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ABSTRACT: To investigate modulation of cytokines on biological activities of scar-derived fibroblasts. This study focused on the effects of interleukin-1 (IL-1) on collagen biosynthesis, nucleic acid, and cell organs of fibroblasts. The results showed the IL-1 could reduce not only the collagen synthesis of fibroblasts, but also quantity of nucleic acid. The authors confirm that IL-1 is a cytokine with down-regulation effect on scar formation, and suggest that IL-1 can play an important role in prevention and treatment of scar.