S Nakamura

Kyushu University, Hukuoka, Fukuoka, Japan

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Publications (571)1621 Total impact

  • [Show abstract] [Hide abstract] ABSTRACT: Intravascular large B-cell lymphoma (IVLBCL) is a distinct disease entity with the peculiar characteristic that tumor cells proliferate within vessels. Despite recent advances in understanding the disease from clinical aspects, the underlying pathogenesis remains unknown. Here we demonstrate analyses of IVLBCL biology using four xenograft mouse models established from primary IVLBCL samples. In all four models, the main characteristic of IVLBCL tumor cell proliferation within vessels was retained. Time-lapse engraftment analyses revealed that the tumor cells initially engrafted and proliferated in the sinusoids and vessels in the liver and then engrafted and proliferated in multiple organs. Intriguingly, serial passage of tumor cells from the adrenal gland of a transplanted mouse developed from primary patient bone marrow cells into a second mouse showed that the tumor cells mainly distributed into the adrenal gland in the second mouse, which implied the existence of clonal selection and/or evolution at engraftment of a specific organ. Gene expression profiling analyses demonstrated that the gene set associated with cell migration was enriched for normal peripheral blood B-cells, which indicated that inhibition of cell migration might be involved in IVLBCL pathogenesis. In conclusion, the mouse xenograft models described here are essential tools for uncovering IVLBCL biology.Leukemia accepted article preview online, 22 March 2016. doi:10.1038/leu.2016.67.
    No preview · Article · Mar 2016 · Leukemia
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    Preview · Article · Jan 2016 · Science Advances
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    [Show abstract] [Hide abstract] ABSTRACT: Blood Cancer Journal is a peer-reviewed, open access online journal publishing pre-clinical and clinical work in the field of hematology with ramifications into translational biology research down to new therapies
    Full-text · Article · Dec 2015 · Blood Cancer Journal
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    [Show abstract] [Hide abstract] ABSTRACT: We have investigated magneto-transport properties in a single crystal of pyrochore-type Nd2Ir2O7. The metallic conduction is observed on the antiferromagnetic domain walls of the all-in all-out type Ir-5d moment ordered insulating bulk state, that can be finely controlled by external magnetic field along [111]. On the other hand, an applied field along [001] induces the bulk phase transition from insulator to semimetal as a consequence of the ?eld-induced modification of Nd-4f and Ir-5d moment con?gurations. A theoretical calculation consistently describing the experimentally observed features suggests a variety of exotic topological states as functions of electron correlation and Ir-5d moment orders which can be finely tuned by choice of rare-earth ion and by magnetic field, respectively.
    Preview · Article · Jun 2015 · Physical Review Letters
  • S. Nakamura · S. Toyoshima · N. Kabeya · K. Katoh · T. Nojima · A. Ochiai
    [Show abstract] [Hide abstract] ABSTRACT: We have synthesized single crystals of ternary intermetallic Yb3Ru4Al12 with a distorted kagome lattice structure, and investigated the low-temperature resistivity, specific heat, magnetization, and magnetic phase transitions. Yb3Ru4Al12 is the first 4f system that has a Gd3Ru4Al12-type crystal structure where antiferromagnetic interaction acts on the spin. The crystal electric field (CEF) ground state of this compound is determined as a well isolated twofold degenerate state that is subjected to a strong easy-plane-type magnetic anisotropy. In the present study, the spin system of Yb3Ru4Al12 is regarded as an AFM XY model of S=1/2. This compound undergoes successive magnetic phase transitions at 1.5 and 1.6 K, and the resistivity exhibits T2 behavior below 1 K. The ratio of the coefficient of the T2 term in the resistivity A, and that of the electronic specific heat coefficient γ0, deviates from the Kadowaki-Woods (KW) law. The successive phase transitions and low-temperature properties of Yb3Ru4Al12 where geometrical frustration and heavy fermion behavior occur are discussed.
    No preview · Article · Jun 2015 · Physical Review B
  • No preview · Conference Paper · May 2015
  • [Show abstract] [Hide abstract] ABSTRACT: We report the case of a 64-year-old woman, troubled by a gall bladder stone, who had a small-sized angiomyolipoma (AML) involving the ipsilateral renal vein as a tumor thrombus. Imaging studies depicted a left renal mass of 15 mm in diameter with a tumor thrombus extending into the inferior vena cava (IVC). On CT scan, the supposed tumor was poorly enhanced and showed CT values similar to those of fatty tissue. Due to the presence of a left renal tumor involving the ipsilateral renal vein, transabdominal radical nephrectomy was performed, together with thrombectomy. The pathological findings of a renal tumor involving the left renal vein were compatible with AML, in which spindle-like cells around the vascular elements, called perivascular epithelia cells (PEC), were found. The mechanism underlying the tumor thrombus in a patient with AML is discussed. Especially in cases where the AML is located around the hilar region adjacent to the renal vein, great attention should be paid to the probability of a growing tumor thrombus, regardless of the size of the AML itself.
    No preview · Article · Jan 2015 · Nishinihon Journal of Urology
  • No preview · Article · Oct 2014 · International Journal of Stroke
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    [Show abstract] [Hide abstract] ABSTRACT: IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by serum IgG4 elevation and the infiltration of IgG4-positive plasma cells in glandular tissues. For definitive diagnosis of IgG4-DS, biopsies of local lesions are recommended to exclude Sjögren's syndrome (SS), malignant tumours, and similar disorders. In this study, we examined the diagnostic utility of submandibular gland (SMG) and labial salivary gland (LSG) biopsies in IgG4-DS. Fourteen patients presenting with swelling of the SMG (eight females and six males) underwent both SMG and LSG biopsies. The sensitivity, specificity, and accuracy of SMG biopsies were all 100.0%. In contrast, those of LSG biopsies were 69.2%, 100.0%, and 71.4%, respectively. Thirty-three out of 61 LSG biopsies (54.1%) from all 14 patients were positive for the diagnostic criteria of IgG4-DS (IgG4-positive/IgG-positive plasma cells >0.4). None of the patients experienced complications such as facial nerve palsy, sialocele, or hyposalivation. The IgG4/IgG ratio showed no significant correlation between the LSG and SMG. The final diagnosis was IgG4-DS in 13 patients and marginal zone B-cell lymphoma (MZL) in one. These results suggest that incisional biopsy of the SMG is useful and appropriate for the definitive diagnosis of IgG4-DS, while diagnosis by LSG biopsy alone requires more caution.
    Full-text · Article · Oct 2014 · International Journal of Oral and Maxillofacial Surgery
  • No preview · Conference Paper · Sep 2014
  • No preview · Conference Paper · Aug 2014
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    [Show abstract] [Hide abstract] ABSTRACT: Introduction and Objective Indocyanine green (ICG) emits infrared light with exposure to laser light. When intravenously injected, it binds to plasma proteins and predominantly persists in the vasculature, which is very useful for definition of the vascular network. The HyperEye Medical System (HEMS; Mizuho Ikakogyo Co., LTD, Tokyo, Japan) is a new device able to identify both near-infrared and visible rays “in situ” without needing to dim the operation room lighting. We speculated that intraoperative ICG imaging would be applicable for kidney transplantation, by providing “in situ” determination of successful vascular anastomosis. Materials and Methods Four patients underwent intraoperative ICG imaging following intravenous administration of 1 mL of a solution containing 0.25% ICG. After performing vascular anastomosis, the allograft was examined using the HEMS light source device. Fluorescent signals were transmitted to a digital video processor connected to a television monitor and evaluated in real time. Results In all 4 patients, intraoperative ICG imaging provided excellent resolution of blood flow at each step in real time, namely, coming from the recipient's artery to the allograft renal artery, circulating throughout the whole grafted kidney, and draining through the allograft renal vein to the recipient's vein. HEMS provides ICG fluorescence image in color, allowing surgeons to clearly discriminate the positional relationship between the target tissue and the surrounding tissue. No complications associated with ICG injection were noted. Conclusion Our preliminary results indicate that HEMS is a feasible and safe ICG imaging system that helps prevent technical failure during vascular anastomosis, and also demonstrates blood supply to the grafted kidney.
    Full-text · Article · Mar 2014 · Transplantation Proceedings
  • No preview · Article · Feb 2014 · Journal of Crohn s and Colitis
  • [Show abstract] [Hide abstract] ABSTRACT: Background IgG4-related disease (IgG4-RD) is a new disease entity characterized by high serum IgG4 levels, infiltration of IgG4-positive plasmacytes and fibrosis in various organs such as the pancreas, salivary and lacrimal glands. Although the clinical features have been clarified recently, the pathogenesis of this disease remains unclear [1]. We previously showed that significantly higher expressions of IL-10, TGFb, and AID in labial salivary glands (LSG) of IgG4-RD than Sjögren’s syndrome (SS) and controls. In LSG of IgG4-RD, increased IL-10 and TGFb might play pathogenic roles in IgG4-specific class switch recombination and fibrosis. AID also might contribute to up-regulation of IgG4-specific class switch recombination along with IL-10 in LSG [2]. Objectives The purpose of this study was to clarify the molecules which played pathogenic roles in IgG4-RD exhaustively. Methods 1) Gene expression was analyzed by DNA microarray using GeneChip Human Genome U133 Plus 2.0 Array (Affymetrix) in LSG of IgG4-RD (N=3) and SS (N=3). Differentially expressed genes (DEGs) in IgG4-RD and SS were identified, and gene-annotation enrichment analysis of these DEGs was performed using Gene Ontology (GO) annotation. 2) Validation of the result was performed by quantitative PCR using LSG from IgG4-RD (N=8), SS (N=11), and controls (N=3) other than the patients analyzed by DNA microarray. 3) We also examined the expression of molecules in protein level by immunofluorescence assay using lacrimal glands from patients with IgG4-RD. Results 1) Gene expression patterns in IgG4-RD and SS were quite different in hierarchical clustering. In IgG4-RD, 580 up-regulated and 280 down-regulated genes were identified as DEGs (false discovery rate <0.05). GO analysis indicated the up-regulated set of DEGs in IgG4-RD encoded proteins that function in T cell activation, T cell differentiation, chemotaxis, mitosis, immune responses, and inflammatory response. 2) PCR validated significantly higher expression of CCL18 which related to chemotaxis and fibrosis, in LSG of IgG4-RD than in SS and controls (P<0.05). 3) Immunofluorescence assay showed that CD68 positive macrophages could produce CCL18 in lacrimal glands of IgG4-RD. Conclusions DNA microarray analysis in this study showed that the gene expression pattern in LSG of IgG4-RD was different from that of SS, suggesting different pathogenic mechanisms of IgG4-RD and SS. CCL18 produced by macrophages might relate to the pathogenesis of IgG4-RD via the chemotaxis of T cells and B cells, and the induction of collagen production from fibroblasts. References Disclosure of Interest: None Declared
    No preview · Article · Jan 2014 · Annals of the Rheumatic Diseases
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    [Show abstract] [Hide abstract] ABSTRACT: The proteasome inhibitor bortezomib has revolutionized the treatment of multiple myeloma. However, bortezomib-induced peripheral neuropathy (BiPN) is a serious complication that compromises clinical outcome. If patients with a risk of developing BiPN could be predicted, physicians might prefer weekly, reduced-dose, or subcutaneous approaches. To seek biomarkers for BiPN, we conducted a multicenter prospective study using a simple and unique system. Multiple myeloma patients received twice-weekly or weekly 1.3 mg/m(2) bortezomib intravenously, and a 2-ml sample of whole blood was obtained before treatment and 2-3 days and 1-3 weeks after the first dose. Induction of gene expression was then quantified by real-time PCR. Of a total of 64 enrolled patients, 53 patient samples qualified for mRNA analysis. The BiPN grade was associated with phytohemagglutinin-induced IL2, IFNG and TNFSF2, as well as with lipopolysaccharide-induced IL6 levels. More importantly, of the 19 patients showing a 3-fold increase in phytohemagglutinin-induced IL2, 14 did not suffer from BiPN (73.7% prediction), whereas of the 34 patients with a <3-fold increase, 23 experienced BiPN (67.6% prediction). Therefore, we concluded that pretreatment of phytohemagglutinin-induced IL2 mRNA levels in whole blood serve as a promising biomarker for predicting BiPN, and this finding warrants validation in a larger study.
    Preview · Article · Oct 2013 · Blood Cancer Journal
    [Show abstract] [Hide abstract] ABSTRACT: Objective: β-tricalcium phosphate (βTCP) block and granular are widely used in clinical application as bone replacement since it shows osteoconductivity and resorbability. Its usefulness is thought to be improved significantly if it has fully interconnected porous structure. Although, polyurethane foam replica method is one of the ways to fabricate such interconnected porous structure or ceramics foam, relatively high temperature is required for the sintering process, since compacting process cannot be employed in the polyurethane foam replica method. The objective of this study is therefore to fabricate βTCP foam and evaluate its tissue response by reconstructing bone defects in rabbit’s with βTCP foam. Method: Two methods were proposed to fabricate the βTCP foam. One was the use of magnesium oxide as βTCP stabilizer (Mg-βTCP foam). The other was the phase transformation of αTCP foam by employing heat treatment below α-β transition temperature (HT-βTCP foam). The tissue response to resultant βTCP foams was evaluated by reconstructing the bone defect of rabbit femur for 20 weeks with these βTCP foams. Result: For Mg-βTCP foam, 3 mol% or larger amount of Mg was found to stabilize βTCP phase even when sintered at 1,500°C. For HT-βTCP, phase of αTCP transformed βTCP keeping its fully interconnected porous structure when αTCP was heat treated at 800°C, 900°C and 1,000°C. In vivo study demonstrated that both βTCP foams showed excellent tissue responses and replacement to bone. HT-βTCP foam showed faster replacement to bone. Mg-βTCP foam almost replaced to new bone, whereas some structure of Mg-βTCP foam still remained in rabbit bone even at 20 weeks. Conclusion: The present study demonstrated that βTCP foams were successfully fabricated and they can be used as ideal bone replacements.
    No preview · Conference Paper · Aug 2013
  • [Show abstract] [Hide abstract] ABSTRACT: Objective: There is increasing interest in oral hygiene of elderly people, who subject to various oral mucosal diseases such as oral candidiasis. Several studies reported that oral candidiasis is closely associated with the changes in oral fungal flora and caused primarily by Candida species in the oral mucosa. Identification of fungal flora at the species level may be useful to initiate an early and appropriate treatment of those patients. Conventional methods used by fungal culture are time-consuming and not always conclusive. In contract, molecular genetic analysis of internal transcribed spacer (ITS) regions of ribosomal DNA is rapid, reproducible and easy to be performed. We thus investigated the fungal flora of patients with oral candidiasis and its change before/after treatments for oral candidiasis by using this method. Method: Twenty-seven patients with oral candidiasis and 23 with healthy controls were studied. Fungal DNA of oral swabs taken from tongue and saliva were extracted and were examined by length heterogeneity polymerization chain reaction (LH-PCR) and nucleotide sequence analyses of the ITS1-5.8S rRNA-ITS2 region. Result: As the results of LH-PCR, fungi in patients with oral candidiasis showed increased diversity and abundance compared with controls. Candida albicans was dominant in both patients and controls. Furthermore, 54 fungal populations were detected in patients with oral candidiasis and 47 in controls. Out of them, 39 populations were common and 15 were specific to patients and 8 were specific to controls. With regard to previously-unidentified fungi, the nucleotide sequence analysis identified some novel fungal populations. In addition, these fungi have reduced after treatment for oral candidiasis. Conclusion: These results suggest that particular unidentified fungi or fungal flora might be related to the pathogenesis of oral candidiasis. Further studies including nucleotide sequence are needed to figure out and characterize virulent fungal species.
    No preview · Conference Paper · Aug 2013
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    [Show abstract] [Hide abstract] ABSTRACT: Purpose: Expansive remodeling (ER) and low endothelial shear stress (ESS) critically determine the natural history of atherosclerosis, but they have only been investigated in a cross-sectional arterial axis. In this study, we assessed the longitudinal variation of remodeling and ESS along the length of individual plaques in human coronary arteries and their relation to subsequent plaque growth. Methods: We performed 3D coronary reconstruction by angiography/IVUS at baseline and at 6-10 months follow-up as part of the PREDICTION Study. In discrete baseline plaques (max thickness >0.5 mm, length 9 to 30 mm), we assessed arterial remodeling and ESS (using computational fluid dynamics) in 3mm-long segments. Plaque growth was evaluated in the same locations at follow-up. Results: In 313 arteries from 220 patients, 371 plaques (average length 16.6±0.4 mm) were identified. Of these plaques, 237 (63.9%) had evidence of remodeling while the remaining 134 (36.1%) showed no remodeling. The vast majority of remodeled plaques (93.2%) displayed heterogeneous remodeling patterns along their length: 52 plaques (23.5%) exhibited two remodeling patterns, 14 (6.3%) exhibited three remodeling patterns and 155 plaques (70.1%) showed a combination of one remodeling pattern in some areas of the plaque with absence of remodeling elsewhere (p<0.001). Of plaques with homogeneous remodeling, 18.8% had Excessive ER, 6.2% Compensatory ER, 12.5% Inadequate ER and 62.5% Constrictive remodeling (p<0.05). Similarly, 75.7% of all plaques demonstrated heterogeneous ESS profiles along their length: 20 plaques (7.1%) exhibited both low and high ESS, 79 (28.1%) both low and moderate ESS, 67 (23.8%) both moderate and high ESS; and 115 plaques (40.9%) showed all three ESS patterns (p<0.001). Of plaques with homogeneous ESS, 40% had low ESS, 20% moderate ESS and 40% high ESS. Segments with Excessive ER were associated with low ESS while constrictively remodeled segments with high ESS (p<0.001). Plaque growth at follow-up was primarily evident in segments with baseline low ESS (OR 1.4, 95% CI 1.1-1.7, p<0.05). Conclusions: Arterial remodeling and ESS patterns are not homogeneously distributed along the length of individual coronary plaques, but show significant longitudinal heterogeneity. Since Excessive ER is related to low ESS and subsequent plaque growth, the detailed characterization of remodeling and ESS profiles along the longitudinal aspect of lesions may enhance early identification of highest-risk plaques.
    Full-text · Conference Paper · Aug 2013
  • [Show abstract] [Hide abstract] ABSTRACT: A 72-year-old man was admitted to our hospital with tarry stools. He had been followed up as a patient with decompensated liver cirrhosis and hepatocellular carcinoma. He had a history of endoscopic injection sclerotherapy for esophageal varices 6 years before this episode and had undergone TACE for heaptocellular carcinoma 7 times during the period. Computed tomography showed dilated varices is the duodenum. Gastrointestinal endoscopic examination revealed a ruptured nodular varix with a white plug on the third portion of the duodenum. The varices were treated with the endoscopic variceal ligation (EVL) method using double balloon enteroscopy. After the EVL treatment endoscopic examination demonstrated disappearance of the duodenal varix with post therapeutic scarrings. EVL using double balloon enteroscopy is considered as a therapeutic option for rupture of duodenal varix in emergency, especially for the patients with decompensated liver cirrhosis.
    No preview · Article · Apr 2013 · Gastroenterological Endoscopy
  • No preview · Article · Feb 2013

Publication Stats

11k Citations
1,621.00 Total Impact Points


  • 1993-2013
    • Kyushu University
      • • Faculty of Dental Science
      • • Department of Oral and Maxillofacial Surgery
      • • Graduate School of Dental Science
      Hukuoka, Fukuoka, Japan
  • 2005-2012
    • Nagoya University
      • Clinical Laboratory
      Nagoya, Aichi, Japan
  • 1993-2012
    • Tohoku University
      • • Institute for Materials Research
      • • Department of Physics
      Sendai, Kagoshima, Japan
  • 2010
    • Keio University
      • Department of Microbiology and Immunology
      Edo, Tōkyō, Japan
  • 2009
    • National Defense Medical College
      • Department of Surgery
      Tokorozawa, Saitama, Japan
  • 1998-2009
    • Hamamatsu University School Of Medicine
      Hamamatu, Shizuoka, Japan
    • Tokoha University
      • School of Medicine
      Hamamatu, Shizuoka, Japan
    • Kokura Memorial Hospital
      Kitakyūshū, Fukuoka, Japan
  • 1995-2007
    • National Cerebral and Cardiovascular Center
      • Department of Cardiovascular Medicine
      Ōsaka, Ōsaka, Japan
  • 2004-2006
    • University of the Ryukyus
      • Faculty of Science
      Okinawa, Okinawa, Japan
  • 1988-2005
    • Osaka City University
      • • Department of Gastroenterology
      • • Third Department of Internal Medicine
      Ōsaka, Ōsaka, Japan
  • 1983-2005
    • Aichi Cancer Center
      Ōsaka, Ōsaka, Japan
  • 1993-2004
    • Gunma University
      • Department of Surgery
      Maebashi, Gunma, Japan
  • 2003
    • Mitsubishi Electric Corporation
      Edo, Tōkyō, Japan
  • 2001-2002
    • Nagoya City University
      • • Department of Internal Medicine
      • • Department of Pathology
      Nagoya, Aichi, Japan
    • Aichi Prefectural Institute of Public Health
      Nagoya, Aichi, Japan
  • 2000
    • Nara Medical University
      Kashihara, Nara, Japan
    • Toho University
      • Department of Internal Medicine
      Funabashi, Chiba-ken, Japan
  • 1999-2000
    • Sophia University
      • Division of Electrical and Electronics Engineering
      Edo, Tōkyō, Japan
    • Shinshu University
      Shonai, Nagano, Japan
    • Dokkyo University
      Edo, Tokyo, Japan
    • Kumamoto Kinoh Hospital
      Kumamoto, Kumamoto, Japan
  • 1992-2000
    • Kanazawa Medical University
      • Department of Internal Medicine (III)
      Kanazawa, Ishikawa, Japan
  • 1987-2000
    • Kanazawa University
      • • Department of Internal Medicine
      • • School of Medicine
      Kanazawa, Ishikawa, Japan
  • 1997
    • Niigata University
      • Department of Physics
      Niahi-niigata, Niigata, Japan
    • Akita University Hospital
      Akita, Akita, Japan
  • 1995-1997
    • The University of Tokyo
      • Department of Pathology
      白山, Tōkyō, Japan
  • 1996
    • Kyushu Dental University
      Kitakyūshū, Fukuoka, Japan
  • 1971-1972
    • Hiratsuka Kyosai Hospital
      Hiratuka, Kanagawa, Japan