Y Miyazaki

The Jikei University School of Medicine, Edo, Tōkyō, Japan

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Publications (747)2430.8 Total impact

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    ABSTRACT: Background The number of elderly patients with IgA nephropathy (IgAN) is increasing in parallel with the increased longevity in the general population. However, information is limited regarding the characteristics of such patients. Methods IgAN patients who were ≥60 years of age at diagnosis were retrospectively analyzed. The clinicopathological features at biopsy, therapies during the follow-up period, renal outcomes and extrarenal complications were evaluated. Results The characteristics of a total of 87 patients were as follows (mean values): 65 years of age, an eGFR of 47 mL/min/1.73 m2, and urinary protein excretion (UPE) of 1.9 g/day. In the initial 1-year follow-up period, UPE decreased from 2.4 to 0.4 g/day in patients treated with corticosteroids and 1.4 to 0.8 g/day in patients treated with conservative therapies, including renin–angiotensin system blockade. During the observation period, 26 % of the patients who received corticosteroids and 38 % of the patients treated with conservative therapies showed a ≥30 % decrease in their eGFR or reached end-stage renal disease. In the analysis of all patients, UPE at 1 year after the diagnosis was identified to be an independent predictor of the subsequent loss of renal function. However, neither corticosteroid therapy nor conservative therapies was identified to be an independent valuable. There was no significant difference in the incidence of the extrarenal complications between patients treated with corticosteroids and those with conservative therapies. Conclusion In elderly IgAN patients, the reduction of proteinuria by therapeutic interventions may lead to better renal outcomes without causing severe extrarenal complications.
    No preview · Article · Feb 2016 · Clinical and Experimental Nephrology
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    ABSTRACT: The Extreme Universe Space Observatory on board the Japanese Experiment Module of the International Space Station, JEM-EUSO, is being designed to search from space ultra-high energy cosmic rays. These are charged particles with energies from a few 1019 eV to beyond 1020 eV, at the very end of the known cosmic ray energy spectrum. JEM-EUSO will also search for extreme energy neutrinos, photons, and exotic particles, providing a unique opportunity to explore largely unknown phenomena in our Universe. The mission, principally based on a wide field of view (60 degrees) near-UV telescope with a diameter of ∼ 2.5 m, will monitor the earth’s atmosphere at night, pioneering the observation from space of the ultraviolet tracks (290-430 nm) associated with giant extensive air showers produced by ultra-high energy primaries propagating in the earth’s atmosphere. Observing from an orbital altitude of ∼ 400 km, the mission is expected to reach an instantaneous geometrical aperture of A g e o ≥ 2 × 105 km2 sr with an estimated duty cycle of ∼ 20 %. Such a geometrical aperture allows unprecedented exposures, significantly larger than can be obtained with ground-based experiments. In this paper we briefly review the history of space-based search for ultra-high energy cosmic rays. We then introduce the special issue of Experimental Astronomy devoted to the various aspects of such a challenging enterprise. We also summarise the activities of the on-going JEM-EUSO program.
    Full-text · Article · Nov 2015 · Experimental Astronomy
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    ABSTRACT: Space-based detectors for the study of extreme energy cosmic rays (EECR) are being prepared as a promising new method for detecting highest energy cosmic rays. A pioneering space device – the “tracking ultraviolet set-up” (TUS) – is in the last stage of its construction and testing. The TUS detector will collect preliminary data on EECR in the conditions of a space environment, which will be extremely useful for planning the major JEM-EUSO detector operation.
    Full-text · Article · Nov 2015 · Experimental Astronomy
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    ABSTRACT: The Extreme Universe Space Observatory on the Japanese Experiment Module (JEM-EUSO) on board the International Space Station (ISS) is the first space-based mission worldwide in the field of Ultra High-Energy Cosmic Rays (UHECR). For UHECR experiments, the atmosphere is not only the showering calorimeter for the primary cosmic rays, it is an essential part of the readout system, as well. Moreover, the atmosphere must be calibrated and has to be considered as input for the analysis of the fluorescence signals. Therefore, the JEM-EUSO Space Observatory is implementing an Atmospheric Monitoring System (AMS) that will include an IR-Camera and a LIDAR. The AMS Infrared Camera is an infrared, wide FoV, imaging system designed to provide the cloud coverage along the JEM-EUSO track and the cloud top height to properly achieve the UHECR reconstruction in cloudy conditions. In this paper, an updated preliminary design status, the results from the calibration tests of the first prototype, the simulation of the instrument, and preliminary cloud top height retrieval algorithms are presented.
    Full-text · Article · Nov 2015 · Experimental Astronomy
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    Full-text · Dataset · Oct 2015
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    ABSTRACT: Background: In patients with IgA nephropathy (IgAN), recurrence after steroid pulse therapy is associated with reduced renal survival. However, the predictors of recurrence have not yet been clarified. Methods: All patients who received 6-month steroid pulse therapy from 2004 to 2010 in our four affiliated hospitals and achieved a reduction of proteinuria to <0.4 g/day 1 year after treatment were retrospectively evaluated. The primary outcome was proteinuria ≥1.0 g/day during follow-up or additional antiproteinuric therapy. Two histological classifications were evaluated, the Oxford Classification with a split system and Japanese histological grades (HGs) with a lumped system. Results: During a median follow-up of 3.4 years, 27 (26.7 %) of the 101 patients showed recurrence. Multivariate analysis showed that HG was the only significant predictor of recurrence, with HG 2+3+4 vs HG 1 having a hazard ratio of 7.38 (95 % confidence interval 1.52-133). Furthermore, in patients with mesangial hypercellularity according to the Oxford Classification, cumulative rate of recurrence-free survival was greater in patients with steroid therapy plus tonsillectomy compared with those who received steroid therapy alone (Log-rank test, P = 0.022). However, this association was not observed in patients without mesangial hypercellularity. Conclusions: HG is a novel predictor of recurrence after steroid pulse therapy in patients with IgAN. Moreover, the combination of steroid pulse therapy plus tonsillectomy may indicate a lower risk of recurrence in patients with mesangial hypercellularity, as defined by the Oxford Classification.
    Full-text · Article · Sep 2015 · Clinical and Experimental Nephrology
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    ABSTRACT: Background: The IgA nephropathy (IgAN) Study Group in Japan conducted a multicenter, randomized, controlled trial of tonsillectomy with steroid pulse therapy (TSP) versus steroid pulse monotherapy in patients with IgAN (UMIN Clinical Trial Registry Number; C000000384). The effects of therapies in relation to pathological severity were analyzed in this study. Methods: The patients with IgAN, urinary protein 1.0-3.5 g/day, serum creatinine of 1.5 mg/dl or less were randomly assigned to receiving TSP (Group A) or steroid pulses alone (Group B). The primary endpoint was the disappearance of proteinuria and/or hematuria. Twenty-six biopsies in Group A and 33 in Group B were available. The histological grades (HG) according to the percentage of glomeruli with crescent or sclerosis and the Oxford classification were analyzed. Results: The patients in Group A had a 4.32- to 12.1-fold greater benefit of disappearance of proteinuria and 3.61- to 8.17-fold greater benefit of clinical remission (disappearance of proteinuria and hematuria) than those in Group B in patients with HG2-3, acute lesions (cellular or fibrocellular crescent) affecting more than 5 % of glomeruli, chronic lesions (fibrous crescents or sclerosis) affecting more than 20 % and S1. In contrast, odds ratios for disappearance of proteinuria or clinical remission in Group A to Group B were not significant in patients with HG 1, acute lesion in 5 % or less of glomeruli, chronic lesion in 20 % or less and S0. The disappearance of hematuria showed no relation to pathological severity. Conclusion: TSP might be better employed according to the pathological severity.
    No preview · Article · Sep 2015 · Clinical and Experimental Nephrology
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    ABSTRACT: Background: Few studies have been conducted to assess the ambulatory blood pressure (ABP) in IgA nephropathy (IgAN) patients. This study aimed to determine the relationships between ABP and renal histopathological findings assessed using the Oxford classification (OC) and the Japanese classification (JC), which have recently established histopathological criteria for IgAN. Methods: This cross-sectional study included biopsy-diagnosed IgAN patients, in whom both a renal biopsy and ABP measurement were performed. The histopathological findings were assessed using the OC and the JC and were analyzed in relation to the ABP. Results: A total of 111 IgAN patients were included. The score of interstitial fibrosis and tubular atrophy (T score) using the OC was a significantly associated factor with both the daytime and nighttime ABP values. In contrast, the other histopathological scores, including mesangial hypercellularity, endocapillary hypercellularity and segmental glomerulosclerosis, did not show significant associations with the ABP. The histological grade (H-grade) using the JC, which was based on the sum of injured glomeruli, was associated with the daytime ABP, but not with the nighttime ABP. The associations between the T score using the OC (%) and the daytime and nighttime ABP values were independent of age, gender, renal function, proteinuria and the use of antihypertensive medications, whereas the H-grade using the JC (%) did not show significant associations after adjusting for these clinical parameters. Conclusions: These results suggest that the T score using the OC is the most relevant renal histopathological parameter associated with abnormalities of circadian blood pressure in IgAN patients.
    Preview · Article · Sep 2015 · CKJ: Clinical Kidney Journal
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    ABSTRACT: Using data collected with the Belle detector in the energy region of the $\Upsilon(10860)$ and $\Upsilon(11020)$ resonances we measure the $e^+e^- \to h_b(nP)\pi^+\pi^-$ $(n=1,2)$ cross sections. Their energy dependences show clear $\Upsilon(10860)$ and $\Upsilon(11020)$ peaks with a small or no non-resonant contribution. We study resonant structure of the $\Upsilon(11020) \to h_b(nP)\pi^+\pi^-$ transitions and find evidence that they proceed entirely via intermediate charged bottomonium-like states $Z_b(10610)$ and/or $Z_b(10650)$ (with current statistics we can not discriminate hypotheses of one or two intermediate states).
    No preview · Article · Aug 2015
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    ABSTRACT: Sometimes, acute and progressive proteinuria increases occur in patients with IgA nephropathy (IgAN) after favorable long-term clinical courses of >10 years, but their clinical and histological characteristics are not well understood. We retrospectively selected 20 IgAN patients who had been followed for >10 years after their initial biopsies ((1st)Bx) and underwent second biopsies ((2nd)Bx), because their proteinuria increased to >1 g/day. Eight patients with acute exacerbations (Group A) showed acute proteinuria increases after long periods of mild proteinuria. Their clinicopathological characteristics were analyzed as a case series and were compared with those in Group B that comprised 12 patients with persistent proteinuria. Group A experienced acute proteinuria increases and significant hematuria increases compared with the -1-year (P = 0.006) and -3-year (P = 0.010) time points before the (2nd)Bx, which contrasted to the clinical course in Group B. In Group A, glomerulosclerosis (GS) and the arteriosclerosis score did not differ between the (2nd)Bx and the (1st)Bx, and most patients (88 %) showed cellular and/or fibrocellular crescents within the (2nd)Bx. Compared with Group B, the (2nd)Bx revealed that the percentage of cellular and/or fibrocellular crescents (P = 0.001) was significantly higher, whereas the percentage of GS (P = 0.012) and the arteriosclerosis score (P = 0.020) were significantly lower in Group A. Rapid proteinuria and hematuria increases, and acute histological lesions characterize acute exacerbations in IgAN after favorable long-term clinical courses.
    Full-text · Article · Aug 2015 · Clinical and Experimental Nephrology
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    ABSTRACT: EUSO-Balloon is a pathfinder for JEM-EUSO, the Extreme Universe Space Observatory which is to be hosted on-board the International Space Station. As JEM-EUSO is designed to observe Ultra-High Energy Cosmic Rays (UHECR)-induced Extensive Air Showers (EAS) by detecting their ultraviolet light tracks “from above”, EUSO-Balloon is a nadir-pointing UV telescope too. With its Fresnel Optics and Photo-Detector Module, the instrument monitors a 50 km2 ground surface area in a wavelength band of 290–430 nm, collecting series of images at a rate of 400,000 frames/sec. The objectives of the balloon demonstrator are threefold: a) perform a full end-to-end test of a JEM-EUSO prototype consisting of all the main subsystems of the space experiment, b) measure the effective terrestrial UV background, with a spatial and temporal resolution relevant for JEM-EUSO. c) detect tracks of ultraviolet light from near space for the first time. The latter is a milestone in the development of UHECR science, paving the way for any future space-based UHECR observatory. On August 25, 2014, EUSO-Balloon was launched from Timmins Stratospheric Balloon Base (Ontario, Canada) by the balloon division of the French Space Agency CNES. From a float altitude of 38 km, the instrument operated during the entire astronomical night, observing UV-light from a variety of ground-covers and from hundreds of simulated EASs, produced by flashers and a laser during a two-hour helicopter under-flight.
    Full-text · Article · Aug 2015 · Experimental Astronomy
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    ABSTRACT: Ultra high energy photons and neutrinos are carriers of very important astrophysical information. They may be produced at the sites of cosmic ray acceleration or during the propagation of the cosmic rays in the intergalactic medium. In contrast to charged cosmic rays, photon and neutrino arrival directions point to the production site because they are not deflected by the magnetic fields of the Galaxy or the intergalactic medium. In this work we study the characteristics of the longitudinal development of showers initiated by photons and neutrinos at the highest energies. These studies are relevant for development of techniques for neutrino and photon identification by the JEM-EUSO telescope. In particular, we study the possibility of observing the multi-peak structure of very deep horizontal neutrino showers with JEM-EUSO. We also discuss the possibility to determine the flavor content of the incident neutrino flux by taking advantage of the different characteristics of the longitudinal profiles generated by different type of neutrinos. This is of grate importance for the study of the fundamental properties of neutrinos at the highest energies. Regarding photons, we discuss the detectability of the cosmogenic component by JEM-EUSO and also estimate the expected upper limits on the photon fraction which can be obtained from the future JEM-EUSO data for the case in which there are no photons in the samples.
    Full-text · Article · Jul 2015 · Experimental Astronomy
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    ABSTRACT: Mounted on the International Space Station(ISS), the Extreme Universe Space Observatory, on-board the Japanese Experimental Module (JEM-EUSO), relies on the well established fluorescence technique to observe Extensive Air Showers (EAS) developing in the earth’s atmosphere. Focusing on the detection of Ultra High Energy Cosmic Rays (UHECR) in the decade of 1020eV, JEM-EUSO will face new challenges by applying this technique from space. The EUSO Simulation and Analysis Framework (ESAF) has been developed in this context to provide a full end-to-end simulation frame, and assess the overall performance of the detector. Within ESAF, angular reconstruction can be separated into two conceptually different steps. The first step is pattern recognition, or filtering, of the signal to separate it from the background. The second step is to perform different types of fitting in order to search for the relevant geometrical parameters that best describe the previously selected signal. In this paper, we discuss some of the techniques we have implemented in ESAF to perform the geometrical reconstruction of EAS seen by JEM-EUSO. We also conduct thorough tests to assess the performances of these techniques in conditions which are relevant to the scope of the JEM-EUSO mission. We conclude by showing the expected angular resolution in the energy range that JEM-EUSO is expected to observe.
    Full-text · Article · Jul 2015 · Experimental Astronomy
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    ABSTRACT: The main goal of the JEM-EUSO experiment is the study of Ultra High Energy Cosmic Rays (UHECR, 1019−1021eV), but the method which will be used (detection of the secondary light emissions induced by cosmic rays in the atmosphere) allows to study other luminous phenomena. The UHECRs will be detected through the measurement of the emission in the range between 290 and 430 m, where some part of Transient Luminous Events (TLEs) emission also appears. This work discusses the possibility of using the JEM-EUSO Telescope to get new scientific results on TLEs. The high time resolution of this instrument allows to observe the evolution of TLEs with great precision just at the moment of their origin. The paper consists of four parts: review of the present knowledge on the TLE, presentation of the results of the simulations of the TLE images in the JEM-EUSO telescope, results of the Russian experiment Tatiana–2 and discussion of the possible progress achievable in this field with JEM-EUSO as well as possible cooperation with other space projects devoted to the study of TLE – TARANIS and ASIM. In atmospheric physics, the study of TLEs became one of the main physical subjects of interest after their discovery in 1989. In the years 1992 – 1994 detection was performed from satellite, aircraft and space shuttle and recently from the International Space Station. These events have short duration (milliseconds) and small scales (km to tens of km) and appear at altitudes 50 – 100 km. Their nature is still not clear and each new experimental data can be useful for a better understanding of these mysterious phenomena.
    Full-text · Article · Jul 2015 · Experimental Astronomy
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    ABSTRACT: The Extreme Universe Space Observatory (EUSO) on–board the Japanese Experimental Module (JEM) of the International Space Station aims at the detection of ultra high energy cosmic rays from space. The mission consists of a UV telescope which will detect the fluorescence light emitted by cosmic ray showers in the atmosphere. The mission, currently developed by a large international collaboration, is designed to be launched within this decade. In this article, we present the reconstruction of the energy of the observed events and we also address the Xmax reconstruction. After discussing the algorithms developed for the energy and Xmax reconstruction, we present several estimates of the energy resolution, as a function of the incident angle, and energy of the event. Similarly, estimates of the Xmax resolution for various conditions are presented.
    Full-text · Article · Jul 2015 · Experimental Astronomy
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    ABSTRACT: We present an extraction of azimuthal correlations between two pairs of charged pions detected in opposite jets from electron-positron annihilation. These correlations may arise from the dependence of the di-pion fragmentation on the polarization of the parent quark in the process $e^+e^- \rightarrow q \bar{q}$. Due to the correlation of the quark polarizations, the cross-section of di-pion pair production, in which the pion pairs are detected in opposite jets in a dijet event, exhibits a modulation in the azimuthal angles of the planes containing the hadron pairs with respect to the production plane. The measurement of this modulation allows access to combinations of fragmentation functions that are sensitive to the quark's transverse polarization and helicity. Within our uncertainties we do not observe a significant signal from the previously unmeasured helicity dependent fragmentation function $G_1^\perp$. This measurement uses a dataset of 938~fb$^{-1}$ collected by the Belle experiment at or near $\sqrt{s}\approx10.58$ GeV.
    Full-text · Article · May 2015
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    ABSTRACT: Toxoplasmic encephalitis represents a rare, but often fatal infection after allogeneic hematopoietic stem cell transplantation. Polymerase chain reaction (PCR)-based preemptive therapy is considered promising for this disease, but is not routinely applied, especially in low seroprevalence countries including Japan. We encountered 2 cases of toxoplasmic encephalitis after transplantation that were successfully treated. The diagnosis of toxoplasmic encephalitis in these cases was confirmed by PCR testing when neurological symptoms were observed. Both patients received pyrimethamine and sulfadiazine treatments within 2 weeks of the development of neurological symptoms, and remained free of recurrence for 32 and 12 months. These results emphasized the importance of the PCR test and immediate treatment after diagnosis for the management of toxoplasmic encephalitis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Full-text · Article · May 2015 · Transplant Infectious Disease
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    ABSTRACT: The renal tissue renin-angiotensin system is activated in chronic kidney diseases. We previously demonstrated that intrarenal angiotensin II is synthesized primarily from the liver-derived angiotensinogen filtered through the glomerulus and that podocyte injury increases the passage of angiotensinogen into the tubular lumen and generation of angiotensin II. In the present study, we tested the effect of cessation of glomerular filtration by ureteral obstruction on renal angiotensin II generation in kidneys with podocyte injury under two experimental conditions. Ureteral obstruction is known to activate the renin-angiotensin system in non-proteinuric kidneys. Transgenic mice expressing hCD25 in podocyte (NEP25) were injected with 1.25 or 10 ng/g body weight of LMB2, a hCD25-targeted immunotoxin, subjected to unilateral ureteral ligation on the following day, and sacrificed 7 and 4 days later, respectively. In both experiments, compared to the kidney in untreated wild-type mice, renal angiotensinogen protein assessed by immunostaining and Western analysis was increased in the contralateral unobstructed kidney. However, it was markedly decreased in the obstructed kidney. Whereas intrarenal angiotensin II content was increased in the contralateral kidney compared to the untreated kidney (248±83 vs. 106±21 and 298±185 vs. 64.8±20 fmol/g kidney, respectively), this increase was suppressed in the obstructed kidney (161±75 and 113±34, respectively), a pattern opposite to what we expected in obstructed kidneys without podocyte injury. Thus, our study indicates that the major source of increased renal angiotensin II in podocyte injury is filtered angiotensinogen. Copyright © 2014, American Journal of Physiology - Renal Physiology.
    Preview · Article · Feb 2015 · American journal of physiology. Renal physiology
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    ABSTRACT: Previous autopsy studies suggested that a reduced nephron number is associated with increased risk of hypertension and chronic kidney disease. However, the significance of the nephron number estimated from a renal biopsy in patients with hypertensive nephrosclerosis (HNS) has not yet been elucidated. In this cross-sectional study, we examined the clinicopathological findings of biopsy-proven HNS patients with preserved renal function (estimated glomerular filtration rate ≥ 60ml/min/1.73 m(2)). The glomerular density (GD; the number of glomeruli per total renal cortical area) in biopsy specimens was evaluated as a surrogate of the nephron number. Renal biopsies from kidney transplant donors were used as healthy controls. A total of 58 HNS patients were enrolled. The GD value in the HNS patients was low compared with those in the kidney transplant donors (2.0 vs. 3.2 /mm(2)). These differences remained significant when globally sclerotic glomeruli were included in the calculation of the GD. Of note, the GD in HNS patients with overt proteinuria (≥1g/day) was significantly lower than that of HNS patients with mild proteinuria (<1g/day; 1.8 vs. 2.2/mm(2), P = 0.014). In contrast, other histopathological parameters, including the severity of global glomerulosclerosis, interstitial fibrosis/tubular atrophy and arterial and arteriole lesions were comparable between the 2 HNS subgroups. In addition, the GD was identified as a factor that was associated with the amount of urinary protein excretion at biopsy, independent of other clinicopathological factors. These results suggest that a low GD is a renal histological characteristic of HNS patients, especially those with overt proteinuria. © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
    No preview · Article · Jan 2015 · American Journal of Hypertension
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    ABSTRACT: Allogeneic hematopoietic SCT (allo-SCT) is a promising therapy that may provide long-term durable remission for adult T-cell leukemia-lymphoma (ATL) patients; however, the incidence of relapse associated with ATL remains high. To determine the clinical features of these patients at relapse, we retrospectively analyzed tumor lesions in 30 or 49 patients who relapsed following allo-SCT or chemotherapy (CHT), respectively, at three institutions in Nagasaki prefecture between 1997 and 2011. A multivariate analysis revealed that the development of abnormal lymphocytes in the peripheral blood of patients at relapse was less frequent after allo-SCT than after CHT (P<0.001). Furthermore, relapse with a new lesion only in the absence of the primary lesion was more frequent in allo-SCT (P=0.014). Lesions were more frequently observed in the central nervous systems of patients who relapsed with new lesions only (P=0.005). Thus, the clinical manifestation of relapsed ATL was slightly complex, especially in post-transplant patients. Our results emphasized the need to develop adoptive modalities for early and accurate diagnoses of relapsed ATL.Bone Marrow Transplantation advance online publication, 26 January 2015; doi:10.1038/bmt.2014.308.
    No preview · Article · Jan 2015 · Bone Marrow Transplantation

Publication Stats

11k Citations
2,430.80 Total Impact Points


  • 2003-2015
    • The Jikei University School of Medicine
      • • Department of Internal Medicine
      • • Division of Kidney and Hypertension
      Edo, Tōkyō, Japan
    • High Energy Accelerator Research Organization
      • Institute of Particle and Nuclear Studies
      Tsukuba, Ibaraki, Japan
    • Toyohashi Sozo College
      Toyohasi, Aichi, Japan
  • 1996-2015
    • Nagasaki University
      • • School of Medicine
      • • Department of Internal Medicine
      Nagasaki, Nagasaki, Japan
  • 2014
    • Kyushu University
      • Department of Physics
      Hukuoka, Fukuoka, Japan
  • 2005-2014
    • Nagoya University
      • Graduate School of Science
      Nagoya, Aichi, Japan
    • Peking University
      • School of Electronics Engineering and Computer Science
      Peping, Beijing, China
      Nagoya, Aichi, Japan
  • 2013
    • Fukui University of Technology
      Hukui, Fukui, Japan
  • 2012
    • Novosibirsk State University
      Novo-Nikolaevsk, Novosibirsk, Russia
  • 2011-2012
    • Seoul National University
      • Department of Physics and Astronomy
      Sŏul, Seoul, South Korea
    • Panjab University
      Chandigarh, Chandīgarh, India
    • Tohoku University
      • Research Center for Electron Photon Science
      Sendai, Kagoshima-ken, Japan
  • 2009-2012
    • University of Seoul
      Sŏul, Seoul, South Korea
  • 1994-2011
    • Sapporo Medical University
      • • School of Medicine
      • • Division of Urology
      Sapporo, Hokkaidō, Japan
  • 1990-2011
    • Nagasaki University Hospital
      Nagasaki, Nagasaki, Japan
  • 2010
    • Kyungpook National University
      Daikyū, Daegu, South Korea
  • 2006-2010
    • École Polytechnique Fédérale de Lausanne
      Lausanne, Vaud, Switzerland
    • Tata Institute of Fundamental Research
      • Department of Biological Sciences
      Mumbai, Mahārāshtra, India
    • Virginia Polytechnic Institute and State University
      • Department of Chemical Engineering
      Blacksburg, Virginia, United States
  • 2006-2009
    • National Taiwan University
      • Department of Physics
      Taipei, Taipei, Taiwan
  • 2008
    • Justus-Liebig-Universität Gießen
      Gieben, Hesse, Germany
    • The Graduate University for Advanced Studies
      Миура, Kanagawa, Japan
  • 2006-2008
    • Institut für Hochenergiephysik Wien
      Wien, Vienna, Austria
    • Budker Institute of Nuclear Physics
      Novo-Nikolaevsk, Novosibirsk, Russia
    • Institute for Theoretical and Experimental Physics
      Moskva, Moscow, Russia
  • 2007
    • Jožef Stefan Institute
      Lubliano, Ljubljana, Slovenia
    • Institute of High Energy Physics
      Protvino, Moskovskaya, Russia
    • Fu Jen Catholic University
      • Department of Physics
      Taipei, Taipei, Taiwan
    • Institute of Nuclear Physics
      Cracovia, Lesser Poland Voivodeship, Poland
  • 2006-2007
    • Kanagawa University
      Yokohama, Kanagawa, Japan
    • University of Cincinnati
      • Department of Physics
      Cincinnati, Ohio, United States
    • Hefei University of Technology
      Luchow, Anhui Sheng, China
  • 2002-2005
    • University of Florida
      • Department of Materials Science and Engineering
      Gainesville, Florida, United States
    • Academia Sinica
      • Institute of Physics
      Taipei, Taipei, Taiwan
  • 2000-2004
    • Università di Pisa
      Pisa, Tuscany, Italy
  • 1993-2004
    • Kansai Medical University
      • First Department of Internal Medicine
      Moriguchi, Ōsaka, Japan
  • 2000-2003
    • Osaka City University
      Ōsaka, Ōsaka, Japan
  • 1998-2002
    • Vanderbilt University
      • • Department of Pediatrics
      • • Department of Medicine
      Нашвилл, Michigan, United States
    • Shinshu University
      • Faculty of Science
      Shonai, Nagano, Japan
  • 1995-1999
    • Oita University
      • Second Department of Internal Medicine
      Ōita, Ōita, Japan