Min Soo Kim

Chonnam National University, Gwangju, Gwangju, South Korea

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Publications (295)635.43 Total impact

  • Seong Hoon Hwang · Min Soo Kim
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    ABSTRACT: • Proposal of a cathode humidification and evaporative cooling system for PEM fuel cells.
    No preview · Article · Jan 2016 · Applied Thermal Engineering
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    ABSTRACT: Many prostate cancer (PCa) patients die of recurrent disease due to the emergence of hormone-independent cancer cells of which the mechanism is not fully understood. Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive growth signals. Since HOXB13 also suppresses p21WAF1/CIP1 (p21) expression, we studied the correlation between HOXB13 and p21 in selected samples of PCa. While there was no statistically significant correlation between expression of HOXB13 and p21, HOXB13-deficient tumors had three times higher odds for expressing p21 than HOXB13-positive tumors. Moreover, CRPC showed more negative correlation than hormone-dependent PCa (HDPC). Further in vitro proliferation assay demonstrated that androgen did not affect the growth-suppressive function of p21 in androgen-dependent PCa cells, suggesting that p21 seems to override the growth-promoting function of androgen and suppression of p21 expression by HOXB13 is an important step in PCa cell survival under no androgen influence. HOXB13 also inhibited AP-1 signals via suppressed expression of JNK/c-Jun. While HOXB13 suppressed p21 expression via regulation of JNK signals, alteration of p21 expression also affected c-Jun and AP-1 activity. Taken together, overexpression of HOXB13 in CRPC is an important step in avoiding the growth-suppressive effect of p21 in a harsh condition such as an androgen-deprived environment.
    No preview · Article · Jan 2016 · Oncology Reports
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    ABSTRACT: The adoptive transfer of autologous T cells engineered to express a chimeric antigen receptor (CAR) has emerged as a promising cancer therapy. Despite impressive clinical efficacy, the general application of current CAR-T-cell therapy is limited by serious treatment-related toxicities. One approach to improve the safety of CAR-T cells involves making their activation and proliferation dependent upon adaptor molecules that mediate formation of the immunological synapse between the target cancer cell and T-cell. Here, we describe the design and synthesis of structurally defined semisynthetic adaptors we refer to as "switch" molecules, in which anti-CD19 and anti-CD22 antibody fragments are site-specifically modified with FITC using genetically encoded noncanonical amino acids. This approach allows the precise control over the geometry and stoichiometry of complex formation between CD19- or CD22-expressing cancer cells and a "universal" anti-FITC-directed CAR-T cell. Optimization of this CAR-switch combination results in potent, dose-dependent in vivo antitumor activity in xenograft models. The advantage of being able to titrate CAR-T-cell in vivo activity was further evidenced by reduced in vivo toxicity and the elimination of persistent B-cell aplasia in immune-competent mice. The ability to control CAR-T cell and cancer cell interactions using intermediate switch molecules may expand the scope of engineered T-cell therapy to solid tumors, as well as indications beyond cancer therapy.
    Full-text · Article · Jan 2016 · Proceedings of the National Academy of Sciences
  • Min Soo Kim · Yoon Nyun Kim · Young Chang Cho

    No preview · Article · Dec 2015
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    ABSTRACT: HNF-1β is a tissue-specific transcription factor that is expressed in the kidney and other epithelial organs. Humans with mutations in HNF-1β develop kidney cysts, and HNF-1β regulates the transcription of several cystic disease genes. However, the complete spectrum of HNF-1β-regulated genes and pathways is not known. Here, using chromatin immunoprecipitation/next generation sequencing and gene expression profiling, we identified 1545 protein-coding genes that are directly regulated by HNF-1β in murine kidney epithelial cells. Pathway analysis predicted that HNF-1β regulates cholesterol metabolism. Expression of dominant negative mutant HNF-1β or kidney-specific inactivation of HNF-1β decreased the expression of genes that are essential for cholesterol synthesis, including sterol regulatory element binding factor 2 (Srebf2) and 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr). HNF-1β mutant cells also expressed lower levels of cholesterol biosynthetic intermediates and had a lower rate of cholesterol synthesis than control cells. Additionally, depletion of cholesterol in the culture medium mitigated the inhibitory effects of mutant HNF-1β on the proteins encoded by Srebf2 and Hmgcr, and HNF-1β directly controlled the renal epithelial expression of proprotein convertase subtilisin-like kexin type 9, a key regulator of cholesterol uptake. These findings reveal a novel role of HNF-1β in a transcriptional network that regulates intrarenal cholesterol metabolism.
    No preview · Article · Dec 2015 · Journal of the American Society of Nephrology
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    Min Soo Kim · Won Sung Lee · Wook Jin
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    ABSTRACT: In metastatic breast cancer, the acquisition of malignant traits has been associated with the increased rate of cell growth and division, mobility, resistance to chemotherapy, and invasiveness. While screening for the key regulators of cancer metastasis, we observed that neurotrophin receptor TrkB is frequently overexpressed in breast cancer patients and breast cancer cell lines. Additionally, we demonstrate that TrkB expression and clinical breast tumor pathological phenotypes show significant correlation. Moreover, TrkB expression was significantly upregulated in basal-like, claudin-low, and metaplastic breast cancers from a published microarray database and in patients with triple-negative breast cancer, which is associated with a higher risk of invasive recurrence. Interestingly, we identified a new TrkB-regulated functional network that is important for the tumorigenicity and metastasis of breast cancer. We demonstrated that TrkB plays a key role in regulation of the tumor suppressors Runx3 and Keap1. A markedly increased expression of Runx3 and Keap1 was observed upon knockdown of TrkB, treatment with a TrkB inhibitor, and in TrkB kinase dead mutants. Additionally, the inhibition of PI3K/AKT activation significantly induced Runx3 and Keap1 expression. Furthermore, we showed that TrkB enhances metastatic potential and induces proliferation. These observations suggest that TrkB plays a key role in tumorigenicity and metastasis of breast cancer cells through suppression of Runx3 or Keap1 and that it is a promising target for future intervention strategies for preventing tumor metastasis and cancer chemoprevention.
    Preview · Article · Dec 2015 · Moleculer Cells
  • Sang Hee Jeon · Min Soo Kim
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    ABSTRACT: For EOR and EGR in the CCS, CO2 must be captured from large-scale CO2 emission sources like power plants, and transported to depleting oil and gas wells to maintain the reservoir pressure and enhance the recovery rate. To achieve this, CO2 should be transported over long distances from the emission sources of developed countries to oil and gas producing regions by pipeline or ship. Compressed or liquefied CO2 transport ship can be used when pipeline is not recommendable. In case of liquefied CO2 transport ship, the BOG should be treated during sailing using methods such as re-liquefaction and adsorption.In the present study, the effects of representative impurities of N2 and O2 on the re-liquefaction cycle of liquefied CO2 transport ship were investigated by simulation. The concentration of impurities with boiling points lower than that of CO2 increased much more in the boil-off gas phase than in the liquid phase. This phenomenon led to low cycle performance compared to that of pure CO2 condition, and the decrease rate according to the concentration of the impurities was significant. In the mixture, the discharge pressure of the highest stage in the cycle increased much more than that of the pure CO2 condition. Therefore, when designing re-liquefaction cycle for treating the BOG of liquefied CO2 transport ship, consideration should be given to the effects of impurities on the cycle performance and safety problem in terms of the design pressure. However, impurities did not significantly increase the discharge temperatures of the compressors to such an extent to cause reliability problem of oil degradation in the compressors. With the same composition in the mixture of the liquid phase, nitrogen had a more negative influence than oxygen.
    No preview · Article · Dec 2015 · International Journal of Greenhouse Gas Control
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    ABSTRACT: Pexophagy is the selective degradation of peroxisomes for maintaining peroxisome homeostasis within cells. Peroxisome dynamics and pexophagy are important events required to maintain the quality control of peroxisomes, thereby preventing peroxisome-associated diseases. To identify novel pexophagy modulators, we developed a cell-based screening system and selected 2,2'-dipyridyl (2,2-DP) as a candidate molecule. 2,2-DP treatment induced peroxisome degradation as evidenced by an increased number of low-pH autolysosomes originating from peroxisomes and a decrease in the expression of peroxisomal proteins such as catalase, Pex14, and PMP70. The phenotype was defined as pexophagy, because 2,2-DP induced autophagy and inhibition of autophagy significantly reduced the degree of peroxisome degradation. Mechanistically, 2,2-DP-dependent pexophagy seemed to be mediated by iron chelation, since another iron chelator displayed a similar effect on pexophagy, but a copper chelator did not. Notably, iron replenishment prevented 2,2-DP-mediated pexophagy. Taken together, our results suggest that 2,2-DP treatment disrupts peroxisome dynamics and promotes pexophagy through iron depletion.
    No preview · Article · Dec 2015 · Biochemical and Biophysical Research Communications
  • Lida Heng · Gyun Eui Yang · Rui Wang · Min Soo Kim · Sang Don Mun
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    ABSTRACT: The Magnetic abrasive finishing (MAF) process is a surface finishing technique in which a magnetic field is used to control abrasive particles during surface finishing of a material. Because smooth surfaces are required for general use, the magnetic abrasive finishing process was developed for finishing surfaces. We studied the effect of CNT particles on the surface roughness of a workpiece. Magnesium alloy bars were used as the cylindrical workpiece and were finished using an MAF process at high workpiece revolution speeds of 1000, 5000, 10000 and 25000 rpm; diamond pastes with diameters of 0.5, 1, and 3 μm were used for comparison. The best value for surface roughness was equivalent to treatment at 0.02 μm when 0.01 g of CNT particles was mixed together with the unbonded magnetic abrasive at 25000 rpm for 20 seconds. CNT particles were applied to the finishing process to improve the surface roughness of the material, because they have many advantageous properties such as very high strength, light weight, elasticity, and high thermal and air stability. CNT particles are particularly effective for the improvement of Mg alloy bar surface roughness in the MAF process. © 2015, The Korean Society of Mechanical Engineers and Springer-Verlag Berlin Heidelberg.
    No preview · Article · Dec 2015 · Journal of Mechanical Science and Technology
  • Syahrizal Muttakin · Min Soo Kim · Dong-Un Lee
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    ABSTRACT: The effects of jet-milling on the physicochemical and sensorial properties of defatted soybean flour (DSF) were investigated. Superfine DSF powder (DSF-JM; D50=4.3±0.1μm) was prepared from DSF powder (DSF-150; D50=257.0±1.7μm) via conventional sifting followed by jet-milling. The jet-milled DSF showed significant increases in hydration properties, with increases in the water-holding capacity, water-solubility index, and swelling capacity of 24%, 39%, and 32%, respectively. Soluble dietary fibre and fat-binding capacity of DSF-JM also increased significantly (p<0.05). A quantitative descriptive analysis by trained panelists indicated that the sensorial properties of DSF were also modified by jet milling. The DSF-JM showed significant reductions in bitterness and roughness, but sweetness increased, and the colour of DSF-JM changed to a brighter achromatic colour. These results indicate that superfine DSF could be an ingredient used to modify physical and sensorial properties of food. Copyright © 2015. Published by Elsevier Ltd.
    No preview · Article · Nov 2015 · Food Chemistry
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    ABSTRACT: Objectives In light of the need to develop an integrated database on poisoning incidents in Korea, this study seeks to determine the characteristics of poisoning incidents in Korea by age, gender, location of incident, causative substance and patient prognosis. Data sources The Korea National Hospital Discharge In-Depth Injury Survey results (2005–2009) from the Korea Centers for Disease Control and Prevention were used. Participants 3826 participants in the survey who had been hospitalised for poisoning incidents. Results The poisoning hospitalisation rate per 100 000 population was higher in women (1.735) than in men (1.372) and increased with age: the rate was 0.458 among individuals aged ≤9 years, 0.481 among those aged 10–19 years, 1.584 among those aged 20–64 years and 4.053 among those aged ≥65 years. The intentional poisoning hospitalisation rate differed by gender and age group. Women aged ≤19 years and 20–64 years showed a higher hospitalisation rate than men, while men aged ≥65 years showed a higher hospitalisation rate than women in the same age group. The most common poisoning substance was pesticides (33.6%), while antiepileptic, sedative-hypnotic and antiparkinsonism drugs and psychotropic drugs, not elsewhere classified were also very common. Poisoning in those aged ≤9 years usually involved other drugs, while pesticides were the most common substances in those aged 20–64 years and ≥65 years. Conclusions This study analysed poisoning incidents in Korea from 2005 to 2009, by age and gender, causative substance, and characteristics. The results of this study may serve as evidence for new strategies in Korea to prevent poisoning.
    Preview · Article · Nov 2015 · BMJ Open
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    Min Soo Kim · Won Sung Lee · Joon Jeong · Seong-Jin Kim · Wook Jin
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    ABSTRACT: In metastatic breast cancers, the acquisition of metastatic ability, which leads to clinically incurable disease and poor survival, has been associated with acquisition of epithelial-mesenchymal transition (EMT) program and self-renewing trait (CSCs) via activation of PI3K/AKT and IL6/JAK2/STAT3 signaling pathways. We found that TrkB is a key regulator of PI3K/AKT and JAK/STAT signal pathway-mediated tumor metastasis and EMT program. Here, we demonstrated that TrkB activates AKT by directly binding to c-Src, leading to increased proliferation. Also, TrkB increases Twist-1 and Twist-2 expression through activation of JAK2/STAT3 by inducing c-Src-JAK2 complex formation. Furthermore, TrkB in the absence of c-Src binds directly to JAK2 and inhibits SOCS3-mediated JAK2 degradation, resulting in increased total JAK2 and STAT3 levels, which subsequently leads to JAK2/STAT3 activation and Twist-1 upregulation. Additionally, activation of the JAK2/STAT3 pathway via induction of IL-6 secretion by TrkB enables induction of activation of the EMT program via induction of STAT3 nuclear translocation. These observations suggest that TrkB is a promising target for future intervention strategies to prevent tumor metastasis, EMT program and self-renewing trait in breast cancer.
    Preview · Article · Oct 2015 · Oncotarget
  • Eunjin Jung · June Key Lee · Min Soo Kim · Hyunsoo Kim
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    ABSTRACT: The leakage current of GaN-based light-emitting diodes (LEDs) was analyzed with a parasitic diode model. Arrhenius plots of forward leakage currents revealed that the threshold voltages of the main diode and the parasitic diode were 2.64 and 0.94 V, respectively. The parasitic diode, however, led to an insignificant change in the reverse leakage mechanism, e.g., a predominant reverse leakage mechanism was Poole–Frenkel conduction in the high-temperature range (>300 K) and the variable range hopping in the low-temperature range (<300 K), as reported previously. The origin of the parasitic diode could be due to the incorporated hydrogen (H) atoms into the top LEDs layers, presumably enhancing the defect-assisted tunneling through the generated H-related deep-level states, particularly generated in the p-cladding or p-AlGaN electron blocking layer.
    No preview · Article · Oct 2015 · IEEE Transactions on Electron Devices
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    ABSTRACT: Conversion of fibroblasts to functional cardiomyocytes represents a potential approach for restoring cardiac function after myocardial injury, but the technique thus far has been slow and inefficient. To improve the efficiency of reprogramming fibroblasts to cardiac-like myocytes (iCMs) by cardiac transcription factors [Gata4, Hand2, Mef2c, and Tbx5 (GHMT)], we screened 192 protein kinases and discovered that Akt/protein kinase B dramatically accelerates and amplifies this process in three different types of fibroblasts (mouse embryo, adult cardiac, and tail tip). Approximately 50% of reprogrammed mouse embryo fibroblasts displayed spontaneous beating after 3 wk of induction by Akt plus GHMT. Furthermore, addition of Akt1 to GHMT evoked a more mature cardiac phenotype for iCMs, as seen by enhanced polynucleation, cellular hypertrophy, gene expression, and metabolic reprogramming. Insulin-like growth factor 1 (IGF1) and phosphoinositol 3-kinase (PI3K) acted upstream of Akt whereas the mitochondrial target of rapamycin complex 1 (mTORC1) and forkhead box o3 (Foxo3a) acted downstream of Akt to influence fibroblast-to-cardiomyocyte reprogramming. These findings provide insights into the molecular basis of cardiac reprogramming and represent an important step toward further application of this technique.
    No preview · Article · Sep 2015 · Proceedings of the National Academy of Sciences
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    ABSTRACT: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with ondansetron can experience PONV. In this study, we investigated whether the Y129S and -100_-102AAG deletion polymorphisms of the 5-HT3B receptor gene affect the efficacy of ondansetron in preventing PONV. Two hundred and forty-five adult patients who underwent laparoscopic cholecystectomy were enrolled. Ondansetron 0.1 mg/kg was intravenously administered 30 minutes before the end of surgery. Genomic DNA was prepared from blood samples using a nucleic acid isolation device. Both the Y129S variant and the -100_-102AAG deletion variant were screened for using a single base primer extension assay and a DNA direct sequencing method, respectively. The relationship between genetic polymorphisms and clinical outcomes of ondansetron treatment was investigated. Among the 5-HT3B AAG deletion genotypes, the incidence of PONV was higher in patients with the homomutant than with other genotypes during the first 2 hours after surgery (p=0.02). There were no significant differences in the incidence of PONV among genotypes at 2-24 hours after surgery. In the Y129S variants of the 5-HT3B receptor gene, there were no significant differences in the incidence of PONV among genotypes during the first 2 hours and at 2-24 hours after surgery. The response to ondansetron for PONV was significantly influenced by the -100_-102AAG deletion polymorphisms of the 5-HT3B gene. Thus, the -100_-102AAG deletion variants may be a pharmacogenetic predictor for responsiveness to ondansetron for PONV.
    Preview · Article · Sep 2015 · Yonsei medical journal
  • Jun Hee Go · Yong Hwa Lim · Min Soo Kim · In Sung Jang

    No preview · Article · Aug 2015
  • Han Sol Jang · Jun Hee Go · Min Soo Kim · In Sung Jang

    No preview · Article · Aug 2015
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    ABSTRACT: The Resource Description Framework (RDF) is widely used for sharing biomedical data, such as gene ontology or the online protein database UniProt. SPARQL is a native query language for RDF, featuring regular expressions in queries for which exact values are either irrelevant or unknown. The use of regular expression indexes in SPARQL query processing improves the performance of queries containing regular expressions by up to two orders of magnitude. In this study, we address the update operation for regular expression indexes in RDF databases. We identify major performance problems of straightforward index update algorithms and propose a new algorithm that utilises unique properties of regular expression indexes to increase performance. Our contributions can be summarised as follows: (1) we propose an efficient update algorithm for regular expression indexes in RDF databases, (2) we build a prototype system for the proposed algorithm in C++ and (3) we conduct extensive experiments demonstrating the improvement of our algorithm over the straightforward approaches by an order of magnitude.
    No preview · Article · Aug 2015 · International Journal of Data Mining and Bioinformatics
  • Min Soo Kim · Kyung Hee Kim · Seok Jin Kwon

    No preview · Article · Jul 2015
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    ABSTRACT: It is widely believed that effective communication is critical for the containment of the spread of emerging infectious diseases. Various media outlets and studies have pointed out communication failure as one of the key components that contributed to the wide and rapid spread of Middle East respiratory syndrome coronavirus in South Korea. To address these concerns, we first outline the definitions of risk and crisis communication and why they are important. We then illustrate communication models and guidelines utilized in three organizations (World Health Organization, US Centers for Disease Control and Prevention, and UK Public Health England) for health or disaster control. By analyzing the current guidelines for infectious diseases in South Korea and they were actually applied during the Middle East respiratory syndrome situation, we will assess what went wrong and what went right. Finally, we will suggest various measures that will help to ensure similar tragedies do not happen again.
    Preview · Article · Jul 2015 · Journal of the Korean Medical Association

Publication Stats

2k Citations
635.43 Total Impact Points

Institutions

  • 2010-2016
    • Chonnam National University
      • • College of Natural Sciences (CNS)
      • • Division of Food and Nutrition
      • • Department of Anatomy
      Gwangju, Gwangju, South Korea
    • Inje University Paik Hospital
      Sŏul, Seoul, South Korea
  • 2015
    • Albert Einstein College of Medicine
      • Diabetes Research Center
      New York, New York, United States
    • Daejeon University
      Daiden, Daejeon, South Korea
    • The California Institute for Biomedical Research
      San Diego, California, United States
    • Wonkwang University
      Riri, Jeollabuk-do, South Korea
  • 2014-2015
    • University of Texas Southwestern Medical Center
      • Department of Clinical Sciences
      Dallas, Texas, United States
    • Chonbuk National University
      • Department of Mechanical Design Engineering
      Tsiuentcheou, Jeollabuk-do, South Korea
    • Sungkyunkwan University
      Sŏul, Seoul, South Korea
  • 2011-2015
    • Chung-Ang University
      • • School of Food Science and Technology
      • • College of Pharmacy
      Sŏul, Seoul, South Korea
    • Inha University
      • Department of Mechanical Engineering
      Sŏul, Seoul, South Korea
  • 2009-2015
    • Korea University
      • Department of Chemical and Biological Engineering
      Sŏul, Seoul, South Korea
  • 2002-2015
    • Yonsei University
      • • College of Dentistry
      • • Department of Mechanical Engineering
      • • College of Medicine
      Sŏul, Seoul, South Korea
    • Kookmin University
      Sŏul, Seoul, South Korea
  • 1999-2015
    • Korea Advanced Institute of Science and Technology
      • • Department of Computer Science
      • • Department of Biological Sciences
      • • Department of Materials Science and Engineering
      Daiden, Daejeon, South Korea
  • 1994-2015
    • Seoul National University
      • • Department of Food and Nutrition
      • • School of Mechanical and Aerospace Engineering
      • • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
  • 2012-2014
    • Dankook University
      • Institute of Tissue Regeneration Engineering (ITREN)
      Eidō, Chungcheongbuk-do, South Korea
    • Seoul National University Bundang Hospital
      • • Department of Anaesthesiology and Pain Medicine
      • • Department of Pathology
      Sŏul, Seoul, South Korea
    • Inje University
      • Department of Medicine and Premedicine
      Kŭmhae, Gyeongsangnam-do, South Korea
  • 2008-2014
    • Hankuk University of Foreign Studies
      • Department of Bioscience and Biotechnology
      Sŏul, Seoul, South Korea
    • Ajou University
      Sŏul, Seoul, South Korea
    • National Medical Center
      Sŏul, Seoul, South Korea
    • Korea Institute of Radiological & Medical Sciences
      Sŏul, Seoul, South Korea
    • Sogang University
      • Department of Chemistry
      Sŏul, Seoul, South Korea
    • University of California, Berkeley
      Berkeley, California, United States
    • University of Seoul
      Sŏul, Seoul, South Korea
  • 2007-2014
    • Hallym University
      • Department of Food Science and Nutrition
      Sŏul, Seoul, South Korea
    • Catholic University of Korea
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2005-2014
    • Chungnam National University
      • College of Pharmacy
      Daiden, Daejeon, South Korea
  • 2013
    • San Diego State University
      San Diego, California, United States
  • 2012-2013
    • Georgia Institute of Technology
      • School of Electrical & Computer Engineering
      Atlanta, Georgia, United States
  • 2010-2013
    • Gachon University
      • Lee Gil Ya Cancer and Diabetes Institute
      Sŏngnam, Gyeonggi-do, South Korea
    • CHA University
      • Department of Neurosurgery
      Sŏul, Seoul, South Korea
  • 2009-2013
    • Hanyang University
      • • School of Business
      • • College of Medicine
      Sŏul, Seoul, South Korea
    • Korea Electrotechnology Research Institute-KERI
      Tsau-liang-hai, Busan, South Korea
  • 2003-2013
    • Yeungnam University
      • • Department of Neurosurgery
      • • Department of Electronic Engineering
      Gyeongsan, Gyeongsangbuk-do, South Korea
  • 2010-2012
    • Keimyung University
      • Dongsan Medical Center
      Sŏul, Seoul, South Korea
  • 2007-2012
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2008-2010
    • Dongguk University
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Toyohashi University of Technology
      • Department of Electrical and Electronic Information Engineering
      Toyohasi, Aichi, Japan
  • 2008-2009
    • Kangwon National University
      • College of Pharmacy
      Shunsen, Gangwon, South Korea
    • National Cancer Center Korea
      QYK, Gyeonggi-do, South Korea
  • 2004-2009
    • Korea Research Institute of Bioscience & Biotechnology KRIBB
      • Chemical Biology Research Center
      Anzan, Gyeonggi Province, South Korea
  • 2004-2008
    • Pusan National University
      • Department of Polymer Science and Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2006-2007
    • Pohang University of Science and Technology
      • Department of Mechanical Engineering
      Geijitsu, Gyeongsangbuk-do, South Korea
  • 2002-2006
    • Samsung Advanced Institute of Technology
      Usan-ri, Gyeonggi Province, South Korea