S.C. Lee

Seoul National University, Sŏul, Seoul, South Korea

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Publications (57)

  • S.C. Lee · K. Lee · S.B. Bae · [...] · J.H. Kang
    Article · Sep 2015
  • G A Kim · T H Rim · S C Lee · [...] · C S Lee
    [Show abstract] [Hide abstract] ABSTRACT: PurposeTo investigate factors associated with good response to intravitreal bevacizumab (IVB) in central serous chorioretinopathy (CSC) patients.Methods We retrospectively reviewed 42 eyes of CSC patients of symptom duration more than 3 months who received a single or multiple successive IVBs on an as-needed basis (0.05 ml, 1.25 mg). High responders (HRs) were defined as complete resolution of subretinal fluid (SRF) on spectral domain optical coherence tomography (SD-OCT). Moderate responders (MRs) were defined as SRF resolution of 50-99% of pretreatment volume and poor responders (PRs) as SRF resolution <50%. Clinical, SD-OCT, fluorescein, and indocyanine green angiography findings were analyzed to find factors associated with HR. Descriptive statistics for all demographic and clinical variables were calculated, and comparisons were made using Wilcoxon's matched-pairs signed-rank test, the Mann-Whitney U-test for means with continuous data, Pearson's χ(2) test, and Fisher's exact test for categorical data.ResultsThe mean number of IVB was 1.9. At postoperative 1 month, there were 10 (24%) HRs, 18 (43%) MRs, and 14 (33%) PRs. At the last follow-up (the mean 8.6 months), there were 25 HRs (60%), 9 MRs (21%), and 8 PRs (19%). Thicker subfoveal choroid (P=0.036), smaller lesion diameter (P=0.019), and better baseline best-corrected visual acuity (P=0.002) predicted HRs at postoperative 1 month. HR at the last follow-up was associated with classic pattern fluorescein angiography finding.Conclusions Suboptimal effects of IVB on persistent CSC suggest primary IVB on selective cases with better vision, smaller lesion, and thicker choroid at baseline.Eye advance online publication, 8 May 2015; doi:10.1038/eye.2015.58.
    Article · May 2015 · Eye (London, England)
  • H.S. Lee · I.J. Lee · T.J. Kim · [...] · S.E. Lee
    Article · Apr 2015 · European Urology Supplements
  • K. Park · B.K. Lee · Y.H. Yun · [...] · T. Webster
    [Show abstract] [Hide abstract] ABSTRACT: The in vitro evaluation of chemotherapeutic delivery systems is essential as a prediction of in vivo chemotherapeutic effi cacy. Generally, the in vitro therapeutic effi cacy of chemotherapeutic agents is evaluated by using cellular monolayers cultured in a fl at-bottomed plastic culture dish prior to expensive and arduous in vivo studies. Despite its ease of handling, cellular monolayers have provided poorly correlated outcomes of in vivo chemotherapeutic effi cacy. Morphological differences among the tumor cells and lack of cell–cell and cell–extracellular matrix (ECM) interactions in two-dimensional (2D) culture environment contribute to the discrepancies in cellular drug responses; in vivo cells are exposed to a 3D microenvironment that is regulated with respect to interactions with the surrounding cells, growth factors, and other biomolecules. Hence, there is a strong need for the development of in vitro 3D tumor models that closely mimic the in vivo microenvironment. A successfully developed in vitro tumor model will provide predictable outcomes of effi ciencies of new drug delivery systems. It will also improve the understanding of drug delivery mechanisms to develop more effi cient drug delivery systems.
    Chapter · Dec 2013
  • H.J. Lee · A.N. Koo · I.K. Kwon · S.C. Lee
    [Show abstract] [Hide abstract] ABSTRACT: Bioactive polymers that can show direct or indirect effect in damaging cancer cells have attracted expanding interest in the pharmaceutical and biomedical fields, because they can play a major role in cytotoxicity for various cancer cells. The recent advances in this field of 'polymer therapeutics' have focused on two classes of bioactive polymers. One is the polyamine analogs that can inhibit cell growth and kill cancer cells. The other is the polymers that can eliminate multidrug resistance by inhibiting the function of P-glycoprotein (Pgp) and therefore indirectly enhance the anti-cancer efficacy of drugs in damaging cancer cells. Each class of polymers has unique mechanisms for cancer treatment and has been applied to treating a variety of cancers. This chapter deals with the background of the advent of 'polymer therapeutics' and a comprehensive review on the class of Pgp-inhibiting polymers as well as the polyamine analogs, structure-activity relationships, the mechanism for cytotoxicity, and their applications in cancer therapy.
    Article · Oct 2013
  • S.Y. Choi · K.Y. Park · K. Li · [...] · S.H. Cho
    [Show abstract] [Hide abstract] ABSTRACT: Background: There are no serologic markers that accurately reflect the severity of atopic dermatitis (AD), many different scoring systems used in clinical practice and for research purposes have been developed for assessing the severity of AD. Objective: The goal of the present study was to evaluate the correlations between severity scoring systems of AD and clinical assessments of physicians and patients. Methods: We graded the severity of 418 AD patients, applying the SCORing of Atopic Dermtaitis (SCORAD), Objective SCORAD (oSCORAD), Eczema Area and Severity Index (EASI), Three Item Severity score, Rajka and Langeland score. Also, we evaluated the Physician's Global Assessment (PGA) and Visual Analog Scale (VAS) of pruritus and sleep loss. Results: here was significant positive correlation between oSCORAD and EASI and oSCORAD showed a good correlation with the other severity scoring systems. oSCORAD was highly correlated with PGA and VAS of pruritus and sleep loss. oSCORAD demonstrated the greatest correlation with body surface area, showing a linear relation. Conclusion: oSCORAD can assess the severity of AD with reflecting clinical assessments of physicians and patients and disease extent.
    Article · Apr 2013 · Korean Journal of Dermatology
  • M.-S. Kim · S.-C. Lee · S.-W. Kim · [...] · Jaesung Song
    [Show abstract] [Hide abstract] ABSTRACT: The effects of sintering time on (Na0.51K0.47Li0.02)(Nb0.8Ta0.2)O3, a textured piezoelectric ceramic, in terms of its electromechanical properties were investigated. Grain growth and enhanced electromechanical properties were manifested in specimens prepared via solid state reaction method up to 1 hour of sintering time. These characteristics were enhanced slightly further and were maintained at comparable values in specimens sintered for 10 hours with a piezoelectric coefficient d33 ~ 194 pC/N. The characteristics diminished drastically in specimens sintered for 20 hours. Degree of orientation substantially increased, in case of textured specimens manufactured by reactive template grain growth method, according to sintering time and consequently, their electromechanical properties continued to increase greatly up to 10 hours of sintering time with a d33 ~ 271 pC/N. Degree of orientation increased much more in specimens sintered for 20 hours, whereas their electromechanical properties decreased slightly with a d33 ~ 238 pC/N. The results indicate that sintering time has an effect on the degree of orientation and electromechanical properties of the textured piezoelectric ceramics.
    Article · Apr 2013 · Journal of Ceramic Processing Research
  • J.K. Oh · C.H. Kim · S.C. Lee · [...] · H. Jung
    Article · Mar 2013 · European Urology Supplements
  • S.J. Jeong · H.S. Lee · K.B. Kim · [...] · S.E. Lee
    Article · Mar 2013 · European Urology Supplements
  • M.-S. Kim · S.-C. Lee · S.-W. Kim · [...] · W.-B. Byun
    [Show abstract] [Hide abstract] ABSTRACT: x mol% (x = 0 ~ 20) Na2CO3 excess Bi2.5Na3.5Nb5O18 (BNN) particles were synthesized using molten salt as a flux. The secondary phases were observed at stoichiometric ratio of BNN precursors and their intensity decreased with increasing Na contents. The results of SEM images showed that all particles existed in a platelet shape and the particle increased in size with higher increasing Na contents. Plate-like NaNbO3 particles were developed using BNN precursor obtained by a topochemical microcrystal conversion. XRD analysis of NaNbO3 particles showed that a single perovskite phase and the intensity of (h00) peaks increased with increasing Na contents in BNN precursor. SEM images showed that the size of plate-like NaNbO3 was significantly changed by controlling Na contents in BNN precursors.
    Article · Nov 2012 · Journal of Ceramic Processing Research
  • Source
    Y.H. Shim · S L Ingale · J S Kim · [...] · I K Kwon
    [Show abstract] [Hide abstract] ABSTRACT: 1. Two experiments were conducted to evaluate a multi-microbe probiotic formulation processed at low (LT) or high (HT) drying temperature. 2. In both the experiments, 640 d-old Ross male chicks were randomly allotted to 4 treatments on the basis of initial BW for 35 d experiments. 3. In experiment one, dietary treatments were a negative control (NC; basal diet without any antimicrobial); positive control (PC; basal diet +10 mg/kg avilamycin); basal diet with 0·3% probiotic LT; and basal diet with 0·3% probiotic HT. 4. Improved overall weight gain, FCR and retention of CP were observed in birds fed the PC and probiotic diets when compared with birds fed the NC diet. At d 21, birds fed the probiotic and NC diets had more caecal Bifidobacterium and total anaerobes than birds fed the PC diet; while birds fed the PC and probiotic diets had fewer caecal Clostridium than birds fed the NC diet at d 35. 5. In experiment two, a 2 × 2 factorial arrangement of treatments was employed to evaluate the effects of two concentrations of probiotic HT (0·30 or 0·60%) and avilamycin (0 or 10 mg/kg). 6. Birds fed the 0·60% probiotic HT diet showed improved overall weight gain and CP retention, higher Lactobacillus and Bifidobacterium in the caecum, and reduced Clostridium and coliforms in the caecum. Inclusion of avilamycin improved the overall weight gain and feed intake, and reduced the caecal Clostridium and Bifidobacterium population. 7. In conclusion, high drying temperature had no effect on the efficacy of the multi-microbe probiotic formulation; while the probiotic HT formulation was more effective at the 0·60% level. Moreover, inclusion of avilamycin improved performance of birds but did not have any interaction with probiotics.
    Full-text Article · Aug 2012 · British Poultry Science
  • C. S. Lee · J. H. Bae · I. H. Jeon · [...] · S. C. Lee
    Article · May 2012 · Retina
  • D.H. Kim · K. Li · N.J. Seo · [...] · S.H. Cho
    [Show abstract] [Hide abstract] ABSTRACT: Background: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease with genetic and environmental backgrounds. While the prevalence of AD is increasing, many patients lack accurate information and understanding about AD. Objective: This study was performed to investigate the understanding of AD among Korean AD patients. Methods: We developed a survey instrument to assess patient understanding of AD. Surveys were conducted over a 6-month period (from May 2010 to October 2010) among 415 patients with AD who visited 10 dermatology clinics at a university teaching hospital affiliated with the Korean Atopic Dermatitis Association. Results: We identified points of understanding in Korean AD patients, such as knowledge and attitudes about AD, awareness of AD treatment, reliability of health care providers and information sources, and acting with AD treatment. As the results of this survey, it was confirmed that the patients' understanding of the cause and prognosis of AD was relatively inadequate, and it could be seen that the perception of the negative attitude toward the medical treatment of AD and inconveniences caused by AD was high. However, the results of the survey on the perception about the medical treatment methods of AD showed that they perceived medical doctors' treatment and prescriptions to have the best curative value, and as the criteria for choosing me treatment methods for AD, they chose the curative value rather than safety and cost. With regard to the information source for AD, they evaluated the treatment postscript on the internet sites and reliability of news media more highly than other information sources, and they responded that the main channel through which they obtain information related to AD was the medical doctors' explanations. Conclusion: We conducted the first systematic questionnaire survey to assess the understanding of AD among Korean AD patients. The results of this survey indicate that in the education and promotion on AD patients, additional education with regard to me cause and prognosis of AD is needed, and it is considered that efforts should be made to reduce the negative perception of AD through smooth communication with the medical team. In education and promotion related to AD, treatment postscripts on news media and the internet sites should also be addressed. Ultimately, the patients' self-discipline capabilities should be reinforced through proper education and development of programs related to AD.
    Article · Mar 2012 · Korean Journal of Dermatology
  • S.J. Jeong · Y.J. Lee · J.K. Lee · [...] · S.E. Lee
    Article · Feb 2012 · European Urology Supplements
  • J.J. Oh · B.B. Byun · S.K. Hong · [...] · S.E. Lee
    Article · Feb 2012 · European Urology Supplements
  • [Show abstract] [Hide abstract] ABSTRACT: A colloidal suspension of carbonaceous nanomaterials for heat exchangers has attracted increasing research attention. In this study, a simple route used to synthesize lithium treated carbonaceous nanomaterials was studied. The dispersion effect, electrical conductivity, thermophysical properties of the Li-carbon-nanocolloids system were introduced and discussed. The results show that these properties were largely enhanced, which could be due to not only the outstanding physical and electrical properties of the carbon nanomaterials but also to the introduction of lithium ions.
    Article · Feb 2012 · Asian Journal of Chemistry
  • Article · Feb 2012 · European Urology Supplements
  • [Show abstract] [Hide abstract] ABSTRACT: Nanofluids have been paid attention because of the intriguing heat transfer enhancement performances as one kind of promising heat transfer media. This paper reports an experimental work on the enhancement of dispersion, thermophysical and electrokinetic properties of aqueous suspensions of metal treated carbon nanoparticles (nanofluids). In this study, a simple route used to synthesize metal (Na, Al, Li) treated carbonaceous nanomaterials was studied. The dispersion effect, electrical conductivity, thermal diffusivities of the metal- carbon-nanofluids system were introduced and discussed. The results show that these properties were significantly enhanced, which could be due to not only the outstanding physical and electrical properties of the carbon nanomaterials but also to the introduction of metal ions.
    Article · Feb 2012 · Asian Journal of Chemistry
  • S.J. Jeong · H.J. Kim · J.K. Lee · [...] · S.E. Lee
    Article · Feb 2012 · European Urology Supplements
  • S. K. Hong · J. J. Oh · S. C. Lee · [...] · S. E. Le
    Article · Sep 2011 · Urology

Publication Stats

267 Citations


  • 2012
    • Seoul National University
      Sŏul, Seoul, South Korea
  • 2011
    • Soonchunhyang University
      Onyang, Chungcheongnam-do, South Korea
  • 2007
    • Korea University
      Sŏul, Seoul, South Korea
  • 2001-2003
    • Korea Atomic Energy Research Institute (KAERI)
      Daiden, Daejeon, South Korea
    • Korea Institute of Energy Research
      Sŏul, Seoul, South Korea
  • 2001-2002
    • Yonsei University
      • Department of Ophthalmology
      Sŏul, Seoul, South Korea