[Show abstract][Hide abstract] ABSTRACT: Di(2-ethylhexyl)phthalate (DEHP), a commonly used plasticiser, induces peroxisome proliferation and hepatocellular carcinomas in rodents on long-term exposure. We examined DEHP-induced biochemical changes that can be correlated with peroxisome proliferation and carcinogenicity. Hepatocellular carcinomas were induced following continuous administration of DEHP for 96 weeks. Rats fed DEHP showed enhanced hepatic lipid peroxidation, with a concomitant increase in adenosine triphosphatase activity. The levels of vitamin E and ascorbic acid declined significantly in animals treated with DEHP as compared to controls. These changes may contribute to the carcinogenic potential of peroxisome proliferators.
[Show abstract][Hide abstract] ABSTRACT: We examined the deleterious effects induced by the plasticiser di(2-ethylhexyl)phthalate (DEHP) in the plasma and erythrocytes of rats. Administration of DEHP for 24 weeks caused decreases in erythrocyte count and uric acid concentration and an increase in the levels of methaemoglobin. The increase in erythrocyte osmotic fragility, which is inversely related to erythrocyte survival, correlated well with a decrease in red cell Na+K+-ATPase activity. The release of the lysosomal enzyme acid phosphatase and the metal catalysts iron and calcium can account for the liver cell damage induced by DEHP.
[Show abstract][Hide abstract] ABSTRACT: This study was undertaken to evaluate the level of glycoproteins and sialic acid in rats fed di (2-ethylhexyl)-phthalate (DEHP) in the diet for 24 weeks. Protein-bound hexose, hexosamine and sialic acid were increased in plasma and liver of rats treated with DEHP, whereas the erythrocyte membrane showed a reduction following DEHP administration. Evaluation of glycoproteins is a useful indicator of the carcinogenic process. It is suggested that profound alterations in membrane components observed in the present study may be related to the carcinogenic potential of DEHP.
No preview · Article · Aug 1995 · Indian journal of physiology and pharmacology