S I Hajdu

University of Southern California, Los Angeles, CA, United States

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Publications (261)1192.83 Total impact

  • Steven I. Hajdu

    No preview · Article · Nov 2015
  • Steven I. Hajdu

    No preview · Article · Mar 2015
  • Steven I. Hajdu

    No preview · Article · Sep 2014
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    ABSTRACT: AimsHistorically, nuclear staining of 10% of invasive tumor cells was used for ER positivity. In 2010, ASCO/CAP guidelines recommended the cut off value be changed to nuclear staining of 1%. This study will analyze the relationships between levels of ER expression and clinicopathological features and clinical outcomes, with an emphasis on the ER 1-10% subgroup. Methods and ResultsWe analyzed clinicopathological features in 5 subgroups based on ER expression levels in 1700 consecutive invasive breast cancer patients diagnosed and treated at our institution between 2000 and 2011. 24% of cases had ER expression <1%, 2% were ER1-10%, 5% were ER11-50%, 5% were ER51-70% and 64% were ER71-100%. We observed four subgroups of patient cohorts (ER <1%, ER1-10%, ER11-70% and ER71-100%) that were unique in Nottingham grade, nuclear grade, PR expression and disease-free survival. Of the 341 patients with follow-up data, we found no significant differences in pathologic features between patients in the ER11-50% and ER51-70% subgroups. Conclusion These data support the important role of ER in breast cancer, and the importance of accurate testing and quantitative reporting for ER. Tumors with ER 1-10% are not common, and further studies are needed to better understand this subgroup of breast cancer.This article is protected by copyright. All rights reserved.
    Full-text · Article · Mar 2014 · Histopathology
  • Steven I Hajdu · Manjunath Vadmal
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    ABSTRACT: In the 2 and half decades reviewed (1970-1995), research established that chromosomal translocation, deletion, and DNA amplification are prerequisites to cancerogenesis and that oncogenes, tumor-suppressor genes, growth factors, and cytokines play crucial roles in the pathomechanism of cancer. Human papillomavirus, human immunodeficiency virus, herpes virus, and hepatitis B virus were identified as cancer-causing viruses. Several laboratory tests were developed for the detection of primary and recurrent cancers, and cancer prevention by screening methods was popularized. Sonography, computerized tomography, magnetic resonance imaging, positron emission tomography, excision of sentinel lymph nodes, and immunohistochemical techniques became routine procedures. Clinicopathologic staging and classification of tumors were standardized. Limited surgery, adjuvant and neoadjuvant chemoradiation, and the therapeutic use of monoclonal antibodies, tumor vaccines, and targeted chemotherapy became routine practice. The decline in cancer incidence and mortality demonstrated that cancer prevention and advancement in oncology are pivotal to success in the crusade against cancer. Above all, it was clearly established that the care of patients with cancer can be accomplished best in a multidisciplinary setting involving surgical oncologists, radiologists, radiation therapists, medical oncologists, surgical pathologists, and laboratory scientists. In conclusion, the 25 years from 1970 and 1995 are the high-water mark in clinical oncology, and this is the period when oncology turned from art to science. Cancer 2015. © 2015 American Cancer Society. © 2015 American Cancer Society.
    No preview · Article · Dec 2013 · Cancer
  • Steven I. Hajdu · Farbod Darvishian
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    ABSTRACT: In the 3 decades from 1910 to 1940, more progress took place in cancer research and the diagnosis and treatment of cancers than during the prior centuries combined. The discovery of several carcinogens, precancerous conditions, and hereditary cancers adduced new thoughts about the genesis of cancers. Even though diagnostic radiology and radiation therapy became apposite specialties, surgery retained its primacy in the treatment of cancer patients. The delineation of new and distinct neoplastic entities, several precancerous lesions, and noninvasive carcinomas as well as the introduction of histopathologic grading of cancers promulgated cogent changes in therapy. Yet, with all the advances in the diagnosis and treatment of cancers, very little betterment could be demonstrated in the overall survival of patients, and by the end of the 1930s, cancer became the second most common cause of death in the United States. Cancer 2013. (c) 2012 American Cancer Society.
    No preview · Article · Apr 2013 · Cancer
  • Steven I. Hajdu

    No preview · Article · Jan 2013
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    Steven I Hajdu
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    ABSTRACT: In the second half of the 19th century, most cancer patients were cared for by surgeons who exerted ascesis and limited their operations to 1 or 2 specific areas. To assist surgeons and other physicians in caring for their patients, pathologists described newly discovered entities, refined the microscopic classification of tumors, and introduced the grading of cancers. The discoveries of Rontgen and the Curies revolutionized the diagnosis and treatment of cancers. The search for the cause of cancers extended to infectious organisms, chemicals, and radioactive materials. The 50 years covered in this review formed the groundwork for the coordinated, specialized care of cancer patients at institutions dedicated to render the most promising treatment. Cancer 2012;118:4914-28. (C) 2012 American Cancer Society.
    Preview · Article · Oct 2012 · Cancer
  • Manjunath S Vadmal · Steven I Hajdu
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    ABSTRACT: We present in this vignette some of the most egregious mistakes committed by a select few renowned pathologists. Our intent is to document for present and future generations of pathologists and laboratory scientists that to err is human, and nobody is impeccable not even the masters of pathology.
    No preview · Article · Sep 2012 · Annals of clinical and laboratory science
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    Steven I Hajdu
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    ABSTRACT: In the early 19th century, microscopy in pathology replaced gross descriptive pathology of the 18th century. Cells became known as the most important and distinct elements of benign and cancerous tissues. Thus, by the mid-1800s, a solid foundation had been laid for microscopy, and surgeons recognized that microscopic diagnosis by pathologists merited attention. In due course, preoperative microscopic diagnoses and classification of cancers in biopsy specimens were incorporated into choosing the most fitting surgical operation.
    Preview · Article · Feb 2012 · Cancer
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    ABSTRACT: Breast-conserving therapy (BCT) is an accepted therapeutic option for most breast cancer patients. However, mastectomy is still performed in 30-50% of patients undergoing surgeries. There is increasing interest in preservation of the nipple and/or areola in hopes of achieving improved cosmetic and functional outcomes; however, the oncologic safety of nipple-areolar complex (NAC) preservation is a major concern. We sought to identify the predictive factors for NAC involvement in breast cancer patients. We analyzed the rates and types of NAC involvement by breast carcinoma, and its association with other clinicopathologic features of the tumors in 787 consecutive therapeutic mastectomies performed at our institution between 1997 and 2009. Among these, 75 cases (9.5%) demonstrated NAC involvement. Only 21 (28%) of 75 of cases with NAC involvement could be identified grossly by inspection of the surgical specimen (seven of these had been clinically identified). NAC involvement was most significantly associated with tumors located in all four quadrants (P<0.0001), tumors>5 cm in size (P=0.0014 for invasive carcinoma and P=0.0032 for in-situ carcinoma), grade 3 tumors (P=0.0192), tumors with higher nuclear grades (P=0.0184), and tumors with HER2 overexpression (P=0.0137). On the basis of our findings, we have developed a mathematical model that is based on the extent and location of the tumor, HER2 expression, and nuclear grade that predicts the probability of NAC involvement by breast cancer. This model may aid in preoperative planning in selecting appropriate surgical procedures based on an individual patient's relative risk of NAC involvement.
    Full-text · Article · Oct 2011 · Annals of Surgical Oncology
  • Steven I Hajdu

    No preview · Article · Sep 2011 · Annals of clinical and laboratory science
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    Steven I Hajdu
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    ABSTRACT: Events that took place in medicine during the 15th, 16th, and 17th centuries signaled the end of the Dark Ages. The Renaissance movement, spreading from Italy across Europe, ended the religious and public prohibitions that had prevented progress in medicine. Pioneer physicians and surgeons who gave their attention to discoveries in anatomy, physiology, and chemistry established the foundations for tumor pathology, surgical oncology, and medical oncology. This review is a summary of their accomplishments.
    Preview · Article · Jun 2011 · Cancer
  • Steven I Hajdu

    No preview · Article · Mar 2011 · Annals of clinical and laboratory science
  • Steven I Hajdu

    No preview · Article · Dec 2010 · Annals of clinical and laboratory science
  • Steven I Hajdu · Farbod Darvishian

    No preview · Article · Sep 2010 · Annals of clinical and laboratory science
  • Steven I Hajdu · Gang He

    No preview · Article · Jun 2010 · Annals of clinical and laboratory science
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    Steven I Hajdu
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    ABSTRACT: Antonio Benivieni, an Italian physician, Theophilus Boneti, a Swiss physician, and Giovanni Battista Mogagni, an Italian physician, pioneered postmortem examination for finding hidden causes of diseases. By correlating the results of their clinical and postmortem examinations, they established the foundation of anatomic pathology, clinical medicine, and oncology.
    Preview · Article · Mar 2010 · Cancer
  • Steven I Hajdu · Manjunath S Vadmal

    No preview · Article · Jan 2010 · Annals of clinical and laboratory science
  • Steven I Hajdu · Ping Tang

    No preview · Article · Sep 2009 · Annals of clinical and laboratory science

Publication Stats

11k Citations
1,192.83 Total Impact Points


  • 2010
    • University of Southern California
      • Department of Pathology
      Los Angeles, CA, United States
  • 2006-2009
    • University of Rochester
      • Department of Pathology and Laboratory Medicine
      Rochester, New York, United States
    • University Center Rochester
      • Department of Pathology
      Rochester, Minnesota, United States
  • 2008
    • University of California, Los Angeles
      Los Angeles, California, United States
  • 2007
    • CUNY Graduate Center
      New York, New York, United States
  • 1973-1999
    • Memorial Sloan-Kettering Cancer Center
      • • Department of Surgery
      • • Department of Pediatrics
      • • Department of Pathology
      • • Head and Neck Service
      New York City, NY, United States
  • 1995
    • Lenox Hill Hospital
      New York, New York, United States
  • 1978-1994
    • Cornell University
      • Department of Medicine
      Ithaca, New York, United States
  • 1986
    • National Cancer Institute (USA)
      베서스다, Maryland, United States
  • 1981
    • Weill Cornell Medical College
      New York, New York, United States
  • 1975
    • Gracie Square Hospital, New York, NY
      New York City, New York, United States
  • 1971
    • Memorial Hospital, TN
      Chattanooga, Tennessee, United States