T Inoue

IVF NAMBA Clinic, Ōsaka, Ōsaka, Japan

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Publications (772)1349.81 Total impact

  • I. Koike · M. Shimizu · K. Mitsudo · T. Inoue · I. Tohnai

    No preview · Article · Nov 2015 · International journal of radiation oncology, biology, physics
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    ABSTRACT: BACKGROUND AND AIM: Luminal nutrients stimulate enteroendocrine L cells to release gut hormones, including intestinotrophic glucagon-like peptide-2 (GLP-2). Because L cells express the bile acid receptor TGR5 and dipeptidyl peptidase-IV (DPPIV) rapidly degrades GLPs, we hypothesized that luminal TGR5 activation may attenuate intestinal injury via GLP-2 release, which is enhanced by DPPIV inhibition. METHODS: Intestinal injury was induced in mice by administration of dextran sulfate sodium (DSS) in drinking water (free access to water containing 5% DSS for 7 days). The selective TGR5 agonist betulinic acid (BTA) and the DPPIV inhibitor sitagliptin phosphate monohydrate (STG) were administered orally for 7 days. Male C57BL/6 mice (6-7 weeks old) were divided into five groups: normal control group, disease control group, BTA low group (drinking water containing 15 mg/L BTA), BTA high group (50 mg/L BTA), and BTA high + STG (3 mg/kg, i.g.) group. RESULTS: The selective TGR5 agonist BTA dose-dependently suppressed disease activity index and mRNA expression of the pro-inflammatory cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in the colon. Nevertheless, STG administration had little additive effect on BTA-induced protection. Fibroblast activation protein mRNA expression, but not expression of other DPP family members, was increased in the colon of DSS-treated mice with increased mucosal DPPIV. Co-administration of the selective GLP-2 antagonist GLP-2 (3-33) reversed the effect of BTA. CONCLUSION: The selective TGR5 agonist BTA ameliorated DSS-induced colitis in mice via the GLP-2 pathway with no effect of DPPIV inhibition, suggesting that other DPP enzymatic activity is involved in GLP-2 degradation.
    Full-text · Article · Mar 2015 · Journal of Gastroenterology and Hepatology
  • N. Nakaigawa · K. Namura · D. Ueno · U. Tateishi · T. Inoue · M. Yao

    No preview · Article · Nov 2014 · European Journal of Cancer
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    ABSTRACT: BACKGROUND: Indomethacin enhances small intestinal epithelial cell apoptosis, which may account for mucosal ulceration. However, the involvement of autophagy in indomethacin-induced enterocyte damage is unreported. METHODS: Using light microscopy and electron microscopy techniques, Western blot analysis, and pharmacological inhibition of autophagy, we investigated the autophagic response of cultured rat enterocytes to indomethacin treatment (200 µM) at various time points. Furthermore, autophagy was examined in enterocytes of rats given indomethacin by gavage (10 mg/kg). RESULTS: Our data indicate that indomethacin induced accumulation of cytoplasmic lipid droplets (LDs) in cultured enterocytes, which was associated with time-dependent autophagic responses. Initially (0-6 h), mediated by endoplasmic reticulum stress and suppression of mammalian target of rapamycin, a predominant cytoprotective lipophagy was activated in indomethacin-treated enterocytes, as evidenced by induction and colocalization of LC3-II with LDs, excessive formation of autophagosomes sequestering LDs (autolipophagosomes; ALPs), and decreased viability of enterocytes on blocking autophagy with 3-methyladenine. On prolonged exposure to indomethacin (6-24 h), there was a decrease of LAMP-2 expression in enterocytes coupled with accumulation of ALPs and LDs with fewer autolysosomes in addition to an elevation of lipoapoptosis. These time-dependent autophagic and apoptotic responses to indomethacin treatment were detected in enterocytes of indomethacin-treated rats, confirming in vitro results. CONCLUSIONS: The findings of this study describe a novel mechanism of enterocyte damage by indomethacin mediated by endoplasmic reticulum stress, accumulation of LDs, and subsequent activation of the early phase of cytoprotective lipophagy. This is followed by a late phase characterized by reduced expression of lysosomal autophagic proteins, accumulation of ALPs, and enhanced lipoapoptosis
    Full-text · Article · Sep 2014 · Journal of Gastroenterology

  • No preview · Article · Sep 2014 · Fertility and Sterility
  • T. Kasuya · U. Tateishi · T. Inoue

    No preview · Article · Sep 2014 · International journal of radiation oncology, biology, physics
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    ABSTRACT: Objective: This article documents the process that led to the publication of the ". Oral CIS (JSOP) Catalog" by the Working Committee on New Histopathological Criteria for Borderline Malignancies of the Oral Mucosa, a group which was organized within the Japanese Society of Oral Pathology between 2004 and 2007. Methods: The committee collected 160 cases histologically diagnosed as oral carcinoma in-situ (CIS) at 20 hospitals to which the committee members belonged, and five sets of hematoxylin and eosin stained sections of those cases were circulated in five routes among 25 committee members for reviewing for their own diagnoses. Their diagnoses were collected, and cases diagnosed as CIS by more than 70% of the members were selected for further discussion. Results: Committee members wanted to emphasize that oral CIS contained greater histological variety than had previously been defined, and they came to the eventual conclusion that two major histological variations of oral CIS, basaloid and differentiated, were distinguishable. In particular, they emphasized that oral CIS had a definite tendency toward keratinization or that it was well differentiated. They also recommended the use of immunohistochemistry for Ki-67 and keratin subtypes as an essential aid tool for oral CIS diagnosis. Conclusion: By referring to the Catalog, which explains histopathological variations, pathologists can more easily make a diagnosis of oral CIS, and oral surgeons can carry out appropriate clinical interventions for treating oral borderline malignancies.
    No preview · Article · Jul 2014
  • T. Maejima · T. Inoue · Y. Kanki · T. Kohro · G. Li

    No preview · Article · Jun 2014 · PLoS ONE
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    ABSTRACT: A 76-year-old woman was diagnosed with pancreatic cancer by endoscopic ultrasonographic fine-needle aspiration (EUS-FNA) biopsy. She had undergone thoracoscopic left lower lobe resection for lung cancer 14 months before presenting to our department. Thyroid transcription factor-1 (TTF-1) was positive in the adenocarcinoma of the resected lung cancer. Since serum CY-FRA and CEA levels, which were negative after the surgery, increased again, recurrence of the lung cancer was suspected. FDG-PET examination showed intense uptake in the pancreatic head, and therefore pancreatic metastasis of lung cancer was suspected. CT and MRI revealed no dilatation of the main pancreatic duct and a deeply stained, ring-like tumor; therefore, these results also supported the diagnosis of pancreatic metastasis of lung cancer. EUS-FNA biopsy was performed, and TTF-1-negative adenocarcinoma was detected. The patient subsequently underwent pylorus-preserving pancreaticoduodenectomy.
    No preview · Article · Jun 2014 · Gastroenterological Endoscopy
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    ABSTRACT: Introduction and Aims: Hypertensive nephrosclerosis is one of the most frequent causes of chronic kidney failure. Proteomic analysis represents one possibility to improve the pathophysiologic knowledge and diagnostic precision of this disorder. In this study, we investigated experimental nephrosclerosis in two-kidney, one-clip (2K1C) hypertensive rats. Methods: The renal cortex proteome from juxtamedullary cortex (JMC) and outer cortex (OC) of 2K1C male Hannover Wistar rats (n=4) was compared to sham-operated controls (n=6) using mass spectrometry based quantitative proteomics. We combined a high abundant plasma protein depletion strategy with an extended liquid chromatographic gradient to improve peptide and protein identification. Immunohistology was used for confirmation of the abundance of a selected protein. Results: In total we identified 1,724 proteins, of which 1,434 could be quantified based on ≥ 2 unique peptides. Comparative proteomics revealed 683 proteins, including PDGFR-β pathway, with different abundance between the non-clipped renal cortex of hypertensive 2K1C rats and of the corresponding kidney in normotensive controls (p<0.05, absolute fold change ≥1.5). A total of 12 proteins were differentially regulated between JMC and OC of 2K1C animals. Among the most significantly altered proteins in the whole cortex, we identified periostin, transgelin and creatine kinase B-type with known association to renal fibrosis. Their relative abundance pattern separates 2K1C and controls based on a 3D scatter plot (Fig. 1A) and on different decision algorithms (Table 1). Also, the relative abundance of periostin alone indicated perfect classification, as assessed by a scatter plot (Fig. 1B). Enrichment of periostin was verified by immunohistology showing no periostin staining in control cortex (Fig. 2A) but clear positivity around fibrotic vessels in nephrosclerosis (Fig. 2B). Conclusions: The proteome is substantially altered in hypertension-induced kidney damage. We propose periostin and especially periostin in combination with transgelin and creatine kinase B-type as a possible proteomic classifier to distinguish hypertensive nephrosclerosis from normal tissue. This classifier needs to be further validated with respect of early fibrosis diagnosis, of prognosis and for its potential as a novel target. View larger version: In this window In a new window Download as PowerPoint Slide
    Full-text · Article · May 2014 · Nephrology Dialysis Transplantation
  • K. Okawa · T. Aoki · W. Ueda · H. Ohba · K. Sano · H. Fukushima · T. Inoue
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    ABSTRACT: Mucosal prolapse syndrome (MPS) is a group of diseases caused by occult and obvious mucosal prolapse with fibromuscular obliteration determined histologically. The endoscopic appearance of MPS varies (polypoid type, ulcerative type and flat type), and a differential diagnosis for cancer and other inflammatory bowel diseases is necessary. Almost all large polypoid types of MPS have an irregular surface, erosions and sloughs mimicking rectal cancer. If the rectal lesion is diagnosed as MPS endoscopically or clinically without fibromuscular obliteration determined from a biopsy specimen, a large specimen obtained by polypectomy, endoscopic mucosal resection or transanal local resection is necessary to demonstrate fibromuscular obliteration histologically. If MPS is misdiagnosed as rectal cancer, there is a possibility that an unnecessary operation will be performed. The flat type of MPS is classified according macular redness just above the anus and circular redness on the Houston valve. If these findings are not recognized, a differential diagnosis is necessary for other inflammatory bowel diseases.
    No preview · Article · Mar 2014 · Gastroenterological Endoscopy
  • K Ito · K Matsuoka · K Matsuzaka · K Morinaga · T Inoue
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    ABSTRACT: AimTo investigate the behavior of dental pulp cells under hypoxic conditions in vivo using an experimental animal model.MethodologyA mini-screw was inserted into the inferior dental nerve canal of rats to arrest the blood supply, which resulted in a reduced oxygen level in the dental pulps of molar teeth used for the experimental group. The decrease in blood supply was evaluated by injected India ink in transparent specimens. The hypoxia marker Hypoxyprobe-1 was investigated by immunohistochemical staining. The mRNA expressions of ATP-binding cassette transporter (ABC) G2 (ABCG2) which is a markers for the capacity to excrete metabolites and for stem-like cells, as well as Dentine sialophosphoprotein (DSPP) and Osteocalcin (OCN) which are markers for mineralization were evaluated by RT-PCR. Protein was evaluated by immunohistochemical staining using ABCG2, Dentine sialoprotein (DSP) OCN.ResultsThe evaluation of India ink indicated a decreased blood supply in the transparent specimens, and Hypoxyprobe-1 immunohistochemical staining showed positive expression. ABCG2, DSPP and OCN mRNA expression increased at 7 and 14 days. Immunohistochemically, ABCG2, DSP, OCN-positive cells were localized in the odontoblastic layer.Conclusions Hypoxic conditions promoted mineralization and differentiation of dental pulp cells of the odontoblastic layer.This article is protected by copyright. All rights reserved.
    No preview · Article · Mar 2014 · International Endodontic Journal
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    ABSTRACT: High power and long-pulse negative ion extractor, which is composed of the plasma grid (PG) and the extraction grid (EXG), is newly developed toward the neutral beam injector for heating and current drive of future fusion machines such as ITER, JT-60 Super Advanced and DEMO reactor. The PG is designed to enhance surface production of negative ions efficiently by applying the chamfered aperture. The efficiency of the negative ion production for the discharge power increased by a factor of 1.3 against that of the conventional PG. The EXG is also designed with the thermal analysis to upgrade the cooling capability for the long pulse operation of >1000 s required in ITER. Though the magnetic field for electron suppression is reduced to 0.75 of that in the conventional EXG due to this upgrade, it was experimentally confirmed that the extracted electron current can be suppressed to the allowable level for the long pulse operation. These results show that newly developed extractor has the high potential for the long pulse extraction of the negative ions.
    No preview · Article · Feb 2014 · The Review of scientific instruments
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    ABSTRACT: In order to realize neutral beam systems in International Thermonuclear Experimental Reactor whose target is to produce a 1 MeV, 200 A/m(2) during 3600 s D(-) ion beam, the electrostatic five-stages negative ion accelerator so-called "MeV accelerator" has been developed at Japan Atomic Energy Agency. To extend pulse length, heat load of the acceleration grids was reduced by controlling the ion beam trajectory. Namely, the beam deflection due to the residual magnetic field of filter magnet was suppressed with the newly developed extractor with a 0.5 mm off-set aperture displacement. The new extractor improved the deflection angle from 6 mrad to 1 mrad, resulting in the reduction of direct interception of negative ions from 23% to 15% of the total acceleration power, respectively. As a result, the pulse length of 130 A/m(2), 881 keV H(-) ion beam has been successfully extended from a previous value of 0.4 s to 8.7 s. This is the first long pulse negative ion beam acceleration over 100 MW/m(2).
    No preview · Article · Feb 2014 · The Review of scientific instruments
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    ABSTRACT: A 40-year-old woman received combination therapy of pegylated interferon alpha-2b and ribavirin for chronic hepatitis C in 2005 and achieved sustained virological response. But since relapse in 2006, she had received only liver supporting therapy. In 2010, abdominal dynamic computed tomography (CT) showed a low attenuation lesion, 2 cm in diameter, in segment 3 of the liver on the arterial to the equilibrium phase. Based on imaging findings, we suspected hypovascular well-differentiated hepatocellular carcinoma (HCC) concomitant with lipid, and performed laparoscopic partial resection of segment 3 of the liver. The resected specimen showed histopathologically cirrhotic liver in which a nodule, 21 mm in diameter, had same structure as the surrounded regenerative nodules. Therefore the nodule was diagnosed large regenerative nodule (LRN). It may be difficult to distinguish LRN from HCC clinically and with imaging modalities. We diagnosed this case as having LRN by laparoscopic resection of the liver.
    No preview · Article · Jan 2014
  • T. Ito · H. Otake · T. Inoue · K. Endo
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    ABSTRACT: Coded aperture ECT is an emission computed tomography (ECT) technique. It uses a gamma camera equipped with a coded aperture in place of an ordinary parallel collimator, and reconstructs the three dimensional (3D) distribution of a radioactive isotope from projected data collected from one direction.
    No preview · Article · Jan 2014
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    M Hata · I Koike · H Wada · E Miyagi · T Kasuya · H Kaizu · T Matsui · Y Mukai · E Ito · T Inoue
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    ABSTRACT: Extramammary Paget's disease (EMPD) is a relatively rare malignancy, and there are few reports related to radiation therapy. In the present study, we investigated the outcome of radiation therapy for EMPD. Forty-one patients with EMPD in the genitalia underwent radiation therapy with curative intent. Fifteen patients had regional lymph node metastases before radiation therapy, but none had distant metastasis. Total doses of 45-80.2 Gy (median, 60 Gy) were delivered to tumor sites in 23-43 fractions (median, 33 fractions). At a median follow-up period of 41 months, 16 patients had developed recurrences, including 5 with local progression within the radiation field and 12 with lymph node or/and distant metastases outside the radiation field. The local progression-free and disease-free rates were 88% and 55% at 3 years, and 82% and 46% at 5 years, respectively. Nine patients died at 6-73 months after irradiation; the causes of death were tumor progression in five patients, infectious pneumonia in two, renal failure in one and old age in one. The overall and cause-specific survival rates were 93% and 96% at 3 years, and 68% and 84% at 5 years, respectively. Tumor invasion into the dermis and regional lymph node metastasis were significant prognostic factors for both distant metastasis and survival. No therapy-related toxicities of grade ≥3 were observed. Radiation therapy is safe and effective for patients with EMPD. It appeared to contribute to prolonged survival owing to good tumor control, and to be a promising curative treatment option.
    Full-text · Article · Dec 2013 · Annals of Oncology
  • Y Mukai · M Hata · K Mitsudo · I Koike · T Koizumi · S Oguri · M Kioi · M Omura · I Tohnai · T Inoue
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    ABSTRACT: The aim of this study was to review the efficacy and toxicity of radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy in the treatment of gingival carcinoma. In all, 34 patients (21 men and 13 women) with squamous cell carcinoma of the gingiva underwent radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy. Treatment consisted of daily external irradiation and concurrent retrograde superselective intra-arterial infusion with cisplatin and docetaxel. A median total dose of 60 Gy in 30 fractions was delivered to tumors. Of the 34 patients, 29 (85 %) achieved a complete response (CR) and 5 had residual tumors. Of the 29 patients with a CR, 2 had local recurrences and 1 had distant metastasis 1-15 months after treatment. Twenty-six of the 36 patients had survived at a median follow-up time of 36 months (range 12-79 months); 4 died of cancer and 4 died of non-cancer-related causes. At both 3 and 5 years after treatment, the overall survival rates were 79 % and the cause-specific survival rates were 85 %. Osteoradionecrosis of the mandibular bone only developed in 1 patient after treatment. Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy was effective and safe in the treatment of gingival carcinoma. This treatment may be a promising curative and organ-preserving treatment option for gingival carcinoma.
    No preview · Article · Nov 2013 · Strahlentherapie und Onkologie
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    Full-text · Article · Nov 2013 · European Journal of Vascular and Endovascular Surgery
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    ABSTRACT: Spatial non-uniformity of the dissociative hydrogen atom (H0) production has been investigated in a large negative ion source (JAEA 10 A source) with the electron energy distribution function (EEDF) obtained by a Monte-Carlo simulation code for electron transport in 3D3V (three dimensional real and velocity) space. It has been shown that the H0 production rate becomes larger in the upper region (one side in the longitudinal direction) of the source chamber. This spatial non-uniformity of the H0 production profile is mainly explained by the non-equilibrium features of the EEDF in the upper region, i.e., the EEDF consists of thermal electron component with kinetic energy ε < 25 eV and fast electron component with energy ε > 25 eV in the upper region, while the EEDF mainly consists of only thermal electrons in the bottom region. These characteristics for the EEDF and the energy dependence of cross-sections for dissociation and dissociative ionization processes lead to the non-uniform profile of the H0 production. The above numerical results of the spatial H0 non-uniformity are validated and confirmed by comparisons with those by spectroscopic measurement. It has been clarified that the non-equilibrium (fast electron) component of the EEDF has a large contribution to the non-uniformity of the H0 production rate.
    No preview · Article · Oct 2013 · Journal of Applied Physics

Publication Stats

10k Citations
1,349.81 Total Impact Points


  • 2011-2014
    • IVF NAMBA Clinic
      Ōsaka, Ōsaka, Japan
  • 2003-2014
    • Yokohama City University
      • • Department of Obstetrics and Gynecology
      • • Department of Medicine
      • • Department of Radiology (YCUH)
      Yokohama, Kanagawa, Japan
  • 1995-2014
    • Japan Atomic Energy Agency
      • Nuclear Science and Engineering Directorate
      Muramatsu, Niigata, Japan
    • ITER
      Marsiglia, Provence-Alpes-Côte d'Azur, France
    • The Jikei University School of Medicine
      • Department of Internal Medicine
      Edo, Tōkyō, Japan
  • 1986-2014
    • Tokyo Dental College
      • • Department of Clinical Pathophysiology
      • • Department of Pathology
      • • Oral Health Science Center
      Tiba, Chiba, Japan
  • 1985-2013
    • Osaka University
      • • Division of Applied Chemistry
      • • Graduate School of Engineering
      • • Department of Oral Physiology
      Suika, Ōsaka, Japan
  • 1990-2012
    • Osaka City University
      • • Graduate School of Medicine
      • • Department of Clinical Hematology
      • • Second Department of Internal Medicine
      • • Department of Laboratory Medicine
      Ōsaka, Ōsaka, Japan
  • 2006-2011
    • Tokyo Medical University
      • • Department of Surgery V
      • • Department of Thoracic Surgery
      Edo, Tōkyō, Japan
  • 2010
    • National Institutes Of Natural Sciences
      Edo, Tokyo, Japan
    • Princeton University
      • Princeton Plasma Physics Laboratory
      Princeton, New Jersey, United States
  • 2000-2010
    • National Institute for Fusion Science
      • Department of Helical Plasma Research
      Tokitsu-chō, Gifu, Japan
    • The University of Tokushima
      • Faculty of Engineering
      Tokusima, Tokushima, Japan
    • Nagoya University
      • Graduate School of Environmental Studies
      Nagoya, Aichi, Japan
  • 1997-2010
    • Showa University
      • Department of Internal Medicine
      Shinagawa, Tōkyō, Japan
    • Tokyo Metropolitan Institute of Gerontology
      Edo, Tōkyō, Japan
  • 1982-2009
    • Hamamatsu University School Of Medicine
      Hamamatu, Shizuoka, Japan
  • 2008
    • Osaka Medical College
      • Second Department of Internal Medicine
      Takatuki, Ōsaka, Japan
  • 2000-2007
    • Hiroshima City University
      • Graduate School of Information Sciences
      Hirosima, Hiroshima, Japan
  • 1997-2007
    • Okayama University
      • • Department of Child Neurology
      • • Department of Pediatrics
      • • Faculty of Engineering
      Okayama, Okayama, Japan
  • 2004-2006
    • Yokohama National University
      Yokohama, Kanagawa, Japan
    • Japan Aerospace Exploration Agency
      • Institute of Space and Astronautical Science (ISAS)
      Chōfu, Tokyo, Japan
  • 2001-2006
    • Osaka City General Hospital
      Ōsaka, Ōsaka, Japan
    • Waseda University
      • Department of Applied Chemistry
      Edo, Tōkyō, Japan
  • 1995-2006
    • Keio University
      • • Faculty of Science and Technology
      • • Department of Information and Computer Science
      Tokyo, Tokyo-to, Japan
  • 2005
    • International University of Health and Welfare
      Otahara, Tochigi, Japan
  • 1992-2005
    • Hamamatsu University School of Medicine
      • Department of Orthopedic Surgery
      Hamamatu, Shizuoka, Japan
    • Shiga University of Medical Science
      • Department of Internal Medicine
      Ōtu, Shiga, Japan
    • The University of Tokyo
      白山, Tōkyō, Japan
    • Kyushu University
      • Graduate School of Engineering
      Hukuoka, Fukuoka, Japan
  • 2003-2004
    • Hokkaido University
      • Division of Applied Physics
      Sapporo, Hokkaidō, Japan
  • 2002
    • Kurchatov Institute
      Moskva, Moscow, Russia
  • 1993-2002
    • Nara Institute of Science and Technology
      • Graduate School of Information Science
      Ikuma, Nara, Japan
  • 1991-2000
    • University of Hamamatsu
      Manda, Aichi, Japan
  • 1995-1999
    • Tokai University
      • School of Engineering
      Hiratuka, Kanagawa, Japan
  • 1998
    • Fujita Health University
      • Department of Internal Medicine
      Nagoya, Aichi, Japan
    • University of Tsukuba
      Tsukuba, Ibaraki, Japan
  • 1993-1998
    • Gunma University
      • School of Medicine
      Maebashi, Gunma, Japan
  • 1991-1998
    • Tokoha University
      • Department of Orthopedic Surgery
      Hamamatu, Shizuoka, Japan
  • 1996
    • National Epilepsy Center
      Sizuoka, Shizuoka, Japan
    • Max Planck Institute for Plasma Physics
      Arching, Bavaria, Germany
  • 1995-1996
    • Kanazawa University
      • School of Medicine
      Kanazawa, Ishikawa, Japan
  • 1994
    • Health Sciences University of Hokkaido
      • School of Dentistry
      Tōbetsu, Hokkaido, Japan
    • Saitama University
      Saitama, Saitama, Japan
  • 1984-1987
    • Kyoto University
      Kioto, Kyōto, Japan
  • 1983
    • St. Marianna University School of Medicine
      • Department of Medicine
      Kawasaki Si, Kanagawa, Japan