Naoto Yamaguchi

Ibaraki Prefectural University of Health Sciences, Ibaragi, Ōsaka, Japan

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Publications (62)140.47 Total impact

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    ABSTRACT: Background: In 2007, non-communicable diseases (NCDs) were reported to represent the highest cause-specific mortality burden among adults in Bangladesh. To date, a comprehensive nationally representative data are lacking on the NCDs using the full protocol of WHO-STEP approach to describe the NCDs risk factors in Bangladesh. The objectives of this study were to describe the prevalence of selected NCD risk factors in Bangladesh through a nationwide analysis. Method: Total 22454 Bangladeshi population more than 15 years old were included in this analysis. The sampling design was multistage stratified clustering including seven divisions of Bangladesh in both rural and urban areas. The target population for this survey includes all men and women aged 15 years or older who consider Bangladesh to be their primary place of residence excluding those who were in military base or group quarters (e.g. a dormitory) and who were institutionalized. Result: Of the study participants that took part in the survey, about 45.9% were males and 54. 1% were females, 52.78% were from rural areas, 47.22% were from urban areas and about one in four (24.4%) had no formal education. Blood pressure, fasting blood sugar and lipid profiles were measured in 99%, 85% and 60% respectively of the 20,039 participants. In Bangladeshi population the total prevalence of selected risk factors are as follows: smoking (21.7%), smokeless tobacco (30.8%), low intake of fruits and vegetables per day (86.9%), inadequate physical activity (41.4%), alcohol consumption (0.7%), raised blood pressure (23.8%), diabetes (10.6%), overweight and obesity (24.1%), abdominal obesity (19.7%), raised total cholesterol (28.0%), hypertriglyceridemia (33.8%), low HDL level (65.7%). Nearly half of the participants use any types of tobacco, 17.8% reported having been diagnosed with high blood pressure, and 6.5% reported having diabetes. Overweight, abdominal obesity, physical inactivity, low intake of fruits and vegetables per day, smokeless tobacco, raised cholesterol and raised blood pressure (BP)were more common in females than males, 25.5% vs 22.7%, 31.1 vs 8.3, 60.1% vs 22.6%, 93.1% vs 80.6%, 31.9 vs 29.6, 30.7% vs 25.3% and 26.6%vs 21.0%. A total of 5.07% of the teenagers had one risk behaviour, 20.74% had two, 28.57% had three, and 43.37% presented all the investigated risk behaviors. Only 2.25% did not display any of the analysed risk behaviours. Conclusion: Diabetes, high blood pressure, high TG, low HDL, and obesity are a public health concerns in Bangladesh. Adequate and continuous monitoring of NCD risk factors in Bangladesh is needed, and the surveillance findings should be used in health promotion and disease prevention activities. Copyright
    No preview · Article · Jun 2015 · Journal of Hypertension
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    ABSTRACT: Objective: High blood pressure is one of the primary risk factor for heart disease,stroke and chronic kidney disease and the leading cause of death worldwide. About 20% of adult populations are hypertensive in Bangladesh. Endothelin-1 (ET-1), a potential marker of endothelial dysfunction has been shown to be elevated in hypertensive subjects. No study yet has investigated the circulatory level of ET-1 and hypertension in a country from South Asia. As racial differences exist in plasma level of ET-1, more research addressing the association between ET-1 and hypertension among other races needs to be investigated. As such, the present study assessed circulating levels of ET-1 in subjects with or without hypertension and further examined the association of ET-1 with clinical and metabolic parameters. Methods: A total of 2052 rural Bangladeshi women with mean age of 44.46years were studied using a cross-sectional survey. Multiple regressions were used to examinethe association between circulatory ET-1 level and hypertension. Results: The prevalence of hypertensionwas30.3%. ET-1 levels were significantly higher in hypertensive (mean 3.08 pg/ml, SE +/- 0.19) than non-hypertensive subjects (mean 2.01 pg/ml, SE +/- 0.30) (p = <0.001). In univariateanalysis after adjusting for age, ET-1 had significant positive associations with diastolic blood pressure (DBP) (p = 0.002), systolic blood pressure (SBP) (p = <0.001), fasting blood glucose (p = 0.002), mean arterial pressure (MAP) (p = 0.001)and a negative significant association with high-density lipoprotein cholesterol (HDL) (p = 0.030). Unlike blood pressures, other variables including, triglycerides, body mass index, and waist circumference were not associated with ET-1. In multiple linear regression analysis after adjusting for age, ET-1 had significant positive associations with fasting blood glucose (p = 0.012) and mean arterial pressure (MAP) (p = 0.05)only. When we performed multiple logistic regression analysis considering hypertension status as dependent variable, hypertensive had significant positive associations with age (p = 0.015), waist circumference (p = <0.001), fasting blood glucose (p = 0.009), triglyceride (p = 0.001) and endothelin-1 (0.026). In tertile analysis, subjects with hypertension significantly increase as levels of ET-1 increase (P for trend = 0.02). Conclusions: Thus the present study demonstrates that there is higher concentration of ET-1 among hypertensive subjects of apparently healthy population in Bangladeshi rural women who did not know they were hypertensive. The relation of ET-1 and hypertension needs further investigations to define the clinical utility and predictive value of serum ET-1 levels in hypertension for South Asian population. Copyright
    No preview · Article · Jun 2015 · Journal of Hypertension
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    ABSTRACT: Objective: To evaluate the prevalence, awareness, treatment and control of hypertension among elderly individuals in Bangladesh. Method: Sociodemographic and anthropometric data and data on blood pressure were obtained for 7839 adults aged 35 years or more from the biomarker sample of the 2011 Bangladesh Demographic and Health Survey (DHS), which was a nationally representative survey with a stratified, multistage, cluster sampling design. Blood pressure values considered normal are less than 120 mmHg for SBP and less than 80 mmHg for DBP. An SBP value of 120-139 mmHg or a DBP value of 80-89 mmHg is classified as prehypertension. Findings: Overall, 73 percent of men and women age 35 and older had their blood pressure measured prior to the survey, and 27 percent had never had their blood pressure measured in their life. Overall prevalence of hypertension - defined by systolic blood pressure >=140 and/or diastolic blood pressure >=90 or reporting history of hypertension - was found to be 32% in Bangladeshi adult women and 19% in adult men. An additional around 28 percent of women and men are pre-hypertensive. Higher rate of hypertension is seen in urban population than in rural population. Both for men and women, highest prevalence of hypertension is seen in Khulna division. 15.9% of survey participant were told by a doctor having high blood pressure. Hypertension has significant association with age, BMI, educational level, working status, geographical region, wealth status, presence of diabetes. In Bangladeshi population, we did not find a significant association with hypertension and smoking. Forty-five percent of women and 57 percent of men are not aware that they have elevated blood pressure. Eleven percent of women and 8 percent of men are aware of their hypertension, but are not treating it. Forty-five percent of women and 36 percent of men with hypertension are taking medication for their condition, but over half of them have not controlled their blood pressure to normal levels. Only 20 percent of women and 16 percent of men with hypertension are taking medication and have their blood pressure under control. Among hypertensive subjects, 25% women and 20% men are aware of their condition, are taking medication to lower the blood pressure, but are unsuccessful in controlling the elevated blood pressure. Conclusion: Our findings emphasize the need to implement effective and low cost management regimens based on absolute levels of cardiovascular risk appropriate for the economic context. From a public health perspective, the only sustainable approach to the high prevalence of hypertension in Bangladesh is through a strategy to reduce the average blood pressure in the population. Copyright
    No preview · Article · Jun 2015 · Journal of Hypertension
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    ABSTRACT: Endothelin-1 (ET-1) is a potential marker of the endothelial dysfunction, which has been shown to be elevated in hypertensive subjects. No previous study has investigated the circulatory level of ET-1 and hypertension in a South Asian country. The present study assessed the circulating levels of ET-1 in subjects with or without hypertension and further examined the association of ET-1 with clinical and metabolic parameters. A total of 2543 rural Bangladeshi women with a mean age of 44.5 years were studied using a cross-sectional survey. Multiple regressions were used to examine the association between the circulatory ET-1 levels and hypertension. The prevalence of hypertension was 29.3%. The ET-1 levels were significantly higher in the hypertensive (mean 3.08 pg ml-1, s.e. (0.19)) than in the non-hypertensive subjects (mean 2.01 pg ml-1, s.e. (0.03)) (P=0.001). After adjusting for age, the ET-1 level had significant positive associations with the diastolic blood pressure (P=0.002), systolic blood pressure (P=0.001), mean arterial pressure (P=0.002) and fasting blood glucose (P=0.002). In a tertile analysis, we found that hypertension in the subjects was significantly increased as the levels of ET-1 increased (P for the trend=0.001). In a stepwise multiple regression analysis, after adjusting for age and all other potential variables, we found that the mean arterial pressure and the fasting plasma levels have significant associations with the ET-1 level. The present study demonstrates that there is a higher concentration of ET-1 among the hypertensive subjects in an apparently healthy population of Bangladeshi rural women. The relationship between ET-1 and hypertension requires further investigation to define the clinical utility and predictive value of serum ET-1 levels for hypertension for a South Asian population.
    Full-text · Article · Nov 2014 · Hypertension Research

  • No preview · Article · Nov 2014

  • No preview · Article · Nov 2014 · Diabetes Research and Clinical Practice

  • No preview · Article · Nov 2014 · Diabetes Research and Clinical Practice

  • No preview · Article · Nov 2014

  • No preview · Article · Nov 2014
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    ABSTRACT: Aims Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sepsis. Endothelin (ET)-1, a potent vasoconstrictor, is implicated in the pathogenesis of sepsis and its complications. Protease-activated receptors (PARs) are shown to play an important role in the interplay between inflammation and coagulation. We examined the time-dependent alterations of ET-1 and inflammatory cytokine, such as tumor necrosis factor (TNF)-α in kidney tissue in lipopolysaccharide (LPS)-induced septic rat model and the effects of PAR2 blocking peptide on the LPS-induced elevations of renal ET-1 and TNF-α levels. Main methods Male Wistar rats at 8 weeks of age were administered with either saline solution or LPS at different time points (1, 3, 6 and 10 hours). Additionally, we treated LPS-administered rats with PAR2 blocking peptide for three hours to assess whether blockade of PAR2 has a regulatory role on the ET-1 level in septic kidney. Key findings An increase in ET-1 peptide level was observed in kidney tissue after LPS administration time-dependently. Levels of renal TNF-α peaked (around 12-fold) at 1 hour of sepsis. Interestingly, PAR2 blocking peptide normalized the LPS-induced elevations of renal ET-1 and TNF-α levels. Significance The present study reveals a distinct chronological expression of ET-1 and TNF-α in LPS-administered renal tissues and that blockade of PAR2 may play a crucial role in treating renal injury, via normalization of inflammation, coagulation and vaso-active peptide.
    No preview · Article · May 2014 · Life sciences
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    ABSTRACT: Aims Endothelin (ET)-1 is the best known potent vasoconstrictor and has been implicated in pathogenesis of sepsis-associated acute kidney injury (AKI) in human or lipopolysaccharide (LPS)-induced AKI in animal models. We have previously shown that ET-1 is highly up-regulated in renal tissues and in plasma after LPS administration. Here, we investigated whether landiolol hydrochloride, an ultra-short-acting beta-blocker, can play an important role in ameliorating levels of LPS-induced up-regulation of renal HIF-1α -ET-1 system and inflammatory cytokines in a rat model of endotoxemia. Main methods Male Wistar rats at 8 weeks of age were either administered with: a) lipopolysaccharide (LPS) only for three hours (3 h) or b) LPS, followed by continuous administration of landiolol for 3 h; c) third group was only treated with vehicle. Key findings At 3 h after LPS administration there was: a) minimal injury in kidney tissues; b) circulatory levels of creatinine, blood urea nitrogen and NGAL increased; c) expression of inflammatory cytokines, such as TNF-α, IL-6 and iNOS increased at the level of both circulatory and renal tissues. In addition, LPS significantly induced renal expression of ET-1and HIF-1α compared to control. Finally, treatment of LPS-administered rats with landiolol for 3 h normalized elevated serum markers of renal injury, up-regulated levels of renal HIF-1α -ET-1 system with normalization of TNF-α. Significance Taken together, these data led us to conclude that landiolol ameliorates the up-regulation of HIF-1α-ET-1 system in minimally morphologically-injured kidney andnormalizes biomarkers of renal injury in early hours of endotoxemia of a rat model.
    Full-text · Article · May 2014 · Life Sciences
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    Full-text · Article · Dec 2013 · Life Sciences
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    Full-text · Article · Dec 2013 · Life Sciences
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    ABSTRACT: Parity increases the risk for coronary heart disease; however, its association with metabolic syndrome among women in low-income countries is still unknown. This study investigates the association between parity or gravidity and metabolic syndrome in rural Bangladeshi women. A cross-sectional study was conducted in 1,219 women aged 15-75 years from rural Bangladesh. Metabolic syndrome was defined according to the standard NCEP-ATP III criteria. Logistic regression was used to estimate the association between parity and gravidity and metabolic syndrome, with adjustment of potential confounding variables. Subjects with the highest gravidity (> = 4) had 1.66 times higher odds of having metabolic syndrome compared to those in the lowest gravidity (0-1) (P trend = 0.02). A similar association was found between parity and metabolic syndrome (P trend = 0.04), i.e., subjects in the highest parity (> = 4) had 1.65 times higher odds of having metabolic syndrome compared to those in the lowest parity (0-1). This positive association of parity and gravidity with metabolic syndrome was confined to pre-menopausal women (P trend <0.01). Among the components of metabolic syndrome only high blood pressure showed positive association with parity and gravidity (P trend = 0.01 and <0.001). Neither Parity nor gravidity was appreciably associated with other components of metabolic syndrome. Multi parity or gravidity may be a risk factor for metabolic syndrome.
    Full-text · Article · Aug 2013 · PLoS ONE
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    ABSTRACT: Background Prevalence of non-communicable diseases are a challenging problems among menopausal women specially in a least developed country like Bangladesh, where majority of women suffering from at least one chronic diseases after menopausal age. So, the main objective of this study was to determine the prevalence of metabolic syndrome and related risk factors in Bangladeshi pre- and post-menopausal women living in the rural setting. Methods This study is based on a community based cross-sectional survey among 1802 rural women aged ≥15 years. Metabolic syndrome was defined according to the criteria of NCEP-ATP III. Logistic regression was used to estimate the association between menopausal status and metabolic syndrome and its components. Results Metabolic syndrome was presented in 25.6% respondents and it was more prevalent among post-menopausal (39.3%) as compared to pre-menopausal (16.8%) women. Logistic regression analysis reveals that prevalence of metabolic syndrome was 1.78 times higher in post-menopausal women than pre-menopausal women (P = 0.001). Prevalence of high blood pressure, elevated fasting blood glucose, and high triglyceride were significantly higher in post-menopausal women than pre-menopausal women (P < 0.05). However, prevalence of low high-density lipoprotein cholesterol was significantly lower in post-menopausal women than pre-menopausal women (P < 0.001). Conclusions Metabolic syndrome seems to be a major health problem among post-menopausal women in many developing countries like Bangladesh and proper policy emphasis should be given on its prevention and control.
    Full-text · Article · Apr 2013 · BMC Research Notes
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    ABSTRACT: Metabolic syndrome (MetS) is associated with impaired angiogenesis, a process that is chiefly regulated by vascular endothelial growth factor (VEGF) upon binding to its specific receptors, VEGF-R1 and VEGF-R2. The purpose of the present study was to assess trends or patterns in plasma levels of VEGF and its soluble receptors in subjects with (MetS) or without (non-MetS) MetS; and further examine their association with clinical or metabolic parameters using a subpopulation of South Asian country. A total of 1,802 rural Bangladeshi women aged ≥15 ye ars were studied using a population-based cross-sectional survey. Plasma levels of VEGF were found to be significantly increased (MetS vs. non-MetS: 483.9 vs. 386.9, p<0.001), whereas, the soluble forms of VEGF receptors, sVEGF-R1 and sVEGF-R2, were significantly decreased in subjects with Mets (sVEGF-R1, MetS vs. non-MetS: 512.5 vs. 631.3, p<0.001; sVEGF-R2, MetS vs. non-MetS: 9,302.8 vs. 9,787.4, p=0.004). After adjustment for age and all potential variables, multiple regression analysis revealed that plasma levels of VEGF had significant positive association with blood glucose (p = 0.019) and body mass index (p = 0.007). We also found that mean plasma levels of VEGF increased in direct proportion to levels of MetS components. The present study is the first ever to demonstrate a positive association between trends in levels of plasma VEGF and MetS using a large sample size from South Asia. The association between plasma VEGF and MetS needs further investigations in order to clearly decipher the clinical predictive value and accuracy of plasma VEGF in MetS.
    No preview · Article · Jan 2013 · Thrombosis and Haemostasis
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    ABSTRACT: We assessed prevalence of metabolic syndrome (MS) in rural women of Bangladesh using 1485 women aged ≥15 years. The prevalence rate of MS was 31.25% (NCEP ATP III modified). And 85.05% population had low HDL values. These findings are important in the development of future health prevention strategies in Bangladesh.
    No preview · Article · Dec 2012 · Diabetes research and clinical practice
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    ABSTRACT: The Patlak plot method of measuring cerebral blood flow (CBF) to improve the repeatability and quantitative capability, by using technetium-99m ethyl cysteinate dimer (99mTc-ECD). We calculated CBF and then statistically analyzed its relationships with various hematological and biochemical parameters. There were significant statistical correlations between these clinical parameters and the measured values of mean CBF (mCBF), also between these biochemical parameters and post-acetazolamide (p-ACZ) mCBF, in terms of estimated glomerular filtration rate (eGFR), serum albumin level, red blood cell count, blood urea nitrogen level, and random blood glucose level. In addition, statistically significant correlations were found between these parameters and increased mCBF. Another significant correlation was found between cerebrovascular reserve capacity (CVR) and platelet count. Values of p-ACZ mCBF and CVR were lower in a group with HbA(1C) >7% and high blood glucose levels than in healthy subjects. In addition, values of resting mCBF and p-ACZ mCBF were lower in a group with kidney dysfunction (eGFR <30 ml/min/1.73 m2) than in subjects with normal renal function or mild dysfunction. A multiple linear regression analysis showed a correlation between resting mCBF value and eGFR. Therefore, there were correlations between CBF and the levels of these parameters of diabetes or chronic kidney disease. These results suggest that our Patlak plot modified method may be a potentially useful tool for analyzing the relationships between CBF and underlying diseases and/or the pathophysiology of CBF dysfunction. The post-ACZ ECD Patlak resting and vascular reserve (p-ACZ ECD Patlak RVR) test provides a way of detecting minor changes in CBF, which is difficult to reveal by only resting Patlak plot method, in patients with lifestyle diseases such as diabetes or chronic kidney disease. In addition, we believe that a new modified method contribute to predict risk of cerebral vascular disorders along with clinical parameters.
    No preview · Article · Nov 2012 · Kaku igaku. The Japanese journal of nuclear medicine
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    ABSTRACT: This study was conducted to standardize treatment and determine patient and renal outcome in Japanese anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis/rapidly progressive glomerulonephritis (AAV/RPGN) patients, because the prognosis of AAV/RPGN patients in Japan had been poor compared with that of other countries. The participants in this retrospective cohort study were 824 ANCA-positive RPGN patients, 705 of whom were only myeloperoxidase (MPO)-ANCA positive. Among the early-years cohort (group A; cases diagnosed between 1988 and 1998), patients frequently died due to opportunistic infection. Therefore, we recommended a reduced dose of prednisolone (oral prednisolone dose <0.8 mg/kg/day) with or without cyclophosphamide for initial treatment of Japanese RPGN patients. After this recommendation, 1-year survival of the patients improved: 75% in group A, 79% in group B (between 1999 and 2002), and 81% in group C (after 2003). During the entire observation period, average serum creatinine level at the start of treatment decreased, and improvement of 1-year renal survival was also found (72% in group A, 83% in group B, and 83% in group C), while the recurrence rate was significantly increased in group C (0.05/patient-year in group A, 0.07/patient-year in group B, and 0.13/patient-year in group C). Oral prednisolone dose <0.8 mg/kg/day with or without cyclophosphamide as an initial treatment could improve patient survival in older Japanese AAV/RPGN patients. However, maintenance treatment avoiding relapse should be established to improve renal outcomes.
    No preview · Article · Feb 2012 · Clinical and Experimental Nephrology
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    ABSTRACT: Metabolic syndrome (MS), defined as a constellation of cardiovascular disease (CVD) risk factors, is one of the fastest growing public health burdens in the Asia-Pacific region. This trend is despite the fact that people in this region are no more overweight than Europeans and Americans. Unfortunately, in South Asia, MS screening has only been performed in a few countries other than Bangladesh. Therefore the present study is designed to conduct a comprehensive screening of MS in Bangladeshi rural women, which includes estimation of prevalence and assessment of risk factor. A total of 1535 rural Bangladesh women aged ≥ 15 years were studied using a population based cross-sectional survey. The prevalence of MS was estimated using NCEP ATP III, modified NCEP ATP III and IDF criteria. The prevalence rates of MS were 25.60% (NCEP ATP III), 36.68% (modified NCEP ATP III), and 19.80% (IDF), as revealed by the present study. Furthermore, based on the NCEP ATP III criteria, 11.60% of the subjects were found to have excess waist circumference; 29.12% had elevated blood pressure, 30.42% had elevated fasting plasma glucose level, 85.47% had low HDL values and 26.91% had increased triglyceride values. Low plasma HDL level was found to be the most common abnormality in the target population and elevated waist circumference was the least frequent component. The present study reveals a high prevalence of MS and its associated risk factors in rural Bangladeshi women. These findings are important in that they provide insights that will be helpful in formulating effective public health policy, notably the development of future health prevention strategies in Bangladesh.
    Full-text · Article · Jan 2012 · BMC Public Health

Publication Stats

682 Citations
140.47 Total Impact Points

Institutions

  • 2006-2014
    • Ibaraki Prefectural University of Health Sciences
      Ibaragi, Ōsaka, Japan
  • 1991-2014
    • University of Tsukuba
      • • Institute of Clinical Medicine
      • • Department of Neurology
      Tsukuba, Ibaraki, Japan