W. Zhang

University of South Alabama, Mobile, Alabama, United States

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Publications (361)672.6 Total impact

  • Source

    Full-text · Dataset · Jan 2016
  • J Liu · H H Jiang · D K Wu · Y X Zhou · H M Ye · X Li · Z Y Luo · Z Guo · Y L Zhang · Y C Wang · W Zhang · H H Zhou · L S Wang
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    ABSTRACT: The adverse reactions of warfarin that were found mainly occurred in the first month. This study was carried out to observe the effect of gene polymorphisms on the warfarin therapy at the initial stage. Four-hundred and sixty Chinese patients began warfarin treatment with daily 2.5 mg after heart valve replacement operations were enrolled. The daily international normalized ratio (INR) for anticoagulation were recorded till the seventh day. Blood samples were collected and used to detect genotypes for VKORC1 rs7294, CYP2C9 rs1057910, CYP4F2 rs2108622 and ORM1 rs17650. INR and their changes were compared among genotypes. INR was partially correlated with the VKORC1 rs7294, CYP2C9 rs1057910, CYP4F2 rs2108622 and ORM1 rs17650 polymorphisms from the third, fourth and sixth day on, respectively. VKORC1 rs7294 and CYP4F2 rs2108622 carriers responded lower than the wild genotype, whereas CYP2C9 rs1057910 and ORM1 rs17650 carriers responded higher, respectively. Fifty percent of AA/*1*3/CC/*S*S patients and 16% of AA/*1*1/CC/*S*S patients were over anticoagulation treated with INR >4.0 at the third day. Ninety percent of VKORC1 rs7294 carrier patients have INR <1.63, a mark of the 25% of lower responders of the wild genotype. Our study provided another kind of evidence that VKORC1 rs7294, CYP2C9 rs1057910, CYP4F2 rs2108622 and ORM1 rs17650 affected the action of warfarin in different styles. Patients with AA/*1*1/CC/*S*S, AA/*1*3/CC/*S*S should use a less initial dosage to avoid over anticoagulation, and patients with VKORC1 rs7294 should use larger initial dose to proof an effective therapy.The Pharmacogenomics Journal advance online publication, 8 December 2015; doi:10.1038/tpj.2015.81.
    No preview · Article · Dec 2015 · The Pharmacogenomics Journal
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    ABSTRACT: As CMOS scales down, hot carrier aging (HCA) scales up and can be a limiting aging process again. This has motivated re-visiting HCA, but recent works have focused on accelerated HCA by raising stress biases and there is little information on HCA under use-biases. Early works proposed that HCA mechanism under high and low biases are different, questioning if the high-bias data can be used for predicting HCA under use-bias. A key advance of this work is proposing a new methodology for evaluating the HCA-induced variation under use-bias. For the first time, the capability of predicting HCA under use-bias is experimentally verified. The importance of separating RTN from HCA is demonstrated. We point out the HCA measured by the commercial Source- Measure-Unit (SMU) gives erroneous power exponent. The proposed methodology minimizes the number of tests and the model requires only 3 fitting parameters, making it readily implementable.
    Full-text · Conference Paper · Dec 2015
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    Full-text · Article · Dec 2015 · Critical care medicine
  • X. Tong · F. Luo · Y. Liu · W. Zhang · Q. Xu · T. Zhang · J. Li · L. Chen · C.M.C. Ma

    No preview · Article · Nov 2015 · International journal of radiation oncology, biology, physics
  • D. Lü · Y. Liu · W. Zhang · Z. Du
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    ABSTRACT: Influence of solution temperature and solution time on microstructure, properties and surface quality of YL113 alloy cast by vacuum high pressure die casting was studied. The results show that, when the solution at temperature more than 505℃ for 15 min, or when the solution time at 490℃ for more than 20 min, there will be easy to generate crack in the microstructure and blisters on the surface of the YL113 alloy engine block cast by vacuum die casting. For the YL113 alloy engine block cast by vacuum die casting, high temperature solution treatment in short-time (solution temperature 490℃, solution time 15 min) can significantly improve the microhardness of the matrix, i. e. higher than that of as cast by 51%, which is mainly attributed to the dissolution of the second phase and significant granulation of eutectic Si phase. ©, 2015, Chinese Mechanical Engineering Society of Heat Treatment. All right reserved.
    No preview · Article · Oct 2015
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    Full-text · Article · Oct 2015 · Nature
  • Z. Yang · H. Liu · Y. Ren · Z. Sun · D. Shao · W. Zhang · B. Sun · W. Tang · S. Nie
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    ABSTRACT: Objective: To study the effect of estrogen on acute lung injury patients with paraquat (PQ) poisoning. Methods: Ninety-six SD rats were randomly (random number) divided into four groups, namely control group, estrogen control group, poisoning of Paraquat (PQ) and PQ treated with estrogen group. The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase in rat lungs tissue were determined at different intervals. The histopathological changes of lung tissue of rats were observed under optic microscope in each group at 14 day. Results: The estrogen decreased the concentration of MDA and activity of SOD and glutathione peroxidase in case of acute poisoning of Paraquat (P<0.05). At same time, treatment with estrogen could alleviate the lung injury and inflammatory cell infiltration in the interstitium of lung. Conclusions: The estrogen can reduce the degree of oxidative stress in case of acute poisoning of Paraquat, alleviating the lung injury.
    No preview · Article · Oct 2015
  • L. Yao · P. Hong · W. Zhang · J. Li · D. Ni
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    ABSTRACT: The SDN architecture decouples the control plane and data plane, and multiple controllers are adopted to solve the scalability and reliability problem in SDN. However, most of the researches are focused on the control architecture and ignore the controller placement problem. Moreover, the mapping between the switches and controllers are static in current proposals, which will lead to the load unbalance of controllers under dynamic flow variations. In this paper, we define a new controller placement metric considering the node weight for a single domain at first, and then propose a dynamic switch migration algorithm to adapt to the flow dynamics and realize controller load balance in multiple SDN domains. Finally, a simple simulation platform is built to verify the proposed scheme.
    No preview · Article · Sep 2015
  • W. Zhang · P. Hong · L. Yao · J. Li · D. Ni
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    ABSTRACT: SDN is a novel network architecture that separates the control plane from the data plane. It usually utilizes a centralized controller to manage all the switches in the network. With the expanding of network scale, both the complexity of computing routes and the amount of messages exchanged between controller and switches are increasing sharply. The limited performance of a single controller will cause congestion in the control plane. Some schemes have been proposed to solve this problem by dividing the network into multiple domains. In this paper, we propose a cross-domain source routing scheme for multi-domain network combining the thinking of source routing with pre-routing. The cross-domain flow set-up requests are generated only in the source domain and the destination domain. Each controller just needs to bear the load that related to the local traffic. The simulation results show that the scheme can reduce the load of controllers comparing with other schemes.
    No preview · Article · Sep 2015
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    ABSTRACT: The nearly continuous light curves with micromagnitude precision provided by the space mission Kepler are revolutionising our view of pulsating stars. They have revealed a vast sea of low-amplitude pulsation modes that were undetectable from Earth. The long time base of Kepler light curves allows an accurate determination of frequencies and amplitudes of pulsation modes needed for in-depth asteroseismic modeling. However, for an asteroseismic study to be successful, the first estimates of stellar parameters need to be known and they can not be derived from the Kepler photometry itself. The Kepler Input Catalog (KIC) provides values for the effective temperature, the surface gravity and the metallicity, but not always with a sufficient accuracy. Moreover, information on the chemical composition and rotation rate is lacking. We are collecting low-resolution spectra for objects in the Kepler field of view with the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, Xinglong observatory, China). All of the requested fields have now been observed at least once. In this paper we describe those observations and provide a database of use to the whole astronomical community.
    Full-text · Article · Aug 2015 · The Astrophysical Journal Supplement Series
  • Z Zeng · S Fan · X Zhang · S Li · M Zhou · W Xiong · M Tan · W Zhang · G Li
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    ABSTRACT: EBER-1 (a non-coding RNA transcribed by EBV) expression was detected in most of Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) patients. However, the relevance between EBER-1 expression and NPC clinical outcome has not been reported. This study aims to assess the possible correlations of EBER-1 expression and clinical parameters and its potential prognostic predictive ability in NPC patient's outcomes. We examined EBER-1 mRNA expression in 301 NPC and 130 non-NPC tissues using in situ hybridization and did statistics. EBER-1 expression was up-regulated in NPC tissues when compared to non-NPC tissues. A receiver operating characteristic analysis revealed that EBER-1 expression could distinguish non-cancerous patients from NPC patients (p < 0.001, sensitivity: 72.5 %, specificity: 83.5 %, AUC = 0.815). A survival analysis revealed that patients with high levels of EBER-1 expression had a significantly good prognosis (Disease-free survival: p = 0.019, overall survival: p = 0.006). These results indicated that EBER-1 expression is a potential prognosis factor of NPC and highly negative correlated with the progress of NPC.
    No preview · Article · Aug 2015 · Clinical and Translational Oncology
  • X. Ren · W. Zhang · S. Ouyang · J. Ye · Z. Wang · C. Wu
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    ABSTRACT: The effect of ferric oxide (i.e., Fe2O3) on the structure and reactivity of typical alite in the simultaneous presence of Na+, K+, etc. was investigated by X-ray powder diffraction with the Rietveld method, thermoluminescence and isothermal calorimetry, respectively. The results show that there is no change on the polymorphic form of alite, the lattice parameter of alite varies linearly with iron content and has a discontinuity at 0.6% Fe2O3 due to the flexible substitution pattern of Fe, which follows the Vegard's law. The original thermoluminescence intensity and hydration reactivity were greatly decreased. It is demonstrated that there is a positive correlation between the hydration reactivity and the original thermoluminescence, which mainly pans out during the nucleation and growth process. This phenomenon could be due to the extra energy stored in alite. Based on these findings, the mechanism of how Fe affects the reactivity of alite was proposed.
    No preview · Article · Aug 2015 · Kuei Suan Jen Hsueh Pao/ Journal of the Chinese Ceramic Society
  • C. Liang · Y. Zhai · D. Xu · N. Ye · X. Zhang · Y. Wang · W. Zhang · J. Yu
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    ABSTRACT: Recently, H. pluvialis has been demonstrated to have significant potential for biofuel production. To explore the correlation between total lipid content and other physiological parameters under s tress conditions, the responses of H. pluvialis to high light intensity (HL), nitrogen deprivation (-N), and high light intensity with nitrogen deprivation (HL-N) were investigated. The total lipid content in the control cells was 12.01% dw, whereas that of the cells exposed to HL, -N, and HL-N conditions was 56.92, 46.71, and 46.87% dw, respectively. The fatty acid profile was similar under all conditions, with the main components including palmitic acid, linoleic acid, and linolenic acid. A good correlation was found between individual carotenoid and total lipids, regardless of culture conditions. P hotosynthetic parameters and lipid content were also found to be well-correlated.
    No preview · Article · Jun 2015 · Grasas y Aceites
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    ABSTRACT: Objective To investigative the chemical components of Subergorgia suberosa collected from the South China Sea. Methods The Et2 O extract of S. Suberosa was purified by repeated column chromatography on silica gel, Sephadex LH- 20 , ODS, and semi-preparative RP-HPLC. The structures of obtained compounds were determined by spectroscopic analysis and comparison with previously reported data. The anti-tumor activity of 10 obtained 9, 11-secosterols were tested with human lung adenocarcinoma A549 cell line and human osteo—sarcoma MG63 cell line; the antifungal activities of them were tested with Candida albicans and Aspergillus /umigatus in vitro. Results and Conclusion Ten 9, 11—secosterols were isolated from Subergorgia suberosa collected from the South China Sea. Compounds 2 and 7 have been obtained for the first time from the genus of gorgonian Subergorgia. In vitro anti-tumor experiment showed that compounds 3 6 and 9 had different degrees of tumor inhibitory effects against cell lines A549 and MG63, with the ICs0 values being 6. 31, 30. 42, 8. 33, 9. 57 and 3. 30 0g/ mL for A549 cell line and 30. 83, 21. 32, 9. 19, 28. 01 and 8. 62 0g/mL for MG63 cell line, respectively. The ten steroids showed no anti-fungi activity against Candida albicans or Aspergillus /umigatus in vitro. © 2015, Second Military Medical University Press. All rights reserved.
    No preview · Article · Jun 2015 · Academic Journal of Second Military Medical University
  • X Tong · F Luo · Y Liu · W Zhang · Q Xu · T Zhang · J Li · L Chen · C Ma
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    ABSTRACT: Extensive in vitro and in vivo studies have shown that pulsed low dose rate (PLDR) radiotherapy has potential to provide significant local tumor control and to reduce normal tissue toxicities. This work investigated the planning and dosimetry of PLDR re-irradiation for recurrent cancers. We analyzed the treatment plans and dosimetry for 13 recurrent patients who were treated with the PLDR technique in this study. All cases were planned with the 3DCRT technique with optimal beam angle selection. The treatment was performed on a Siemens accelerator using 6MV beams. The target volume ranged between 161 and 703cc. The previous RT dose was 40-60Gy while the re-irradiation dose was 16-60Gy. The interval between previous RT and re-irradiation was 13-336 months, and the follow-up time was up to 27months. The total prescription dose was administered in 2Gy/day fractions with the daily dose delivered in 10 sub-fractions (pulses) of 20cGy with a 3min interval between the pulses to achieve an effective dose rate of 6.7cGy/min. The clinical outcome was analyzed based on the treatment plans. All pulses were kept with Dmax<40cGy. The PLDR treatments were effective (CR: 3 patients, PR: 10 patients). The acute and late toxicities were all acceptable (generally grade II or under). Two patients died three months after the PLDR re-irradiation, one due to massive cerebral infarction and the other due to acute cardiac failure. All others survived more than 8 months. Five patients showed good conditions at the last follow-up. Among them two recurrent lung cancer patients had survived 23 months and one nasopharyngeal cancer patient had survived 27 months. The PLDR technique was effective for the palliative treatment of head and neck, lung, spine and GYN cancers. Further phase II and III studies are warranted to quantify the efficacy of PLDR for recurrent cancers.
    No preview · Article · Jun 2015 · Medical Physics
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    ABSTRACT: Although the role of the ErbB2/HER2 oncogene in cancers has been extensively studied, how ErbB2 is regulated remains poorly understood. A novel microRNA, mir-4728, was recently found within an intron of the ErbB2 gene. However, the function and clinical relevance of this intronic miRNA are completely unknown. Here, we demonstrate that mir-4728 is a negative regulator of MAPK signaling through directly targeting the ERK upstream kinase MST4 and exerts numerous tumor-suppressive properties in vitro and in animal models. Importantly, our patient sample study shows that mir-4728 was under-expressed in breast tumors compared with normal tissue, and loss of mir-4728 correlated with worse overall patient survival. These results strongly suggest that mir-4728 is a tumor-suppressive miRNA that controls MAPK signaling through targeting MST4, revealing mir-4728's significance as a potential prognostic factor and target for therapeutic intervention in cancer. Moreover, this study represents a conceptual advance by providing strong evidence that a tumor-suppressive miRNA can antagonize the canonical signaling of its host oncogene.
    Full-text · Article · May 2015 · Cell Death & Disease
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    ABSTRACT: The Large sky Area Multi-Object Spectroscopic Telescope (LAMOST) General Survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects both in the pilot survey and the first year general survey are included in the LAMOST First Data Release (DR1). The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The general survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2,955,336 spectra, of which 1,790,879 spectra have observed signal-to-noise S/N >10. All data with S/N>2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2,204,696 spectra, of which 1,944,329 are stellar spectra, 12,082 are galaxy spectra and 5,017 are quasars. The DR1 includes not only spectra, but also three stellar catalogues with measured parameters: AFGK-type stars with high quality spectra (1,061,918 entries), A-type stars (100,073 entries), and M stars (121,522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. Description of the FITS structure of spectral files and parameter catalogues is also provided.
    Full-text · Article · May 2015
  • Z. Wang · H. Wu · M. Fan · L. Zhang · W. Zhang · Y. Rao
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    ABSTRACT: We theoretically investigate the role of point reflector's reflectivity in the performance of forward-pumped high power random fiber lasing, and demonstrate that the maximum 1st-oder random lasing output power can even increase when the reflectivity decreases from 0.9 to 0.01.
    No preview · Article · May 2015
  • Q. Sun · X. Luo · Y.Q. Yang · B. Huang · N. Jin · W. Zhang · G.M. Zhao
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    ABSTRACT: The model based on fracture mechanics is developed to evaluate the fracture toughness Γ of the fiber/matrix interface in titanium alloys reinforced by SiC monofilaments. Theoretical model for single fiber push-out testing is obtained by shear-lag method. The influences of several key factors (such as the applied stress needed for crack advance, crack length, and interfacial frictional shear stress) are discussed. Using the model, the interfacial toughness of typical composites including Sigma1240/Ti-6-4, SCS-6/Ti-6-4, SCS-6/Timetal 834, SCS-6/Timetal 21s, SCS-6/Ti-24-11 and SCS-6/Ti-15-3 are successfully predicted compared with previous results of these composites. It is verified that the model can reliably predict the interfacial toughness of the titanium matrix composites as well as other metal matrix composites, due to interfacial debonding usually occurs at the bottom face of the samples in such composites.
    No preview · Article · May 2015 · Composites Part B Engineering

Publication Stats

5k Citations
672.60 Total Impact Points


  • 2015
    • University of South Alabama
      Mobile, Alabama, United States
    • Qingdao University of Science and Technology
      Tsingtao, Shandong Sheng, China
  • 2011-2015
    • Northwestern Polytechnical University
      • • State Key Laboratory of Solidification Processing
      • • Key Laboratory for Space Bioscience and Biotechnology
      Xi’an, Liaoning, China
    • Sun Yat-Sen University
      • State Key Laboratory of Oncology
      Shengcheng, Guangdong, China
    • Xidian University
      • School of Mechano-Electronic Engineering
      Ch’ang-an, Shaanxi, China
  • 2009-2015
    • Central South University
      • • Clinical Pharmacy and Pharmacology Research Institute
      • • Key Laboratory of Carcinogenesis
      • • State Key Laboratory of Powder Metallurgy
      Ch’ang-sha-shih, Hunan, China
    • Chinese Academy of Sciences
      • • Institute of Genetics and Developmental Biology
      • • Institute of Semiconductors
      • • Key Laboratory of Semiconductor Materials
      Peping, Beijing, China
    • Beijing University of Technology
      Peping, Beijing, China
    • Chinese Center For Disease Control And Prevention
      • Institute for Nutrition and Food Safety
      Peping, Beijing, China
  • 2014
    • University of Southern Denmark
      • Institute of Sports Science and Clinical Biomechanics
      Odense, South Denmark, Denmark
    • Lanzhou University of Technology
      Kao-lan-hsien, Gansu Sheng, China
  • 2013-2014
    • Zhejiang University
      Hang-hsien, Zhejiang Sheng, China
    • Peking Union Medical College Hospital
      • Department of Rheumatology
      Peping, Beijing, China
    • Cancer Research Institute
      New York, New York, United States
  • 2009-2014
    • Loma Linda University
      • School of Dentistry
      Loma Linda, California, United States
  • 2008-2014
    • University of Nottingham
      • Division of Academic Rheumatology
      Nottigham, England, United Kingdom
    • Nanjing Sanhome Pharmaceutical Co., Ltd.
      Nan-ching, Jiangsu, China
  • 2006-2014
    • Hefei Institute of Physical Sciences, Chinese Academy of Sciences
      Luchow, Anhui Sheng, China
  • 2010-2013
    • Flinders University
      • School of Medicine
      Tarndarnya, South Australia, Australia
    • Tongji Hospital
      Wu-han-shih, Hubei, China
  • 2009-2013
    • Shanghai Jiao Tong University
      • Department of Materials Science and Engineering (MSE)
      Shanghai, Shanghai Shi, China
    • Liverpool John Moores University
      • Electrical Electronic Engineering Research Centre
      Liverpool, England, United Kingdom
    • Peking University
      • Laboratory of Nano/Micro Fabrication Technology
      Peping, Beijing, China
  • 2007-2013
    • Fourth Military Medical University
      • • Department of Urology
      • • Department of General Surgery
      • • Department of Biochemistry and Molecular Biology
      Xi’an, Liaoning, China
  • 2012
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
    • Second Military Medical University, Shanghai
      Shanghai, Shanghai Shi, China
    • China Academy of Traditional Chinese Medicine
      Peping, Beijing, China
  • 2011-2012
    • Tsinghua University
      Peping, Beijing, China
  • 2010-2012
    • Zhengzhou University
      Cheng, Henan Sheng, China
  • 2009-2012
    • Harbin Institute of Technology
      Charbin, Heilongjiang Sheng, China
  • 2004-2011
    • University of Michigan
      • Department of Surgery
      Ann Arbor, Michigan, United States
  • 2001-2010
    • Sichuan University
      • • Analytical Center
      • • Biotherapy and Cancer Centre
      Hua-yang, Sichuan, China
  • 2007-2008
    • The University of Edinburgh
      • Osteoarticular Research Group
      Edinburgh, Scotland, United Kingdom
  • 2003
    • Concordia University–Ann Arbor
      Ann Arbor, Michigan, United States
  • 1999
    • Georgetown University
      Washington, Washington, D.C., United States