[Show abstract][Hide abstract] ABSTRACT: The adverse reactions of warfarin that were found mainly occurred in the first month. This study was carried out to observe the effect of gene polymorphisms on the warfarin therapy at the initial stage. Four-hundred and sixty Chinese patients began warfarin treatment with daily 2.5 mg after heart valve replacement operations were enrolled. The daily international normalized ratio (INR) for anticoagulation were recorded till the seventh day. Blood samples were collected and used to detect genotypes for VKORC1 rs7294, CYP2C9 rs1057910, CYP4F2 rs2108622 and ORM1 rs17650. INR and their changes were compared among genotypes. INR was partially correlated with the VKORC1 rs7294, CYP2C9 rs1057910, CYP4F2 rs2108622 and ORM1 rs17650 polymorphisms from the third, fourth and sixth day on, respectively. VKORC1 rs7294 and CYP4F2 rs2108622 carriers responded lower than the wild genotype, whereas CYP2C9 rs1057910 and ORM1 rs17650 carriers responded higher, respectively. Fifty percent of AA/*1*3/CC/*S*S patients and 16% of AA/*1*1/CC/*S*S patients were over anticoagulation treated with INR >4.0 at the third day. Ninety percent of VKORC1 rs7294 carrier patients have INR <1.63, a mark of the 25% of lower responders of the wild genotype. Our study provided another kind of evidence that VKORC1 rs7294, CYP2C9 rs1057910, CYP4F2 rs2108622 and ORM1 rs17650 affected the action of warfarin in different styles. Patients with AA/*1*1/CC/*S*S, AA/*1*3/CC/*S*S should use a less initial dosage to avoid over anticoagulation, and patients with VKORC1 rs7294 should use larger initial dose to proof an effective therapy.The Pharmacogenomics Journal advance online publication, 8 December 2015; doi:10.1038/tpj.2015.81.
No preview · Article · Dec 2015 · The Pharmacogenomics Journal
[Show abstract][Hide abstract] ABSTRACT: As CMOS scales down, hot carrier aging (HCA) scales
up and can be a limiting aging process again. This has
motivated re-visiting HCA, but recent works have focused on
accelerated HCA by raising stress biases and there is little
information on HCA under use-biases. Early works proposed
that HCA mechanism under high and low biases are different,
questioning if the high-bias data can be used for predicting
HCA under use-bias. A key advance of this work is proposing
a new methodology for evaluating the HCA-induced variation
under use-bias. For the first time, the capability of predicting
HCA under use-bias is experimentally verified. The
importance of separating RTN from HCA is demonstrated.
We point out the HCA measured by the commercial Source-
Measure-Unit (SMU) gives erroneous power exponent. The
proposed methodology minimizes the number of tests and the
model requires only 3 fitting parameters, making it readily
[Show abstract][Hide abstract] ABSTRACT: Objective: To study the effect of estrogen on acute lung injury patients with paraquat (PQ) poisoning. Methods: Ninety-six SD rats were randomly (random number) divided into four groups, namely control group, estrogen control group, poisoning of Paraquat (PQ) and PQ treated with estrogen group. The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase in rat lungs tissue were determined at different intervals. The histopathological changes of lung tissue of rats were observed under optic microscope in each group at 14 day. Results: The estrogen decreased the concentration of MDA and activity of SOD and glutathione peroxidase in case of acute poisoning of Paraquat (P<0.05). At same time, treatment with estrogen could alleviate the lung injury and inflammatory cell infiltration in the interstitium of lung. Conclusions: The estrogen can reduce the degree of oxidative stress in case of acute poisoning of Paraquat, alleviating the lung injury.
[Show abstract][Hide abstract] ABSTRACT: The SDN architecture decouples the control plane and data plane, and multiple controllers are adopted to solve the scalability and reliability problem in SDN. However, most of the researches are focused on the control architecture and ignore the controller placement problem. Moreover, the mapping between the switches and controllers are static in current proposals, which will lead to the load unbalance of controllers under dynamic flow variations. In this paper, we define a new controller placement metric considering the node weight for a single domain at first, and then propose a dynamic switch migration algorithm to adapt to the flow dynamics and realize controller load balance in multiple SDN domains. Finally, a simple simulation platform is built to verify the proposed scheme.
[Show abstract][Hide abstract] ABSTRACT: SDN is a novel network architecture that separates the control plane from the data plane. It usually utilizes a centralized controller to manage all the switches in the network. With the expanding of network scale, both the complexity of computing routes and the amount of messages exchanged between controller and switches are increasing sharply. The limited performance of a single controller will cause congestion in the control plane. Some schemes have been proposed to solve this problem by dividing the network into multiple domains. In this paper, we propose a cross-domain source routing scheme for multi-domain network combining the thinking of source routing with pre-routing. The cross-domain flow set-up requests are generated only in the source domain and the destination domain. Each controller just needs to bear the load that related to the local traffic. The simulation results show that the scheme can reduce the load of controllers comparing with other schemes.
[Show abstract][Hide abstract] ABSTRACT: The nearly continuous light curves with micromagnitude precision provided by
the space mission Kepler are revolutionising our view of pulsating stars. They
have revealed a vast sea of low-amplitude pulsation modes that were
undetectable from Earth. The long time base of Kepler light curves allows an
accurate determination of frequencies and amplitudes of pulsation modes needed
for in-depth asteroseismic modeling. However, for an asteroseismic study to be
successful, the first estimates of stellar parameters need to be known and they
can not be derived from the Kepler photometry itself. The Kepler Input Catalog
(KIC) provides values for the effective temperature, the surface gravity and
the metallicity, but not always with a sufficient accuracy. Moreover,
information on the chemical composition and rotation rate is lacking. We are
collecting low-resolution spectra for objects in the Kepler field of view with
the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, Xinglong
observatory, China). All of the requested fields have now been observed at
least once. In this paper we describe those observations and provide a database
of use to the whole astronomical community.
Full-text · Article · Aug 2015 · The Astrophysical Journal Supplement Series
[Show abstract][Hide abstract] ABSTRACT: EBER-1 (a non-coding RNA transcribed by EBV) expression was detected in most of Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) patients. However, the relevance between EBER-1 expression and NPC clinical outcome has not been reported. This study aims to assess the possible correlations of EBER-1 expression and clinical parameters and its potential prognostic predictive ability in NPC patient's outcomes.
We examined EBER-1 mRNA expression in 301 NPC and 130 non-NPC tissues using in situ hybridization and did statistics.
EBER-1 expression was up-regulated in NPC tissues when compared to non-NPC tissues. A receiver operating characteristic analysis revealed that EBER-1 expression could distinguish non-cancerous patients from NPC patients (p < 0.001, sensitivity: 72.5 %, specificity: 83.5 %, AUC = 0.815). A survival analysis revealed that patients with high levels of EBER-1 expression had a significantly good prognosis (Disease-free survival: p = 0.019, overall survival: p = 0.006).
These results indicated that EBER-1 expression is a potential prognosis factor of NPC and highly negative correlated with the progress of NPC.
No preview · Article · Aug 2015 · Clinical and Translational Oncology
[Show abstract][Hide abstract] ABSTRACT: The effect of ferric oxide (i.e., Fe2O3) on the structure and reactivity of typical alite in the simultaneous presence of Na+, K+, etc. was investigated by X-ray powder diffraction with the Rietveld method, thermoluminescence and isothermal calorimetry, respectively. The results show that there is no change on the polymorphic form of alite, the lattice parameter of alite varies linearly with iron content and has a discontinuity at 0.6% Fe2O3 due to the flexible substitution pattern of Fe, which follows the Vegard's law. The original thermoluminescence intensity and hydration reactivity were greatly decreased. It is demonstrated that there is a positive correlation between the hydration reactivity and the original thermoluminescence, which mainly pans out during the nucleation and growth process. This phenomenon could be due to the extra energy stored in alite. Based on these findings, the mechanism of how Fe affects the reactivity of alite was proposed.
No preview · Article · Aug 2015 · Kuei Suan Jen Hsueh Pao/ Journal of the Chinese Ceramic Society
[Show abstract][Hide abstract] ABSTRACT: Recently, H. pluvialis has been demonstrated to have significant potential for biofuel production. To explore the correlation between total lipid content and other physiological parameters under s tress conditions, the responses of H. pluvialis to high light intensity (HL), nitrogen deprivation (-N), and high light intensity with nitrogen deprivation (HL-N) were investigated. The total lipid content in the control cells was 12.01% dw, whereas that of the cells exposed to HL, -N, and HL-N conditions was 56.92, 46.71, and 46.87% dw, respectively. The fatty acid profile was similar under all conditions, with the main components including palmitic acid, linoleic acid, and linolenic acid. A good correlation was found between individual carotenoid and total lipids, regardless of culture conditions. P hotosynthetic parameters and lipid content were also found to be well-correlated.
No preview · Article · Jun 2015 · Grasas y Aceites
[Show abstract][Hide abstract] ABSTRACT: Extensive in vitro and in vivo studies have shown that pulsed low dose rate (PLDR) radiotherapy has potential to provide significant local tumor control and to reduce normal tissue toxicities. This work investigated the planning and dosimetry of PLDR re-irradiation for recurrent cancers.
We analyzed the treatment plans and dosimetry for 13 recurrent patients who were treated with the PLDR technique in this study. All cases were planned with the 3DCRT technique with optimal beam angle selection. The treatment was performed on a Siemens accelerator using 6MV beams. The target volume ranged between 161 and 703cc. The previous RT dose was 40-60Gy while the re-irradiation dose was 16-60Gy. The interval between previous RT and re-irradiation was 13-336 months, and the follow-up time was up to 27months. The total prescription dose was administered in 2Gy/day fractions with the daily dose delivered in 10 sub-fractions (pulses) of 20cGy with a 3min interval between the pulses to achieve an effective dose rate of 6.7cGy/min.
The clinical outcome was analyzed based on the treatment plans. All pulses were kept with Dmax<40cGy. The PLDR treatments were effective (CR: 3 patients, PR: 10 patients). The acute and late toxicities were all acceptable (generally grade II or under). Two patients died three months after the PLDR re-irradiation, one due to massive cerebral infarction and the other due to acute cardiac failure. All others survived more than 8 months. Five patients showed good conditions at the last follow-up. Among them two recurrent lung cancer patients had survived 23 months and one nasopharyngeal cancer patient had survived 27 months.
The PLDR technique was effective for the palliative treatment of head and neck, lung, spine and GYN cancers. Further phase II and III studies are warranted to quantify the efficacy of PLDR for recurrent cancers.
[Show abstract][Hide abstract] ABSTRACT: Although the role of the ErbB2/HER2 oncogene in cancers has been extensively studied, how ErbB2 is regulated remains poorly understood. A novel microRNA, mir-4728, was recently found within an intron of the ErbB2 gene. However, the function and clinical relevance of this intronic miRNA are completely unknown. Here, we demonstrate that mir-4728 is a negative regulator of MAPK signaling through directly targeting the ERK upstream kinase MST4 and exerts numerous tumor-suppressive properties in vitro and in animal models. Importantly, our patient sample study shows that mir-4728 was under-expressed in breast tumors compared with normal tissue, and loss of mir-4728 correlated with worse overall patient survival. These results strongly suggest that mir-4728 is a tumor-suppressive miRNA that controls MAPK signaling through targeting MST4, revealing mir-4728's significance as a potential prognostic factor and target for therapeutic intervention in cancer. Moreover, this study represents a conceptual advance by providing strong evidence that a tumor-suppressive miRNA can antagonize the canonical signaling of its host oncogene.
Full-text · Article · May 2015 · Cell Death & Disease
[Show abstract][Hide abstract] ABSTRACT: The Large sky Area Multi-Object Spectroscopic Telescope (LAMOST) General
Survey is a spectroscopic survey that will eventually cover approximately half
of the celestial sphere and collect 10 million spectra of stars, galaxies and
QSOs. Objects both in the pilot survey and the first year general survey are
included in the LAMOST First Data Release (DR1). The pilot survey started in
October 2011 and ended in June 2012, and the data have been released to the
public as the LAMOST Pilot Data Release in August 2012. The general survey
started in September 2012, and completed its first year of operation in June
2013. The LAMOST DR1 includes a total of 1202 plates containing 2,955,336
spectra, of which 1,790,879 spectra have observed signal-to-noise S/N >10. All
data with S/N>2 are formally released as LAMOST DR1 under the LAMOST data
policy. This data release contains a total of 2,204,696 spectra, of which
1,944,329 are stellar spectra, 12,082 are galaxy spectra and 5,017 are quasars.
The DR1 includes not only spectra, but also three stellar catalogues with
measured parameters: AFGK-type stars with high quality spectra (1,061,918
entries), A-type stars (100,073 entries), and M stars (121,522 entries). This
paper introduces the survey design, the observational and instrumental
limitations, data reduction and analysis, and some caveats. Description of the
FITS structure of spectral files and parameter catalogues is also provided.
[Show abstract][Hide abstract] ABSTRACT: We theoretically investigate the role of point reflector's reflectivity in the performance of forward-pumped high power random fiber lasing, and demonstrate that the maximum 1st-oder random lasing output power can even increase when the reflectivity decreases from 0.9 to 0.01.
[Show abstract][Hide abstract] ABSTRACT: The model based on fracture mechanics is developed to evaluate the fracture toughness Γ of the fiber/matrix interface in titanium alloys reinforced by SiC monofilaments. Theoretical model for single fiber push-out testing is obtained by shear-lag method. The influences of several key factors (such as the applied stress needed for crack advance, crack length, and interfacial frictional shear stress) are discussed. Using the model, the interfacial toughness of typical composites including Sigma1240/Ti-6-4, SCS-6/Ti-6-4, SCS-6/Timetal 834, SCS-6/Timetal 21s, SCS-6/Ti-24-11 and SCS-6/Ti-15-3 are successfully predicted compared with previous results of these composites. It is verified that the model can reliably predict the interfacial toughness of the titanium matrix composites as well as other metal matrix composites, due to interfacial debonding usually occurs at the bottom face of the samples in such composites.
No preview · Article · May 2015 · Composites Part B Engineering