M Delcroix's scientific contributionswhile working at Hôpital Saint Philibert, Ломм, Nord-Pas-de-Calais, France and other institutions

Publications (26)

Publications citing this author (135)

    • IgM and IgA antibodies increase in parallel. Several reports have indicated the role that specific IgA plays in the acute infection process (Decoster et al., 1988; Huskinson et al., 1990; Stepick-Biek et al., 1990; Decoster et al., 1992; Gross et al., 1992; Saathoff and Seitz 1992; Gross et al., 1993). During the course of toxoplasmosis infection, the kinetics of IgA antibodies are similar to those displayed by IgM antibodies (Decoster et al., 1988; Wong and Remington, 1994;); therefore, joint detection of IgA and IgM antibodies may be useful regardless of whether it may be discriminated at the expense of which antibody of reaction proved positive.
    Full-text · Article · Nov 2013
    • Using the confidence interval method enabled us to determine the levels of neopterin concentration in human breast milk obtained at various times after delivery. In the first of a small number of reports on the breast milk content of neopterin, Dhondt et al. [23] revealed that 1 week after delivery, the concentration of this compound was equal to 15.8±7.4 nmol/L, thus being similar to the level observed in our study during the initial stage of lactation.
    [Show abstract] [Hide abstract] ABSTRACT: The aim of this work was to determine the physiological level of neopterin in human breast milk, and to study its variability depending on the duration of a single feeding and the lactation stage. Breast milk samples from 74 women were collected between 2 and 4 days after delivery, and at 15, 30, and 90 days after delivery. Additionally, breast milk samples from eight women were collected before and after 7 and 15 min of breastfeeding. The concentration of neopterin in breast milk was determined by an immunoenzymatic assay. The range of breast milk neopterin concentration at various stages of lactation amounted to 15.4–19.2 nmol/L at 2–4 days after delivery, 20.2–23.0 nmol/L at day 15, 20.8–24.5 nmol/L at day 30, and 16.9–20.4 nmol/L at day 90. The level of neopterin 2–4 days after delivery was significantly lower than that at days 15 and 30; moreover, the concentration of neopterin at day 30 was significantly higher than that at day 90. No significant differences were documented between neopterin concentrations at various phases of a single feeding. While the breast milk concentration of neopterin changes depending on the stage of lactation, it remains stable throughout a single feeding.
    Full-text · Article · Jan 2015
    • Despite the theoretical risk of bleeding, these studies failed to demonstrate an increased incidence of hemorrhage. At the end of 1980s and in 1990, especially in European countries, some authors were considering the use of heparin for the treatment of HELLP syndrome [11,12] in the attempt to interrupt the progression of the compensated consumption coagulopathy. In addition , Rathgeber et al. [13], in 1990, suggested that heparin could be a valuable tool to trap the excess coagulation which is present in preeclampsia and in HELLP syndrome.
    [Show abstract] [Hide abstract] ABSTRACT: HELLP syndrome is a severe complication of pregnancy characterized by microangiopathic hemolytic anemia, hepatic dysfunction and thrombocytopenia. Though delivery is the ultimate therapeutic option, medical treatments, including the use of heparin or corticosteroids, have been employed in the attempt to improve maternal prognosis. The aim of this retrospective study was to compare the time course of recovery and the incidence of complications in women with HELLP syndrome receiving either heparin or dexamethasone. Between January 1990 and December 1998, 32 patients with HELLP syndrome were cared for at the Institute of Obstetrics and Gynecology of the University of Florence: 20 patients were treated with heparin, administered subcutaneously at a dose of 5000 IU every 12 h, whereas 12 women received dexamethasone, administered intravenously at a dose of 10 mg every 12 h. Categorical data were evaluated with chi-square and Fisher's exact test; continuous data were analyzed with Mann–Whitney U test; P<.05 was considered significant. In the subgroup treated with heparin the incidence of disseminated intravascular coagulation (DIC) (P<.02), the number of patients requiring blood transfusion (P<.05) and the length of stay at the Intensive Care Unit (ICU) (P<.04) were significantly increased as compared with the subgroup receiving dexamethasone; in this latter subgroup, significantly higher platelet count and hematocrit values, and significantly lower levels of lactate dehydrogenase (LDH) could be documented starting from day 2 after delivery. The results of our investigation suggest that the use of dexamethasone in patients with HELLP syndrome is associated with faster regression and lower incidence of complications in comparison to heparin.
    Full-text · Article · Apr 2001
    • Compared to adults, infants harbor an intestinal microbiota (i.e., the assemblage of microorganisms which occupy the gut) that is transient and minimally complex [4, 5]. A number of factors are known to influence the microbial composition within the infant gut including age678, mode of delivery [9, 10], diet111213, antibiotic use141516, and disease [17, 18] , making it difficult to delineate their respective effects. An important function of the microbiota beyond digestion and metabolism is to prevent the propagation of pathogenic microorganisms192021.
    [Show abstract] [Hide abstract] ABSTRACT: Background Infant botulism is the most prevalent form of botulism in the USA, representing 68.5 % of cases reported from 2001–2012. Infant botulism results when botulinum toxin-producing clostridia (BTPC) colonize the infant gut with concomitant in vivo production of the highly potent botulinum neurotoxin (BoNT). The gut microbiota of infants with botulism is largely uncharacterized; therefore, it remains unclear whether the microbiota profile of these patients are distinct in composition, abundance, or diversity. To address this uncertainty, we employed 16S rRNA gene profiling to characterize the fecal microbiota in 14 stool samples among laboratory-confirmed and non-confirmed infant botulism cases. Results Seven bacterial phyla were identified among all 14 infant stool samples examined. Compared to samples from non-confirmed cases, the fecal microbiota of infant botulism patients displayed significantly higher Proteobacteria abundance. Of the 20 bacterial families identified, Enterobacteriaceae was significantly more abundant in samples from infants with botulism. Firmicutes abundance and the abundance ratio of Firmicutes/Proteobacteria was significantly lower in samples from infants with botulism. Lactobacillus spp. abundance was notably reduced in 12 of the 14 samples. Clostridium botulinum and Clostridium baratii were identified in low relative abundances in confirmed and non-confirmed samples based on their 16S rRNA gene profiles, although their toxigenicity remained undetermined. No significant differences were observed in the number of operational taxonomic units (OTUs) observed or in fecal microbiota diversity between laboratory-confirmed and non-confirmed samples. Correlations between individual phylum abundances and infant age were variable, and no significant differences were shown in number of OTUs observed or in fecal microbiota diversity between samples delineated by overall mean age. Conclusions Significant differences in Proteobacteria, Firmicutes, and Enterobacteriaceae abundances were identified in the fecal microbiota of infants with botulism when compared to samples from non-confirmed cases. Fecal microbiota diversity was not significantly altered in infants with botulism, and a limited presence of BTPC was shown. It could not be determined whether the fecal microbiota profiles shown here were comparable prior to patient illness, or whether they were the direct result of infant botulism. The results of this study do, however, provide a detailed and descriptive observation into the infant gut microbiota after intestinal colonization by BTPC.
    Full-text · Article · Dec 2015