Yu Zhang

Shanghai Institute of Applied Physics, Shanghai, Shanghai Shi, China

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Publications (668)2068.94 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The collection and consumption of wild edibles is an important part in livelihood strategies throughout the world. There is an urgent need to document and safeguard the wild food knowledge, especially in remote areas. The aims of this study are to accomplish detailed investigation of wild edibles used by the Naxi in Baidi village and evaluate them to identify innovative organic food products. Also, we aim to explore the characteristics of distribution and transmission of the traditional knowledge (TK) on wild edibles among the Naxi. Data was collected through a semi-structured interview of key informants above the age of 20 years, chosen carefully by a snowball sampling. The interviews were supplemented by free lists and participatory observation methods. Informants below 20 years were interviewed to test their knowledge of traditional practices. A quantitative index like Cultural Importance Index (CI) was used to evaluate the relative importance of the different wild edibles. Linear regression and t-test were performed to test variation in the TK among the informants of different age groups and genders. Altogether 173 wild edible plant species belonging to 76 families and 139 genera were recorded in the study. Cardamine macrophylla, C. tangutorum and Eutrema yunnanense, have traditionally been consumed as an important supplement to the diet, particularly during food shortages as wild vegetables. The age was found to have a significant effect on TK, but there was no significant difference between male and female informant in knowledge abundance. The traditional food knowledge was dynamic and affected by social factors. Also, it was descending partly among younger generations in Baidi. Baidi village is a prime example of a rapidly changing community where local traditions compete with modern ways of life. Overall, this study provides a deeper understanding of the Naxi peoples’ knowledge on wild edibles. Some wild edibles might have an interesting dietary constituent, which need in-depth studies. Such detail studies can help to promote the market in one hand and protect TK in the other. Protecting TK from disappearing in succeeding generations is necessary, and understanding the dynamics of TK is one important solution to this dilemma.
    No preview · Article · Dec 2016 · Journal of Ethnobiology and Ethnomedicine
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    ABSTRACT: Microwave irradiation (MWI) and ionic liquid (IL) assisted methods were chosen to strengthen the alkali pretreatment process to improve saccharification efficiency of sugarcane bagasse (SCB). Four different pretreatment approaches namely alkali, IL, MWI-alkali and IL-alkali pretreatments were compared. The chemical composition, morphology and crystal performance of the substrates were analyzed by the standardized methods of the National Renewable Energy Laboratory, field emission scanning electron microscope (SEM) and X-ray diffraction (XRD), respectively. IL assisted treatment brought the highest lignin removal (78.51%), and the glucan and xylan conversion achieved 99.51% and 92.76%, respectively, after 72 h of enzymatic hydrolysis. The similar effect occurred for MWI assisted alkali-pretreatment approach. SEM and XRD analyses showed that the strengthened process obviously changed the structure and crystallinity of the substrates. Moreover, as a persuasive tool, the fractal-like theory was used to study the enzymatic hydrolysis kinetics.
    No preview · Article · Mar 2016 · Fuel Processing Technology
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    ABSTRACT: 2D layered transition metal dichalcogenides (TMDCs) have emerged as new possibilites beyond conventional particulate catalysts in facilitating efficient electrochemical hydrogen evolution. This is mainly mediated by the ultrahigh surface-to-volume ratio and the effective coupling of all active sites with supporting electrodes. Especially, the facile chemical vapor deposition (CVD) method has enabled morphological engineering of monolayer TMDC catalysts toward development of abundant active edge sites within the 2D plane. Here, two pathways to achieve such purpose are highlighted, either by non-equilibrium growth of MoS2 dendrites or throughout high-density nucleation of MoS2 nanoflakes directly on the electrode materials. Furthermore, future research directions have also been proposed and discussed to further enhance the efficiency of such unique catalysts.
    No preview · Article · Feb 2016 · Advanced Materials
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    ABSTRACT: The use of functional nanodiamonds (fNDs) to deliver CpG oligonucleotides (ODNs) for sustained immunostimulation is reported. It is demonstrated that monotherapy using this immunostimulatory agent significantly suppresses the tumor growth in two murine tumor models. This fND-based nanoagent opens new opportunities for immunotherapy, as well as clinical applications of various types of therapeutic nucleic acids.
    No preview · Article · Feb 2016 · Advanced Materials

  • No preview · Article · Feb 2016 · Chinese Physics B
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    ABSTRACT: Angelica sinensis polysaccharide (ASP), extracted from the roots of A. sinensis (Oliv.) Diels, is a β-d-pyranoid polysaccharide with an average molecular weight of 72,900Da. In this study, we investigated the protective effects of ASP against concanavalin A-induced liver failure and the underlying mechanisms. Concentrations of ASP ranging from 5 to 125μg/mL could inhibit concanavalin A (ConA)-induced lymphoproliferative response. The potential hepatoprotective activity of ASP was demonstrated by the significant decrease in serum transaminase (ALT and AST) levels and the attenuation of liver inflammation damage exhibited by H&E stain of the liver. Furthermore, ASP pretreatment significantly decreased proinflammatory cytokines (TNF-α, IFN-γ, IL-2 and IL-6) and alleviated oxidative stress by reducing MDA and ROS levels and by enhancing SOD activity after ConA administration in mice. Results of Western blot analysis indicated that ASP attenuated Caspase-3-dependent apoptosis by Caspase-8 and JNK-mediated pathway and inhibited the activation of IL-6/STAT3 and NF-κB signaling pathways in ConA-induced liver damage in mice. In conclusion, ASP pretreatment could attenuate concanavalin A-induced liver injury through its anti-inflammatory and anti-oxidant actions in mice.
    No preview · Article · Feb 2016 · International immunopharmacology
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    ABSTRACT: Prolonged therapeutic action over an extended period of time on single dose is vital in designing an ideal drug delivery system. Nanoparticle-based vehicles for drug delivery serves as an ideal technology, however, utilization of them remains controversial due to potential safety concerns and transient drug retention. Nanodiamonds (NDs), with excellent biocompatibility and diversity of potential conjugates, have emerged as alternative promising materials in this regard. Here, we developed sodium alginate functionalized NDs (fNDs) for drug delivery. Cisplatin (DDP) was chosen as a model drug and coated on the negatively charged fNDs clusters. Our work demonstrated that fNDs were capable of enhancing drug accumulation and retention time in tumor cells, leading to continued tumor cell killing effect after clearance of drug treatment. Furthermore, fNDs-DDP treatment improved drug safety compared to DDP treatment. Thus, this new platform may have strong potential for further biomedical application.
    No preview · Article · Feb 2016 · Carbon
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    ABSTRACT: Although the involvement of protein arginine methyltransferase 1 (PRMT1) in tumorigenesis has been reported, its roles in breast cancer progression and metastasis has not been elucidated. Here we identified PRMT1 as a key regulator of the epithelial-mesenchymal transition (EMT) in breast cancer. We showed that the EMT program induced by PRMT1 endowed the human mammary epithelial cells with cancer stem cell properties. Moreover, PRMT1 promoted the migratory and invasive behaviors in breast cancer cells. We also demonstrated that abrogation of PRMT1 expression in breast cancer cells abated metastasis in vivo in mouse model. In addition, knockdown of PRMT1 arrested cell growth in G1 tetraploidy and induced cellular senescence. Mechanistically, PRMT1 impacted EMT process and cellular senescence by mediating the asymmetric dimethylation of arginine 3 of histone H4 (H4R3me2as) at the ZEB1 promoter to activate its transcription, indicating the essential roles of this epigenetic control both in EMT and in senescence. Thus, we unraveled a dual function of PRMT1 in modulation of both EMT and senescence via regulating ZEB1. This finding points to the potent value of PRMT1 as a dual therapeutic target for preventing metastasis and for inhibiting cancer cell growth in malignant breast cancer patients.
    Preview · Article · Jan 2016 · Scientific Reports
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    ABSTRACT: It is well established that the trigonal β-form is favorable and effective for toughening isotactic polypropylene (iPP). The content of β-phase, based on the conventional view, should be achieved as high as possible to realize excellent toughness in iPP. Nevertheless, in this study, it is demonstrated that the morphology plays a more important role in improving the impact strength of iPP than β-crystal content. Variable crystal morphologies in the inner regions of the samples are acquired by the variation of nucleant concentrations. Three types of β-crystalline morphologies, β-spherulite (0.02 wt.% and 0.05 wt.%), leaf-like transcrystalline entity (0.1 wt.%), and bundle like one (0.2 wt.% and 0.5 wt.%), are sequentially generated. The leaf like transcrystalline iPP wins the best impact strength. Testing by 2D-WAXD, furthermore, the special six-peak structure of (300) azimuthal diffraction arc is presented with the sample PP0.1 which also has the longest long period.
    No preview · Article · Jan 2016
  • Yi Wang · Jing-Chun Feng · Xiao-Sen Li · Yu Zhang · Gang Li
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    ABSTRACT: The Pilot-Scale Hydrate Simulator (PHS), a three-dimensional 117.8. L pressure vessel, is applied to study the methane hydrate dissociation below the quadruple point in the sandy sediment in this work. The hydrate dissociation behaviors below and above the quadruple point are compared. The influences of the production pressure, the initial reservoir temperature, and the water saturation on the hydrate dissociation below the quadruple point by depressurization are investigated. The results indicate that methane hydrate dissociation below the quadruple point causes ice formation, which can strongly enhance the dissociation rate of the hydrate. The water generated from hydrate dissociation below the quadruple point may immediately form ice and the pore water in the reservoir turns into ice at the same time. Meanwhile, the hydrate dissociation below the quadruple point consumes the latent heat released by ice formation. The lower production pressure causes the higher driving force for hydrate dissociation and ice formation, which results in the higher dissociation rate of the hydrate. In addition, when the production pressure is lower than the quadruple point, a lower initial reservoir temperature is favorable for ice formation, which leads to the higher hydrate dissociation rate. The experimental results from hydrate dissociation in the 'water-saturated' reservoir and 'gas-saturated' reservoir indicate that the rate of ice formation is slower in the 'water-saturated' reservoir.
    No preview · Article · Jan 2016
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    Jinyun Pu · Yu Zhang · Jianhua Zhou
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    ABSTRACT: Epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells is a vital mechanism of renal fibrosis. Mounting evidence suggests that miR-200a expression decreases in tubular epithelial cells in unilateral ureteral obstruction (UUO) rats. Moreover, it has been demonstrated that Huai Qi Huang (HQH) can ameliorate tubulointerstitial damage in adriamycin nephrosis and delay kidney dysfunction in primary glomerular disease. However, the effect of HQH on EMT of tubular epithelial cells in UUO rats and its molecular mechanism is unclear. In order to explore the effect of HQH on EMT and its molecular mechanism in renal fibrosis, in vitro and in vivo experiments were performed in our study. Our results showed that HQH increased miR-200a expression in UUO rats and in TGF- β 1 stimulated NRK-52E cells. Meanwhile, HQH decreased ZEB1 and ZEB2 (the transcriptional repressors of E-cadherin), α -SMA expression in renal tubular epithelial cells in vitro and in vivo . Furthermore, we found that HQH protected kidney from fibrosis in UUO rats. The results demonstrated that HQH regulated miR-200a/ZEBs pathway and inhibited EMT process, which may be a mechanism of protecting effect on tubular cells in renal fibrosis.
    Preview · Article · Jan 2016 · Evidence-based Complementary and Alternative Medicine
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    ABSTRACT: The crude polysaccharide was obtained from the root of Angelica sinensis (AS) to investigate its effect on tumor growth and iron metabolism in H22-bearing mice. In our study, we showed that Angelica sinensis polysaccharide (ASP) was mainly composed of arabinose, glucose and galactose in a molar ratio of 1 : 1 : 1.75, with a molecular weight of 80 900 Da and a sugar content of 88.0%. Animal experimental results revealed that three doses of ASP all had anti-tumor effects with inhibition ratios of 27.11%, 31.65% and 37.05%. With respect to iron metabolism, the mean levels of serum hepcidin, interleukin-6 (IL-6), ferritin, transferrin (Tf), transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2) in H22-bearing mice were promoted, and serum iron concentration decreased significantly. After treatment with ASP, these iron-related indicators recovered in different degrees. The findings suggested that the anti-tumor activity of ASP may be affected by its regulation on iron metabolism in H22-bearing mice.
    No preview · Article · Jan 2016
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    ABSTRACT: To predict the performance and evaluate the optimized process operation, kinds of kinetic models were conducted in batch experiment for UASB-anammox biomass and EGSB-anammox biomass. Following time series with substrate variation, the reaction of mixed culture were separated into three phases: anammox reaction, denitrifiacrion and cell lysis. Among of the selected 6 kinetic models, the Hanlev and Luong models were found to be the most appropriated models with the prospected rmax of 0.28, 0.30 gN•gVS-1, Ks of 53.38, 52.52 mgNH4+-N•L-1 and inhibition constants of 900 and 928 mg N•L-1, respectively. The simulated specific anammox activity (SAA) had significant differences in the two reactors following longitudinal distribution. EGSB-Anammox biomass owning the highest rmax of 0.30gN•gVS-1 and Ks of 53.38mg NH4+- N•L-1 (123.84 mgN•L-1) validated both in models and experiment. Contrastly, UASB-anammox biomass varied largely from 0.1 to 0.6 gN•gVS-1 from top to bottom of the reactor, but lower removal efficiency of the whole system. Moreover, the addition of a second feeding tended to increase the SAA for higher purity anammox biomass.
    Full-text · Article · Jan 2016 · RSC Advances
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    ABSTRACT: Ferric hydroxide (FHO), which has high phosphate adsorption capacity, was prepared by precipitation at industrial scale and then fabricated via the drum granulation method with cross-linked poly(vinyl alcohol) as the binder. The optimum binder/FHO powder ratio was 0.6 for producing a granular adsorbent with a high phosphate adsorption capacity and stability. The Langmuir maximum adsorption capacities of powder and granular FHOs were 74.07 mg g(-1) and 56.18 mg g(-1) at pH 7.0 ± 0.2, respectively, which were higher than those of other reported phosphate adsorbents under neutral or acidic conditions. Phosphate-loaded granular FHO could be regenerated by NaOH solution. Columns containing the granular FHO were used for phosphate removal from ozonated secondary effluents of a municipal wastewater treatment plant at space velocity (SV) of 2 and 5 h(-1). During more than 2 months' operation, the average removal percentage of PO4(3-) was more than 90% and the turbidity and concentration of CODMn in the effluents were lower than in the influents. In addition, energy dispersive X-ray results suggested that active sites inside the granular FHO were available for phosphate removal. The results demonstrated that granular FHO can be applied as an assist technology for phosphate removal from secondary effluents.
    Full-text · Article · Dec 2015 · Water Science & Technology
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    Preview · Article · Dec 2015
  • Yu Zhang · Nan Wang · Wei Wang · Junhong Wang · Zuoyi Zhu · Xue Li
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    ABSTRACT: The objectives of this study were to identify peptides that inhibit α-glucosidase using a quantitative structure-activity relationship (QSAR) screening method and a database of silkworm peptides. This study compared the docking characteristics of several peptides with high inhibitory activity against α-glucosidase and summarized the molecular mechanisms by which the silkworm peptides affected α-glucosidase. Four peptides that strongly inhibited α-glucosidase were obtained: Gln-Pro-Gly-Arg with IC50 at 65.8μmol/L, Ser-Gln-Ser-Pro-Ala at 20μmol/L, Gln-Pro-Pro-Thr at 560μmol/L and Asn-Ser-Pro-Arg at 205μmol/L. Studies docking the peptides to the active site of α-glucosidase (PDB ID: 2QMJ) showed that a common characteristic was Lys776 in 2QMJ, which could be a critical target for α-glucosidase trapping of inhibitory peptides. The results revealed that the four peptides, especially Ser-Gln-Ser-Pro-Ala, could be potential drugs for treating diabetes.
    No preview · Article · Dec 2015 · Peptides
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    ABSTRACT: Decomposition conditions of methane hydrate in marine sediments from South China Sea were measured using multi-step decomposition method. Four different samples of the marine sediments were used in the experiments. The pore distribution, the surface area, particle size and the surface texture were measured and observed. The experimental results indicated that the final decomposition temperatures are shifted lower than those for bulk hydrates at the same pressure for different marine sediments and different water saturations. Temperature shifts are more negative for smaller initial water saturation. The surface textures and pore of the sediments both affect the equilibrium condition of methane hydrate. Using the Clausius-Clapeyron equation, the enthalpy of hydrate dissociation in marine sediments was calculated. It was found that the enthalpy of hydrate dissociation in marine sediments with lower water saturation is higher than that at the bulk state.
    No preview · Article · Dec 2015 · Fluid Phase Equilibria
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    ABSTRACT: HIV-1 infected patients frequently have osteolytic bone disease, which is caused by the dysregulation of the bone remodeling system that involves the interaction between osteoblasts and osteoclasts, but the relationship between osteolytic disease and HIV-1 infection remains unclear. In this study we tested whether HIV-1 infection of osteoclasts affects their differentiation. We prepared human osteoclasts from CD14+ monocytes and examined them for their susceptibility to HIV-1. Furthermore, we investigated the effect of HIV-1 infection on osteoclast differentiation. CD14-derived osteoclasts were shown to express CD4, CCR5, and CXCR4 each at the similar level to that shown with macrophages. R5-tropic HIV-1 and X4-tropic HIV-1 were found to infect CD14-derived osteoclasts and replicate in them. Furthermore, HIV-1 infection induced formation of larger osteoclastst, enhanced the expression of mRNAs for three osteoclast specific marker molecules (tartrate-resistant acid phosphatase, cathepsin K, and the calcitonin receptor), and up-regulated osteoclast bone resorption activity. Our results suggest that osteoclasts serve as a novel target for HIV-1 infection, which may enhance the osteoclast differentiation contributing to the development of osteolytic disease in HIV-1-infected patients.
    Preview · Article · Dec 2015 · Retrovirology
  • Jing-Chun Feng · Yi Wang · Xiao-Sen Li · Yu Zhang

    No preview · Article · Nov 2015 · Energy & Fuels
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    ABSTRACT: Cellular senescence impedes cancer progression by limiting uncontrolled cell proliferation. To identify new genetic events controlling senescence, we performed a small interfering RNA screenin human cancer cellsand identified a number of targets potentially involved in senescence of MDA-MB-231 human breast cancer cells. Importantly, we showed that knockdown of RAD21 resulted in the appearance of several senescent markers, including enhanced senescence-associated β-galactosidase activity and heterochromatin focus formation, as well as elevated p21 protein levels andRB1 pathway activation. Further biochemical analyses revealed that RAD21 knockdown led to the downregulation of c-Myc and its targets, including CDK4, a negative regulator of RB1, and blockedRB1 phosphorylation (pRB1) and the RB1-mediated transcriptional repression of E2F. Moreover, c-Myc downregulation was partially mediated by proteasome-dependent degradation within promyelocytic leukemia (PML) nuclear bodies, which were found to be highly abundant during RAD21 knockdown-induced senescence. Exogenous c-Myc reconstitution rescued cells from RAD21 silencing-induced senescence. Altogether, data arising from this study implicate a novel function of RAD21 in cellular senescence in MDA-MB-231 cells that is mainly dependent onRB1 pathway activation via c-Myc downregulation. This article is protected by copyright. All rights reserved.
    No preview · Article · Nov 2015 · Journal of Cellular Biochemistry

Publication Stats

12k Citations
2,068.94 Total Impact Points


  • 2012-2016
    • Shanghai Institute of Applied Physics
      Shanghai, Shanghai Shi, China
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
  • 2008-2016
    • Huazhong University of Science and Technology
      • • School of Pharmacy
      • • School of Public Health
      • • Wuhan National Laboratory for Optoelectronics
      • • Key Laboratory of Environment and Health, MOE
      Wu-han-shih, Hubei, China
    • Kunming Medical College
      Yün-nan, Yunnan, China
    • National Institute of Advanced Industrial Science and Technology
      Tsukuba, Ibaraki, Japan
    • Harbin Engineering University
      Charbin, Heilongjiang Sheng, China
  • 2002-2016
    • Chinese Academy of Sciences
      • • State Key Laboratory of Environmental Aquatic Chemistry
      • • Laboratory of Energy Systems and Renewable Energy
      • • State Key Laboratory of Drug Research
      • • Research Center for Eco-Environmental Sciences
      • • Dalian Institute of Chemical Physics
      • • Graduate School
      Peping, Beijing, China
  • 2015
    • Taiyuan University of Technology
      Yangkü, Shanxi Sheng, China
  • 2014-2015
    • Xi'an Jiaotong University
      • Department of Infectious Diseases
      Ch’ang-an, Shaanxi, China
    • Peking University
      • Department of Materials Science & Engineering
      Peping, Beijing, China
    • North China University of Water Conservancy and Electric Power
      Cheng, Henan Sheng, China
    • University of South China
      Heng-nan, Hunan, China
    • Peking University School of Stomatology
      Peping, Beijing, China
    • Ministry Of Environmental Protection China
      Peping, Beijing, China
  • 2013-2015
    • Harbin Medical University
      • Department of Pharmacology
      Charbin, Heilongjiang Sheng, China
  • 2010-2015
    • Wuhan University
      • • State Key Laboratory of Virology
      • • College of Life Sciences
      Wu-han-shih, Hubei, China
  • 2008-2015
    • Shanghai Jiao Tong University
      • • School of Medicine
      • • Department of Neurology
      • • Institute of Andrology
      Shanghai, Shanghai Shi, China
    • East China University of Science and Technology
      • • School of Materials Science and Engineering
      • • School of Pharmacy
      Shanghai, Shanghai Shi, China
  • 2007-2015
    • Kunming University of Science and Technology
      Yün-nan, Yunnan, China
  • 2006-2015
    • Tianjin University
      • State Key Laboratory of Precision Measurement Technology and Instruments
      T’ien-ching-shih, Tianjin Shi, China
    • Sichuan University
      • • State Key Laboratory of Polymer Material Engineering
      • • Department of General Surgery
      • • Key Laboratory of Green Chemistry and Technology
      • • State Key Laboratory of Biotherapy
      • • Department of Chemistry
      Hua-yang, Sichuan, China
  • 2012-2014
    • University of Massachusetts Medical School
      • Gene Therapy Center
      Worcester, Massachusetts, United States
  • 2011-2014
    • Zhejiang Academy of Agricultural Sciences
      Zhegang, Jiangxi Sheng, China
    • Jilin University
      • State Key Laboratory on Integrated Optoelectronics
      Yung-chi, Jilin Sheng, China
  • 2010-2014
    • Tongji Hospital
      Wu-han-shih, Hubei, China
  • 2007-2014
    • Northeast Normal University
      • • Department of Chemistry
      • • The Institute of Genetics and Cytology
      Hsin-ching, Jilin Sheng, China
  • 2012-2013
    • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
      Hua-yang, Sichuan, China
    • Zhengzhou University
      • Department of Chemistry
      Cheng, Henan Sheng, China
  • 2009-2013
    • Tsinghua University
      • Department of Chemical Engineering
      Peping, Beijing, China
  • 2007-2013
    • Hunan University
      • College of Environmental Science and Engineering
      Ch’ang-sha-shih, Hunan, China
    • University of Science and Technology of China
      • • School of Life Sciences
      • • Department of Modern Physics
      Luchow, Anhui Sheng, China
  • 2011-2012
    • Shanghai Ocean University
      Pootung, Shanghai Shi, China
    • Fudan University
      • Department of Medicinal Chemistry
      Shanghai, Shanghai Shi, China
  • 2009-2011
    • Harbin Institute of Technology
      • • School of Computer Science and Technology
      • • Research Center of Computer Network and Information Security
      Charbin, Heilongjiang Sheng, China
  • 2007-2011
    • National Institutes of Health
      • • Section on Developmental Genetics
      • • Laboratory of Cell and Developmental Biology
      Maryland, United States
  • 2006-2010
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • Dalian Institute of Chemical Physics
      Lü-ta-shih, Liaoning, China
  • 2003-2010
    • Shanghai Institutes for Biological Sciences
      Shanghai, Shanghai Shi, China
  • 2008-2009
    • Institute Of High Performance Computing
      Tumasik, Singapore
    • North China Electric Power University
      • School of Business Administration
      Peping, Beijing, China
  • 2007-2008
    • Leiden University
      • Molecular and Development Genetics
      Leyden, South Holland, Netherlands
    • The National Institute of Diabetes and Digestive and Kidney Diseases
      Maryland, United States
  • 2006-2008
    • University of Pennsylvania
      • Department of Computer and Information Science
      Philadelphia, PA, United States
  • 2005
    • National University of Singapore
      • Department of Computer Science
      Tumasik, Singapore
  • 2001-2004
    • Nanyang Technological University
      • School of Electrical and Electronic Engineering
      Tumasik, Singapore