[Show abstract][Hide abstract] ABSTRACT: Wild type mumps viruses are highly neurotropic and a frequent cause of aseptic meningitis in unvaccinated humans. To test
whether attenuated mumps viruses used in the manufacture of mumps vaccines have neurovirulent properties, a monkey neurovirulence
safety test (MNVT) is performed. However, results with several mumps virus MNVTs have raised questions as to whether the test
can reliably discriminate neurovirulent from nonneurovirulent mumps virus strains. Here, various mumps virus strains representing
a wide range of neuropathogenicity were tested in a standardized MNVT. A trend of higher neurovirulence scores was observed
in monkeys inoculated with wild type mumps virus versus vaccine strains, although differences were not statistically significant.
Results indicated the need for further examination and refinement of the MNVT or for development of alternative MNVTs.
Full-text · Article · Sep 1999 · The Journal of Infectious Diseases