Sciences
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    Doaa A Yones · Gamal A Taher · Zedan Z Ibraheim
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    ABSTRACT: The present work evaluated the effects of alcoholic extracts of salvia (Salvia officinalis), thyme (Thymus vulgaris), and 2 pure compounds (thymol and menthol) on the viability of Echinococcus granulosus protoscolices in vitro. Four different concentrations of each extract (2,500, 1,500, 1,000, and 500 µg/ml) and 3 different concentrations each of thymol and menthol (50, 10, and 1 µg/ml) were used. Concentration of 2,500 µg/ml of both extracts showed a significant protoscolicidal activity on the 6th day. Complete loss of viability of protoscolices occurred with 500 µg/ml concentration of both extracts at day 6 and day 7 post-treatment (PT), respectively. Pure compounds, i.e., menthol and thymol, showed potent effects with 50 µg/ml concentration at day 2 and day 5 PT, respectively. These effects were compared with those of albendazole sulfoxide (800 µg/ml), a commonly used treatment drug for hydatidosis. Krebs-Ringer solution and the hydatid cystic fluid at a ratio of 4:1 was a good preservative solution which kept the protoscolices viable for 15 days.
    Full-text · Article · Sep 2011 · The Korean Journal of Parasitology
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    Zedan Z Ibraheim · Amany S Ahmed · Yaser G Gouda
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    ABSTRACT: Chromatographic fractionation of the alcoholic extract of the dried fronds of Adiantum capillus-veneris L. (Adiantaceae) yielded seven compounds: four triterpenoidal compounds belonging to adiantane and filicane groups were isolated from the hexane fraction and identified as isoadiantone (1); isoadiantol-B (2); 3-methoxy-4-hydroxyfilicane (3) and 3,4-dihydroxyfilicane (4) and three flavonoids were isolated from the ethyl acetate fraction and identified as: quercetin (5), quercetin-3-O-glucoside (6) and quercetin-3-O-rutinoside (rutin) (7). The identification of the isolated compounds has been established through their physical, chemical and spectroscopic methods including IR, (1)H NMR, (13)C NMR, HSQC, HMBC, NOESY and MS. Biological studies of the total alcoholic extract, hexane fraction and some of the isolated compounds showed an anti-inflammatory activity while the hypoglycemic study of the total alcoholic extract showed a significant activity.
    Preview · Article · Apr 2011 · Saudi Pharmaceutical Journal
  • Zedan Z. Ibraheim · Yaser G. Gouda
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    ABSTRACT: Reinvestigation of the chloroform. soluble fraction of the chloroform- methanol (1:1) extract of the dried roots of Rubia cordifolia L. using different chromatographic techniques led to isolation of one new naphthohydroquinone dimer (1) and four known compounds identified as 3-beta-friedelinol (2), atraric acid (3), vanillic acid (4) and D-3-O-methoxy-chiro-inositol (5). The identification of the isolated compounds was carried out using different physical, chemical and spectral methods of analysis.
    No preview · Article · Dec 2010 · Bulletin of Pharmaceutical Sciences
  • O. M. ABDALLAH · Z. Z. IBRAHEIM
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    No preview · Article · Aug 2010 · ChemInform
  • H. A. Hassanean · Z. Z. Ibraheim · K. Takeya · H. Itorawa
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    No preview · Article · Jul 2010 · ChemInform
  • Z.Z. Ibraheim · A.S. Ahmed · M.A. Ramadan
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    ABSTRACT: The hexane fraction obtained from the total alcohol extract of the aerial parts of Maerua crassifolia Forssk grown in Egypt upon repeated column chromatography afforded one new compound identified as 1, 23 dimethoxy tricosa-6-one (1), along with six known compounds identified as long chain hydrocarbon (triacontane) (2), ceryl alcohol (3), lupeol palmitate (4), β-sitosterol palmitate (5), lupeol acetate (6), and α-amyrin (7). The identification of the isolated compounds was carried out using different physical, chemical and spectral methods and co-chromatography with authentic samples.
    No preview · Article · Jan 2008 · Saudi Pharmaceutical Journal
  • Z.Z. Ibraheim · A.S. Ahmed
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    ABSTRACT: From the aerial parts of Crotalaria thebaica (Del) DC (Fabaceae) three δ pyrones (1-3) together with an isoflavone (tecreroginin) (4) were isolated. The structures of the isolated compounds were characterized by using different methods of spectral analysis including, IR, UV, NMR and MS.
    No preview · Article · Jul 2007 · Saudi Pharmaceutical Journal
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    A. M. A. ABD EL-MAWLA · A. S. AHMED · Z. Z. IBRAHEIM · L. ERNST

    Full-text · Article · Jan 2005
  • Zedan Z Ibraheim · Hashem A Hassanean · Daoud W Bishay
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    ABSTRACT: From the saponin fraction of the total methanolic extract of the dried root and stem barks of Taverniera aegyptiaca Boiss, six new triterpenoidal saponins of oleanane type were isolated and identified as 28-methyl serratagenate-3-beta-O-beta-xylopyranosyl (1-->2)-beta-glucopyranoside (2), 28-methyl serratagenate 3-beta-O-alpha-rhamnopyranosyl (1-->2)-beta-glucopyranoside (3), 3beta-O-alpha-rhamnopyranosyl (1-->2) beta-glucopyranosyl-olean-11,13(18)-dien-1beta, 3beta, 22beta-triol (4), 3beta-O-beta-glucopyranosyl (1-->2)-beta-glucuronopyranosylolean-11,13(18)-dien-1beta,3beta,22beta-triol (5), 3beta-O-beta-xylopyranosyl(1-->2)-beta-glucuronopyranosylolean-11,13(18)-dien-1beta,3beta,22beta-triol (6), 3beta-O-alpha-rhamnopyranosyl (1-->2)-beta-glucuronopyranosylolean-11,13(18)-dien-1beta, 3beta, 22beta-triol (7) together with the known oleanolic acid 3-beta-O-beta-glucoside (1). The identification of the isolated compounds was done on the basis of chemical and spectral evidences.
    No preview · Article · Apr 2003 · Phytochemistry
  • HA Hassanean · Z Z Ibraheim · K Takeya · H Itorawa
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    ABSTRACT: Two new quinoidal dimers, a new naphthohydroquinone anhydride, a known naphthoic acid ester derivative and two known benzoic acid derivatives were isolated from the chloroform fraction of a chloroform-methanol (1:1) extract of Rubia cordifolia L. The identification of these compounds was based on spectral analysis.
    No preview · Article · May 2000 · Pharmazie
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    ABSTRACT: A new lupin alkaloid (+)-15β-hydroxy-17-oxolupanine was isolated from the ethanol extract of the seeds ofLupinus albus together with (+)-tetrahy
    No preview · Article · Dec 1994 · Phytochemistry
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    A M A Abd · Zedan Z Ibraheim
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    ABSTRACT: One distinct glucosyltransferase (GT) has been partially purified and characterized from cell cultures of Astragalus sieberi DC.; Family Leguminosae. Callus cultures were established from shoots of sterile germinated seeds maintained on solid MS medium supplemented with 4.5 μM 1-naphthylacetic acid (NAA) and 2.3 μM kinetin (KIN). The cell suspension cultures were obtained by transport of callus cultures to liquid MS medium with the same hormone supplementation. The GT was found to exhibit maximum activity at pH 7.5 and an incubation temperature of 35°. The preferred substrate of GT was found to be kaempferol, the second best substrate was quercetin. The isolated enzymatic products were detected by TLC and HPLC and identified by spectral analysis and comparison with authentic compounds. This experiment from economic point of view provides the best conditions for large scale production of glucosides of kaempferol, quercetin and isorahmnetin.
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