T Erbengi

Akdeniz University, Antalya, Antalya, Turkey

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Publications (27)42.17 Total impact

  • T. Erbengi · F. Sevilen · E. Sencer · A. Bilir · R. Demir
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    ABSTRACT: Summary Summary The ultrastructure of the placenta at 8 weeks' gestational age from intra-uterine (normal and an anembryonic pregnancy), a spontaneous tubal ectopic pregnancy and an ‘artificial' tubal ectopic pregnancy occurring after intraperitoneal insemination with husband's washed capacitated spermatozoa, was compared. Poorly developed chorionic villus epithelium and reduced stromal differentiation in an anembryonic intra-uterine pregnancy shows the importance of the embryo for placental development. In a spontaneous ectopic pregnancy chorionic villous epithelium and cellular differentiation with vasculogenesis in the stroma did not show the same developmental capacity as normal intrauterine pregnancies. Electron microscope observations showed close similarity between normal intra-uterine and an artificial tubal pregnancy. Husband's washed capacitated spermatozoa may affect placenta development beneficially.
    No preview · Article · Jul 2009 · Journal of Obstetrics and Gynaecology
  • R. Demir · N. Demir · İ. Üstünel · İ. Tirak · T. Erbengi
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    ABSTRACT: Summary The development of chorionic villus trees emerging from the chorionic plate in early intra-uterine and tubal pregnancy was studied by scanning electron microscopy. Early human placental samples between 4 and 10 weeks of pregnancy were obtained from legal abortions and hysterectomies. The chorionic villus trees which emerge from the chorionic plate divide gradually into branches of which ramify as buds. These buds gradually grow and are transformed into shoots. The numbers of developing new villi appears to increase gradually from 28 days after conception to 12 weeks after the last menstrual period. From 4 weeks massive trophoblastic sprouts were observed on the surface of the main chorionic villi, which transform into primary, secondary and tertiary villus trees. When placental villus formation in ectopic pregnancy was compared with intra-uterine pregnancy, no fundamental difference was observed. In ectopic pregnancy, the configurations of placental villi were compressed and also shrunken on three-dimensional analysis. The ramifications and new villus formation seen in normal placenta were decreased in magnitude and less frequent. Some placental villus samples displayed gradual thinning in the terminal region.
    No preview · Article · Jul 2009 · Journal of Obstetrics and Gynaecology
  • R. Demir · M. Üner · T. Erbengi · M. Kaya
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    ABSTRACT: Placental villi from all three trimesters of pregnancy, from 60 non-smoking women and 171 who smoked cigarettes were examined. Numbers of syncytial knots increased and syncytial buds decreased as pregnancy proceeded. More vascular-syncytial membranes and less Hofbauer cells and Langhans cells were present in the second and third trimesters. Numbers of avascular villi and cell islands diminished through pregnancy. In the smokers, in the third trimester, syncytial knots were increased, and syncytial buds decreased; there were less vasculo-syncytial membranes. Hofbauer cells were decreased and Langhans cells increased in the smokers. By electron microscopy, the villi from smokers had abnormalities of the microvilli, focal syncytial necrosis, decreased syncytial pinocytotic activity, thickening of the syncytial coarse and smooth endoplasmic reticulum, and thickening of the trophoblastic basal lamina. There was increased collagen in the villous stroma and degenerative epithelial changes in the fetal capillaries, in the smokers.
    No preview · Article · Jul 2009 · Journal of Obstetrics and Gynaecology
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    ABSTRACT: We investigated the effects of percutaneous gasserian glycerol injection in dogs and reviewed the histopathological changes. Experiments were performed in 16 adult healthy mongrel dogs. In group 1 (8 dogs) normal saline and in group 2 (8 dogs) pure glycerol was injected in the right trigeminal ganglion. After these procedures, dogs in each group were sacrificed after 24 h (3 dogs), 7 days (3 dogs), 21 days (2 dogs). The trigeminal ganglion and nerve of both sides were removed by using microsurgical techniques and examined by light and electron microscopy. Group 1: in all sections, nerve cells, myelinated and nonmyelinated fibers revealed normal patterns with slight fibrosis. Group 2: in all sections, myelinated fibers showed disintegration and swelling of the myelin sheath, rupture of axon continuity, destruction of basal lamina, deformation of the myelin-axon relationship by both light microscopy and electron microscopy. The sections examined by electron microscopy also showed axonolysis in nonmyelinated fibers. The changes after 7 and 21 days were less prominent than after 24 h. In the left sides, there are no pathological changes. Glycerol has a neurolytic effect on the dog's trigeminal ganglion. These effects were not specific and selective for myelinated and nonmyelinated nerve fibers.
    No preview · Article · Feb 2002 · Stereotactic and Functional Neurosurgery
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    ABSTRACT: Cerebral vasospasm after subarachnoid hemorrhage (SAH) has remained a major cause of morbidity and mortality in patients with SAH. Excitatory neurotransmitters are gathered in the extracellular space during ischemia due to cerebral vasospasm and initiate or stimulate a series of pathophysiological biochemical processes which consequently lead to neuronal death. Tizanidine (Sandoz compound DS 103-282, 5-chloro-4,2 (2-imidazolin-2-yl-amino)-2,1,3-benzothiazol hydrochloride) is a centrally-acting muscle relaxant and a selective alpha 2 adrenoreceptor agonist which shows its effect by stimulating presynaptic alpha 2 adrenoreceptors in central ASPergic and GLUergic system by inhibiting aspartic acid and glutamic acid release. In this study, the effect of Tizanidine on vasospasm was evaluated. We used a femoral artery vasospasm model in rats which has been described by Okada et al. 60 rats were examined in three groups. The first group was used as control group (Control) (n = 20), in the second group subarachnoid hemorrhage was performed (SAH) (n = 20), in the third group Tizanidine was administered in addition to SAH (SAH + Tizanidine administration) (n = 20). Animals in SAH + Tizanidine administration group received 0.3 mg/kg/day intraperitoneally for 7 days. Seven days after the experiment, after perfusion-fixation, 10 mm segments of both femoral arteries were removed and the femoral artery was prepared for light microscope examination, scanning and transmission electron microscopy and for morphometric analysis. There was a statistically significant difference between the electron, scanning and light microscopic observations and morphometric analysis of SAH + Tizanidine administration group and SAH group, and no statistically significant difference between SAH + Tizanidine administration group and control group. This study has disclosed that Tizanidine administration before the vasospasm reduces ultrastructural and morphometric vasospastic insult significantly. However, the clinical application of Tizanidine as a protective and therapeutic agent in cerebral vasospasm needs further studies including the employment of clinically more relevant SAH models.
    No preview · Article · Feb 2000 · Acta Neurochirurgica

  • No preview · Article · Jan 2000 · Acta Neurochirurgica
  • Nejat Isik · Pamir MN · Benli K · Erbengi A · Erbengi T · Ruacan Ş

    No preview · Conference Paper · May 1995
  • R Demir · N Demir · I Ustunel · T Erbengi · I Trak · P Kaufmann
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    ABSTRACT: The aim of this study was to examine the development of chorionic villous trees during early periods of normal intrauterinal and ectopic (tubal) pregnancies, and to study the structural specializations on the free surface of mature placental villi by scanning and transmission electron microscope (SEM and TEM). In order to study the structures of placental villi between 28 and 34 days old (pc), early, 6-8 week normal and ectopic, and full term human placenta samples were obtained from legal curettage and hysterectomized cases, and spontaneous deliveries, and tissues samples were prepared for SEM and TEM. Three-dimensional configurations of the developing chorionic villous trees were observed as large main villus groups, covered with abundant microvilli of different size and diameters. It appeared that the chorionic villous trees which emerged from the chorionic plate divided gradually into branches of which ramifications originated as buds. These buds gradually grew and were transformed into shoots. The number of developing new villi appeared to increase gradually from 28 days to 9 weeks (pm) of gestation. From the 4th week onwards the massive trophoblastic sprouts were observed on the surface of main chorionic villi which transformed into primary, secondary and tertiary villous trees. When the placental villi formation in ectopic pregnancy was compared with the intra-uterinal pregnancy, an arrested development was remarkable. The configurations of ectopic placental villi seemed to be disparate, such as curved lines or compressed and wrinkled positions so that the three dimensional aspect had been wizened. The ramification and new villi formation seen as in the normal placenta were not only decreased but also infrequent. Some placental villi samples displayed a gradually thinning terminal region. Trophoblastic degenerations were frequently found on the surface of ectopic villi ultrastructurally. According to these results, we comment that in ectopic pregnancy the placental villi formation and development could have been delayed. At term, some specialized structural modifications were observed on the free surface of the mature placental villi. The presence of some dome-like balloonings and many crateriform hollows were the most striking features of the mature intermediate and terminal villi. According to the increasing physiological needs of the growing fetus, these special structures that are related to lung-like and kidney-like functions and named "nephropneumonic-like units", formed in the mature placental barrier. We have observed that these special units were showing a smooth surface similar to an inflated balloon.(ABSTRACT TRUNCATED AT 400 WORDS)
    No preview · Article · May 1995 · Zentralblatt für Pathologie
  • R. Demir · Ayse Demir · T. Erbengi
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    ABSTRACT: Placental tissue was obtained from normal full term pregnancies. Septal cells derived from decidua and trophoblast were investigated by electron microscopy. Intranuclear inclusions were found to form in typical decidual cells. The precursors of the inclusions, near the centre of the nuclei, were round in shape and button-like. During the decidual cell degeneration, there appeared to be five stages: (a) formation and maturation of intranuclear particle complexes; (b) alteration of nuclear chromatin and cytoplasmic organelles; (c) degeneration of nuclear and cytoplasmic structures; (d) intranuclear inclusion formation and their migration to cytoplasm; and (e) cell degeneration and death. During cell aging and degeneration: (a) the cytoplasmic membrane line along the cell border ruptured; (b) cytoplasm flaps covering the irregular cell surface formed; (c) intranuclear chromatin degenerated and cell organelles ruptured and disintegrated; (d) large dispersed vesicles and small vesicles and semi-dense and amorphous material formed.
    No preview · Article · Mar 1995 · Journal of Obstetrics and Gynaecology
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    ABSTRACT: Proliferative angiopathy represents the morphological basis of delayed cerebral vasospasm. The initial vasoconstriction and endothelial damage of the vasospastic arteries leads to an exaggerated response of the smooth muscle cells within the media leading to subintimal thickening and myonecrosis. Heparin reduces the exposure of the media to platelet derived growth factor, a mitogen from aggregating platelets responsible for the migration and proliferation of the myofibroblasts. Since systemic heparin in the setting of a subarachnoid haemorrhage would be unacceptable, we have tested the effect of heparin on proliferative angiopathy by injecting autologous non-heparinized blood into two groups of rats (N=12 each) and then inject the heparin into the spinal fluid of one group after one hour. We were able to show histologically that intracisternal heparin injection after the subarachnoid haemorrhage has reduced the vascular wall changes to a great degree. Heparinization of the cerebrospinal fluid carried out in conjunction with early operation for aneurysms may be a promising approach to prevent the morbid complications of SAH in the clinical setting.
    Full-text · Article · Feb 1994 · Acta Neurochirurgica
  • Y. Gedikoglu · A. Çolak · K. Benli · T. Erbengi
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    ABSTRACT: The reactions of periventricular tissue of the lateral ventricle to non-infected and infected (Staphylococcus Epidermidis) silicone shunt tubing were examined by light and transmission electron microscopy. It was shown that reactive changes occurred in periventricular tissue in response to the implant of sterile shunt tubing. On the other hand in infected implanted silicone shunt tubing, proliferation of inflammatory cells within the ventricle and periventricular tissue, loss of integrity of the ependyma, glial cell proliferation, and excessive extracellular oedema were demonstrated. Proliferation of ependymal cells combined with inflammatory responses may be a factor in the pathogenesis of infected shunt obstruction.
    No preview · Article · Aug 1993 · Acta Neurochirurgica
  • R DEMIR · T ERBENGI · N DEMIR · M ELIBOL

    No preview · Article · Jul 1993 · Placenta
  • Y Gedikoğlu · A Colak · K Benli · T Erbengi
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    ABSTRACT: In this study, the efficacy of ampicillin/sulbactam combination in reactions of periventricular tissue of the lateral ventricle induced by the presence of infected (Staphylococcus epidermidis) silicone rubber shunt tubing was examined by using light and scanning electron microscopy. It was demonstrated that reactive changes to implants had occurred in periventricular tissue in the control group. In infected shunt tubing without given prophylactic antibiotic group, generalized meningitis and ventriculitis, loss of integrity of ependymal cells, numerous inflammatory cells, bacterial colonies, exuda and even pus were seen. It was also shown that rarely inflammatory reactions, minimal disintegration of ependymal cells, no bacterial colonies, and phagocytes were present in the group which was given prophylactic ampicillin/sulbactam combination per and postoperatively. We think that ampicillin/sulbactam combination is very effective in prevention and treatment of shunt infections.
    No preview · Article · Apr 1993 · Journal of neurosurgical sciences
  • M N Pamir · T A Zirh · M M Ozek · Aydin Sav · Canan Erzen · Türkan Erbengi
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    ABSTRACT: Idiopathic giant cell granulomatous hypophysitis is a rare disorder of pituitary gland characterised by a chronic inflammatory process. It can also be an extremely rare cause of hyperprolactinaemia. In this paper, we present our experience with two cases of idiopathic giant cell granulomatous hypophysitis manifested by hyperprolactinaemia, and their neuroradiological evaluation including preoperative MRI studies in one of them, and discuss our findings in the light of the literature.
    No preview · Article · Feb 1993 · Neurochirurgia
  • B Açikgöz · T Ozgen · O E Ozcan · S Ruacan · T Erbengi · M Sumnu
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    ABSTRACT: In prolactinoma surgery, especially in macro-adenomas, it is not always possible to remove the tumour totally. Cell remnants may cause a regrowth and continue hypersecretion. In order to find out whether tumour remnants could be destroyed by local application of bromocriptine, a research model has been designed. First, prolactin secreting pituitary tumours, removed during surgery, were implanted bilaterally into the brain tissue of rats. In eight rats, the viability of tumour transplants was proven histopathologically and their prolactin secretion was shown immunocytochemically. In a second step, on eight rats, sterile bromocriptine solution was applied topically to the tumour transplants on one side. The other side served as control. Histopathological examination of these treated tissues revealed fibrosis. Immunocytochemical analysis showed no secretory activity. Ultrastructural investigations also revealed evidence of degeneration of the treated cells. The natural course of the transplanted tumour tissues of the other side, as a control group, was also observed during the same 55-day period.
    No preview · Article · Feb 1993 · Acta Neurochirurgica
  • Y Gedikoglu · A Colak · K Benli · T Erbengi
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    ABSTRACT: The reactions of periventricular tissue of the lateral ventricle to non-infected and infected (Staphylococcus Epidermidis) silicone shunt tubing were examined by light and transmission electron microscopy. It was shown that reactive changes occurred in periventricular tissue in response to the implant of sterile shunt tubing. On the other hand in infected implanted silicone shunt tubing, proliferation of inflammatory cells within the ventricle and periventricular tissue, loss of integrity of the ependyma, glial cell proliferation, and excessive extracellular oedema were demonstrated. Proliferation of ependymal cells combined with inflammatory responses may be a factor in the pathogenesis of infected shunt obstruction.
    No preview · Article · Feb 1993 · Acta Neurochirurgica
  • T Dalkara · R Onur · N Subutay · B Unol · T Kücükali · T Erbengi · T Zileli
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    ABSTRACT: Systemic administration of acute idiopathic demyelinating polyneuropathy (AIDP) immunoglobulins to mice for two weeks resulted in reduced sural nerve action potential amplitudes and reduced (rotarod) motor performance. Electron microscopic examination of the sciatic nerves of the AIDP-immunoglobulin-treated animals revealed loosening of myelin lamellae with widening of interperiod lines and multivesicular disruption of myelin. Vacuolar degeneration was detected in half of the nerves examined by light microscopy. Injection of AIDP-immunoglobulins for three days led to only minor changes, and mice receiving healthy human immunoglobulins showed no abnormalities. These data show that some features of AIDP can be transferred to mice by systemic administration of immunoglobulins and suggest that humoral factors have a pathogenic role in AIDP in addition to cellular factors.
    No preview · Article · Nov 1990 · Neuroreport
  • S Palaoğlu · Aykut Erbengi · Selvi Kaya · Türkan Erbengi · R.Kazim Türker
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    ABSTRACT: The cytoprotective effect of iloprost on the viability and survival of embryonic cortical brain tissue grafts was examined ultrastructurally under light and electron microscopy before and 4 weeks after transplantation surgery. It was shown that neural grafts stored in iloprost solution (50 ng/mL) for 3 hours were more or less in a normal cytoarchitecture compared with saline-preserved grafts. Moreover, it was demonstrated that 4 weeks after transplantation, graft tissues stored in iloprost solution for 3 hours before implantation maintained a successful survival. Thus, a higher cellular population with new vascularization areas and preservation of myelin formation were accepted as a desirable integration of the graft tissue into the host brain tissue. The mechanism of action of iloprost is discussed.
    No preview · Article · Nov 1990 · Surgical Neurology
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    ABSTRACT: SYSTEMIC administration of acute idiopathic demyelinating polyneuropathy (AIDP) immunoglobulins to mice for two weeks resulted in reduced sural nerve action potential amplitudes and reduced (rotarod) motor performance. Electron microscopic examination of the sciatic nerves of the AIDP-immunoglobulin-treated animals revealed loosening of myelin lamellae with widening of interperiod lines and multivesicular disruption of myelin. Vacuolar degeneration was detected in half of the nerves examined by light microscopy. Injection of AIDP-immunoglobulins for three days led to only minor changes, and mice receiving healthy human immunoglobulins showed no abnormalities. These data show that some features of AIDP can be transferred to mice by systemic administration of immunoglobulins and suggest that humoral factors have a pathogenic role in AIDP in addition to cellular factors.
    No preview · Article · Oct 1990 · Neuroreport
  • S Palaoglu · A Erbengi · A Sav · T Erbengi · R K Turker
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    ABSTRACT: The cytoprotective effect of iloprost was studied on isolated embryonic cortical brain tissue grafts of rats, using light and transmission electronmicroscopy. The brain tissue pieces were stored either in saline or 50 ng/ml iloprost solution for 30 minutes, 3, 6, 24 hours at +4 degrees C. It was demonstrated that iloprost significantly protected the neuronal integration of the tissue pieces compared with saline preserved pieces. Tissues preserved in iloprost showed only minimal dissolution of the tissue with minimal extracellular edema only in the later stages of preservation. The mechanism of action of the cytoprotective effect of iloprost is discussed.
    No preview · Article · Apr 1990 · Prostaglandins Leukotrienes and Essential Fatty Acids

Publication Stats

299 Citations
42.17 Total Impact Points

Institutions

  • 1989-2009
    • Akdeniz University
      • • Faculty of Medicine
      • • Department of Histology and Embryology
      Antalya, Antalya, Turkey
  • 1988-2009
    • Istanbul University
      • • Department of Histology & Embryology
      • • Department of Family Medicine (Istanbul Medical Faculty)
      İstanbul, Istanbul, Turkey
    • Istanbul Medical University
      İstanbul, Istanbul, Turkey
  • 1993
    • Balikesir State Hospital
      Hadrianutherae, Balıkesir, Turkey
    • Marmara University
      • Department of Neurosurgery
      İstanbul, Istanbul, Turkey
  • 1990
    • Ankara University
      • Department of Medical Pharmacology
      Engüri, Ankara, Turkey