Y. Özgök

Gulhane Military Medical Academy, Engüri, Ankara, Turkey

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Publications (15)12.25 Total impact

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    ABSTRACT: Prostate cancer is the second most common cancer in men worldwide. Although the aetiology of this disease remains largely unclear, several lines of evidence suggest that oxidative stress plays a role in prostate carcinogenesis. The antioxidant enzyme glutathione peroxidase 1 (GPX1) is part of the enzymatic antioxidant defence, preventing oxidative damage to DNA, proteins and lipids by detoxifying hydrogen and lipid peroxides that may contribute to prostate cancer development. Some studies indicate an association between GPX1 Pro198Leu polymorphism and an increased risk of cancer. The purpose of the present study was to determine the possible association of GPX1 Pro198Leu polymorphism and erythrocyte GPX activity with the risk of developing prostate cancer and to clarify whether erythrocyte GPX activity levels were correlated with the GPX1 Pro198Leu genotype in the Turkish population. The GPX1 Pro198Leu genotype was determined in 33 prostate cancer patients and 91 control individuals. As evident from our results, there was no difference between genotype and/or allele frequencies in prostate cancer patients and controls. No significant difference was found in GPX1 genotype or allele frequency between aggressive and non-aggressive prostate cancer patients. It can be suggested with these findings that individual susceptibility of prostate cancer may be modulated by GPX1 polymorphism, but it needs further studies.
    Full-text · Article · Jun 2011 · Human & Experimental Toxicology

  • No preview · Conference Paper · Sep 2009

  • No preview · Article · Sep 2009 · Toxicology Letters
  • E. Huri · E. Başok · O. Uğurlu · C. Gürbüz · T. Akgül · S. Bedir · Y. Özgök

    No preview · Article · Sep 2009 · European Urology Supplements
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    ABSTRACT: We undertook the present study to develop a validated HPLC method for the determination of malondialdehyde (MDA) levels and to use this method for determination of MDA levels in patients with prostate cancer and benign prostatic hyperplasia. MDA levels were estimated in the erythrocyte and plasma sample of the 25 non-metastatic prostate cancer patients, 36 benign prostatic hyperplasia (BPH) patients and 24 age- and sex-matched healthy subjects (controls) in HP Chromatographic systems consisting of a Model Agilent 1100 Series. We report a very rapid and simple isocratic reversed-phase HPLC separation of MDA in normal human plasma and erythrocytes without previous purification of the MDA-TBA complex. All validation parameters were performed in our methods. Using this methods we have found elevated MDA in the plasma and erythrocyte of the prostate cancer group as compared to controls and BPH group. We have improved and validated an analytical HPLC method for determination of MDA in plasma and erythrocyte, which is simple to perform and having high sensitivity, specificity and substantial improvement in column life. This method has been successfully applied to determination of MDA levels in prostate cancer patients and offers an oportunity to further characterize the role of oxidative injury in the pathogenesis of this disease specifically.
    Full-text · Article · Jul 2007 · Journal of Liquid Chromatography & Related Technologies
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    ABSTRACT: Introduction: Although Wilms' tumor (WT) is the most common renal tumor in children, in adults it is exceptionally rare. We reviewed our experience regarding adult patients with WT to assess their clinical characteristics and treatment guidelines according to stage. Materials and Methods: A total of 4 adult patients were enrolled in this study between 1998 and 2004. Clinical data were obtained by reviewing patient charts. In preoperative period all patients were evaluated with physical examination, abdominal ultrasonography (USG), abdomino-pelvic computerized tomography (CT), chest-x ray or CT scan of the chest. The patients were staged according to the National Wilms' Tumor Study Group 4 (NWTS) staging system. Results: The median patient age at the time of diagnosis was 21.3 years. There were two patients with stage II disease and two patients with stage III disease. None of the patients had stage I disease. All patients underwent radical nephrectomy. The lymph node sampling was performed in all patients. Two patients with stage II disease received adjuvant chemotheraphy. These patients received a two drug regimen and no radiotheraphy and two patients with stage III disease received a three drug chemotheraphy regimen and radiotheraphy to the hemiabdomen. There was no recurrence and progression in a 28 months follow-up period. All tumors had favorable histology. Conclusion: Compared with children, adults with WT are reported to have a worse prognosis. It usually cannot be differentiated from other renal masses preoperatively. Because of the rarity of this disease, adults with WT are at a risk of either undertreatment or incorrect treatment. We believe that early diagnosis and treatment can improve the prognosis of adult WT.
    No preview · Article · Mar 2007 · Turk Uroloji Dergisi
  • Y. Kibar · Y. Özgök · F. Erdemir · S. Göktaş · A. Özcan · A.F. Peker
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    ABSTRACT: Introduction: Benign fibrous tumors of the testis and paratesticular tissues are uncommon lesions. A 23year-old man admitted to our clinic with a complaint of painless palpable mass of the right scrotal content. Based on the preoperative diagnosis of testicular or paratesticular tumor, exploration and frozen examination were performed. Because of frozen evaluation revealed benign features, local excision including tunica albuginea was performed. The pathological diagnosis was fibrous pseudotumor of tunica vaginalis. Although a relatively rare disease, a fibrous pseudotumor should be considered in the differential diagnosis of testicular and paratesticular malign tumors.
    No preview · Article · Jun 2006 · Turk Uroloji Dergisi
  • E.O. Güven · M. Kilciler · S. Bedir · A. Avci · Y. Özgök
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    ABSTRACT: Introduction: Although penetrating traumas of the genital region are extremely rare, these cases are true urologic emergencies as they directly affect the sexual, urinary and endocrine functions. Bullet or pellet caused isolated penile traumas are very rare in literature. In these cases the therapy should be aimed to conserve the erectile and the urinary functions. In this report a penile trauma which was caused by the pellets and unique by the way it happens is described and the literature is reviewed with the detailed discussion of the pathophysiology, classification and therapy of this kind of wounds.
    No preview · Article · Jun 2006 · Turk Uroloji Dergisi
  • Y. Kibar · Y. Özgök · S. Göktaş · O. Kuzhan · L. Tahmaz · A.F. Peker
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    ABSTRACT: Introduction: Small cell carcinoma of the bladder is a rare entity characterized clinically by an aggressive behavior with a high incidence of systemic metastases. We report the clinicopathologic findings of five cases. Materials and methods: We reviewed five consecutive patients with small cell carcinoma of the bladder treated at our clinic. In each case, the following clinical data were recorded: age, sex, presenting symptoms, endoscopically determined location of the tumor, clinical staging, treatment, follow-up and outcome. Results: There were four male and one female patients, age range 47 to 71 years, mean 57.6 years. The clinical presentation was not different from conventional transitional cell carcinoma, with hematuria being the most frequent complaint (four cases). Microscopic examination revealed oat cells in all cases. At the time of diagnosis, the tumors were staged as T3bN0M0 in three cases and T2N0M0 in two cases. Primary therapy consisted of radical cystectomy and chemotheraphy in all cases. Four patients died of progressive disease, with survival from the time of diagnosis ranging from seven to 16 months (mean, 12.2 months). Conclusion: Our study shows that primary small cell carcinoma of the urinary bladder is as aggressive as its pulmonary counterpart and the overall prognosis of this tumor is very poor. The management that seems to give a better survival is the combination of radical cystectomy and chemotherapy.
    No preview · Article · Mar 2006 · Turk Uroloji Dergisi
  • M. Kilciler · F. Erdemir · S. Bedir · H. Çoban · K. Erten · Y. Özgök
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    ABSTRACT: Introduction: Most of the stones are located in the upper urinary system and urinary calculi are rarely (1%) seen in the urethra. Urethral stones are encountered infraquently in urological practice and the studies published in the literature consist of small series and several case reports. Herein, we present 17 patients with uretral stones. Materials and methods: Between January 1994 and February 2005 a total of 17 patients with urethral calculi were enrolled into the study. The evaluation covered age, detail history, symptoms, direct urinary system graphy, urinary ultrasonography, urinalysis, urine culture, biochemical and hematologic analysis. Also cystouretroscopy was performed if needed. A retrograde urethrogram was performed if associated urethral pathology was suspected. Physical examination included palpation of the urethra and rectal examination. For anterior urethral calculi 2% lidocaine jelly was instilled in the urethra under aseptic techniques to alleviation of spasm of the external urethral sphincter and urethral musculature, and lubrication of the urethral surface as described in the literature. Urethral calculi were analyzed with regard to symptoms anatomical sites, associated diseases and management. Results: The mean age and mean follow up period of the patients was 37.2 years (range 11-68 year) and 27 months (range 4-33), respectively. In 15 (88.2%) patients urethral stones were detected by direct urinary system graphy. In the remaining 2 (11.8%) patients, urethral stones were detected with the help of urethroscopy. Location of the urethral calculi was fossa navicularis in 5 (35.4%) patients, posterior urethra in 4 (23.5%) patients and the other part of the anterior urethra in 8 (47.1%) patients. Associated urethral stricture was found in 2 patients. These two patients treated with open surgery. Ventral meatotomy was performed in 3 cases in whom the stones were lying in the fossa navicularis. Eight patients had urinary calculi located in the other pats of the urinary system at the time of presentation (vesical 4, ureteral and renal 4). Furthermore, 6 men with anterior urethral calculi were treated by intraurethral instillation of 2% lidocaine jelly. Stones were milked through external meatus after a lidocain gel application in these 6 patients. Four patients presented with acute retention of urine, while others presented with the complaints of dysuria, burning micturation, poor stream, urinary tract infection, and penil or perineal pain. Posterior urethral calculi were maniplated endoscopically into the urinary bladder. Four patients needed transient suprapubic cystostomy and mechanical lithotripsy was performed in 4 cases after the stones were pushed back into the bladder and then removed. All stones were solitary. Urinary tract infection was detected in 13 cases: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae. Six patients gave a past history of passing urinary stones and two patients had ESWL of upper urinary stones. Conclusion: Management of urethral calculi varied according to localization, size and associated urethral pathology. Retrograde manipulation into the urinary bladder and then to perform litholopaxy or lithotripsy is suitable procedure for posterior urethral calculi. Furthermore, anterior urethral calculi can be treated with instillation of 2% lidocaine jelly or ventral meatotomy according to their localization. Also, bigger stones should be treated with open surgery. Besides, if the urethra has an associated stricture or has been damaged by prior attempts at extraction urethroplasty and stone removal are preferable.
    No preview · Article · Sep 2005 · Turk Uroloji Dergisi
  • Y. Kibar · A. Avci · O. Akay · I. Gün · M. Kilciler · Y. Özgök
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    ABSTRACT: Introduction: Leiomyoma of the female urethra is an uncommon but benign condition. Only a few cases of leiomyoma of the female urethra have been reported in the literature. To our knowledge, urethral leiomyoma with unusual clinical symptoms such as stress urinary incontinence is exceedingly rare.
    No preview · Article · Jan 2005 · Turk Uroloji Dergisi
  • Y. Kibar · S. Bedir · M. Kilciler · S. Deveci · Y. Özgök
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    ABSTRACT: Leukemic infiltration of the prostate has rarely been reported. The majority of the published cases with prostatic involvement were chronic lymphocytic leukemia (CLL). An autopsy series of leukemia patients documented an actual prevalence of prostatic involvement higher than clinical series. To our knowledge, this is the first report of a case with coexistence of autosomal dominant polycystic kidney disease (ADPKD), CLL and its prostatic infiltration diagnosed by transrectal ultrasonography (TRUS) guided prostate biopsy.
    No preview · Article · Sep 2004 · Gulhane Medical Journal
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    ABSTRACT: Here we report on a patient with recurrent irritative voiding symptoms without urinary tract infection where ultrasonographic investigation simulated as bladder tumor. Transurethral resection of the mass was carried out and histopathology revealed cystitis cystica (CC). So, we suggest that CC should be added to the sonographic differential diagnosis of intravesical soft tissue masses.
    No preview · Article · Sep 2003
  • A. Avci · L. Tahmaz · A. Özgök · S. Yaǧci · F. Yazar · Y. Özgök
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    ABSTRACT: Introduction: Transrectal ultrasound-guided prostate biopsy is the most important method for diagnosis of prostate cancer. But, the prostate biopsy is an invasive method. We studied efficacy of intrarectal local anesthesia with lidocaine gel before transrectal ultrasound-guided prostate biopsy. Materials and Methods: Between 1998 and 2002 years; 117 patients, whose prostatic specific antigen (PSA) level is higher than 4 ng/ml, were underwent transrectal ultrasound-guided prostate biopsy. Patients were assigned to two groups. All patients had transrectal ultrasound-guided 12 cores prostate biopsies. In the first group, 58 patients underwent TRUS-guided prostate biopsy with %2 lidocaine gel (Instillagel, Germany.) intrarectally, in the second group, 59 patients underwent TRUS-guided prostate biopsy with liquid vaseline (no local anesthesia). We performed double-blind, placebo controlled study to assess pain score and efficacy of intrarectale lidocaine gel administration during TRUS-guided prostate biopsy. Results: The average of pain score of 58 patients in the first group with intrarectale lidocaine gel was between 1-5 (2.638±1.165), the average of pain score of 59 patients in the second group with liquid vaseline was between 3-7 (5.068±1.172) No complication has been determined in all the patients. Mean pain scores for intrarectale lidocaine gel group and placebo liquid vaseline group were significantly and statistically different (t=11.240; p<0.001). Conclusions: Intrarectale lidocoine gel before transrectal ultrasound-guided prostate biopsy results in a more comfortable and effective on the pain score of the procedure for the patients. TRUS-guided prostate biopsy with local anesthesia can reduce the discomfort of the patient. It is easy, non-invasive, cheap, saves from loosing time. Moreover, if prostate re-biopsy is needed, those effects of the patient will be more.
    No preview · Article · Jan 2003
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    ABSTRACT: Introduction: We studied the analyses results of Y chromosome microdeletions in idiopatic severe oligozoospermic and azoospermic infertile males in Turkish population. Materials and Methods: 28 infertile patients who admitted to Department of Urology of Gülhane Military Medical Academy were divided into 4 groups as azoospermia, severe oligozoospermia, oligozoospermia and normozoospermia according to their semen parameters. Testis biopsies were performed in azoospermic patients. Serum FSH, LH, prolactin and testesteron levels were measured. After these examinations, patients without varicocele, ejaculatory dysfunction, endocrinopathies, gonadotoxin related dysfunction, infection were classified as 'idiopathic infertile'. Y chromosomal microdeletions were studied by YDDS (Y Deletions Detection System) in patients having idiopathic severe oligozoospermic and azoospermic patients. Results: Microdeletions were found in 7 of 29 patients. 5 of which were azoospermic and 2 were severe oligozoospermic. These were no statistical difference in FSH levels between patients with or without deletions (p=0.183; p=0.602). All patients had deletions on AZFc region and none of them had on AZFc region. Two patients the same deletions, but their testicular phenotype was different from each other. One patient having deletion on AZFc+AZFd+AZFb region had a testicular phenotype of hypospermatogenesis. However, one patient having deletion only on one STS had a testicular phenotype of Sertoli cell only and spermatositik arrest. Conclusion: Most of idiopathic infertile men had Y chromosome microdeletion. As there wasn't a relation between testicular phenotype and microdeletion, no data could be obtained about treatment options.
    No preview · Article · Jan 2003 · Turk Uroloji Dergisi