[Show abstract][Hide abstract] ABSTRACT: The objective of this study is to investigate the pathological changes which occurred in prostatic cancer shortly after the commencement of endocrine therapy.
Fourty-three patients underwent radical prostatectomy immediately after the short term endocrine therapy (treatment period was within one month) and the histological pictures of operative specimens were compared to those obtained from the pretreatment biopsy specimens.
Degenerative changes of cancer cells, such as nuclear and cytoplasmic vacuole, collapse of the cytoplasm and the appearance of naked hyperchromatic nucleus were noticed after the short term endocrine therapy. Especially in the cases which were histologically evaluated to be poorly differentiated in the biopsy specimens, not only degenerative changes but also destruction of cancer nests caused by cell death were observed. The histological effects affected by short term endocrine treatment had no relation to the prognosis, but in the cases of stage D2, the pathological grade judged by post-therapeutic specimens were found to be useful for the prediction of prognosis.
Endocrine therapy induces remarkable pathological changes in prostatic cancer within a very short time after beginning treatment.
Preview · Article · Aug 1996 · Nippon Hinyōkika Gakkai zasshi. The japanese journal of urology
[Show abstract][Hide abstract] ABSTRACT: We reviewed the cases of 14 spinal cord injury (SCI) patients who had been treated with ileal conduit urinary diversion between 1968 and 1990, in order to determine the rate of preservation of their renal function. Late complications, pyelography and renal function were analyzed in these patients. The follow-up period ranged from 3 to 17 years. Late complications (18 in total) occurred in 50% of the patients. Of 18 complications, 7 required surgical correction. Calculi were the most common complication. Postoperative excretory urography was performed for all patients. Of 28 renal units, 24 (85%) showed moderate improvement and remained stable, while 4 (15%) showed progression of the hydronephrosis. However, in all of the damaged kidneys, the existing renal function could be preserved. The serum BUN and creatinine levels remained within the normal range. Follow-up tests were performed periodically. To evaluate the complication rate and the rate of progression of the hydronephrosis, SCI patients were divided into 3 groups, these being Group A, 14 SCI patients with ileal conduit; Group B, 14 SCI patients urinating voluntarily; and Group C, 30 SCI patients with indwelling catheters. The complication rates for each group were 50% (group A), 70% (group B) and 92% (group C). The complication rate was significantly lower in group A than in the other groups. The rate of progression of the hydronephrosis for each group was 15% (group A), 25% (group B) and 12% (group C). The progression of the hydronephrosis occurred with equal frequency within each of these groups. To conclude, these data suggest that ileal conduit urinary diversion is generally useful for lessening the complications encountered by SCI patients.
[Show abstract][Hide abstract] ABSTRACT: We reported two cases of primary sclerosing lipogranuloma in the scrotum. We performed tumor resection in both cases, but in one of the two cases tumor recurrence was observed 7 days after the removal. Sixty-three cases have been reported in our country, and we discuss the diagnosis and treatment with reference to previous reports.
No preview · Article · Mar 1994 · Hinyokika kiyo. Acta urologica Japonica