[Show abstract][Hide abstract] ABSTRACT: Catecholamines and arginine vasopressin (AVP) release can affect arterial blood pressure (ABP) and hemodynamic stability in standing, sedated horses. Six mature horses were included in this prospective, randomized, crossover, blinded, experimental study. All the horses were sedated with detomidine (DET) alone (0.01 mg/kg, IV) or combined with methadone (MET) (0.01 mg/kg DET and 0.2 mg/kg MET, IV). Cardiopulmonary data and blood samples were collected 30 minutes before (prebaseline and baseline) and for 120 minutes postinjection. The combination DET/MET produced a significant increase (31%) in mean ABP (MAP) 5 minutes after drug administration which lasted for 120 minutes. Detomidine alone induced only a short-term increase in MAP (15%) at 5 minutes compared with baseline. There were significant differences between groups at 5, 15, and from 60 to 120 minutes. Plasma AVP concentrations were higher in horses receiving the treatment DET from 60 to 120 minutes than those in the combination group, for the same period. There were no significant differences in norepinephrine and epinephrine serum concentrations respect to baseline and between treatments. Detomidine induces a short-term MAP increase, and this effect was prolonged and potentiated by MET association. There is no evidence of AVP, norepinephrine, and epinephrine involvement in this effect.
Full-text · Article · Nov 2015 · Journal of Equine Veterinary Science
[Show abstract][Hide abstract] ABSTRACT: Invasive blood pressure measurement (IBP) using peripheral arteries is a commonly used technique in equine anaesthesia, alt- hough the accuracy has not been demonstrated. Non-invasive blood pressure monitoring (NIBP) may be indicated for field anaesthesia, short procedures and foal anaesthesia. In the present report, the agreement of various IBP and NIBP measuring sites compared to carotid artery pressure was tested in anaesthetised experimental ponies. Six ponies were anaesthetised in lateral recumbency with sevoflurane and received either saline or dexmedetomidine boli followed by constant rate infusion (CRI). Invasive blood pressure measurements were obtai- ned simultaneously from the carotid, facial and metatarsal arteries. NIBP measurements over both median arteries, metatarsal and middle coccygeal arteries were performed in random order. All blood pressure readings obtained were compared to carotid pressure by Bland- Altman analysis. Non-invasive blood pressure measurements had larger bias and poorer limits of agreement compared to IBP measure- ments. NIBP measurement from the coccygeal artery had the best repeatability and best limits of agreement of all NIBP positions and was not affected by the use of dexmedetomidine. The facial artery had smaller limits of agreement with dexmedetomidine treatment. There was no difference between the facial and metatarsal arteries during dexmedetomidine treatment in MAP and DAP. Systolic arterial pressures from the metatarsal artery showed larger bias and larger limits of agreement compared to facial artery. In conclusion, NIBP measurement from the tail artery is a reliable alternative to direct arterial blood pressure measurement. Both the metatarsal and facial arteries have acceptable agreement with carotid artery pressure so the choice can be based on the logistics of the procedure.
[Show abstract][Hide abstract] ABSTRACT: Objective
To review the literature with regard to the use of different intravenous agents as supplements to inhalational anaesthesia in horses. The Part 2 of this review will focus in the use of opioids and (2)-agonists. Databases usedPubmed and Web of Science. Search terms: horse, inhalant anaesthesia, balanced anaesthesia, partial intravenous anaesthesia, opioids, morphine, pethidine, butorphanol, methadone, fentanyl, alfentanil, remifentanil, sufentanil, xylazine, romifidine, detomidine, medetomidine and dexmedetomidine. Conclusions
Different drugs and their combinations can be administered systemically in anaesthetized horses aiming to reduce the amount of the volatile agent while improving the recovery qualities and providing a multimodal analgesic approach. However, full studies as to whether these techniques improve cardiopulmonary status are not always available and potential disadvantages should also be considered.
No preview · Article · Jul 2014 · Veterinary Anaesthesia and Analgesia
[Show abstract][Hide abstract] ABSTRACT: Twenty adult healthy horses undergoing elective surgery were involved in this prospective, blinded, clinical study. Horses were randomly allocated to receive a constant rate infusion (CRI) of morphine or dexmedetomidine. After induction, anaesthesia was maintained with isoflurane in oxygen/air and mechanical ventilation applied. The end-tidal isoflurane concentration (FÉISO) was initially set at 0.9% and adjusted by the anaesthetist, to maintain a light surgical plane of anaesthesia, according to an objective flow-chart. The cardiopulmonary function was only minimally different between groups and maintained within clinically normal ranges. Less ketamine was required, FÉISO was lower after 1h and fewer alterations in the anaesthetic depth were needed in horses receiving dexmedetomidine, with better recoveries. One horse receiving morphine developed post-operative colic and pulmonary oedema and two showed box-walking behaviour. This study showed that a dexmedetomidine CRI produced a more stable anaesthetic depth, reduced isoflurane requirements and better recoveries, without post-operative complications compared with a morphine CRI.
No preview · Article · Oct 2013 · Research in Veterinary Science
[Show abstract][Hide abstract] ABSTRACT: To compare the effects of a constant rate infusion (CRI) of dexmedetomidine and morphine to those of morphine alone on the minimum end-tidal sevoflurane concentration necessary to prevent movement (MACNM ) in ponies.
Prospective, randomized, crossover, 'blinded', experimental study.
Five healthy adult gelding ponies were anaesthetized twice with a 3-week washout period.
After induction of anaesthesia with sevoflurane in oxygen (via nasotracheal tube), the ponies were positioned on a surgical table (T0), and anaesthesia was maintained with sevoflurane (Fe'SEVO 2.5%) in 55% oxygen. Monitoring included pulse oximetry, electrocardiography and measurement of anaesthetic gases, arterial blood pressure and body temperature. The ponies were mechanically ventilated and randomly allocated to receive IV treatment M [morphine 0.15 mg kg(-1) (T10-T15) followed by a CRI (0.1 mg kg(-1) hour(-1) )] or treatment DM [dexmedetomidine 3.5 μg kg(-1) plus morphine 0.15 mg kg(-1) (T10-T15) followed by a CRI of dexmedetomidine 1.75 μg kg(-1) hour(-1) and morphine 0.1 mg kg(-1) hour(-1) ]. At T60, a stepwise MACNM determination was initiated using constant current electrical stimuli at the skin of the lateral pastern region. Triplicate MACNM estimations were obtained and then averaged in each pony. Wilcoxon signed-rank test was used to detect differences in MAC between treatments (α = 0.05).
Sevoflurane-morphine MACNM values (median (range) and mean ± SD) were 2.56 (2.01-4.07) and 2.79 ± 0.73%. The addition of a continuous infusion of dexmedetomidine significantly reduced sevoflurane MACNM values to 0.89 (0.62-1.05) and 0.89 ± 0.22% (mean MACNM reduction 67 ± 11%).
Co-administration of dexmedetomidine and morphine CRIs significantly reduced the MACNM of sevoflurane compared with a CRI of morphine alone at the reported doses.
No preview · Article · Sep 2013 · Veterinary Anaesthesia and Analgesia
[Show abstract][Hide abstract] ABSTRACT: Reasons for performing study: Dexmedetomidine has been administered in the equine as a constant-rate infusion (CRI) during inhalation anaesthesia, preserving optimal cardiopulmonary function with calm and coordinated recoveries. Inhalant anaesthetic sparing effects have been demonstrated in other species, but not in horses.
Objectives: To determine the effects of a CRI of dexmedetomidine on the minimal alveolar concentration (MAC) of sevoflurane in ponies.
Methods: Six healthy adult ponies were involved in this prospective, randomised, crossover, blinded, experimental study. Each pony was anaesthetised twice (3 weeks washout period). After induction with sevoflurane in oxygen (via nasotracheal tube), the ponies were positioned on a surgical table (T0), and anaesthesia was maintained with sevoflurane (expired sevoflurane fraction 2.5%) in 55% oxygen. The ponies were randomly allocated to treatment D (dexmedetomidine 3.5 µg/kg bwt i.v. [T10–T15] followed by a CRI of dexmedetomidine at 1.75 µg/kg bwt/h) or treatment S (bolus and CRI of saline at the same volume and rate as treatment D). After T60, MAC determination, using a classic bracketing technique, was initiated. Stimuli consisted of constant-current electrical stimuli at the skin of the lateral pastern region. Triplicate MAC estimations were obtained and averaged in each pony. Monitoring included pulse oximetry, electrocardiography, anaesthetic gas monitoring, arterial blood pressure measurement and arterial blood gases. Normocapnia was maintained by mechanical ventilation. Analysis of variance (treatment and period as fixed factors) was used to detect differences between treatments (α= 0.05).
Results: An intravenous (i.v.) dexmedetomidine CRI decreased mean ± s.d. sevoflurane MAC from 2.42 ± 0.55 to 1.07 ± 0.21% (mean MAC reduction 53 ± 15%).
Conclusions and potential relevance: A dexmedetomidine CRI at the reported dose significantly reduces the MAC of sevoflurane.
No preview · Article · Aug 2012 · Equine Veterinary Journal
[Show abstract][Hide abstract] ABSTRACT: In order to provide one lung ventilation in an anesthetized adult horse undergoing thoracoscopy and exploratory thoracotomy, an alternative to the described techniques was developed using a homemade endobronchial blocker construction. An orifice (with a diameter of 1 cm) was made 15 cm distally to the proximal end of a standard 28 mm ID endotracheal tube (ETT) allowing the placement of a standard broncho-alveolar catheter. The adapted ETT was advanced up to the larynx in the anesthetized horse. Prior to the intubation of the trachea, the broncho-alveolar catheter was passed through the ETT and positioned into the left main bronchus under endoscopic guidance. If it would have been required, the cuff of the broncho-alveolar catheter could have been inflated, allowing OLV. However, one lung ventilation was not required during the surgical procedure.
Preview · Article · Mar 2012 · Vlaams Diergeneeskundig Tijdschrift
[Show abstract][Hide abstract] ABSTRACT: Patent ductus arteriosus (PDA) is one of the most common congenital vascular abnormalities in the dog. In veterinary medicine, surgical ligation (SL) and transarterial occlusion (TO) are two possible treatments that require general anesthesia.
Two 4-month-old dogs were anesthetized for the correction of PDA, one by SL and the other by TO. Two different anesthetic and analgesic protocols were used, and were chosen to avoid potential complications.
This case report describes two possible anesthetic approaches for PDA corrective surgery (SL and TO).
Preview · Article · Jan 2012 · Vlaams Diergeneeskundig Tijdschrift
[Show abstract][Hide abstract] ABSTRACT: Many articles on anesthesia in llamas have been published. Xylazine, combined with ketamine is the most frequently used injectable anesthetic protocol and it warrants an effective and reliable anesthesia to perform short procedures. The use of other α2-agonists is far less documented in the literature. A study was carried out to evaluate and compare the anesthetic and cardiorespiratory effects of intramuscular medetomidine-ketamine and dexmedetomidine-ketamine in llamas. The induction of anesthesia, cardiorespiratory parameters and the recovery time were similar in both groups. However, during recovery, significantly more ataxia was observed in the llamas that received medetomidine than in the llamas that received dexmedetomidine.