Ying Zhang

China Medical University (PRC), Feng-t’ien, Liaoning, China

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Publications (26)25.99 Total impact

  • Shuang Lei · Ying Zhang · Kaiqiang Zhang · Jian Li · Lu Liu
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    ABSTRACT: Exposure to high levels of fluoride (F-) can result in dental fluorosis in different individuals, but the mechanism of dental fluorosis remains unclear. Autophagy is a highly conserved intracellular digestion process that degrades damaged organelles and protein aggregates. This study examined the effect of sodium fluoride (NaF) on the expression of Beclin1 and mTOR to elucidate the development mechanisms of dental fluorosis. HAT-7 cells were incubated with various concentrations of NaF, and autophagic vacuoles were studied by transmission electron microscopy. At both mRNA and protein level, expression of Beclin1, which is required for autophagosome formation and decreases the expression of mTOR, an autophagy-related complex, was increased at 1.2 mmol/l NaF compared to baseline (0 mmol/l NaF). Additionally, immunohistochemical analysis was performed on paraffin-embedded rat incisor sections to identify the expression of Beclin1 and mTOR proteins in vitro. Highly significant differences were detected compared to controls. In summary, our results demonstrate unequivocally that excessive amounts of fluoride cause autophagy of HAT-7 cells, indicating that autophagy is involved in dental fluorosis.
    No preview · Article · Nov 2015 · Cells Tissues Organs
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    Lu Liu · Ying Zhang · Wei Wu · Ruibo Cheng
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    ABSTRACT: The etiologies of oral disease are generally progressive and cumulative, such that compared with younger individuals, middle-aged and elderly people are at greater risk of active dental caries and periodontal disease risk. They usually suffer from multiple oral diseases, and obstacles to their use of dental care services are numerous. The objectives of this study were to investigate the characteristics of dental care-seeking behaviors and related sociodemographic factors in a middle-aged and elderly population in northeast China. This was a cross-sectional study of 1188 subjects, including 792 middle-aged (35-44 years-old) and 396 elderly (65-74 years-old) residents of northeast China. Information on dental care-seeking behaviors and sociodemographic characteristics was collected during face-to-face structured interviews conducted between May and June 2010. Chi square tests, Ridit scoring, and multivariate logistic regression analysis were employed to characterize dental care-seeking behaviors and their associations with sociodemographic factors. A greater proportion of middle-aged participants reported a need for dental visits compared with the elderly participants (75.8 % vs. 60.9 %; P < 0.01), as did more urban that rural residents (P < 0.05). The majority of individuals in both the middle-aged and elderly groups obtained for dental care at their own expense, and they predominantly chose private dental clinics. Ridit analyses showed that education level and income were significantly associated with oral care in both middle-aged and elderly people (Ps < 0.05). In addition, logistic regression analysis indicated that rural residence was negatively associated with dental visits in both middle-aged (odds ratio = 0.649, 95 % confidence interval: 0.447-0.884) and elderly (odds ratio = 0.604, 95 % confidence interval: 0.394-0.924) individuals. The rate of dental care visits is low in the middle-aged and elderly populations of northeast China. Among sociodemographic factors, education level and income are positively associated with dental care visits, and rural residence is negatively associated with the frequency of such visits.
    Preview · Article · Jun 2015 · BMC Oral Health
  • Jian Li · Ying Zhang · Lin Ma · Kai-Qiang Zhang · Shuang Lei · He-Feng Gu
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    ABSTRACT: To study the effect of GRP-78 and caspase-12 on fluoride-induced endoplasmic reticulum stress and apoptosis in rat ameloblast, and explore whether fluoride-induced endoplasmic reticulum stress results in the occurrence of apoptosis. The cell activity of ameloblast cultured in various concentrations of fluoride was measured by CCK8 and flow cytometry; Real-time RT-PCR and Western blot were used to analyze the endoplasmic reticulum chaperone GRP-78 and caspase-12 genes and the expression of related proteins. The data was analyzed with SPSS13.0 software package. With the increasing concentration of fluoride, the cell activity of rat ameloblasts decreased gradually, and flow cytometry also showed that the number of apoptosis gradually increased; Real-time RT-PCR and Western blot showed the expression of GRP-78 and caspase-12 increased while the fluoride concentration increased. Excessive fluoride induces endoplasmic reticulum stress of rat ameloblast, and leads to cell apoptosis. Supported by National Natural Science Foundation of China (81072245) and Natural Science Foundation of Liaoning Province (20102278).
    No preview · Article · Feb 2015 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • Lu Liu · Ying Zhang · Hefeng Gu · Kaiqiang Zhang · Lin Ma
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    ABSTRACT: The present study investigated the effects of fluoride on endoplasmic reticulum (ER) stress (ERS) and osteoblast apoptosis in vivo. Forty-eight Wistar rats were randomly divided into four groups (12/group) and exposed to 0, 50, 100, and 150 mg/L of fluoride in drinking water for 8 weeks, respectively. Peripheral blood samples and bilateral femurs were used to monitor the progression of fluorosis in the animals. Hematoxylin and eosin (H&E) staining of the bone tissues was used to determine the severity of osteofluorosis. The expression of ERS chaperones (glucose-regulated protein 78 (GRP78), X-box binding protein l (XBP1), cysteine aspartate specific protease-12 (caspase-12), and growth arrest and DNA damage-inducible gene 153 (Gadd153/CHOP) was analyzed by immunohistochemistry staining, and osteoblast apoptosis was determined by TUNEL staining and flow cytometry. Accumulation of fluoride in bone was associated with the severity of osteofluorosis. The expression of GRP78, XBP1, caspase-12, and CHOP was increased in a dose-dependent manner. Fluoride-induced apoptosis in osteoblasts was also dose-dependent. High concentrations of fluoride induced ERS and osteoblast apoptosis in vivo. The increased expression of GRP78 and XBP1 increased the adaptation of osteoblasts to ERS to a certain extent. Caspase-12 and CHOP activation was associated with ERS and osteoblast apoptosis.
    No preview · Article · Dec 2014 · Biological Trace Element Research
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    ABSTRACT: To evaluate the effect of fluoride on viability of rat ameloblasts in vitro. The ameloblasts of rat was exposed to different concentrations of NaF (0, 0.4, 0.8, 1.6, 3.2, 6.4 mmol/L) for 24, 48 and 72 hours. CCK-8 assays were performed to measure the cells proliferation; The morphology of apoptosis was observed by Hoechst 33258 staining and the rate of apoptosis was determined by flow cytometry. The data was analyzed using SPSS 13.0 software package. (1)The proliferation of ameloblasts was increased when concentrations of NaF between 0.4 mmol/L and 0.8 mmol/L, whereas inhibited at 1.6 mmol/L NaF and above. The effects were in time-dependent manner.(2)Cells in the 1.6 mmol/L NaF groups showed unclear karyorrhexis and apoptotic cell morphology. The effects were in concentration-dependent manner. (1)Fluoride has two-phase effects to ameloblasts: At low doses, it promoted cell proliferation while at high doses it had negative effects. (2)1.6 mmol/L NaF could induce apoptosis of ameloblasts. Supported by National Natural Science Foundation of China (81072245) and Natural Science Foundation of Liaoning Province (20102278).
    No preview · Article · Oct 2014 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
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    ABSTRACT: Purpose: To investigate the effect of fluoride on the metabolism of teeth and bone in rats, and to probe the mechanism of pathogenesis of dental fluorosis. Methods: A total of 48 Wistar rats were randomly and equally divided into 4 groups including control group (distilled water), low-dose group(NaF,50 mg/L), medium-dose group (NaF,100 mg/L) and high-dose group (NaF, 150 mg/L). After 8 weeks, the rats were sacrificed under anesthesia, and serums were collected. The biochemical technique was used to test serum calcium. Changes in the fluorine content in serums and teeth of each group were analyzed with fluoride ion selective electrode method. Radioimmunoassay was employed to detect the levels of osteocalcin (OC), parathormone (PTH) and calcitonin (CT), respectively. SPSS13.0 software package was used for statistical analysis. Results: The fluorine content in serum and teeth in the fluoride group were significantly higher than that of the control group (P<0.05), and increased with the increasing concentrations (F value was 11.234 and 275.148 respectively, P<0.01). The level of calcium in serum (F=3.906, P<0.05) in the fluoride group was significantly lower than in the control group. The level of PTH and OC in serum in medium and high-dose group were significantly higher than in the control group (P<0.01), with the level of CT in high-dose group decreased significantly (P<0.01). The differences of the level of OC, PTH, CT between groups were significant (F value was 8.548, 3.801 and 5.121 respectively, P<0.05). Conclusions: Fluoride affects the metabolism of teeth and bone in rats and OC, PTH, CT plays a key role in the pathogenesis of dental fluorosis.
    No preview · Article · Apr 2014 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
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    Lu Liu · Ying Zhang · Wei Wu · Min Cheng · Yan Li · Ruibo Cheng
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    ABSTRACT: The present study aimed to investigate the prevalence and correlates of dental caries in elderly population in northeast China. A community-based, cross-sectional study among 2376 elderly subjects (age: 65-74 years) from nine urban areas and nine rural areas in three provinces of northeast China was conducted using multistage stratified random sampling per the World Health Organization oral health survey methodology. Decayed-missing-filled teeth (DMFT) and decayed-filled teeth (DFT) indices were used to evaluate the prevalence of dental caries. Face-to-face questionnaire survey on oral health was performed in a randomly selected subset (n = 1197). T test and chi square test were employed to compare groups for continuous and categorical variables, respectively. Multivariate logistic regression was used to estimate odds ratios (ORs) and corresponding confidence intervals (CIs). 67.5% of elderly subjects reported dental caries (average DFT = 2.68±3.40), and the prevalence was higher in urban areas (P<0.01). Missing teeth accounted for 80.72% of DMFT, and filled teeth due to caries accounted for 2.08% with a rate higher in urban areas (P<0.01). Logistic regression analysis indicated significant association among elderly population in urban areas (OR 1.713; 95% CI 1.337-2.195), smoking (OR 1.779; 95% CI 1.384-2.288), and individuals without dental insurance (OR 2.050; 95% CI 1.120-3.754) with dental caries. The prevalence of dental caries in the elderly population in northeast China is high. The elderly from urban areas who smoke and who do not have a dental insurance are at a higher risk to develop dental caries.
    Preview · Article · Nov 2013 · PLoS ONE
  • Kai-Qiang Zhang · Ying Zhang · Lu Liu · He-Feng Gu · Lin Ma
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    ABSTRACT: To investigate the effect of different concentrations of fluoride on the expression of endoplasmic reticulum chaperone, and to explore the mechanism of dental fluorosis in rat. Thirty Wistar rats were randomly divided into 3 groups. Immunohistochemistry was used to detect the expression of CRT, GRP78, XBP-1 and caspase-12 in rat incisors. Metamorph microscope images analysis system and SPSS 13.0 software package was used to analyze the data. Typical features of dental fluorosis were found in the fluoride group. Results of immunohistochemistry showed that CRT (F=238.6, P<0.05), GRP78 (F=27.42, P<0.05), XBP-1 (F=139.7, P<0.05) and caspase-12 (F=43.91, P<0.05) were significantly different among the 3 groups. Excessive fluoride can increase the secretion of CRT, GRP78, XBP-1 and caspase-12 suggest the ameloblasts and in status of endoplasmic reticulum stress and caspase-12 plays an important role during ameloblast apoptosis. Supported by National Natural Science Foundation of China (81072245) and Natural Science Foundation of Liaoning Province (20102278).
    No preview · Article · Oct 2013 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • Ruibo Cheng · Li Ma · Ying Zhang
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    ABSTRACT: EpiData is a free software designed for data inputting and management in epidemiological surveys. This software can enhance the accuracy of data input, reduce the error in inputting data, increase work efficiency, and optimize data management. The methods of establishing, inputting, and exporting data in the EpiData database for oral epidemiological investigations are introduced by providing examples in the present study.
    No preview · Article · Oct 2013 · Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • Lu Liu · Ying Zhang · Rui-Bo Cheng · Yan-Mei Xu · Zhen-Fu Lu
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    ABSTRACT: To investigate the non-public oral medical institutions in Liaoning province in 2011, and to analyze the status of dental manpower in non-public dental institutions in Liaoning province. A mass survey on dental manpower was made in non-public dental institutions in Liaoning province in 2011 by means of questionnaire investigation, which included the institution type, dental devices, and the number, structure, composition, distribution of dental manpower in non-public dental institutions in Liaoning province. Data was entered with EpiData 3.0 and analyzed with SPSS 13.0 software package. There were 1649 non-public dental institutions with 3132 dentists, 1265 nurses, 540 technicians and 3490 dental chairs in Liaoning province. 85.69% of the dental manpower were young and middle-aged. 33.17% of the dentists had primary professional titles, 42.53% of them had college degree and 87.96% of the dentists was general dentistry. In the dental auxiliaries, the primary professional title accounted for the majority. 95.97% of the nurses majored in general dentistry and 60.40% of the nurses' educational background were below junior college degree. 72.59% of the technicians majored in prosthetic dentistry and 67.78% of their educational background were below junior college degree. The ratio of the dentists to nurses to technicians was 6:2:1. The ratio of the nurses to dental chairs was 1:2.76. The distribution and composition of dental manpower are not reasonable in non-public dental institutions in Liaoning province. We should strengthen effective utilization of oral health resources and the oral health service ability of non -public dental institutions in Liaoning province. Supported by Key Science and Technology Projects of Liaoning Province (2012225015).
    No preview · Article · Oct 2013 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
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    ABSTRACT: CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its role and study the regulation of CRMP-2's expression in cilia we carried out the following experiments. We find that in fibroblasts CRMP-2 localizes to the centrosome and is associated with the basal body and -at a low level- is present in primary cilia. Phosphorylated pCRMP-2 can only be detected at the basal body. RNAi knockdown of CRMP-2 interfered with primary cilium assembly demonstrating a critical requirement for CRMP-2. Deletion analysis of CRMP-2 identified a 51 amino acid sequence in the C-terminus that is required for targeting to the basal body and primary cilium. This domain contains GSK-3β phosphorylation sites as well as two repeats of the VxPx motif, previously identified as a cilium targeting signal in other primary cilium proteins. To our surprise, mutation of the CRMP-2 VxPx motifs did not eliminate primary cilium targeting. Instead, mutation of the GSK-3β phosphorylation sites abolished CRMP-2 targeting to the primary cilium without affecting basal body localization. Treatment of cells with lithium, a potent GSK-3β inhibitor, or with two specific GSK-3β inhibitors (the L803-mts peptide inhibitor and CHIR99021) resulted in cilium elongation and decreased basal body levels of pCRMP-2 as well as increased levels of total CRMP-2 at the primary cilium. In summary, we identified CRMP-2 as a protein critically involved in primary cilia formation. To our knowledge this is the first demonstration of modulation of primary cilium targeting by GSK-3β.
    Preview · Article · Nov 2012 · PLoS ONE
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    ABSTRACT: Kinesin light chain 3 (KLC3) is the only known kinesin light chain expressed in post-meiotic male germ cells. We have reported that in rat spermatids KLC3 associates with outer dense fibers and mitochondrial sheath. KLC3 is able to bind to mitochondria in vitro and in vivo employing the conserved tetratrico-peptide repeat kinesin light chain motif. The temporal expression and association of KLC3 with mitochondria coincides with the stage in spermatogenesis when mitochondria move from the spermatid cell periphery to the developing midpiece suggesting a role in midpiece formation. In fibroblasts, expression of KLC3 results in formation of large KLC3 aggregates close to the nucleus that contain mitochondria. However, the molecular basis of the aggregation of mitochondria by KLC3 and its role in sperm tail midpiece formation are not clear. Here we show that KLC3 expression from an inducible system causes mitochondrial aggregation within 6h in a microtubule dependent manner. We identified the mitochondrial outer membrane porin protein VDAC2 as a KLC3 binding partner. To analyze a role for KLC3 in spermatids we developed a transgenic mouse model in which a KLC3ΔHR mutant protein is specifically expressed in spermatids: this KLC3 mutant protein binds mitochondria and causes aggregate formation, but cannot bind outer dense fibers. Male transgenic mice display significantly reduced reproductive efficiency siring small sized litters. We observed defects in the mitochondrial sheath structure in a number of transgenic spermatids. Transgenic males have a significantly reduced sperm count and produce spermatozoa that exhibit abnormal motility parameters. Our results indicate that KLC3 plays a role during spermiogenesis in the development of the midpiece and in the normal function of spermatozoa.
    Full-text · Article · Apr 2012 · Developmental Biology
  • Zhen-fu Lu · Ying Zhang · Rui-bo Cheng · Lu Liu · Yan-mei Xu
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    ABSTRACT: The aim of this investigation was to determine and analyze the distribution of the medical institutions of stomatology and dental manpower in Liaoning province. The data of institutions and manpower was collected by mass examination using tables filled by every institution and personally. Epidata 3.02 database was used to input the data and statistical analysis was performed using the SPSS12.0 software package. The results showed that there were 2155 dental institutions and 5617 dentists in Liaoning province. Among all the institutes, 71.0% was private clinics. About 80.5% of institutions and 87.8% of dentists were in the urban area, which was significantly higher than the percent of dentists working in the rural area. The ratio between dentists and the general population was about 13.02/10 million. There were fewer dental auxiliary in dental institutions, the ratio between dentists, nurses and dental technician was 6:2:1. The title and degree of the dentists in the rural area were lower than those in urban area, but the dentists in the rural area provided service for a large population. The results suggest that the distribution of oral health resource in Liaoning province should be rationally readjusted, and continuing education and training should be strengthened in order to improve the efficiency of oral health service and social health justice. Supported by Key Medical Professional Construction Project of Liaoning Province (Grant No.200809).
    No preview · Article · Apr 2010 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • Ying Zhang · Min Cheng · Yan Li · Rui-Bo Cheng · Lu Liu
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    ABSTRACT: To study the dental caries status of the 65-74 years old people in northeast of China, analyze the distribution of caries in the group of people, and provide scientific basis for establishing the oral health care policies. The representative samples were selected by multi-stage, stratified and random sampling from the three province of northeast of China. Dental caries of 2 364 people aged 65-74 were recorded according to WHO criteria. SPSS 12.0 software was used to analyze the data. 1) Among 2,364 elderly people in northeast of China, the prevalence of dental caries was 67.5% and DFT was 2.68, the composition of filling was 10.82%. 2) The prevalence of coronal caries was 66.4% and DFT was 2.55. The composition of filling was 11.37%. 3) The prevalence of root surface caries was 48.4% and DFT was 1.64. The composition of filling was only 1.8%. The prevalence of dental caries among elderly people in northeast of China is still very high, and the filling rate is low. The community based oral health promotion should be strengthened and preventive-oriented oral health care systems are needed in northeast of China.
    No preview · Article · May 2009 · Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • Rui-bo Cheng · Ying Zhang · Min Cheng · Yan Li · Lu Liu
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    ABSTRACT: To investigate the current status and the distribution of tooth loss in middle-aged people and elders in Northeast China, and provide scientific basis for the establishment of oral health care policies. An equal-sized stratified multi-stage random sampling design was applied according to the third national oral health investigation of epidemiology, tooth loss was examined among 4752 people aged 35-44 and 65-74 in northeast China. The data were analyzed with SPSS13.0 statistical software for independent-sample t test and Chi-square test. Of all the subjects, 3135 people had tooth loss, the rate of tooth loss was 66.80%, mean tooth loss was 4.95; 392 persons were half edentulous, the rate of edentulous jaw was 8.35%, 223 persons were edentulous, the rate edentulous jaw was 4.75%. Statistical analysis showed tooth loss rate in females was significantly higher than that in males(P<0.05). There was significantly difference of tooth loss between city and rural area (P<0.05). There was significant difference in the amount and rate of tooth loss between Jilin Province and Liaoning Province, and Jilin Province and Heilongjiang Province as well (P<0.05). The tooth loss rate is very high in middle-aged people and elders in Northeast China. Measures should be taken to prevent dental caries and periodontal disease in these population so that to promote the status of middle-aged people and elders on oral health and to improve their quality of life.
    No preview · Article · Feb 2009 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • Ying Zhang · Min Cheng · Yan Li · Rui-bo Cheng · Lu Liu
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    ABSTRACT: To assess the oral health status of the 65-74 years old people in the northeast of China, analyze the distribution of caries and periodontal diseases in this group of people, and provide scientific basis for establishing oral health care policies. The representative samples were selected by multi-stage, stratified and random sampling from the three provinces of northeast of China. The diagnostic standard of dental caries and periodontal diseases were based on WHO criteria. SPSS 12.0 software package was used to analyze the data. Among 2364 people aged 65-74 years, the prevalence of dental caries was 67.5% and DFT was 2.68, and the data in urban was higher than in rural. The prevalence rate of periodontal disorders, such as health, gingival bleeding, dental calculus, periodontal pockets, loss of attachment was respectively 15.4%,72.0%,86.6%,58.0% and 60.1%, the prevalence rate of Heilongjiang and Liaoning province was lower than that of Jilin Province. Dental caries and periodontal diseases were the common diseases in northeast of China, systematic community based oral health promotion should be strengthened and preventive-oriented oral health care systems are needed in the northeast of China.
    No preview · Article · Jan 2009 · Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • Ying Zhang · Lu Liu · Rui-bo Cheng · Zhen-fu Lu
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    ABSTRACT: To study the dental caries status in the primary dentition of 5-year-old children and analyze the difference of oral health behavior of family between urban and rural in Liaoning province. The representative samples were selected by multi-stage, stratified and random sampling from Liaoning province. Dental caries of 792 children at five years were recorded according to World Health Organization criteria. The questionnaries were finished by 396 parents of the children and analyzed the oral health behavior of family in urban and rural by chi-squre test. The prevalence and dmft of dental caries of 5-year-old children in Liaoning province was 73.86% and 4.38, respectively. The prevalence of dental caries in 5-year-old children was 64.14% in urban and 83.59% in rural. There was significant difference on the consumption of sweets, chocolate, water with sugar and beverage between the children in urban and rural. More urban children had good toothbrushing behavior such as the time of beginning brush tooth, the frequency of brushing and daily use of fluoridated toothpaste compared with the rural children. The parents in urban had high level of education and incomes and there were more children in urban have regular dental visit pattern than in rural. This study has shown that there is an urgent need for the implementation of a systematic education on oral health behavior of family on rural children in Liaoning province.
    No preview · Article · Mar 2008 · Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • Rui-Bo Cheng · Wei Tao · Ying Zhang · Min Cheng · Yan Li
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    ABSTRACT: To survey the tooth decay of the first molars among the people in area of northeast China in order to provide the foundation for prevention and treatment strategies of caries. According to the third national oral health investigation of epidemiology, the dental caries of first permanent molars were examined among 9394 people aged 5, 12, 35-44 and 65-74 in northeast China. The data were analyzed by SPSS 13.0 statistical software. Dental caries prevalence rate and DMFT (dmft) of first permanent molar were calculated. The prevalence of crown and root dental caries in northeast China were 26.86% and 3.81% respectively, mean DMFT (dmft) of crown and root dental caries were 0.41 and 0.04 respectively. There were significant differences of dental caries among provinces in northeast China. Mandibular first molar suffered from dental caries easily. The prevalence of caries of female was higher than that of male (P<0.01), but there was not significant difference of prevalence of root caries between two sexes (P>0.05). Except Jilin province, there were significant differences of prevalence of crown caries between city and rural area in Liaoning and Heilongjiang provinces (P<0.01). It was no significant difference of prevalence and mean DMFT (dmft) of root caries between city and rural area in each province (P>0.05). The prevalence of dental caries of the first molar among the people in northeast China is high. The dental caries prevention and cure of first permanent molar should be emphasized in oral health field.
    No preview · Article · Feb 2008 · Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • Rui-Bo Cheng · Ying Zhang · Wei Tao · Lu Liu
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    ABSTRACT: To study the status of teeth loss and their restorations of the middle-aged and elders in Liaoning province. Investigated the tooth losing and their restoration of middle-aged (35-44 years old) and elders (65-74 years old) according the method of the third national epidemiological investigation of oral health. The data was statistically analyzed by SPSS 11.0 software. Of all 1,584 the subjects, the sum of tooth loss were 6,776, mean tooth loss were 4.28. The rate of completion of dentition was 37.44%. There were 104 middle-aged and elders who happened deletion of dentition. There were 887 middle-aged and elders who happened defection of dentition. The tooth loss of maxillary and mandible was 3,550 and 3,226 respectively. The rate of prosthetic restoration was 52.77%. The oral health status of middle-aged and elders should be taken vey importance, especially those who lived in rural area. Dental caries and periodontal disease should be prevented so that to promote the status of middle-aged and elders oral health and to improve the quality of life.
    No preview · Article · Jan 2008 · Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • Ying Zhang · Rui-bo Cheng · Min Cheng · Yan Li
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    ABSTRACT: To study the prevalence of dental caries in primary dentition of 5-year-old children in Northeast of China, and assess the risk factors for dental caries. The representative samples were selected by multi-stage, stratified and random sampling from the three provinces of Northeast of China. Dental caries of 2353 children at five-year age were recorded according to WHO criteria. The questionnaire were finished by 1191 parents of the children and analyzed with X(2) test and logistic regression using SPSS 12.0 software package. The prevalence of dental caries in 5-year-old children was 75.82% and dmft was 4.63. The lowest caries prevalence was noted in Heilongjiang province. The important predictors of dental caries were the educational level of parents (P<0.001) and eating sweet food before sleep (P=0.006). To reduce the dental caries in primary dentition, oral health education for the parents should be emphasized and sugar-intake before sleeping should be controlled.
    No preview · Article · Dec 2007 · Shanghai kou qiang yi xue = Shanghai journal of stomatology